Abstract:
PURPOSE:Behaviour of the vein thrombus is determined by the activity ratio of coagulation factors to factors of fibrinolytic system. The aim of the study is to evaluate activity of some coagulation and fibrinolytic factors in the vein thrombus. MATERIAL AND METHODS:The activity of platelets aggregating factors, tissue factor, thrombin, antithrombins, antiheparin factors, plasminogen activators, plasmin (plasminogen) and antiplasmins of the vein thrombus homogenate was determined using coagulative, fibrinolytic and caseinolytic tests. Retracted blood clot was a compared material. RESULTS:Tissue factor activity in the vein thrombus was above twofold higher and antiheparin activity was nearly twice higher in comparison to the blood clot. The vein thrombus contains also active thrombin. Plasminogen activators activity in the vein thrombus was twofold higher and activity of plasmin (plasminogen) was threefold higher than in the blood clot. High activity of the tissue factor, substances neutralizing heparin and presence of thrombin intensify the thrombus enlargement. However, the thrombotic tendency may be balanced by a high activity of plasminogen activators and high activity of plasmin (plasminogen). CONCLUSIONS:1) Vein thrombus is characterized by high activity of tissue factor, presence of active thrombin and high antiheparin activity. 2) High coagulative potential of vein thrombus is balanced to a certain grade by high fibrinolytic potential: high activity of plasminogen activators and high activity of plasmin (plasminogen), as well as absence of antiplasmins activity.
journal_name
Adv Med Scijournal_title
Advances in medical sciencesauthors
Guzowski A,Gacko M,Worowska A,Kowalewski R,Ostapowicz R,Ploński Asubject
Has Abstractpub_date
2006-01-01 00:00:00pages
205-7eissn
1896-1126issn
1898-4002journal_volume
51pub_type
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journal_title:Advances in medical sciences
pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
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journal_title:Advances in medical sciences
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journal_title:Advances in medical sciences
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更新日期:2007-01-01 00:00:00
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journal_title:Advances in medical sciences
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doi:
更新日期:2007-01-01 00:00:00
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更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2013-01-01 00:00:00
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journal_title:Advances in medical sciences
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更新日期:2007-01-01 00:00:00
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journal_title:Advances in medical sciences
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doi:
更新日期:2007-01-01 00:00:00
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journal_title:Advances in medical sciences
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更新日期:2009-01-01 00:00:00
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journal_title:Advances in medical sciences
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更新日期:2013-01-01 00:00:00
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journal_title:Advances in medical sciences
pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
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journal_title:Advances in medical sciences
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更新日期:2007-01-01 00:00:00
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