Abstract:
PURPOSE:Cerebral metastases develop in 10-30% of patients with breast cancer (BC) and in around 3.3 to 4% of patients with ovarian cancer (OC). The aim of the multicenter study is to investigate the correlation between the expression of estrogen alpha receptors (ERα), progesterone receptors (PR), human epidermal growth factor receptor 2 (HER2), stromal cell-derived factor 1 (SDF1) and its receptor C-X-C chemokine receptor type 4 (CXCR4), breast cancer metastasis suppressor 1 (BRMS1), astrocyte elevated gene 1 (AEG1), depending on the status of BRCA1 protein, in patients suffering from OC and BC with brain metastases. PATIENTS AND METHODS:The analysis included 51 patients: 29 with BC and 22 with OC, in whom brain metastases were disclosed. RESULTS:In most patients (65.5% of BC patients and 68.2% of patients with OC tumors) BRCA1 protein loss was found. No correlation was disclosed between the levels of ERα, PR receptors, HER2, SDF1, CXCR4, AEG1, BRMS1 and BRCA1 status, patient age, stage of disease advancement, grade of histological maturity of the cells, presence of metastases to lymph nodes. A statistically significant correlation was disclosed between the negative expression of PR receptors and a high expression of CXCR4 in patients with BC. High values of the AEG1 protein (linked to metastases) were detected alongside a high expression of BRMS1 (a suppressor of metastases). CONCLUSIONS:Patients with BC and OC and brain metastases have a frequent loss of BRCA1 expression. The role of ERα, PR, HER2, SDF1, CXCR4, AEG1, BRMS1 in metastatic process needs further studies.
journal_name
Adv Med Scijournal_title
Advances in medical sciencesauthors
Szarszewska M,Markowska A,Jach R,Marszałek A,Filas V,Bednarek W,Olejek A,Tomczak P,Sajdak S,Nowak-Markwitz E,Jaszczyńska-Nowinka K,Stanisławiak-Rudowicz J,Gryboś A,Chudecka-Głaz A,Gryboś M,Adamska K,Ramlau R,Markowska Jdoi
10.1016/j.advms.2018.12.007subject
Has Abstractpub_date
2019-09-01 00:00:00pages
235-240issue
2eissn
1896-1126issn
1898-4002pii
S1896-1126(18)30155-Xjournal_volume
64pub_type
杂志文章,多中心研究abstract:PURPOSE:To characterize the interaction between tiagabine (TGB) and valproate (VPA)--two antiepileptic drugs in the mouse pentylenetetrazole (PTZ)-induced clonic seizure model, type I isobolographic analysis for non-parallel dose-response relationship curves (DRRCs) was used. MATERIAL AND METHODS:Clonic seizures were ...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/v10039-009-0006-7
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abstract:PURPOSE:Methylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in endothelial nitric oxide synthase (eNOS) coupling and homocysteine metabolism. The rs1801133 polymorphism of the MTHFR gene affects risk of coronary artery disease. We assessed its influence on 5-year survival of patients with ST-elevation acu...
journal_title:Advances in medical sciences
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doi:10.2478/v10039-012-0010-1
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abstract:PURPOSE:In recent years, many reports have focused on clinical changes in the oral cavity of orthodontic patients, manifested in general inflammation of the mucosa. In order to better understand histopathological alterations in the mouth and the use of easily available diagnostic material, we decided to assess the morp...
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doi:
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journal_title:Advances in medical sciences
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doi:10.2478/v10039-012-0068-9
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abstract::Melanoma is a malignant tumor which is inclined to metastasize promptly into the lymphatic system and other organs such as lung, liver, brain or bone. Therefore early diagnosis remains crucial for improving clinical outcome for melanoma patients. Current chemotherapy and chemo-immunotherapy regimes have shown little c...
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journal_title:Advances in medical sciences
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doi:
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journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1016/j.advms.2015.09.001
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journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
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journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/ams-2013-0010
更新日期:2013-01-01 00:00:00
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journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2017.11.001
更新日期:2018-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.advms.2013.07.001
更新日期:2014-03-01 00:00:00
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journal_title:Advances in medical sciences
pub_type: 临床试验,杂志文章
doi:10.1016/j.advms.2015.02.006
更新日期:2015-09-01 00:00:00
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journal_title:Advances in medical sciences
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doi:10.2478/v10039-011-0048-5
更新日期:2011-01-01 00:00:00
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
doi:
更新日期:2006-01-01 00:00:00
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journal_title:Advances in medical sciences
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更新日期:2016-03-01 00:00:00
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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doi:
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:NT-proBNP and BNP concentrations in CHF correlate with NYHA class and LVEE Little research has been conducted to compare the clinical performance of these two natriuretic peptides in heterogeneous CHF population. Purpose: to evaluate and compare the clinical performance of NT-proBNP and BNP in heterogeneous gro...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
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journal_title:Advances in medical sciences
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更新日期:2011-01-01 00:00:00
abstract:PURPOSE:Non-alcoholic fatty liver disease (NAFLD) is increasingly being recognized in the pediatric population, therefore, the search for non-invasive parameters to predict progression of NAFLD is of great interest. The aim of this study was to assess serum concentration of sCD36 in children with obesity and to determi...
journal_title:Advances in medical sciences
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
abstract:PURPOSE:Stroke and subclinical "silent infarcts" are major causes of morbidity in children with Sickle Cell Disease (SCD). Ischemic strokes are more common in younger children while hemorrhagic strokes are more frequent in adults. The goal of neuroimaging in acute stroke is to document whether the stroke is ischemic or...
journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
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更新日期:2010-01-01 00:00:00
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journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/v10039-008-0045-5
更新日期:2008-01-01 00:00:00
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journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:The purpose of the studies performed was an attempt to establish a potential relationship between total antioxidant status of unstimulated whole saliva, patients' ages, oral hygiene status and dental caries. MATERIAL AND METHODS:The study involved 120 non-smokers. Mean age of the study subjects was 18.40 ± 1.7...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/v10039-012-0015-9
更新日期:2012-06-01 00:00:00