Abstract：
PURPOSE:To evaluate the serum levels of tumor necrosis factor (TNF) alpha and its soluble receptors in obese children with non-alcoholic fatty liver disease (NAFLD). MATERIAL/METHODS:Fasting serum levels of TNFalpha and its receptors were determined in 45 consecutive obese children with suspected liver disease and 20 lean controls. The degree of liver steatosis was graded in ultrasound according to Saverymuttu. 1H-MR spectroscopy was performed with 1.5T scanner with PRESS sequence. RESULTS:A fatty liver was confrmed in 32 children by ultrasonography (group I); 16 of them also had increased ALT activity (group Ia - NAFLD). Serum concentrations of TNFalpha and its receptors were significantly higher in obese children with NAFLD compared to controls. Significant correlation was found between ultrasonographic grade of liver steatosis and TNFalpha level but serum level of this adipokine was not significantly different in children with advanced liver steatosis (grade 2-3, n=13) compared to patients with mild steatosis (grade 1, n=19). The ability of TNFalpha and its receptors (R1, R2) to differentiate children with advanced liver steatosis from those with mild steatosis was insignificant. However, the ability of serum TNFalpha to differentiate obese children with liver steatosis from those without steatosis was significant (AUC=0.7448, p=0.0291). CONCLUSION:Although TNFalpha does not predict advanced liver steatosis, it may be suitable serum marker in predicting liver steatosis in obese children.
journal_name
Adv Med Scijournal_title
Advances in medical sciencesauthors
Lebensztejn DM,Kowalczuk D,Tarasów E,Skiba E,Kaczmarski Mdoi
10.2478/v10039-010-0008-5subject
Has Abstractpub_date
2010-01-01 00:00:00pages
74-9issue
1eissn
1896-1126issn
1898-4002pii
S1896-1126(14)60010-9journal_volume
55pub_type
杂志文章abstract：PURPOSE:The aim of this study was to assess the quality of life of the osteoarthritis (OA) and rheumatoid arthritis (RA) patients of Outpatient Clinic Rehabilitation in Poznań. MATERIAL AND METHODS:The study consisted of 97 OA patients, including 86 women and 11 men. Almost 123 patients with RA included of 102 women a...
journal_title：Advances in medical sciences
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journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
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journal_title：Advances in medical sciences
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abstract：PURPOSE:Ulcerative colitis (UC) carries a high risk of developing colorectal cancer (CRC). FK506-binding protein 51 (FKBP51) is a key regulator of glucocorticoid resistance and inflammatory tumor microenvironment. This study aimed to investigate the role of FKBP51 in UC-CRC prognosis. MATERIALS AND METHODS:The FKBP51 ...
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journal_title：Advances in medical sciences
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journal_title：Advances in medical sciences
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journal_title：Advances in medical sciences
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doi：
更新日期：2006-01-01 00:00:00
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journal_title：Advances in medical sciences
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doi：
更新日期：2006-01-01 00:00:00
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journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
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更新日期：2007-01-01 00:00:00
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journal_title：Advances in medical sciences
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journal_title：Advances in medical sciences
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更新日期：2007-01-01 00:00:00
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更新日期：2013-01-01 00:00:00
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journal_title：Advances in medical sciences
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更新日期：2006-01-01 00:00:00
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更新日期：2006-01-01 00:00:00
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journal_title：Advances in medical sciences
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journal_title：Advances in medical sciences
pub_type： 杂志文章
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更新日期：2006-01-01 00:00:00
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journal_title：Advances in medical sciences
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更新日期：2006-01-01 00:00:00
abstract：PURPOSE:In this multicenter retrospective analysis of the Polish Myeloma Group we assessed the real-life application of allogeneic transplantations (alloHCT) in multiple myeloma (MM) outside clinical trials in Poland. METHODS:Anonymized clinical data of patients who underwent alloHCT were retrospectively collected fro...
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更新日期：2006-01-01 00:00:00
abstract：PURPOSE:Glioblastoma is the most common and the deadliest brain cancer. The aim of this study was to analyze the impact of resveratrol and its five analogs: 3,4,4'-trimethoxy, 3,4,2'-trimethoxy, 3,4,2',4'-tetramethoxy, 3,4,2',6'-tetramethoxy and 3,4,2',4',6'-pentamethoxy-trans-stilbenes (MS) on human glioblastoma T98G ...
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abstract：:The increasing demand in studying cellular functions in cultured cells under various levels of oxygen and hydrogen peroxide (H2O2) is only partly fulfilled by conventional approaches such as hypoxia chambers, bolus additions of H2O2 or redox-cycling drugs. This article describes the recently developed enzymatic GOX/CA...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-009-0042-3
更新日期：2009-01-01 00:00:00
