Abstract：
PURPOSE:The aim of the present study was to assess the effect of tumor advancement and surgery treatment on P-selectin expression (CD 62P), level of sP-selectin and platelet count. MATERIAL AND METHODS:The study involved 27 colorectal cancer patients (CRC). They were divided into two groups: group B1--18 patients (T2-3N0M0) and group B2--9 patients (T2-4N+M0). In CRC patients the blood was collected three times: 1) before surgery (A0), 2) 3 days after surgery and 3) 12 days after surgery. RESULTS:The results obtained showed that CD 62P expression in CRC patients was twice higher (5.36%) than in control (2.58%) (p < 0.001). The level of sP-selectin concentration in both groups (B1--74.22 ng/mL and B2--70.33 ng/mL) was significantly higher than in control (46.01 ng/mL) (p < 0.001). There was no significant differences in CD 62P expression, plasma sP-selectin concentration and in PLT count between group B1 and B2. Three days after surgery in both groups of patients we observed decreased CD 62P expression and sP-selectin level compared to the results before surgery (p < 0.05). Twelve days after surgery we found an increase in the CD 62P-positive platelets and sP-selectin in group B1 and B2. We found positive correlation between plasma sP-selectin concentration and PLT count in CRC. CONCLUSIONS:In the current study on colorectal cancer we observed platelet hyperactivation, irrespective of tumor clinical advancement. Surgical procedure, in the early period following radical tumor resection, does not totally eliminate platelet activation in vivo.
journal_name
Adv Med Scijournal_title
Advances in medical sciencesauthors
Dymicka-Piekarska V,Matowicka-Karna J,Osada J,Kemona H,Butkiewicz AMsubject
Has Abstractpub_date
2006-01-01 00:00:00pages
304-8eissn
1896-1126issn
1898-4002journal_volume
51pub_type
杂志文章abstract：PURPOSE:Glioblastoma is the most common and the deadliest brain cancer. The aim of this study was to analyze the impact of resveratrol and its five analogs: 3,4,4'-trimethoxy, 3,4,2'-trimethoxy, 3,4,2',4'-tetramethoxy, 3,4,2',6'-tetramethoxy and 3,4,2',4',6'-pentamethoxy-trans-stilbenes (MS) on human glioblastoma T98G ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2020.11.001
更新日期：2020-11-22 00:00:00
abstract：PURPOSE:In spite of the general consensus on the issue, to point to major dilemmas which appear in this matter of multidisciplinary interest, and to review current concepts on how to achieve optimal diagnostic and therapeutic outcome. RESULTS:Recent literature data show that the rate of gestational breast cancer, acco...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：10.2478/v10039-008-0037-5
更新日期：2008-01-01 00:00:00
abstract：PURPOSE:Adaptation of the colorimetric method for the determination of β-d-galactosidase, β-d-glucuronidase and α-l-fucosidase activities in serums from hemolyzed blood, the material currently being discarded. MATERIALS AND METHODS:The materials included serums from hemolyzed and non-hemolyzed blood, obtained from 26 ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2018.04.005
更新日期：2018-09-01 00:00:00
abstract：UNLABELLED:Factors believed to affect masticatory efficiency include loss of postcanine teeth, bite force, severity of malocclusion, occlusal contact area, body size and oral motor function. THE AIM:to record if there is relationship between masticatory efficiency and the state of dentition at patients whose occlusion...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:The aim of this study was to assess the quality of life of the osteoarthritis (OA) and rheumatoid arthritis (RA) patients of Outpatient Clinic Rehabilitation in Poznań. MATERIAL AND METHODS:The study consisted of 97 OA patients, including 86 women and 11 men. Almost 123 patients with RA included of 102 women a...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:The aim of the study was to investigate the voice quality parameters in 72 rheumatoid arthritis (RA) patients and their relationships with the clinical manifestations and disease activity. The control group consisted of 30 healthy subjects. MATERIAL AND METHODS:All RA patients were evaluated by extensive clini...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2015.06.004
更新日期：2015-09-01 00:00:00
abstract：PURPOSE:The study aimed to examine the volumes of cerebellum and the brain stem in children with cerebral palsy (CP). MATERIAL AND METHODS:The present study included 21 children with spastic diplegic CP (11 girls and 10 boys). Twenty-one patients with CP were age- and gender-matched with the control patients. All subj...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:HCV chronic infection still presents a very serious epidemiological and clinical problem. Apart from its cytopathic effect on liver parenchyma, its detrimental effect on lipid and carbohydrate metabolism has recently been emphasized. The aim of the study was to assess lipid and carbohydrate parameters in childr...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-011-0048-5
更新日期：2011-01-01 00:00:00
abstract：PURPOSE:The current study objective was to compare blood platelet indices in preterm newborns (PTN) and full term newborns (FTN). MATERIALS AND METHODS:We introduced to our study 51 PTN (25 females, 26 males) and 55 FTN (25 females, 30 males). Platelet indices were estimated in blood samples collected from the umbilic...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-009-0034-3
更新日期：2009-01-01 00:00:00
abstract：PURPOSE:To determine reference values and tolerance limits of between-side differences for the calibers of the common femoral artery (CFA), superficial femoral artery (SFA), popliteal artery (PA), dorsalis pedis artery (DPA), and posterior tibial artery (PTA). MATERIALS AND METHODS:Calibers of arteries, defined as the...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2019.10.001
更新日期：2020-03-01 00:00:00
abstract：:Autoimmune pancreatitis (AIP) is a particular type of pancreatitis that is thought to have an autoimmune etiology. Before therapy for AIP is begun, accurate diagnosis of AIP is necessary. It is important to distinguish AIP from pancreatic cancer. Since there is currently no diagnostic serological marker for AIP, AIP s...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：10.2478/v10039-008-0033-9
更新日期：2008-01-01 00:00:00
abstract：PURPOSE:The aim of this prospective randomized trial was to assess the influence of the sequence of pulmonary vessel ligation, during anatomic resection, on long term survival in patients with NSCLC. MATERIAL/METHODS:This prospective randomized study included 385 patients treated surgically with lobectomy or pneumonec...
journal_title：Advances in medical sciences
pub_type： 杂志文章,随机对照试验
doi：10.2478/v10039-012-0061-3
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:The data concerning the relation between subclinical hypothyroidism (SH) and the risk of cardiovascular disease are divergent. We aimed to assess myocardial perfusion in contrast-enhanced echocardiography and intima-media thickness (IMT) in patients with SH. MATERIAL/METHODS:Forty females with SH without sympt...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-012-0068-9
更新日期：2013-01-01 00:00:00
abstract：:Apelin is an endogenous peptide, which is expressed in a vast board of organs such as the brain, placenta, heart, lungs, kidneys, pancreas, testis, prostate and adipose tissues. The apelin receptor, called angiotensin-like-receptor 1 (APJ), is also expressed in the brain, spleen, placenta, heart, liver, intestine, pro...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：10.1016/j.advms.2020.02.002
更新日期：2020-03-01 00:00:00
abstract：PURPOSE:The aim of the study was to evaluate factors related to bone formation and resorption in Polish children and adolescents with cystic fibrosis and to examine the effect of nutritional status, biochemical parameters and clinical status on bone mineral density. MATERIALS AND METHODS:The study group consisted of 1...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2015.05.002
更新日期：2015-09-01 00:00:00
abstract：PURPOSE:Sarcoidosis affected lungs detected in more than 90% of patients. The relationship between different stages of pulmonary sarcoidosis and pulmonary function tests (PFT) as well as bronchoalveolar lavage fluid (BALF) cells can be established. Geographic and ethnic factors are known to be linked to the specific ch...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-008-0014-z
更新日期：2008-01-01 00:00:00
abstract：PURPOSE:In a retrospective analysis of the prevalence of KRAS mutations in patients with advanced non-small cell lung cancer (NSCLC), we detected a unique and not earlier described case of a double combination of mutations at codons 12 and 13 of the KRAS gene in a patient with lung adenocarcinoma. MATERIAL/METHODS:To ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-012-0080-0
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:Defining the level of protective factors in saliva of patients suffering from decompensated type 2 diabetes. MATERIAL AND METHODS:50 Patients with diagnosis of decompensated type 2 diabetes, including 32 women and 18 men at the age of 57.9±9.2 years. The control group consisted of 50 people among whom there we...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2016.06.005
更新日期：2017-09-01 00:00:00
abstract：PURPOSE:To evaluate the role of 12/15-lipoxygenase (LOX) in regulation of synthesis of selected eicosanoids in mice sensitized and challenged with Dermatophagoides pteronyssinus (Dp) allergen extract. MATERIALS AND METHODS:Both C57Bl and 12/15-LOX knockout mice were sensitized by 2 intraperitoneal injections and subse...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2015.11.001
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:In this multicenter retrospective analysis of the Polish Myeloma Group we assessed the real-life application of allogeneic transplantations (alloHCT) in multiple myeloma (MM) outside clinical trials in Poland. METHODS:Anonymized clinical data of patients who underwent alloHCT were retrospectively collected fro...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2020.08.003
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:In the literature, the manifestations of gastric cancer have been described based on all patients. In recent times, interest has focused on the subgroup of young patients. In the following analysis, the subgroup of young patients (< 50y) is compared with an older reference group (≥ 50y). MATERIAL AND METHODS:B...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-012-0052-4
更新日期：2012-01-01 00:00:00
abstract：PURPOSE:To characterize the interaction between tiagabine (TGB) and valproate (VPA)--two antiepileptic drugs in the mouse pentylenetetrazole (PTZ)-induced clonic seizure model, type I isobolographic analysis for non-parallel dose-response relationship curves (DRRCs) was used. MATERIAL AND METHODS:Clonic seizures were ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-009-0006-7
更新日期：2009-01-01 00:00:00
abstract：:Melanoma is a malignant tumor which is inclined to metastasize promptly into the lymphatic system and other organs such as lung, liver, brain or bone. Therefore early diagnosis remains crucial for improving clinical outcome for melanoma patients. Current chemotherapy and chemo-immunotherapy regimes have shown little c...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：10.1016/j.advms.2014.12.002
更新日期：2015-03-01 00:00:00
abstract：PURPOSE:To compare soluble Fas, FasL and Bcl-2 in Graves' disease (GD) and Hashimoto's thyroiditis (HT) to the markers of humoral response: aTPO, aTG and aTSHR. MATERIAL AND METHODS:5 groups of subjects: 1) 14 patients with GD in euthyreosis on methimazol (euGD); 2) 20 patients with hyperthyroid GD (hrGD); 3) 15 patie...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:We present 21 studies of cases of lung cancer in patients with situs inversus totalis (SIT) published worldwide. The first case was described in 1952. Thirteen patients were from Japan, 4 from Eastern Europe, including 2 Polish cases from the authors` center (Department of Thoracic Surgery, Pomeranian Medical Universi...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：10.2478/v10039-012-0083-x
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:To evaluate intravascular xenotransplantation of macroencapsulated pancreatic islet cells in the process of the treatment of diabetes mellitus type 1 without immunosuppressive therapy. MATERIAL AND METHODS:Xenogenic intravascular transplantation was performed in 19 patients with diabetes mellitus (type 1) havi...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-008-0045-5
更新日期：2008-01-01 00:00:00
abstract：PURPOSE:Lipoxygenases (LOX) have been implicated in carcinogenesis, however both pro- and anti-carcinogenic effects have been reported in different cancer models. Using transgenic mice, which specifically overexpress human 15-lipoxygenase (ALOX15) in endothelial cells (EC), we previously demonstrated significant inhibi...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2019.11.006
更新日期：2020-03-01 00:00:00
abstract：:Hepatitis C virus (HCV) infection is a common problem. Combined treatment with interferon and ribavirin improved treatment efficacy, but still high percentage of infected patients has not reached virus elimination. It was found that HCV infection course, but also treatment efficacy among other things can depend on pat...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：10.2478/v10039-009-0002-y
更新日期：2009-01-01 00:00:00
abstract：PURPOSE:Our question was whether two biochemical markers of preeclampsia, E-selectin and P-selectin, keep their prognostic value in particular stages of labour, or they lose it during labour. MATERIAL AND METHODS:The study group consisted of 36 healthy parturient women who gave physiological births (in control 15 heal...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:Glaucoma is one of the most important reason causes of the blindness, associated with retinal ganglion cells (RGC) death. This process is not fully understood, however apoptosis due to hypoxia is one of the most important processes leading to RGC death. Glaucomatous optic neuropathy is characterized by remodeli...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2015.07.007
更新日期：2016-03-01 00:00:00
