Abstract:
PURPOSE:Molecular features of non-small cell lung cancer (NSCLC) in never-smokers are not well recognized. We assessed the expression of genes potentially related to lung cancer etiology in smoking vs. never-smoking NSCLC patients. METHODS:We assayed frozen tumor samples from surgically resected 31 never-smoking and 54 clinically pair-matched smoking NSCLC patients, and from corresponding normal lung tissue from 27 and 43 patients, respectively. Expression of 21 genes, including cell membrane kinases, sex hormone receptors, transcription factors, growth factors and others was assessed by reverse transcription - quantitative PCR. RESULTS:Expression of 5 genes was significantly higher in tumors of non-smokers vs. smokers: CSF1R (p<0.0001), RRAD (p<0.0001), PR (p=0.0004), TGFBR2 (p=0.0027) and EPHB6 (p=0.0033). Expression of AKR1B10 (p<0.0001), CDKN2A (p<0.0001), CHRNA6 (p<0.0001), SOX9 (p<0.0001), survivin (p<0.0001) and ER2 (p=0.002) was significantly higher in tumors compared to normal lung tissue. Expression of AR (p<0.0001), EPHB6 (p<0.0001), PR (p<0.0001), TGFBR2 (p<0.0001), TGFBR3 (p<0.0001), ER1 (p=0.0006) and DLG1 (p=0.0016) was significantly lower in tumors than in normal lung tissue. Expression of IGF2 was higher in tumors than in healthy lung tissue in never-smokers (p=0.003), and expression of AHR (p<0.0001), CSF1R (p<0.0001) and RRAD (p<0.0001) was lower in tumors than in healthy lung tissue in smokers. CONCLUSION:Expression of several genes in NSCLC is strongly related to smoking history. Lower expression of PR and higher expression of ER2 in tumors suggests a possibility of hormonal therapeutic intervention in selected NSCLC patients. Distinct molecular features of NSCLC in never-smokers, e.g. CHRNA6 upregulation, may prompt new treatment strategies.
journal_name
Adv Med Scijournal_title
Advances in medical sciencesauthors
Szymanowska-Narloch A,Jassem E,Skrzypski M,Muley T,Meister M,Dienemann H,Taron M,Rosell R,Rzepko R,Jarząb M,Marjański T,Pawłowski R,Rzyman W,Jassem Jdoi
10.2478/ams-2013-0025subject
Has Abstractpub_date
2013-01-01 00:00:00pages
196-206issue
2eissn
1896-1126issn
1898-4002pii
S1896-1126(14)60190-5journal_volume
58pub_type
杂志文章abstract:PURPOSE:Stroke and subclinical "silent infarcts" are major causes of morbidity in children with Sickle Cell Disease (SCD). Ischemic strokes are more common in younger children while hemorrhagic strokes are more frequent in adults. The goal of neuroimaging in acute stroke is to document whether the stroke is ischemic or...
journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
doi:10.2478/v10039-010-0045-0
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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doi:
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abstract:PURPOSE:The biggest problem with the occurrence of breast cancer is late diagnosis, which is associated with high mortality rates. The aim of the study was to appraise the number of circulating endothelial precursors and the concentration of vascular endothelial growth factor A (VEGF-A) and the soluble forms of its rec...
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journal_title:Advances in medical sciences
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doi:
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
pub_type: 杂志文章,多中心研究
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更新日期:2019-09-01 00:00:00
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journal_title:Advances in medical sciences
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doi:
更新日期:2007-01-01 00:00:00
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journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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journal_title:Advances in medical sciences
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更新日期:2007-01-01 00:00:00
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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doi:
更新日期:2006-01-01 00:00:00
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journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
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更新日期:2014-03-01 00:00:00
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journal_title:Advances in medical sciences
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pub_type: 临床试验,杂志文章
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