Abstract:
PURPOSE:Psoriasis is a chronic, recurrent, inflammatory disease. Recent investigations indicate its autoimmune pathogenesis. Apoptosis plays an important role in the development of many autoimmune diseases. The aim of this study was to evaluate the influence of topical treatment of psoriasis on soluble Fas (sFas) and soluble Fas-ligand (sFasL). MATERIAL/METHODS:Serum concentrations of sFas and sFasL were measured using ELISA in 40 psoriatic patients before and after topical treatment with dithranol and compared to the values obtained from 16 healthy subjects. Data were analyzed with respect to severity of psoriasis, duration of the disease and coexisting obesity, diabetes and hypertension. RESULTS:We found that serum levels of sFas before (11.9±2.4ng/mL) and after treatment (12.2±2.5ng/mL) were significantly higher in patients with psoriasis as compared to the control group (6.4±1.8ng/mL). Concentrations of sFasL did not differ significantly from healthy subjects, but increased after treatment. The sFas/sFasL ratio was significantly higher in psoriasis (128±47) than in the control group and, even though it tended to decrease after treatment, it still remained higher than in the control group (65±22). Additionally we observed a positive correlation of sFas/sFasL ratio with the age of patients and duration of the disease. Psoriatic patients suffering from hypertension and overweight had significantly higher sFas/sFasL ratio than other psoriatic patients. CONCLUSIONS:Our data indicate upregulation of the sFas/sFasL system in psoriatic patients. We demonstrate association of sFas/sFasL with commorbidities - components of metabolic syndrome.
journal_name
Adv Med Scijournal_title
Advances in medical sciencesauthors
Myśliwiec H,Baran A,Myśliwiec P,Górska M,Flisiak Idoi
10.1016/j.advms.2014.10.005subject
Has Abstractpub_date
2015-03-01 00:00:00pages
64-8issue
1eissn
1896-1126issn
1898-4002pii
S1896-1126(14)00094-7journal_volume
60pub_type
杂志文章abstract::We present 21 studies of cases of lung cancer in patients with situs inversus totalis (SIT) published worldwide. The first case was described in 1952. Thirteen patients were from Japan, 4 from Eastern Europe, including 2 Polish cases from the authors` center (Department of Thoracic Surgery, Pomeranian Medical Universi...
journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
doi:10.2478/v10039-012-0083-x
更新日期:2013-01-01 00:00:00
abstract:UNLABELLED:Factors believed to affect masticatory efficiency include loss of postcanine teeth, bite force, severity of malocclusion, occlusal contact area, body size and oral motor function. THE AIM:to record if there is relationship between masticatory efficiency and the state of dentition at patients whose occlusion...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::Lung cancer causes an estimated 1.6 million deaths each year, being the leading cause of cancer-related deaths in the world. Late diagnosis and, in some cases, the high aggressiveness of the tumour result in low overall five-year survival rates of 12% among men and 7% among women. The cure is most likely in early-stag...
journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
doi:10.1016/j.advms.2017.12.002
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:The concentration of nucleic acids that undergo apoptosis (ssDNA) determines the actual activity of programmed cell death. ssDNA concentrations in liver tissue of patients with chronic HBV, HCV and HCV and HIV infections were assessed. The concentration of this nucleic acid was analyzed in relation to the conce...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:To determine the time point at which thrombocytopenia after TAVI procedure is an indicator of the worst prognosis, with special consideration of perioperative platelet and coagulation activation as its potential causes. METHODS:Thirty two patients (mean age 78.5±7.9years, 62% females) qualified for TAVI proced...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2017.11.001
更新日期:2018-03-01 00:00:00
abstract::PET is a successful modality to detect cancer and in recent years has demonstrated a great diagnostic value in large series of tumour types. PET combines high sensitivity and reasonable resolution, and offers the ability to perform whole body scans. 18F-deoxyglucose (FDG)-PET has also been used to diagnose tumours of ...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::In liver surgery, accurate assessments of liver resection volume and anatomical variation are mandatory for preoperative planning of safe curative hepatectomy. In living donor liver transplantation (LDLT), estimation of hepatic venous drainage is important to avoid liver graft and donor residual liver congestion. This...
journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
doi:
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:Defining the level of protective factors in saliva of patients suffering from decompensated type 2 diabetes. MATERIAL AND METHODS:50 Patients with diagnosis of decompensated type 2 diabetes, including 32 women and 18 men at the age of 57.9±9.2 years. The control group consisted of 50 people among whom there we...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2016.06.005
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:The aim of this study was to assess the quality of life of the osteoarthritis (OA) and rheumatoid arthritis (RA) patients of Outpatient Clinic Rehabilitation in Poznań. MATERIAL AND METHODS:The study consisted of 97 OA patients, including 86 women and 11 men. Almost 123 patients with RA included of 102 women a...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:Cardiogenic shock (CS) is a severe complication of acute coronary syndromes (ACS). Intra-aortic balloon pump (IABP) is considered important mechanical therapy for acute CS. We aimed to analyze the natural history and possible prognostic factors in patients with CS complicating ACS. PATIENTS/METHODS:All 126 pat...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2013.12.003
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:Desmin regulates function of mitochondria, T-tubular system and cytosolic Ca(2+) transients. We investigated whether desmin remodeling correlates with diastolic dysfunction and whether progressive desmin abnormalities are accompanied by increasing diastolic dysfunction stages. PATIENTS AND METHODS:Eighty five ...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2015.01.009
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:Genetic variability of hepatitis C virus (HCV) is considered to be an important factor defining viral pathogenesis, persistence and resistance to treatment. The aim of the present study was to characterize HCV genetic heterogeneity within a hypervariable region 1 (HVR-1) before and during the early period of pe...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/v10039-012-0024-8
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:The aim of the study was to establish whether preoperative serum levels of HE4 and CA125 could be a good predictor for lymphadenectomy in the early stage of endometrioid adenocarcinoma of the uterus. MATERIAL AND METHODS:Preoperative serum HE4 and CA125 were measured in 78 postmenopausal patients treated surgi...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2015.07.010
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:The objective of this study was to evaluate thevitamin D concentration in patients with recurrent respiratory infections with or without immunoglobulin G, A or M (IgG, IgA, IgM) deficiency, and to find a correlation between the vitamin D concentration and the response to hepatitis B vaccination. MATERIALS AND ...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2017.08.001
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:In spite of the general consensus on the issue, to point to major dilemmas which appear in this matter of multidisciplinary interest, and to review current concepts on how to achieve optimal diagnostic and therapeutic outcome. RESULTS:Recent literature data show that the rate of gestational breast cancer, acco...
journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
doi:10.2478/v10039-008-0037-5
更新日期:2008-01-01 00:00:00
abstract::Nailfold videocapillaroscopy (NVC) is one of the best diagnostic non-invasive imaging techniques to evaluate microcirculation in vivo and is increasingly employed in the field of rheumatology. Indeed, at present, the most important utility of NVC is in the identification of microvascular involvement in many rheumatic ...
journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
doi:10.2478/v10039-008-0038-4
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:The aim of this prospective randomized trial was to assess the influence of the sequence of pulmonary vessel ligation, during anatomic resection, on long term survival in patients with NSCLC. MATERIAL/METHODS:This prospective randomized study included 385 patients treated surgically with lobectomy or pneumonec...
journal_title:Advances in medical sciences
pub_type: 杂志文章,随机对照试验
doi:10.2478/v10039-012-0061-3
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:Sarcoidosis affected lungs detected in more than 90% of patients. The relationship between different stages of pulmonary sarcoidosis and pulmonary function tests (PFT) as well as bronchoalveolar lavage fluid (BALF) cells can be established. Geographic and ethnic factors are known to be linked to the specific ch...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/v10039-008-0014-z
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:We aimed to examine the polymorphism of the promoter and exon 5 of the TNFSF11 gene and their impact on bone mineral density (BMD) and the frequency of bone fractures. TNFSF11 encodes the receptor activator of the NF-kB ligand (RANKL), a key regulator of bone metabolism and osteoporosis drug targets. BMD is an ...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2020.05.001
更新日期:2020-09-01 00:00:00
abstract::Adhesive molecules are responsible for the cell-cell interaction and the surrounding intercellular environment creating normal tissue architecture. The role of adhesion proteins in cancer refers to angiogenesis, loss of tissue continuity, and deprivation of intercellular contact with the extracellular matrix, promotin...
journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
doi:10.1016/j.advms.2019.08.003
更新日期:2019-09-01 00:00:00
abstract:PURPOSE:Lipoxygenases (LOX) have been implicated in carcinogenesis, however both pro- and anti-carcinogenic effects have been reported in different cancer models. Using transgenic mice, which specifically overexpress human 15-lipoxygenase (ALOX15) in endothelial cells (EC), we previously demonstrated significant inhibi...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2019.11.006
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:The assessment of satisfaction of women after mastectomy for nursing care. MATERIAL AND METHODS:The research was carried out on a group of 217 patients after radical mastectomy and took place at Surgical Clinic of Swietokrzyskie Oncology Centre in Kielce. Authors' assessment scale was used in research. RESULT...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::Apelin is an endogenous peptide, which is expressed in a vast board of organs such as the brain, placenta, heart, lungs, kidneys, pancreas, testis, prostate and adipose tissues. The apelin receptor, called angiotensin-like-receptor 1 (APJ), is also expressed in the brain, spleen, placenta, heart, liver, intestine, pro...
journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
doi:10.1016/j.advms.2020.02.002
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:To characterize the interaction between tiagabine (TGB) and valproate (VPA)--two antiepileptic drugs in the mouse pentylenetetrazole (PTZ)-induced clonic seizure model, type I isobolographic analysis for non-parallel dose-response relationship curves (DRRCs) was used. MATERIAL AND METHODS:Clonic seizures were ...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/v10039-009-0006-7
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:In recent years, many reports have focused on clinical changes in the oral cavity of orthodontic patients, manifested in general inflammation of the mucosa. In order to better understand histopathological alterations in the mouth and the use of easily available diagnostic material, we decided to assess the morp...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::Autoimmune pancreatitis (AIP) is a particular type of pancreatitis that is thought to have an autoimmune etiology. Before therapy for AIP is begun, accurate diagnosis of AIP is necessary. It is important to distinguish AIP from pancreatic cancer. Since there is currently no diagnostic serological marker for AIP, AIP s...
journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
doi:10.2478/v10039-008-0033-9
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:Among 264 children suspected of GERD, acid GER was confirmed in 138 children on the basis of 24-hour pH monitoring. AIMS OF THE STUDY:Comparative analysis of parameters of 24-hour intraesophageal pH monitoring with dual-channel probe (in proximal channel) in children with acid GER: primary and secondary to cow...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:Molecular features of non-small cell lung cancer (NSCLC) in never-smokers are not well recognized. We assessed the expression of genes potentially related to lung cancer etiology in smoking vs. never-smoking NSCLC patients. METHODS:We assayed frozen tumor samples from surgically resected 31 never-smoking and 5...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.2478/ams-2013-0025
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:Adaptation of the colorimetric method for the determination of β-d-galactosidase, β-d-glucuronidase and α-l-fucosidase activities in serums from hemolyzed blood, the material currently being discarded. MATERIALS AND METHODS:The materials included serums from hemolyzed and non-hemolyzed blood, obtained from 26 ...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:10.1016/j.advms.2018.04.005
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:The aim of the work was to use and to evaluate the usefulness of the slow variable magnetic fields to aid the treatment of the teeth chosen for extraction. The marginal paradontium of periapical bone of teeth was in a state of extensive destruction. The teeth were chosen for extraction. MATERIAL AND METHODS:13...
journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00