Abstract:
PURPOSE:The aim of the study was to evaluate factors related to bone formation and resorption in Polish children and adolescents with cystic fibrosis and to examine the effect of nutritional status, biochemical parameters and clinical status on bone mineral density. MATERIALS AND METHODS:The study group consisted of 100 children and adolescents with cystic fibrosis with a mean age 13.4 years old. Anthropometric measurements, included body height, body mass and body mass index (BMI); bone mineral densitometry and biochemical testing were performed. Bone mineral density was measured using a dual-energy X-ray absorption densitometer. Biochemical tests included serum calcium, phosphorus, parathyroid hormone and vitamin D concentrations, as well as 24-h urine calcium and phosphorus excretion. Pulmonary function was evaluated using FEV1%, and clinical status was estimated using the Shwachman-Kulczycki score. RESULTS:Standardized body height, body mass and BMI were significantly lower than in the reference population. Mean serum vitamin D concentration was decreased. Pulmonary disease was generally mild, with a mean FEV1% of 81%. Multivariate linear regression revealed that the only factors that had a significant effect on bone marrow density were BMI and FEV1%. There were no significant correlations between bone mineral density and the results of any of the biochemical tests performed. CONCLUSIONS:Nutritional status and bone mineral density were significantly decreased in children and adolescents with cystic fibrosis. In spite of abnormalities in biochemical testing, the factors that were found to have the strongest effect on bone mineral density were standardized BMI and clinical status.
journal_name
Adv Med Scijournal_title
Advances in medical sciencesauthors
Sands D,Mielus M,Umławska W,Lipowicz A,Oralewska B,Walkowiak Jdoi
10.1016/j.advms.2015.05.002subject
Has Abstractpub_date
2015-09-01 00:00:00pages
315-20issue
2eissn
1896-1126issn
1898-4002pii
S1896-1126(15)00030-9journal_volume
60pub_type
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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更新日期:2012-06-01 00:00:00
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更新日期:2007-01-01 00:00:00
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journal_title:Advances in medical sciences
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