Non-syncytium-inducing HIV type 1 isolated from infected individuals replicates in MT-2 cells.

abstract：:Given the rising HIV incidence in men who have sex with men (MSM) despite repeatedly proven effectiveness of oral HIV pre-exposure prophylaxis, behaviorally congruent periodic dosing strategies, such as dosing microbicides as lubricants, are now in demand. Rectal microbicide gel studies largely administer gels using v...

journal_title：AIDS research and human retroviruses

authors： Shieh EC,Weld ED,Fuchs EJ,Hiruy H,Buckheit KW,Buckheit RW Jr,Breakey J,Hendrix CW

更新日期：2017-08-01 00:00:00

abstract：:The feline immunodeficiency virus (FIV) Rev protein and its cognate sequence the Rev response element (RRE) are essential for virus replication. Thus, the inhibition of either Rev or RRE function can significantly inhibit FIV replication. In the present study, we constructed a ribozyme that targets the RRE sequence an...

journal_title：AIDS research and human retroviruses

authors： Mergia A,Blackwell J,Chari S

更新日期：1997-10-10 00:00:00

abstract：:Despite dramatic reduction of the levels of human immunodeficiency virus type I (HIV-1) virions in blood and seminal plasma of infected patients, highly active antiretroviral therapy (HAART) does not eradicate HIV-1. Three patients, with less than 50 copies/ml of plasma viral RNA, were enrolled in this eradication pro...

journal_title：AIDS research and human retroviruses

authors： Nunnari G,Leto D,Sullivan J,Xu Y,Mehlman KE,Kulkosky J,Pomerantz RJ

更新日期：2005-09-01 00:00:00

abstract：:Extensive studies have been carried out on native Amerindian populations living in French Guiana in an attempt to detect human T cell leukemia virus type 2 (HTLV-2). However, the first strain of this virus identified in this region was not detected in these populations, but in a Brazilian woman of Amerindian origin. C...

journal_title：AIDS research and human retroviruses

authors： Kazanji M,Benoit B,Meddeb M,Meertens L,Marty C,Gessain A,Talarmin A

更新日期：2001-04-10 00:00:00

abstract：:We previously reported that passive transfer of a murine V3-specific monoclonal antibody (BAT123) to hu-PBL-SCID mice challenged with HIV-1LAI confers postexposure protection from infection. The role of the Fc fragment of this antibody as well as the involvement of the complement system in protection were evaluated in...

journal_title：AIDS research and human retroviruses

authors： Gauduin MC,Weir R,Fung MS,Koup RA

更新日期：1998-02-10 00:00:00

abstract：:We analyzed the HIV-1 pol gene from patients in Cape Town to determine the genetic diversity of HIV-1 in the region and to assess the baseline HIV-1 resistance level of treatment-naive patients. Plasma was collected prior to the national antiretroviral therapy (ART) program. RNA was extracted, followed by RT-PCR and a...

journal_title：AIDS research and human retroviruses

authors： Jacobs GB,Laten A,van Rensburg EJ,Bodem J,Weissbrich B,Rethwilm A,Preiser W,Engelbrecht S

更新日期：2008-07-01 00:00:00

abstract：:Chronic hepatitis C virus (HCV) infection is associated with lower serum concentration of low-density lipoprotein (LDL-C), the primary cholesterol metabolite targeted pharmaceutically to modulate cardiovascular risk. Chronic infection with human immunodeficiency virus (HIV) and treatment with antiretrovirals (ARVs) ar...

journal_title：AIDS research and human retroviruses

authors： Townsend K,Meissner EG,Sidharthan S,Sampson M,Remaley AT,Tang L,Kohli A,Osinusi A,Masur H,Kottilil S

更新日期：2016-05-01 00:00:00

abstract：:The purpose of this study was to investigate the mechanism of acquired cellular resistance to AZT, a mechanism that has been described as a potential source of drug resistance in addition to viral mutations. To study this phenomenon the kinetics parameters of thymidine kinase (TK) activity have been defined in CEMazt,...

journal_title：AIDS research and human retroviruses

authors： Antonelli G,Turriziani O,Verri A,Narciso P,Ferri F,D'Offizi G,Dianzani F

更新日期：1996-02-10 00:00:00

abstract：:The advent of antiretroviral treatment (ART) has resulted in a dramatic reduction in AIDS-related morbidity and mortality. However, the emergence and spread of antiretroviral drug resistance (DR) threaten to negatively impact treatment regimens and compromise efforts to control the epidemic. It is recommended that sur...

journal_title：AIDS research and human retroviruses

authors： Cheriro W,Kiptoo M,Kikuvi G,Mining S,Emonyi W,Songok E

更新日期：2015-12-01 00:00:00

abstract：:To better understand the emergence of HIV-1 variants in Barbados and the association with transmission modes, we analyzed phylogenetic relationships and genetic variability among HIV-1 strains collected in 1996 from 36 antiretroviral therapy-naive patients. Only subtype B variants were present in this sampling, based ...

journal_title：AIDS research and human retroviruses

authors： Gittens MV,Roth WW,Roach T,Stringer HG Jr,Pieniazek D,Bond VC,Levett PN

更新日期：2003-04-01 00:00:00

abstract：:DNA vaccines have the potential of giving rise to a potent cell-mediated immune response by inducing intracellular synthesis and subsequent antigenic presentation of encoded antigens. We have tested a DNA vaccine specific for human immunodeficiency virus type 1 (HIV-1) by the injection of animals with expression plasm...

journal_title：AIDS research and human retroviruses

authors： Okuda K,Bukawa H,Hamajima K,Kawamoto S,Sekigawa K,Yamada Y,Tanaka S,Ishi N,Aoki I,Nakamura M

更新日期：1995-08-01 00:00:00

abstract：:Adult T cell leukemia/lymphoma has only rarely been reported in Europe. We aimed to determine the clinical characteristics and outcome of adult T cell leukemia/lymphoma patients in a nonendemic country. Cases of adult T cell leukemia/lymphoma managed at Hospital Universitari Vall d'Hebron, Barcelona, Spain were review...

journal_title：AIDS research and human retroviruses

authors： Lopez-Lerma I,Caballero E,Palacio C,Garcia-Patos V

更新日期：2013-04-01 00:00:00

abstract：:Epidemiological and experimental data suggest that both robust neutralizing antibodies and potent cellular responses play important roles in controlling primary HIV-1 infection. In this study we have investigated the induction of systemic and mucosal immune responses to HIV gp120 monomer immunogen administered intrana...

journal_title：AIDS research and human retroviruses

authors： Bielinska AU,Janczak KW,Landers JJ,Markovitz DM,Montefiori DC,Baker JR Jr

更新日期：2008-02-01 00:00:00

abstract：:Several regulatory sequences have been characterized in the HTLV-I promoter. We report here identification of a sequence element downstream of the transcriptional start site within the first 52 nucleotides of the 5' R region, which acts negatively on the activity of the HTLV-I promoter. Determination of the half-lives...

journal_title：AIDS research and human retroviruses

authors： Montagne J,Jalinot P

更新日期：1995-09-01 00:00:00

abstract：:To investigate the changes of neutralizing antibodies and viruses during simian and human immunodeficiency virus (SHIV) infection, we examined the cross-neutralizing ability of sequential sera from three macaques infected with SHIV, NM-3rN, and analyzed the sensitivity of the reisolate to neutralizing antibodies. Neut...

journal_title：AIDS research and human retroviruses

authors： Miyazaki Y,Kuwata T,Takehisa J,Hayami M

更新日期：2002-04-10 00:00:00

abstract：:HIV prevalence in the Limpopo Province has increased rapidly within the past 10 years, as in other parts of South Africa. Little is known about the genetic and biological properties of HIV circulating in this region including the baseline drug resistance profiles. We therefore collected blood samples from 42 HIV-1-inf...

journal_title：AIDS research and human retroviruses

authors： Bessong PO,Larry Obi C,Cilliers T,Choge I,Phoswa M,Pillay C,Papathanasopoulos M,Morris L

更新日期：2005-01-01 00:00:00

abstract：:The transmembrane envelope (TM) protein gp41 of HIV-1 is an attractive target when designing a vaccine to induce neutralizing antibodies. A few broadly neutralizing antibodies (2F5, 4E10, and 10E8) that target conserved epitopes in the membrane proximal external region (MPER) of gp41 have been isolated from infected i...

journal_title：AIDS research and human retroviruses

authors： Strasz N,Morozov VA,Kreutzberger J,Keller M,Eschricht M,Denner J

更新日期：2014-05-01 00:00:00

abstract：:Histone deacetylases (HDACs) act on histones within the nucleosome-bound promoter of human immunodeficiency virus type 1 (HIV-1) to maintain proviral latency. HDAC inhibition leads to promoter expression and the escape of HIV from latency. We evaluated the ability of the potent inhibitor recently licensed for use in o...

journal_title：AIDS research and human retroviruses

authors： Archin NM,Espeseth A,Parker D,Cheema M,Hazuda D,Margolis DM

更新日期：2009-02-01 00:00:00

abstract：:Despite the considerable progress that has been made in identifying cellular factors and pathways that contribute to establishment and maintenance of the latent HIV reservoir, it remains the major obstacle to eradicating this virus. Most recently, noncoding genes have been implicated in regulation of HIV expression. I...

journal_title：AIDS research and human retroviruses

authors： Heinson AI,Woo J,Mukim A,White CH,Moesker B,Bosque A,Spina CA,Woelk CH,Macarthur BD,Beliakova-Bethell N

更新日期：2020-11-10 00:00:00

abstract：:Here we report the construction, sequencing, and biological characterization of a molecular clone of HIV-1(92UG001), a virus representative of subtype D strains circulating in Uganda. The virus produced by the clone has an aggressive syncytium-inducing phenotype, which matches that of the parental virus. This phenotyp...

journal_title：AIDS research and human retroviruses

authors： Novelli P,Vella C,Oxford J,Daniels RS

更新日期：2002-01-01 00:00:00

abstract：:The development of HIV vaccines is an urgent priority and there is need to generate reagents representing multiple subtypes that can be used to screen HIV-1-specific responses. We used Aldrithiol-2 (AT-2), a mild oxidizing reagent, to eliminate the infectivity of HIV while maintaining its structure and ability to be p...

journal_title：AIDS research and human retroviruses

authors： Rutebemberwa A,Bess JW Jr,Brown B,Arroyo M,Eller M,Slike B,Polonis V,McCutchan F,Currier JR,Birx D,Robb M,Marovich M,Lifson JD,Cox JH

更新日期：2007-04-01 00:00:00

abstract：:Multiple drug effect analyses with mismatched double-stranded RNA (mismatched dsRNA or Ampligen) as a core drug were performed to identify other agents and mechanisms through which mismatched dsRNA may potentiate effective therapeutic intervention in human immunodeficiency virus (HIV) infection. Antiviral activities w...

journal_title：AIDS research and human retroviruses

authors： Montefiori DC,Robinson WE Jr,Mitchell WM

更新日期：1989-04-01 00:00:00

abstract：:This study examines the association between presence of drug resistance mutations and phenotypic resistance at baseline to virologic response to salvage therapy in a community setting. The study population consisted of 58 antiretroviral drug-experienced patients with HIV-1 infection who had recently switched therapy b...

journal_title：AIDS research and human retroviruses

authors： Ross L,Liao Q,Gao H,Pham S,Tolson J,Hertogs K,Larder B,Saag MS

更新日期：2001-10-10 00:00:00

abstract：:We have determined that polymeric IgA in saliva of HIV-1-uninfected individuals binds in varying degrees to components of culture supernatants containing HIV-1 recombinant proteins when ELISA is used for the determination. This finding did not extend to salivary IgG antibodies. Further, such problems were not encounte...

journal_title：AIDS research and human retroviruses

authors： Jackson S,Prince S,Kulhavy R,Mestecky J

更新日期：2000-04-10 00:00:00

abstract：:Lymphoid tissues are the focus of critical events in HIV pathogenesis. Persistent and high levels of virus production, extensive trapping of virus particles in germinal centers, and progressive degenerative changes in lymph node architecture are characteristics of progressive HIV-1 infection. Infiltrates of granzyme B...

journal_title：AIDS research and human retroviruses

authors： Koopman G,Haaksma AG,ten Velden J,Hack CE,Heeney JL

更新日期：1999-03-01 00:00:00

abstract：:The pharmacokinetics and short-term safety of atazanavir 150 and 200 mg, when coadministered with saquinavir/ritonavir 1600/100 mg once daily, were evaluated. On day 1, atazanavir 150 mg once daily, was added to saquinavir/ritonavir regimens and sampling was performed to evaluate saquinavir, ritonavir, and atazanavir ...

journal_title：AIDS research and human retroviruses

authors： Boffito M,Maitland D,Dickinson L,Back D,Hill A,Fletcher C,Moyle G,Nelson M,Gazzard B,Pozniak A

更新日期：2006-08-01 00:00:00

abstract：:Human T cell leukemia virus protein induces T cells to permanent IL-2-dependent growth. These cells occasionally convert to factor independence. The viral oncoprotein Tax acts as an essential growth factor of transformed lymphocytes and stimulates the cell cycle in the G(1) phase. In T cells and fibroblasts Tax enhanc...

journal_title：AIDS research and human retroviruses

authors： Haller K,Ruckes T,Schmitt I,Saul D,Derow E,Grassmann R

更新日期：2000-11-01 00:00:00

abstract：:Genetic polymorphisms within the MHC encoding region have the strongest impact on HIV disease progression of any in the human genome and provide important clues to the mechanisms of HIV immune control. Few analyses have been undertaken of HLA alleles associated with rapid disease progression. HLA-B*07:02 is an HLA cla...

journal_title：AIDS research and human retroviruses

authors： Kløverpris HN,Adland E,Koyanagi M,Stryhn A,Harndahl M,Matthews PC,Shapiro R,Walker BD,Ndung'u T,Brander C,Takiguchi M,Buus S,Goulder P

更新日期：2014-05-01 00:00:00

abstract：:The surface molecule CD4 plays a key role in initiating cellular entry by the human immunodeficiency virus type 1 (HIV-1), and it is now recognized as acting synergistically with select chemokine receptors (coreceptors) in the infection process. The present study was undertaken to determine whether the extracellular r...

journal_title：AIDS research and human retroviruses

authors： Esser U,Speck RF,Deen KC,Atchison RE,Sweet R,Goldsmith MA

更新日期：2000-11-20 00:00:00

abstract：:The molecular epidemiology of HIV-1 in Argentina is more complex than was previously appreciated. One circulating recombinant form, CRF12_BF, and many related BF recombinant forms predominate in the capital city, Buenos Aires. This study of HIV-1 subtypes acquired perinatally between 1984 and 2000 has permitted, for t...

journal_title：AIDS research and human retroviruses

authors： Gomez Carrillo M,Avila M,Hierholzer J,Pando M,Martinez PL,McCutchan FE,Carr JK

更新日期：2002-05-01 00:00:00