Abstract:
:Vascular calcification (VC) is highly prevalent in patients with chronic kidney disease (CKD) and is strongly associated with cardiovascular mortality and morbidity. Accumulating evidence over the past decade has challenged the hypothesis of close interaction between bone and VC what raises the possibility of a common underlying pathophysiological mechanism. Lately, bone regulatory proteins such as: osteoprotegerin (OPG) and Receptor Activator for Nuclear Factor κB Ligand (RANKL) has attracted attention of researchers as a possible key mediators of bone-vascular calcification imbalance. The literature search was carried out using the MEDLINE/PubMed database and a combination of keywords and MeSH terms, and only papers published since January 2005 to July 2016 were selected. The search resulted in 562 potential articles. After selection according to the eligibility criteria, 107 studies fulfilled were included (102 full texts and 5 was case reports). OPG and RANKL plays essential role in the regulation of bone metabolism and may be regarded as a possible link between VC, bone and mineral metabolism in CKD patients. Further studies are required to determine the diagnostic significance of these proteins in evaluation of progression and severity of VC process in CKD patients. Finally, the efficacy and safety, especially in regard to VC, of anti-RANKL therapy in CKD patients requires well-designed prospective, randomized trials.
journal_name
Adv Med Scijournal_title
Advances in medical sciencesauthors
Znorko B,Oksztulska-Kolanek E,Michałowska M,Kamiński T,Pawlak Kdoi
10.1016/j.advms.2016.08.001subject
Has Abstractpub_date
2017-03-01 00:00:00pages
52-64issue
1eissn
1896-1126issn
1898-4002pii
S1896-1126(16)30034-7journal_volume
62pub_type
杂志文章,评审abstract:PURPOSE:The aim of the work was to use and to evaluate the usefulness of the slow variable magnetic fields to aid the treatment of the teeth chosen for extraction. The marginal paradontium of periapical bone of teeth was in a state of extensive destruction. The teeth were chosen for extraction. MATERIAL AND METHODS:13...
journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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