Fetal membranes as a source of stem cells.

Abstract:

:In recent years, a constant growth of knowledge and clinical applications of stem cells have been observed. Mesenchymal stromal cells, also described as mesenchymal stem cells (MSCs) represent a particular cell type for research and therapy because of their ability to differentiate into mesodermal lineage cells. The most investigated source of MSCs is bone marrow (BM). Yet, collection of BM is an invasive procedure associated with significant discomfort to the patient. The procedure results in a relatively low number of these cells, which can decrease with donor's age. Therefore, it seems to be very important to find other sources of mesenchymal stem cells nowadays. A human placenta, which is routinely discarded postpartum, in spite of its natural aging process, is still a rich source of stem cells capable to proliferate and in vitro differentiate in many directions. Besides homing and differentiation in the area of injury, MSCs there elicit strong paracrine effects stimulating the processes of repair. In this review, we focus on the biology, characteristics and potential clinical applications of cells derived from human fetal membranes: amnion and chorion.

journal_name

Adv Med Sci

authors

Kmiecik G,Niklińska W,Kuć P,Pancewicz-Wojtkiewicz J,Fil D,Karwowska A,Karczewski J,Mackiewicz Z

doi

10.2478/ams-2013-0007

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

185-95

issue

2

eissn

1896-1126

issn

1898-4002

pii

S1896-1126(14)60189-9

journal_volume

58

pub_type

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