Abstract：
PURPOSE:To investigate the synergistic effects of nerve growth factor (NGF), ciliary neurotrophic factor (CNTF) and glia cell line-derived neurotrophic factor (GDNF) on survival and growth of sensory neurons and motoneurons, as well as on the functional recovery following sciatic nerve injury in rats. METHODS:Experimental rats and neurons were randomized into 8 groups: NGF group, CNTF group, GDNF group, NGF+CNTF group, CNTF+GDNF group, NGF+GDNF group, NGF+CNTF+GDNF group and control group. Each group received local intramuscular injection of indicated NTFs according to the treatment protocol. The sciatic nerve function index (SFI), nerve conduction velocity and wet weight recovery rate of gastrocnemius muscle were tested to evaluate the functional recovery in vivo. A 2 (presence or absence of NGF) x 2 (presence or absence of CNTF) x 2 (presence or absence of GDNF) analysis of variance (ANOVA) was used to examine the main effects and interactions among NGF, CNTF and GDNF, and one-way ANOVA was calculated for multiple comparison. RESULTS:NGF and GDNF acted significantly on the survival of sensory neuron and motoneuron, respectively. CNTF was a dominant factor promoting cell body development, and GDNF had the most powerful effect on neurite outgrowth and elongation of sensory neurons and motoneurons. Combined administration of the three factors resulted in optimal functional recovery following sciatic nerve injury in rats. CONCLUSIONS:It is demonstrated that differential and complementary biological effects of various neurotrophic factors contribute to synergistic promotion of nervous function recovery.
journal_name
Adv Med Scijournal_title
Advances in medical sciencesauthors
Chen J,Chu YF,Chen JM,Li BCdoi
10.2478/v10039-010-0020-9subject
Has Abstractpub_date
2010-01-01 00:00:00pages
32-42issue
1eissn
1896-1126issn
1898-4002pii
S1896-1126(14)60005-5journal_volume
55pub_type
杂志文章abstract：:Gastroesophageal reflux disease (GERD) is a problem frequently occurring among physically and intellectually disabled individuals. In this group of patients GERD is often overlooked, since the symptoms are usually non-specific. We present two cases of disabled children, who developed complications of GERD in the form ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:This pilot study was aimed to establish techniques for assessing and observing trends in endothelial function, antioxidant status and vascular compliance in newly diagnosed HFE haemochromatosis during the first year of venesection. PATIENTS/METHODS:Untreated newly diagnosed HFE haemochromatosis patients were t...
journal_title：Advances in medical sciences
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journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
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journal_title：Advances in medical sciences
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journal_title：Advances in medical sciences
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pub_type： 临床试验,杂志文章
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journal_title：Advances in medical sciences
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doi：
更新日期：2007-01-01 00:00:00
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journal_title：Advances in medical sciences
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doi：
更新日期：2006-01-01 00:00:00
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journal_title：Advances in medical sciences
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journal_title：Advances in medical sciences
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更新日期：2007-01-01 00:00:00
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更新日期：2006-01-01 00:00:00
abstract：:Apelin is an endogenous peptide, which is expressed in a vast board of organs such as the brain, placenta, heart, lungs, kidneys, pancreas, testis, prostate and adipose tissues. The apelin receptor, called angiotensin-like-receptor 1 (APJ), is also expressed in the brain, spleen, placenta, heart, liver, intestine, pro...
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journal_title：Advances in medical sciences
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更新日期：2006-01-01 00:00:00
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journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
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更新日期：2008-01-01 00:00:00
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journal_title：Advances in medical sciences
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doi：
更新日期：2006-01-01 00:00:00
