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Vitamin D deficiency in children with recurrent respiratory infections, with or without immunoglobulin deficiency.

Abstract：

PURPOSE:The objective of this study was to evaluate thevitamin D concentration in patients with recurrent respiratory infections with or without immunoglobulin G, A or M (IgG, IgA, IgM) deficiency, and to find a correlation between the vitamin D concentration and the response to hepatitis B vaccination. MATERIALS AND METHOD:The study involved 730 patients with recurrent respiratory infections. The concentration of 25-hydroxyvitamin D (25(OH)D), immunoglobulins G, A and M, anti-HBs was determined. RESULTS:The tests showed that 11% of patients presented IgG levels below the age related reference values. Children with reduced IgG concentration were also found to have significantly lower vitamin D concentrations in comparison to children with normal IgG. Vitamin D deficiency was observed in schoolchildren between 7 and 18 years of age. No correlation was found between 25(OH)D concentration and Hbs antibody levels. CONCLUSIONS:An investigation of a large group of patients who have recurrent infection found patients with IgG deficiency to whom special proceeding have to be performed: 1. Significantly lower vitamin D concentration observed in the group of children with IgG deficiency implicated in long-lasting monitoring of vitamin D level require adding to the practice guidelines for Central Europe 2013. 2. Intervention treatment with suitable doses of vitamin D to clarified metabolism of vitamin D has to be plan for children with IgG deficiency and significant lower vitamin D concentration.

journal_name

Adv Med Sci

journal_title

Advances in medical sciences

authors

Dąbrowska-Leonik N,Bernatowska E,Pac M,Filipiuk W,Mulawka J,Pietrucha B,Heropolitańska-Pliszka E,Bernat-Sitarz K,Wolska-Kuśnierz B,Mikołuć B

doi

10.1016/j.advms.2017.08.001

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

173-178

issue

1

eissn

1896-1126

issn

1898-4002

pii

S1896-1126(17)30057-3

journal_volume

63

pub_type

杂志文章

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