Abstract：
PURPOSE:The question of whether or not non-sporadic breast malignancies have different immunohistochemical features than sporadic malignancies has not been investigated previously. Consequently, the purpose of this study was to compare the expression of E-cadherin (EC) in breast cancer patients with positive and negative oncologic histories. MATERIAL AND METHODS:The study included 98 breast cancer patients divided into two groups: 1) without the personal or familial history of previous malignancies, and 2) with the personal history of previous malignancies and/or with the data on cancer episodes in first- and/or second-degree relatives. RESULTS:There were no significant differences in the expression of EC between breast malignancies of the two groups. Moreover, statistical relationships were not observed between the positive or negative oncologic history, the age, and the menopausal status of patients, or histological tumor grade. CONCLUSIONS:Although the results of our series revealed no significant differences in the expression of EC between assumed sporadic and assumed non-sporadic malignancies, there is a need for further comparative studies on the immunohistochemistry of both the breast carcinoma types in order to find the other biological markers that could suggest or exclude cancer susceptibility in a given patient. Nevertheless, the results of our study suggest that EC immunohistochemistry cannot be used as a surrogate marker for screening for hereditary breast cancer.
journal_name
Adv Med Scijournal_title
Advances in medical sciencesauthors
Bruzewicz S,Matkowski R,Swiatoniowski G,Suder E,Setta M,Połozowski A,Zychowicz K,Szynglarewicz B,Kornafel Jdoi
10.2478/v10039-008-0007-ysubject
Has Abstractpub_date
2008-01-01 00:00:00pages
251-5issue
2eissn
1896-1126issn
1898-4002pii
84307Q1855452875journal_volume
53pub_type
杂志文章abstract：PURPOSE:In recent years, many reports have focused on clinical changes in the oral cavity of orthodontic patients, manifested in general inflammation of the mucosa. In order to better understand histopathological alterations in the mouth and the use of easily available diagnostic material, we decided to assess the morp...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:Desmin regulates function of mitochondria, T-tubular system and cytosolic Ca(2+) transients. We investigated whether desmin remodeling correlates with diastolic dysfunction and whether progressive desmin abnormalities are accompanied by increasing diastolic dysfunction stages. PATIENTS AND METHODS:Eighty five ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2015.01.009
更新日期：2015-03-01 00:00:00
abstract：PURPOSE:Promoter hypermethylation and reduced expression of many genes have been found in gastric cancer. DNA methyltransferases are enzymes potentially affecting promoter hypermethylation. MATERIAL AND METHODS:We analyzed proteins expression of DNA methyltransferase 1 and 3b by immunohistochemistry in 47 surgically r...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2014.10.002
更新日期：2015-03-01 00:00:00
abstract：PURPOSE:The aim of the present study was to assess the effect of tumor advancement and surgery treatment on P-selectin expression (CD 62P), level of sP-selectin and platelet count. MATERIAL AND METHODS:The study involved 27 colorectal cancer patients (CRC). They were divided into two groups: group B1--18 patients (T2-...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:C-kit positive interstitial cells of Cajal (ICCs) play an important role in the regulation of the smooth muscle motility, acting as pacemakers to provide the slow wave activity in various organs. Recent studies have shown that c-kit positive ICCs are widely distributed in the urinary tract of animals and humans...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/ams-2013-0002
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:Willow herb has been traditionally used in folk medicine and currently it is a potential raw material for production of phytopharmaceuticals. The aim of this work was to determine the highest amount of flavonoids and the highest radical scavenging activity of willow herb, which was collected in different vegeta...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2013.10.002
更新日期：2014-03-01 00:00:00
abstract：PURPOSE:Accumulating evidence has linked long noncoding RNAs (lncRNAs) to autoimmune and inflammatory disorders. This study aimed to detect the expression levels of five lncRNAs (lnc0640, lnc3643, lnc5150, lnc7514 and lncagf) in peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus (S...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2019.08.002
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:To evaluate the role of 12/15-lipoxygenase (LOX) in regulation of synthesis of selected eicosanoids in mice sensitized and challenged with Dermatophagoides pteronyssinus (Dp) allergen extract. MATERIALS AND METHODS:Both C57Bl and 12/15-LOX knockout mice were sensitized by 2 intraperitoneal injections and subse...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2015.11.001
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:The primary aim of this study is to compare the clinical course and laboratory parameters of acute cholecystitis in patients with diabetes vs. patients without diabetes. MATERIALS AND METHODS:The study involved patients who underwent emergency cholecystectomy in the Department of General, Endocrine and Transpl...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2020.08.001
更新日期：2020-09-01 00:00:00
abstract：:In recent years, a constant growth of knowledge and clinical applications of stem cells have been observed. Mesenchymal stromal cells, also described as mesenchymal stem cells (MSCs) represent a particular cell type for research and therapy because of their ability to differentiate into mesodermal lineage cells. The m...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：10.2478/ams-2013-0007
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:In this multicenter retrospective analysis of the Polish Myeloma Group we assessed the real-life application of allogeneic transplantations (alloHCT) in multiple myeloma (MM) outside clinical trials in Poland. METHODS:Anonymized clinical data of patients who underwent alloHCT were retrospectively collected fro...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2020.08.003
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:Lipoxygenases (LOX) have been implicated in carcinogenesis, however both pro- and anti-carcinogenic effects have been reported in different cancer models. Using transgenic mice, which specifically overexpress human 15-lipoxygenase (ALOX15) in endothelial cells (EC), we previously demonstrated significant inhibi...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2019.11.006
更新日期：2020-03-01 00:00:00
abstract：PURPOSE:The aim of the study was to evaluate factors related to bone formation and resorption in Polish children and adolescents with cystic fibrosis and to examine the effect of nutritional status, biochemical parameters and clinical status on bone mineral density. MATERIALS AND METHODS:The study group consisted of 1...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2015.05.002
更新日期：2015-09-01 00:00:00
abstract：PURPOSE:The assessment of satisfaction of women after mastectomy for nursing care. MATERIAL AND METHODS:The research was carried out on a group of 217 patients after radical mastectomy and took place at Surgical Clinic of Swietokrzyskie Oncology Centre in Kielce. Authors' assessment scale was used in research. RESULT...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:The aim of this study was to estimate the incidence of M. hominis and U. urealyticum infections among men with urethritis and its complications. MATERIAL AND METHODS:Material for analysis were urethral swabs and EPS. Mycoplasma IST 2 kit was applied to diagnose mycoplasmal infections. All patients were additio...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:Cardiogenic shock (CS) is a severe complication of acute coronary syndromes (ACS). Intra-aortic balloon pump (IABP) is considered important mechanical therapy for acute CS. We aimed to analyze the natural history and possible prognostic factors in patients with CS complicating ACS. PATIENTS/METHODS:All 126 pat...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2013.12.003
更新日期：2014-09-01 00:00:00
abstract：PURPOSE:The excess and deficit of serotonin can be the cause of somatic and mental disorders. The aim of this study was to evaluate serotonin levels in blood and ascitic fluid as well as excretion of 5-hydroxyindoleacetic acid (5-HIAA) in urine in patients with hepatic encephalopathy (HE). MATERIAL AND METHODS:The stu...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/ams-2013-0010
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:We aimed to examine the polymorphism of the promoter and exon 5 of the TNFSF11 gene and their impact on bone mineral density (BMD) and the frequency of bone fractures. TNFSF11 encodes the receptor activator of the NF-kB ligand (RANKL), a key regulator of bone metabolism and osteoporosis drug targets. BMD is an ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2020.05.001
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:Existing anti-epileptic drugs (AED) have limited efficiency in many patients, necessitating the search for alternative approaches such as stem cell therapy. We report the use of autologous patient-derived mesenchymal stem cells (MSC) as a therapeutic agent in symptomatic drug-resistant epilepsy in a Phase I ope...
journal_title：Advances in medical sciences
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.advms.2016.12.004
更新日期：2017-09-01 00:00:00
abstract：PURPOSE:NT-proBNP and BNP concentrations in CHF correlate with NYHA class and LVEE Little research has been conducted to compare the clinical performance of these two natriuretic peptides in heterogeneous CHF population. Purpose: to evaluate and compare the clinical performance of NT-proBNP and BNP in heterogeneous gro...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:To assess the prognostic significance of clinicopathological factors, especially histological parameters of new Jass classification, following sphincter-sparing total mesorectal excision (TME) for high-risk rectal cancer. MATERIAL AND METHODS:Forty-five consecutive patients treated with curative intent in 1998...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:Chronic obstructive pulmonary disease is the most common chronic lung disease, which may be caused by different pathological processes, including inflammation. Furthermore, signs of changes in thyroid hormone levels are found in some patients. Deiodinases (DIOs) are selenoproteins (enzymes) involved in the synt...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2019.04.001
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:Cerebral metastases develop in 10-30% of patients with breast cancer (BC) and in around 3.3 to 4% of patients with ovarian cancer (OC). The aim of the multicenter study is to investigate the correlation between the expression of estrogen alpha receptors (ERα), progesterone receptors (PR), human epidermal growth...
journal_title：Advances in medical sciences
pub_type： 杂志文章,多中心研究
doi：10.1016/j.advms.2018.12.007
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:To compare soluble Fas, FasL and Bcl-2 in Graves' disease (GD) and Hashimoto's thyroiditis (HT) to the markers of humoral response: aTPO, aTG and aTSHR. MATERIAL AND METHODS:5 groups of subjects: 1) 14 patients with GD in euthyreosis on methimazol (euGD); 2) 20 patients with hyperthyroid GD (hrGD); 3) 15 patie...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Hepatitis C virus (HCV) infection is a common problem. Combined treatment with interferon and ribavirin improved treatment efficacy, but still high percentage of infected patients has not reached virus elimination. It was found that HCV infection course, but also treatment efficacy among other things can depend on pat...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：10.2478/v10039-009-0002-y
更新日期：2009-01-01 00:00:00
abstract：PURPOSE:To assess the serum fetuin A concentration as a potential marker of subclinical atherosclerosis in obese children with NAFLD. MATERIAL/METHODS:A prospective analysis of 45 obese children initially diagnosed with liver pathology (elevated serum ALT activity and/or ultrasonographic liver brightness and/or hepato...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2013.08.003
更新日期：2014-03-01 00:00:00
abstract：PURPOSE:Ulcerative colitis (UC) carries a high risk of developing colorectal cancer (CRC). FK506-binding protein 51 (FKBP51) is a key regulator of glucocorticoid resistance and inflammatory tumor microenvironment. This study aimed to investigate the role of FKBP51 in UC-CRC prognosis. MATERIALS AND METHODS:The FKBP51 ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2021.01.003
更新日期：2021-01-15 00:00:00
abstract：:Melanoma is a malignant tumor which is inclined to metastasize promptly into the lymphatic system and other organs such as lung, liver, brain or bone. Therefore early diagnosis remains crucial for improving clinical outcome for melanoma patients. Current chemotherapy and chemo-immunotherapy regimes have shown little c...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：10.1016/j.advms.2014.12.002
更新日期：2015-03-01 00:00:00
abstract：PURPOSE:Our question was whether two biochemical markers of preeclampsia, E-selectin and P-selectin, keep their prognostic value in particular stages of labour, or they lose it during labour. MATERIAL AND METHODS:The study group consisted of 36 healthy parturient women who gave physiological births (in control 15 heal...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:The purpose of this study was to investigate the influence of selective agonists of the retinoid receptor X (RXR) and the retinoid acid receptor (RAR) on bone metabolism in rats. METHODS:Thirty six male Wistar rats were divided into three groups: receiving bexarotene, or tazarotene, or to control group. Serum ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2015.09.001
更新日期：2016-03-01 00:00:00
