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Treatment of refractory epilepsy patients with autologous mesenchymal stem cells reduces seizure frequency: An open label study.

Abstract：

PURPOSE:Existing anti-epileptic drugs (AED) have limited efficiency in many patients, necessitating the search for alternative approaches such as stem cell therapy. We report the use of autologous patient-derived mesenchymal stem cells (MSC) as a therapeutic agent in symptomatic drug-resistant epilepsy in a Phase I open label clinical trial (registered as NCT02497443). PATIENTS AND METHODS:The patients received either standard treatment with AED (control group), or AED supplemented with single intravenous administration of undifferentiated autologous MSC (target dose of 1×106cells/kg), followed by a single intrathecal injection of neurally induced autologous MSC (target dose of 0.1×106cells/kg). RESULTS:MSC injections were well tolerated and did not cause any severe adverse effects. Seizure frequency was designated as the main outcome and evaluated at 1 year time point. 3 out of 10 patients in MSC therapy group achieved remission (no seizures for one year and more), and 5 additional patients became responders to AEDs, while only 2 out of 12 patients became responders in control group (difference significant, P=0.0135). CONCLUSIONS:MSC possess unique immunomodulatory properties and are a safe and promising candidate for cell therapy in AED resistant epilepsy patients.

journal_name

Adv Med Sci

journal_title

Advances in medical sciences

authors

Hlebokazov F,Dakukina T,Ihnatsenko S,Kosmacheva S,Potapnev M,Shakhbazau A,Goncharova N,Makhrov M,Korolevich P,Misyuk N,Dakukina V,Shamruk I,Slobina E,Marchuk S

doi

10.1016/j.advms.2016.12.004

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

273-279

issue

2

eissn

1896-1126

issn

1898-4002

pii

S1896-1126(17)30023-8

journal_volume

62

pub_type

杂志文章,随机对照试验

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