Abstract:
PURPOSE:In this multicenter retrospective analysis of the Polish Myeloma Group we assessed the real-life application of allogeneic transplantations (alloHCT) in multiple myeloma (MM) outside clinical trials in Poland. METHODS:Anonymized clinical data of patients who underwent alloHCT were retrospectively collected from eight transplant centers and analyzed to identify factors affecting the outcome. RESULTS:Sixty patients (34 males, 26 females) at median age of 45 (22-59) years who received alloHCT between 1993 and 2016 were included. In this group, 16 (27%) patients underwent myeloablative conditioning and 44 (73%) reduced-intensity conditioning alloHCT. Acute graft versus host disease (GvHD) occurred in 27 (45%) patients, while chronic GvHD was diagnosed in 13 (22%) patients. With the median observation time after alloHCT of 10 months, the relapse rate was 38%. Median progression-free survival (PFS) reached 9 months (0-183) while median overall survival (OS) was 23 months (0-183). Main causes of death included disease progression in 16 (43%), infections in 10 (27%), and GvHD in 7 patients (19%). Presence of chronic GvHD was the only factor associated with prolonged PFS (28 vs. 6 months; p = 0.05), however its impact on OS was not statistically significant (73 vs. 8 months; p = 0.09). CONCLUSIONS:In this relatively small and heterogeneous study we observed that alloHCT was associated with high risk of severe complications, but resulted in long-term survival in a proportion of patients. Decisions on optimal indications and timing of the alloHCT in MM need to be taken in the broader context of reported outcomes including data from large studies.
journal_name
Adv Med Scijournal_title
Advances in medical sciencesauthors
Gołos A,Gil L,Puła B,Boguradzki P,Hałaburda K,Sawicki W,Sobczyk-Kruszelnicka M,Helbig G,Dybko J,Jurczyszyn A,Dębek S,Warzocha K,Jamroziak Kdoi
10.1016/j.advms.2020.08.003subject
Has Abstractpub_date
2020-09-01 00:00:00pages
429-436issue
2eissn
1896-1126issn
1898-4002pii
S1896-1126(20)30035-3journal_volume
65pub_type
杂志文章abstract:PURPOSE:We analyzed the usefulness and prognostic value of intraoperative monitoring for identification of the oculomotor (III) and the abducens (VI) nerve in patients with cavernous sinus meningiomas. MATERIAL/METHODS:43 patients diagnosed with cavernous sinus meningiomas were divided according to their topography. F...
journal_title:Advances in medical sciences
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abstract::Autoimmune pancreatitis (AIP) is a particular type of pancreatitis that is thought to have an autoimmune etiology. Before therapy for AIP is begun, accurate diagnosis of AIP is necessary. It is important to distinguish AIP from pancreatic cancer. Since there is currently no diagnostic serological marker for AIP, AIP s...
journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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doi:
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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更新日期:2006-01-01 00:00:00
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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更新日期:2006-01-01 00:00:00
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更新日期:2011-01-01 00:00:00
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journal_title:Advances in medical sciences
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
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journal_title:Advances in medical sciences
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更新日期:2007-01-01 00:00:00