The detection of in vivo and in vitro HIV type 1 B/F profiles in Brazil using a real-time PCR assay for five HIV type 1 genomic regions.

abstract：:The predictive value of virological response to lopinavir (LPV)/ritonavir (r) was assessed in 126 HIV-infected patients who failed antiretroviral therapy and had begun a rescue intervention based on LPV/r. At 3 months, subjects with < or =6 protease (PRO) resistance mutations showed a higher rate of virological respon...

journal_title：AIDS research and human retroviruses

authors： González de Requena D,Gallego O,Valer L,Jiménez-Nácher I,Soriano V

更新日期：2004-03-01 00:00:00

abstract：:For a HIV vaccine to be effective, it will be essential that it protect against the virus variants to which individuals are most frequently exposed. HIV-1 is predominantly a sexually acquired virus, thus, variants in genital secretions are a potentially important reservoir of viruses that are transmitted. Because ther...

journal_title：AIDS research and human retroviruses

authors： Overbaugh J,Anderson RJ,Ndinya-Achola JO,Kreiss JK

更新日期：1996-01-20 00:00:00

abstract：:We have studied a woman with transfusion-acquired HIV who appears to have contained infectious virus to consistently undetectable levels over a 13-year period without antiviral treatment. She received the infected transfusion for intra- and postpartum blood loss immediately after delivery of her second child in 1981. ...

journal_title：AIDS research and human retroviruses

authors： Schwartz D,Sharma U,Busch M,Weinhold K,Matthews T,Lieberman J,Birx D,Farzedagen H,Margolick J,Quinn T

更新日期：1994-12-01 00:00:00

abstract：:We show that the squirrel monkey Saimiri sciureus is susceptible to experimental infection with either syngeneic or allogeneic HTLV-1-immortalized cells. As in humans, such experimental inoculation leads to chronic infection, and HTLV-1 provirus was detected in PBMCs by PCR. Chronically infected monkeys developed high...

journal_title：AIDS research and human retroviruses

authors： Kazanji M

更新日期：2000-11-01 00:00:00

abstract：:Both HIV and EIAV belong to the retroviridae family and lentivirus genus. Two variable regions (V3 and V4) of equine infectious anemia virus (EIAV) gp90 and two variable regions (V1 and V2) of HIV gp120 possibly adopt the same topology. We have studied the N-glycosylation properties and B cell linear epitope distribut...

journal_title：AIDS research and human retroviruses

authors： Li H,Zhang X,Fan X,Shen T,Tong X,Shen R,Shao Y

更新日期：2005-12-01 00:00:00

abstract：:The derivation of ethyl-methanesulfonate (EMS) mutagenized subclones from the CEM T-cell line has been described. These clones expressed CD4 and bound soluble gp120, however, two of the generated clones were markedly reduced in their ability to form syncytia after infection with either gp160-vaccinia vector or cell-fr...

journal_title：AIDS research and human retroviruses

authors： Gruber MF,Hewlett IK,Simms T,Vujcic L,Manischewitz J,Golding H

更新日期：1992-06-01 00:00:00

abstract：:In order to investigate how human immunodeficiency virus (HIV) gains entry to the placenta, we have performed in vitro experiments in which highly purified trophoblast cells isolated from term human placentas were examined for their susceptibility to HIV infection. Trophoblast cells were exposed to cell-free HIV-1 for...

journal_title：AIDS research and human retroviruses

authors： Douglas GC,Fry GN,Thirkill T,Holmes E,Hakim H,Jennings M,King BF

更新日期：1991-09-01 00:00:00

abstract：:Monitoring HIV subtype distribution is important for understanding transmission dynamics. Subtype B has historically been dominant in Australia, but in recent years new clades have appeared. Since 2000, clade data have been collected as part of HIV surveillance in South Australia. The aim of this study was to evaluate...

journal_title：AIDS research and human retroviruses

authors： Hawke KG,Waddell RG,Gordon DL,Ratcliff RM,Ward PR,Kaldor JM

更新日期：2013-02-01 00:00:00

abstract：:To understand the evolution of HIV-1, the genetic and biological characteristics of viruses that infect persons living in regions in which the virus has been evolving for several decades must be studied. Thus, we investigated teh genetic subtypes, coreceptor usage, and syncytium-inducing ability of viruses in 47 HIV-1...

journal_title：AIDS research and human retroviruses

authors： Zhong P,BUrda S,Konings F,Urbanski M,Ma L,Zekeng L,Ewane L,Agyingi L,Agwara M,Saa,Afane ZE,Kinge T,Zolla-Pazner S,Nyambi P

更新日期：2003-12-01 00:00:00

abstract：:Thirty years after its beginning, the HIV/AIDS epidemic is still raging around the world. According to UNAIDS, in 2011 alone 1.7M deaths were attributable to AIDS, and 2.5M people were newly infected by the virus. Despite the success in treating HIV-infected people with potent antiretroviral drugs, preventing HIV infe...

journal_title：AIDS research and human retroviruses

authors： Romano J,Kashuba A,Becker S,Cummins J,Turpin J,Veronese F,Antiretroviral Pharmacology In HIV Prevention Think Tank Participants.

更新日期：2013-11-01 00:00:00

abstract：:Both chronic hepatitis C and nevirapine (NVP) use are risk factors for transaminase elevation under highly active antiretroviral therapy. NVP is metabolized in the liver and its clearance could be altered in the presence of chronic hepatitis C virus (HCV) infection, enhancing the risk of liver toxicity. We examined NV...

journal_title：AIDS research and human retroviruses

authors： Núñez M,González-Requena D,González-Lahoz J,Soriano V

更新日期：2003-03-01 00:00:00

abstract：:The HIV-1 subtype A epidemic affecting injecting drug users (IDU) in former Soviet Union (FSU) countries started dramatically in Odessa, southern Ukraine, in 1995, and is caused by a variant of monophyletic origin, often designated IDU-A. We phylogenetically analyzed one near full-length genome and two partial sequenc...

journal_title：AIDS research and human retroviruses

authors： Thomson MM,de Parga EV,Vinogradova A,Sierra M,Yakovlev A,Rakhmanova A,Delgado E,Casado G,Muñoz M,Carmona R,Vega Y,Pérez-Alvarez L,Contreras G,Medrano L,Osmanov S,Nájera R

更新日期：2007-12-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) viral genes nef and tat play an important role in disease progression. In this study we characterized the Nef and Tat proteins from a group of HLA-B57 typed pediatric perinatally infected long-term survivors (LTS) with ≥10 years of infection. We identified 19 therapy-naive L...

journal_title：AIDS research and human retroviruses

authors： Neogi U,Palchaudhuri R,Bommana S,Shet A

更新日期：2013-12-01 00:00:00

abstract：:The full-length RNA of human immunodeficiency virus type 1 (HIV-1) serves both as a messenger (mRNA) to direct the translation of Pr55(gag) proteins and as genomic or viral particle RNA (vpRNA) to be packaged into virions. In this study, we have assessed a putative cis-acting effect of Pr55(gag) translation on HIV-1 R...

journal_title：AIDS research and human retroviruses

authors： Liang C,Hu J,Russell RS,Wainberg MA

更新日期：2002-10-10 00:00:00

abstract：:Investigations into the use of baboons as organ donors for human transplant recipients, a procedure called xenotransplantation, have raised the specter of transmitting baboon viruses to humans and possibly establishing new human infectious diseases. Retrospective analysis of tissues from two human transplant recipient...

journal_title：AIDS research and human retroviruses

authors： Allan JS,Broussard SR,Michaels MG,Starzl TE,Leighton KL,Whitehead EM,Comuzzie AG,Lanford RE,Leland MM,Switzer WM,Heneine W

更新日期：1998-07-01 00:00:00

abstract：:In vitro and in vivo studies have demonstrated that HIV can infect thymocytes at different maturational stages and lead to changes in the thymic microenvironment. To determine the effect of HIV on thymic stromal cells and the production of cytokines important in thymocyte development, three types of adherent thymic cu...

journal_title：AIDS research and human retroviruses

authors： Sandborg CI,Imfeld KL,Zaldivar F Jr,Berman MA

更新日期：1994-10-01 00:00:00

abstract：:Tuberculosis (TB) is the major opportunistic infection of HIV-infected patients in developing countries and is associated with activation of the immune system and increased HIV-1 expression. The aim of this study was to explore the biological properties of HIV-1 isolates from patients with active TB. Ten HIV-1 subtype...

journal_title：AIDS research and human retroviruses

authors： Morris L,Cilliers T,Bredell H,Phoswa M,Martin DJ

更新日期：2001-05-20 00:00:00

abstract：:Surveillance of drug resistance mutations in antiretroviral-experienced HIV(+) patients may provide useful information regarding options available for rescue interventions. All resistance tests performed from 1999 to 2005 on antiretroviral-experienced individuals at one reference laboratory in Madrid were examined. On...

journal_title：AIDS research and human retroviruses

authors： de Mendoza C,Garrido C,Corral A,Ramírez-Olivencia G,Jiménez-Nacher I,Zahonero N,Gonzalez-Lahoz J,Soriano V

更新日期：2007-07-01 00:00:00

abstract：:Epstein-Barr virus (EBV) infection is associated with Burkitt's lymphoma (BL) in normal individuals and immunoblastic B cell lymphomas in immunosuppressed or HIV-infected individuals. SCID mice reconstituted with human peripheral blood leukocytes (hu-PBL-SCID) from EBV-seropositive donors also may develop spontaneous ...

journal_title：AIDS research and human retroviruses

authors： Mosier DE,Picchio GR,Kirven MB,Garnier JL,Torbett BE,Baird SM,Kobayashi R,Kipps TJ

更新日期：1992-05-01 00:00:00

abstract：:The conditioned medium of a HTLV-I-carrying T cell line HUT-102 showed cytotoxic activity against a mouse fibroblast cell line L-M. We prepared the cDNA library from HUT-102 poly(A)+ RNA and screened it using oligonucleotide probes that correspond to the amino acid sequences conserved in tumor necrosis factor (TNF) an...

journal_title：AIDS research and human retroviruses

authors： Kato S,Miki T,Takahashi N,Ohmori M,Hemmi H,Numao N,Kondo K

更新日期：1989-12-01 00:00:00

abstract：:A highly purified saponin from Q. saponaria (QS-21) was tested in juvenile rhesus macaques for adjuvant activity and toxicity. The QS-21 was tested alone or as part of an experimental subunit HIV-1 vaccine containing a truncated recombinant HIV-1 envelope protein (gp160D) adsorbed to alum. Antibody responses were meas...

journal_title：AIDS research and human retroviruses

authors： Newman MJ,Wu JY,Coughlin RT,Murphy CI,Seals JR,Wyand MS,Kensil CR

更新日期：1992-08-01 00:00:00

abstract：:Although Cameroon, in west central Africa, has a relatively low HIV prevalence of 5-6%, all HIV-1 groups (M, N, O, and P), nearly all HIV-1 group M subtypes, and numerous intersubtype recombinant forms have been identified in Cameroon. In this report, we describe the near full-length sequence of 04CMU11421, an HIV-1 g...

journal_title：AIDS research and human retroviruses

authors： Yamaguchi J,Vallari A,Ngansop C,Makamche F,Ndembi N,Mbanya D,Kaptué L,Gürtler LG,Devare SG,Brennan CA

更新日期：2010-06-01 00:00:00

abstract：:HIV-1 infection is characterized by genetic diversity, with multiple subtypes and recombinant variants circulating, particularly in sub-Saharan Africa. During the Rwandan genocide, many women experienced multiple rapes and some became HIV-1 infected. We studied plasma and peripheral blood mononuclear cells (PBMCs) fro...

journal_title：AIDS research and human retroviruses

authors： Kemal KS,Anastos K,Weiser B,Ramirez CM,Shi Q,Burger H

更新日期：2013-06-01 00:00:00

abstract：:Adult T cell leukemia/lymphoma has only rarely been reported in Europe. We aimed to determine the clinical characteristics and outcome of adult T cell leukemia/lymphoma patients in a nonendemic country. Cases of adult T cell leukemia/lymphoma managed at Hospital Universitari Vall d'Hebron, Barcelona, Spain were review...

journal_title：AIDS research and human retroviruses

authors： Lopez-Lerma I,Caballero E,Palacio C,Garcia-Patos V

更新日期：2013-04-01 00:00:00

abstract：:There is an urgent need for a prophylactic vaccine to protect individuals from AIDS and to help abate the growing epidemic. In October 1993, the Conference on Advances in AIDS Vaccine Development reviewed the state-of-the-art in vaccine research and confirmed both the progress that has been made and the challenges tha...

journal_title：AIDS research and human retroviruses

authors： Johnston MI,Noe JS,Killen JY

更新日期：1994-01-01 00:00:00

abstract：:We have characterized human foamy virus (HFV) proviral DNA and determined HFV expression in a persistent infection model, the Dami megakaryocytic cell line. Molecular studies were performed on parental persistently infected cells (Dami-P), as well as on derived clones (Dami-Cl). We report that in these nonlytic and no...

journal_title：AIDS research and human retroviruses

authors： Wybier-Franqui J,Tobaly-Tapiero J,Coronel A,Giron ML,Chopin-Robert C,Peries J,Emanoil-Ravier R

更新日期：1995-07-01 00:00:00

abstract：:We examined risk factors for avascular bone necrosis (AVN) particularly focusing o the question of whether antiretroviral treatment (ART) is associated with the emergence of osteonecrosis. After 11 years of following the entire cohort, 26 patients were found to have AVN. Compared to 260 concurrent HIV-infected control...

journal_title：AIDS research and human retroviruses

authors： Hasse B,Ledergerber B,Egger M,Flepp M,Bachmann S,Bernasconi E,Egger M,Guyot S,Hirschel B,Weber R,Günthard HF,Swiss HIV Cohort Study.

更新日期：2004-09-01 00:00:00

abstract：:Nucleotide sequences for long terminal repeat (LTR), gag, the protease gene, and pol of a human T-lymphotropic virus type 1 (HTLV-1) isolate of probable Caribbean origin (HTLV-1CH) and a Zairian isolate (HTLV-1EL) were determined providing complete proviral sequences for these isolates. These sequences were compared w...

journal_title：AIDS research and human retroviruses

authors： Ratner L,Philpott T,Trowbridge DB

更新日期：1991-11-01 00:00:00

abstract：:Studies of HIV molecular evolution and pathogenesis have relied on the polymerase chain reaction (PCR) to provide sequence information from infected tissues. Until recently, studies have been constrained by the limited length of fragments that can be reliably amplified. The addition of a thermostable 3'-exonuclease ac...

journal_title：AIDS research and human retroviruses

authors： Yang YL,Wang G,Dorman K,Kaplan AH

更新日期：1996-03-01 00:00:00

abstract：:Am important aspect of human immunodeficiency virus (HIV-1) infection is the regulation of its expression by nuclear factor kappa B (NF-kappa B) by redox-controlled signal transduction pathways. In this study, we demonstrate that selenium supplementation can effectively increase glutathione peroxidase (GPx) activity i...

journal_title：AIDS research and human retroviruses

authors： Sappey C,Legrand-Poels S,Best-Belpomme M,Favier A,Rentier B,Piette J

更新日期：1994-11-01 00:00:00