Abstract：
BACKGROUND:Current risk stratification after acute myocardial infarction (MI) depends on left ventricular ejection fraction. Microvolt T-wave alternans (MTWA) is one of promising markers to predict cardiac events in patients after acute MI treated according to current guidelines. METHODS:In this single center study, 112 consecutive patients with the first anterior ST-elevation MI undergoing PCI <12 hours from symptom onset, were enrolled prospectively. Demographics, established risk factors, myocardial contrast echocardiography (MCE) perfusion, index event data and MTWA were assessed. Composite cardiac events (CCE) defined as: death, recurrent MI, sustained ventricular tachycardia (sVT) or readmission for acute heart failure (HF) were recorded during follow-up. RESULTS:MTWA test was negative in 76, positive in 18 and undetermined in 7 patients. MTWA negative patients had significantly higher LVEF at 30 days. At 4 years, 26 patients experienced CCE (10 died, 2 reinfarcted and 14 HF events). In multivariate Cox proportional hazard model maximum CKMB, non-negative MTWA and reduced LVEF made the best model to predict CCE. Four year CCE free survival was 77% and was significantly lower for non-negative MTWA (94% vs 50%, p<0.003). CONCLUSIONS:Non-negative MTWA with infarct size index and reduced LVEF could predict cardiac events in patients with anterior STEMI treated with primary PCI. MTWA non-negative patients have significantly worse outcome.
journal_name
Adv Med Scijournal_title
Advances in medical sciencesauthors
Wita K,Filipecki A,Bochenek T,Tabor Z,Myszor J,Turski M,Doruchowska A,Trusz-Gluza Mdoi
10.2478/v10039-012-0033-7subject
Has Abstractpub_date
2012-01-01 00:00:00pages
328-33issue
2eissn
1896-1126issn
1898-4002pii
S1896-1126(14)60093-6journal_volume
57pub_type
杂志文章abstract：PURPOSE:This pilot study was aimed to establish techniques for assessing and observing trends in endothelial function, antioxidant status and vascular compliance in newly diagnosed HFE haemochromatosis during the first year of venesection. PATIENTS/METHODS:Untreated newly diagnosed HFE haemochromatosis patients were t...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2013.07.001
更新日期：2014-03-01 00:00:00
abstract：PURPOSE:The question of whether or not non-sporadic breast malignancies have different immunohistochemical features than sporadic malignancies has not been investigated previously. Consequently, the purpose of this study was to compare the expression of E-cadherin (EC) in breast cancer patients with positive and negati...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-008-0007-y
更新日期：2008-01-01 00:00:00
abstract：:Lung cancer causes an estimated 1.6 million deaths each year, being the leading cause of cancer-related deaths in the world. Late diagnosis and, in some cases, the high aggressiveness of the tumour result in low overall five-year survival rates of 12% among men and 7% among women. The cure is most likely in early-stag...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：10.1016/j.advms.2017.12.002
更新日期：2018-09-01 00:00:00
abstract：UNLABELLED:Factors believed to affect masticatory efficiency include loss of postcanine teeth, bite force, severity of malocclusion, occlusal contact area, body size and oral motor function. THE AIM:to record if there is relationship between masticatory efficiency and the state of dentition at patients whose occlusion...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:Glaucoma is one of the most important reason causes of the blindness, associated with retinal ganglion cells (RGC) death. This process is not fully understood, however apoptosis due to hypoxia is one of the most important processes leading to RGC death. Glaucomatous optic neuropathy is characterized by remodeli...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2015.07.007
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:To assess the prevalence of spontaneous bacterial peritonitis (SBP) in asymptomatic patients with decompensated liver cirrhosis. MATERIAL AND METHODS:Patients (pts) with symptoms of decompensation of liver cirrhosis, ascites, and no signs indicating SBP were included to our study. Exclusion criteria include: 1...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-011-0010-6
更新日期：2011-01-01 00:00:00
abstract：PURPOSE:It is essential in the medical care for immunocompromised patients that the environment should create minimal infection risk. Particularly, it concerns fungal infections. Fungi belonging to the Aspergillus genus are second frequent group of nosocomial pathogens producing opportunistic infections. MATERIAL AND ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-010-0039-y
更新日期：2010-01-01 00:00:00
abstract：PURPOSE:The biggest problem with the occurrence of breast cancer is late diagnosis, which is associated with high mortality rates. The aim of the study was to appraise the number of circulating endothelial precursors and the concentration of vascular endothelial growth factor A (VEGF-A) and the soluble forms of its rec...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2019.02.001
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:Genetic variability of hepatitis C virus (HCV) is considered to be an important factor defining viral pathogenesis, persistence and resistance to treatment. The aim of the present study was to characterize HCV genetic heterogeneity within a hypervariable region 1 (HVR-1) before and during the early period of pe...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-012-0024-8
更新日期：2012-01-01 00:00:00
abstract：PURPOSE:Existing anti-epileptic drugs (AED) have limited efficiency in many patients, necessitating the search for alternative approaches such as stem cell therapy. We report the use of autologous patient-derived mesenchymal stem cells (MSC) as a therapeutic agent in symptomatic drug-resistant epilepsy in a Phase I ope...
journal_title：Advances in medical sciences
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.advms.2016.12.004
更新日期：2017-09-01 00:00:00
abstract：PURPOSE:C-kit positive interstitial cells of Cajal (ICCs) play an important role in the regulation of the smooth muscle motility, acting as pacemakers to provide the slow wave activity in various organs. Recent studies have shown that c-kit positive ICCs are widely distributed in the urinary tract of animals and humans...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/ams-2013-0002
更新日期：2013-01-01 00:00:00
abstract：:In recent years, a constant growth of knowledge and clinical applications of stem cells have been observed. Mesenchymal stromal cells, also described as mesenchymal stem cells (MSCs) represent a particular cell type for research and therapy because of their ability to differentiate into mesodermal lineage cells. The m...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：10.2478/ams-2013-0007
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:The objective of this study was to evaluate thevitamin D concentration in patients with recurrent respiratory infections with or without immunoglobulin G, A or M (IgG, IgA, IgM) deficiency, and to find a correlation between the vitamin D concentration and the response to hepatitis B vaccination. MATERIALS AND ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2017.08.001
更新日期：2018-03-01 00:00:00
abstract：PURPOSE:Chronic obstructive pulmonary disease is the most common chronic lung disease, which may be caused by different pathological processes, including inflammation. Furthermore, signs of changes in thyroid hormone levels are found in some patients. Deiodinases (DIOs) are selenoproteins (enzymes) involved in the synt...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2019.04.001
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:Vitamin A takes part in many physiological and pathological processes in women's reproductive organs. The study objective was to compare the carotenoid content in benign and malignant lesions of the breast, ovary and uterus, and to demonstrate quantitative and qualitative similarities or differences between the...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-008-0047-3
更新日期：2008-01-01 00:00:00
abstract：PURPOSE:Our question was whether two biochemical markers of preeclampsia, E-selectin and P-selectin, keep their prognostic value in particular stages of labour, or they lose it during labour. MATERIAL AND METHODS:The study group consisted of 36 healthy parturient women who gave physiological births (in control 15 heal...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:In the literature, the manifestations of gastric cancer have been described based on all patients. In recent times, interest has focused on the subgroup of young patients. In the following analysis, the subgroup of young patients (< 50y) is compared with an older reference group (≥ 50y). MATERIAL AND METHODS:B...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-012-0052-4
更新日期：2012-01-01 00:00:00
abstract：PURPOSE:We aimed to examine the polymorphism of the promoter and exon 5 of the TNFSF11 gene and their impact on bone mineral density (BMD) and the frequency of bone fractures. TNFSF11 encodes the receptor activator of the NF-kB ligand (RANKL), a key regulator of bone metabolism and osteoporosis drug targets. BMD is an ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2020.05.001
更新日期：2020-09-01 00:00:00
abstract：:In liver surgery, accurate assessments of liver resection volume and anatomical variation are mandatory for preoperative planning of safe curative hepatectomy. In living donor liver transplantation (LDLT), estimation of hepatic venous drainage is important to avoid liver graft and donor residual liver congestion. This...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2006-01-01 00:00:00
abstract：:Melanoma is a malignant tumor which is inclined to metastasize promptly into the lymphatic system and other organs such as lung, liver, brain or bone. Therefore early diagnosis remains crucial for improving clinical outcome for melanoma patients. Current chemotherapy and chemo-immunotherapy regimes have shown little c...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：10.1016/j.advms.2014.12.002
更新日期：2015-03-01 00:00:00
abstract：PURPOSE:In spite of the general consensus on the issue, to point to major dilemmas which appear in this matter of multidisciplinary interest, and to review current concepts on how to achieve optimal diagnostic and therapeutic outcome. RESULTS:Recent literature data show that the rate of gestational breast cancer, acco...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：10.2478/v10039-008-0037-5
更新日期：2008-01-01 00:00:00
abstract：:We present 21 studies of cases of lung cancer in patients with situs inversus totalis (SIT) published worldwide. The first case was described in 1952. Thirteen patients were from Japan, 4 from Eastern Europe, including 2 Polish cases from the authors` center (Department of Thoracic Surgery, Pomeranian Medical Universi...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：10.2478/v10039-012-0083-x
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:The aim of this prospective randomized trial was to assess the influence of the sequence of pulmonary vessel ligation, during anatomic resection, on long term survival in patients with NSCLC. MATERIAL/METHODS:This prospective randomized study included 385 patients treated surgically with lobectomy or pneumonec...
journal_title：Advances in medical sciences
pub_type： 杂志文章,随机对照试验
doi：10.2478/v10039-012-0061-3
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:NT-proBNP and BNP concentrations in CHF correlate with NYHA class and LVEE Little research has been conducted to compare the clinical performance of these two natriuretic peptides in heterogeneous CHF population. Purpose: to evaluate and compare the clinical performance of NT-proBNP and BNP in heterogeneous gro...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Epidemiological evidence strongly indicates that Helicobacter pylori infection is an essential factor for the development of most non-cardia gastric cancer. Furthermore, the identification of an effective animal model and a plausible biological hypothesis provide further compelling evidence for its pathogenic role. Ne...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:In this multicenter retrospective analysis of the Polish Myeloma Group we assessed the real-life application of allogeneic transplantations (alloHCT) in multiple myeloma (MM) outside clinical trials in Poland. METHODS:Anonymized clinical data of patients who underwent alloHCT were retrospectively collected fro...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2020.08.003
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:The study aimed to examine the volumes of cerebellum and the brain stem in children with cerebral palsy (CP). MATERIAL AND METHODS:The present study included 21 children with spastic diplegic CP (11 girls and 10 boys). Twenty-one patients with CP were age- and gender-matched with the control patients. All subj...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:To evaluate the role of 12/15-lipoxygenase (LOX) in regulation of synthesis of selected eicosanoids in mice sensitized and challenged with Dermatophagoides pteronyssinus (Dp) allergen extract. MATERIALS AND METHODS:Both C57Bl and 12/15-LOX knockout mice were sensitized by 2 intraperitoneal injections and subse...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2015.11.001
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:To determine the time point at which thrombocytopenia after TAVI procedure is an indicator of the worst prognosis, with special consideration of perioperative platelet and coagulation activation as its potential causes. METHODS:Thirty two patients (mean age 78.5±7.9years, 62% females) qualified for TAVI proced...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2017.11.001
更新日期：2018-03-01 00:00:00
abstract：:Gastroesophageal reflux disease (GERD) is a problem frequently occurring among physically and intellectually disabled individuals. In this group of patients GERD is often overlooked, since the symptoms are usually non-specific. We present two cases of disabled children, who developed complications of GERD in the form ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
