Abstract：
PURPOSE:To compare soluble Fas, FasL and Bcl-2 in Graves' disease (GD) and Hashimoto's thyroiditis (HT) to the markers of humoral response: aTPO, aTG and aTSHR. MATERIAL AND METHODS:5 groups of subjects: 1) 14 patients with GD in euthyreosis on methimazol (euGD); 2) 20 patients with hyperthyroid GD (hrGD); 3) 15 patients with HT in euthyreosis on levothyroxine (euHT); 4) 16 patients with hypothyroid HT (hoHT); 5) 12 healthy volunteers age and sex-matched to group 1-4. Serum concentrations of Fas, FasL, Bcl-2, aTPO and aTG were determined by ELISA and aTSHR by RIA. RESULTS:Levels of sFas were the highest in hoHT: 8.7 (7.2-9.8) ng/ml as compared to the controls (p < 0.01) and euHT (p < 0.05). We found positive correlations between sFas and aTPO in all studied groups (r = 0.25, p < 0.05) and between sFas and TSH in HT (r = 0.4, p < 0.05). In GD there was a positive correlation between sFasL and aTG (r = 0.5, p < 0.01) and negative correlations between sFasL and Fas (r = -0.39, p < 0.01) and between sFasL and period of methimazol administration (r = -0.32, p < 0.05). Levels of sBcl-2 were significantly increased in euHT: 31.0 (13.5-44.1) ng/ml as compared to the controls (p < 0.05) and euGD (p < 0.05). CONCLUSIONS:Fas/FasL mediated apoptosis plays an important role in the active stage of the autoimmune process of both Hashimoto's thyroiditis and Graves' disease, however, in Hashimoto's thyroiditis they contribute to irreversible damage of thyreocytes. Early detection of Hashimoto's and Graves' diseases allows for the initiation of the proper treatment that probably leads to the reduction of the autoimmune process intensity.
journal_name
Adv Med Scijournal_title
Advances in medical sciencesauthors
Myśliwiec J,Okota M,Nikołajuk A,Górska Msubject
Has Abstractpub_date
2006-01-01 00:00:00pages
119-22eissn
1896-1126issn
1898-4002journal_volume
51pub_type
杂志文章abstract：:Idiopathic retroperitoneal fibrosis (IRF) entirely confined to the pelvic cavity is an extremely rare clinical entity. Herein, is described the case of a 36- year old male who presented with clinical and imaging manifestations of a large pelvic tumor. Exploratory laparotomy revealed a large mass in the right pelvis or...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-009-0029-0
更新日期：2009-01-01 00:00:00
abstract：PURPOSE:Chronic obstructive pulmonary disease is the most common chronic lung disease, which may be caused by different pathological processes, including inflammation. Furthermore, signs of changes in thyroid hormone levels are found in some patients. Deiodinases (DIOs) are selenoproteins (enzymes) involved in the synt...
journal_title：Advances in medical sciences
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更新日期：2019-09-01 00:00:00
abstract：PURPOSE:Non-alcoholic fatty liver disease (NAFLD) is increasingly being recognized in the pediatric population, therefore, the search for non-invasive parameters to predict progression of NAFLD is of great interest. The aim of this study was to assess serum concentration of sCD36 in children with obesity and to determi...
journal_title：Advances in medical sciences
pub_type： 杂志文章
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更新日期：2020-12-01 00:00:00
abstract：PURPOSE:Solid tumors modulate their environment to keep non-malignant stromal cells in a tumor-promoting state. The main cells in the stroma of epithelial derived tumors are cancer associated fibroblasts (CAF) that are critical to tumorigenesis and angiogenesis. CAFs also supply the tumor cells with growth factors and ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2015.04.006
更新日期：2015-09-01 00:00:00
abstract：PURPOSE:In this multicenter retrospective analysis of the Polish Myeloma Group we assessed the real-life application of allogeneic transplantations (alloHCT) in multiple myeloma (MM) outside clinical trials in Poland. METHODS:Anonymized clinical data of patients who underwent alloHCT were retrospectively collected fro...
journal_title：Advances in medical sciences
pub_type： 杂志文章
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abstract：PURPOSE:We analyzed the usefulness and prognostic value of intraoperative monitoring for identification of the oculomotor (III) and the abducens (VI) nerve in patients with cavernous sinus meningiomas. MATERIAL/METHODS:43 patients diagnosed with cavernous sinus meningiomas were divided according to their topography. F...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2014.08.009
更新日期：2015-03-01 00:00:00
abstract：PURPOSE:Anthranilic acid is an important, the aromatic intermediate in the degradation of tryptophan in kynurenine pathway. This compound plays an important role in the regulation of immunological processes as well shows antibacterial activity. The aim of our study was to estimate the concentration of anthranilic acid ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:To investigate the synergistic effects of nerve growth factor (NGF), ciliary neurotrophic factor (CNTF) and glia cell line-derived neurotrophic factor (GDNF) on survival and growth of sensory neurons and motoneurons, as well as on the functional recovery following sciatic nerve injury in rats. METHODS:Experime...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-010-0020-9
更新日期：2010-01-01 00:00:00
abstract：PURPOSE:Genetic variability of hepatitis C virus (HCV) is considered to be an important factor defining viral pathogenesis, persistence and resistance to treatment. The aim of the present study was to characterize HCV genetic heterogeneity within a hypervariable region 1 (HVR-1) before and during the early period of pe...
journal_title：Advances in medical sciences
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doi：10.2478/v10039-012-0024-8
更新日期：2012-01-01 00:00:00
abstract：PURPOSE:Sarcoidosis affected lungs detected in more than 90% of patients. The relationship between different stages of pulmonary sarcoidosis and pulmonary function tests (PFT) as well as bronchoalveolar lavage fluid (BALF) cells can be established. Geographic and ethnic factors are known to be linked to the specific ch...
journal_title：Advances in medical sciences
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doi：10.2478/v10039-008-0014-z
更新日期：2008-01-01 00:00:00
abstract：PURPOSE:Our question was whether two biochemical markers of preeclampsia, E-selectin and P-selectin, keep their prognostic value in particular stages of labour, or they lose it during labour. MATERIAL AND METHODS:The study group consisted of 36 healthy parturient women who gave physiological births (in control 15 heal...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:The aim of this study was to check the pro-apoptotic mechanism of prosthetic reconstruction on epithelial cells of the oral mucosa. PATIENTS AND METHODS:The research was carried out on the saliva of healthy patients using prostheses. The sample swabs were stained using the May-Grünwald-Giemsa method and proces...
journal_title：Advances in medical sciences
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abstract：PURPOSE:To evaluate the role of 12/15-lipoxygenase (LOX) in regulation of synthesis of selected eicosanoids in mice sensitized and challenged with Dermatophagoides pteronyssinus (Dp) allergen extract. MATERIALS AND METHODS:Both C57Bl and 12/15-LOX knockout mice were sensitized by 2 intraperitoneal injections and subse...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2015.11.001
更新日期：2016-03-01 00:00:00
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journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:A femoral artery pseudoaneurysm - is the most common complication associated with invasive coronary interventions. The aim of the study was to analyze the effectiveness of various methods used for femoral pseudoaneurysm treatment and to assess how routine use of radial approach leads to reduction of these site ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-011-0027-x
更新日期：2011-01-01 00:00:00
abstract：PURPOSE:Response to steroids is included in the diagnostic criteria for IgG4-related sclerosing cholangitis (IgG4-SC). To assess how to appropriately conduct steroid trials for IgG4-related SC, we examined the clinical pictures of steroid responsiveness in IgG4-SC patients. MATERIAL AND METHODS:A total of 29 patients ...
journal_title：Advances in medical sciences
pub_type： 临床试验,杂志文章
doi：10.1016/j.advms.2015.02.006
更新日期：2015-09-01 00:00:00
abstract：:PET is a successful modality to detect cancer and in recent years has demonstrated a great diagnostic value in large series of tumour types. PET combines high sensitivity and reasonable resolution, and offers the ability to perform whole body scans. 18F-deoxyglucose (FDG)-PET has also been used to diagnose tumours of ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:Vitamin A takes part in many physiological and pathological processes in women's reproductive organs. The study objective was to compare the carotenoid content in benign and malignant lesions of the breast, ovary and uterus, and to demonstrate quantitative and qualitative similarities or differences between the...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-008-0047-3
更新日期：2008-01-01 00:00:00
abstract：PURPOSE:Accumulating evidence has linked long noncoding RNAs (lncRNAs) to autoimmune and inflammatory disorders. This study aimed to detect the expression levels of five lncRNAs (lnc0640, lnc3643, lnc5150, lnc7514 and lncagf) in peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus (S...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2019.08.002
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:NT-proBNP and BNP concentrations in CHF correlate with NYHA class and LVEE Little research has been conducted to compare the clinical performance of these two natriuretic peptides in heterogeneous CHF population. Purpose: to evaluate and compare the clinical performance of NT-proBNP and BNP in heterogeneous gro...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:The aim of the study was to establish whether preoperative serum levels of HE4 and CA125 could be a good predictor for lymphadenectomy in the early stage of endometrioid adenocarcinoma of the uterus. MATERIAL AND METHODS:Preoperative serum HE4 and CA125 were measured in 78 postmenopausal patients treated surgi...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2015.07.010
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:The study aimed to determine the effect of OSA and obesity on the plasma levels of adiponectin and the long-term effect of CPAP on its plasma levels and obesity parameters. MATERIAL/METHODS:A prospective observational study included 159 newly diagnosed OSA patients. The cohort was divided into CPAP treated (n=...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2015.10.004
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:To explore the response pattern of plasma adipokine and ghrelin levels to coronary artery bypass graft (CABG) surgery in patients with (on-pump) and without (off-pump) cardiopulmonary bypass (CPB). MATERIAL/METHODS:Sixteen consecutive patients (age: 62 ± 10 years, male: 10) with obstructive coronary artery dis...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2014.04.002
更新日期：2014-09-01 00:00:00
abstract：PURPOSE:To assess the prevalence of spontaneous bacterial peritonitis (SBP) in asymptomatic patients with decompensated liver cirrhosis. MATERIAL AND METHODS:Patients (pts) with symptoms of decompensation of liver cirrhosis, ascites, and no signs indicating SBP were included to our study. Exclusion criteria include: 1...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-011-0010-6
更新日期：2011-01-01 00:00:00
abstract：:Epidemiological evidence strongly indicates that Helicobacter pylori infection is an essential factor for the development of most non-cardia gastric cancer. Furthermore, the identification of an effective animal model and a plausible biological hypothesis provide further compelling evidence for its pathogenic role. Ne...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
abstract：:We present 21 studies of cases of lung cancer in patients with situs inversus totalis (SIT) published worldwide. The first case was described in 1952. Thirteen patients were from Japan, 4 from Eastern Europe, including 2 Polish cases from the authors` center (Department of Thoracic Surgery, Pomeranian Medical Universi...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
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更新日期：2013-01-01 00:00:00
abstract：PURPOSE:Lipoxygenases (LOX) have been implicated in carcinogenesis, however both pro- and anti-carcinogenic effects have been reported in different cancer models. Using transgenic mice, which specifically overexpress human 15-lipoxygenase (ALOX15) in endothelial cells (EC), we previously demonstrated significant inhibi...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2019.11.006
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:Current risk stratification after acute myocardial infarction (MI) depends on left ventricular ejection fraction. Microvolt T-wave alternans (MTWA) is one of promising markers to predict cardiac events in patients after acute MI treated according to current guidelines. METHODS:In this single center study, 1...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-012-0033-7
更新日期：2012-01-01 00:00:00
abstract：PURPOSE:The aim of this study was to assess the quality of life of the osteoarthritis (OA) and rheumatoid arthritis (RA) patients of Outpatient Clinic Rehabilitation in Poznań. MATERIAL AND METHODS:The study consisted of 97 OA patients, including 86 women and 11 men. Almost 123 patients with RA included of 102 women a...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:In recent years, many reports have focused on clinical changes in the oral cavity of orthodontic patients, manifested in general inflammation of the mucosa. In order to better understand histopathological alterations in the mouth and the use of easily available diagnostic material, we decided to assess the morp...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
