Abstract：
PURPOSE:Chronic obstructive pulmonary disease is the most common chronic lung disease, which may be caused by different pathological processes, including inflammation. Furthermore, signs of changes in thyroid hormone levels are found in some patients. Deiodinases (DIOs) are selenoproteins (enzymes) involved in the synthesis of thyroid hormones. It has been found that these molecules are involved in inflammatory processes. We carried out this preliminary study to investigate the levels of two deiodinases, i.e. type 1 deiodinase (DIO1) and type 3 deiodinase (DIO3), and their possible association with COPD and specific clinical parameters. PATIENTS AND METHODS:Serum levels of DIO1 and DIO3 as well as lung function parameters were measured in 50 patients suffering from COPD and 30 healthy control subjects. The Mann-Whitney U test and Pearson's correlation coefficient were used to compare and correlate data. RESULTS:Serum levels of DIO1 and DIO3 were significantly elevated in COPD patients (97.9 ± 55.6 versus 28.2 ± 28.3 U/L for DIO1 and 19.6 ± 10.7 versus 6.4 ± 6.3 U/L for DIO3; p < 0.001). No correlation between serum levels of the examined DIOs and other sociodemographic and clinical parameters was identified in this study. CONCLUSION:For the first time we observed that peripheral DIO1 and DIO3 concentrations were elevated in COPD; hence, we may cautiously begin considering these molecules as potential circulating biomarkers of COPD. It may also be beneficial to conduct further studies to confirm and clarify their potential role.
journal_name
Adv Med Scijournal_title
Advances in medical sciencesauthors
Gałecka E,Kumor-Kisielewska A,Górski Pdoi
10.1016/j.advms.2019.04.001subject
Has Abstractpub_date
2019-09-01 00:00:00pages
344-348issue
2eissn
1896-1126issn
1898-4002pii
S1896-1126(18)30214-1journal_volume
64pub_type
杂志文章abstract：PURPOSE:The biggest problem with the occurrence of breast cancer is late diagnosis, which is associated with high mortality rates. The aim of the study was to appraise the number of circulating endothelial precursors and the concentration of vascular endothelial growth factor A (VEGF-A) and the soluble forms of its rec...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2019.02.001
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:The excess and deficit of serotonin can be the cause of somatic and mental disorders. The aim of this study was to evaluate serotonin levels in blood and ascitic fluid as well as excretion of 5-hydroxyindoleacetic acid (5-HIAA) in urine in patients with hepatic encephalopathy (HE). MATERIAL AND METHODS:The stu...
journal_title：Advances in medical sciences
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doi：10.2478/ams-2013-0010
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abstract：:PET is a successful modality to detect cancer and in recent years has demonstrated a great diagnostic value in large series of tumour types. PET combines high sensitivity and reasonable resolution, and offers the ability to perform whole body scans. 18F-deoxyglucose (FDG)-PET has also been used to diagnose tumours of ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
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abstract：PURPOSE:The question of whether or not non-sporadic breast malignancies have different immunohistochemical features than sporadic malignancies has not been investigated previously. Consequently, the purpose of this study was to compare the expression of E-cadherin (EC) in breast cancer patients with positive and negati...
journal_title：Advances in medical sciences
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doi：10.2478/v10039-008-0007-y
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journal_title：Advances in medical sciences
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journal_title：Advances in medical sciences
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journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-008-0014-z
更新日期：2008-01-01 00:00:00
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journal_title：Advances in medical sciences
pub_type： 杂志文章,多中心研究
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abstract：PURPOSE:The data concerning the relation between subclinical hypothyroidism (SH) and the risk of cardiovascular disease are divergent. We aimed to assess myocardial perfusion in contrast-enhanced echocardiography and intima-media thickness (IMT) in patients with SH. MATERIAL/METHODS:Forty females with SH without sympt...
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journal_title：Advances in medical sciences
pub_type： 杂志文章
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journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:Willow herb has been traditionally used in folk medicine and currently it is a potential raw material for production of phytopharmaceuticals. The aim of this work was to determine the highest amount of flavonoids and the highest radical scavenging activity of willow herb, which was collected in different vegeta...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2013.10.002
更新日期：2014-03-01 00:00:00
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journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2015.10.004
更新日期：2016-03-01 00:00:00
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journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2013.07.001
更新日期：2014-03-01 00:00:00
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journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2020.08.001
更新日期：2020-09-01 00:00:00
abstract：:Adhesive molecules are responsible for the cell-cell interaction and the surrounding intercellular environment creating normal tissue architecture. The role of adhesion proteins in cancer refers to angiogenesis, loss of tissue continuity, and deprivation of intercellular contact with the extracellular matrix, promotin...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：10.1016/j.advms.2019.08.003
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:The aim of the research was to investigate correlation between strain on the spine, work place and years spent in work. MATERIAL AND METHODS:Research was carried out on a group of 937 nurses working in health care units in the Warsaw district area. The study was conducted using the method of diagnostic survey ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:Idiopathic retroperitoneal fibrosis (IRF) entirely confined to the pelvic cavity is an extremely rare clinical entity. Herein, is described the case of a 36- year old male who presented with clinical and imaging manifestations of a large pelvic tumor. Exploratory laparotomy revealed a large mass in the right pelvis or...
journal_title：Advances in medical sciences
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doi：10.2478/v10039-009-0029-0
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journal_title：Advances in medical sciences
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doi：10.1016/j.advms.2019.11.006
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journal_title：Advances in medical sciences
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doi：10.1016/j.advms.2015.07.007
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journal_title：Advances in medical sciences
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doi：10.2478/v10039-009-0034-3
更新日期：2009-01-01 00:00:00
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journal_title：Advances in medical sciences
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doi：
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:Stroke and subclinical "silent infarcts" are major causes of morbidity in children with Sickle Cell Disease (SCD). Ischemic strokes are more common in younger children while hemorrhagic strokes are more frequent in adults. The goal of neuroimaging in acute stroke is to document whether the stroke is ischemic or...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
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journal_title：Advances in medical sciences
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更新日期：2012-01-01 00:00:00
abstract：PURPOSE:Ulcerative colitis (UC) carries a high risk of developing colorectal cancer (CRC). FK506-binding protein 51 (FKBP51) is a key regulator of glucocorticoid resistance and inflammatory tumor microenvironment. This study aimed to investigate the role of FKBP51 in UC-CRC prognosis. MATERIALS AND METHODS:The FKBP51 ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2021.01.003
更新日期：2021-01-15 00:00:00
abstract：BACKGROUND:Current risk stratification after acute myocardial infarction (MI) depends on left ventricular ejection fraction. Microvolt T-wave alternans (MTWA) is one of promising markers to predict cardiac events in patients after acute MI treated according to current guidelines. METHODS:In this single center study, 1...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-012-0033-7
更新日期：2012-01-01 00:00:00
abstract：:Hepatitis C virus (HCV) infection is a common problem. Combined treatment with interferon and ribavirin improved treatment efficacy, but still high percentage of infected patients has not reached virus elimination. It was found that HCV infection course, but also treatment efficacy among other things can depend on pat...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：10.2478/v10039-009-0002-y
更新日期：2009-01-01 00:00:00
abstract：PURPOSE:The purpose of the studies performed was an attempt to establish a potential relationship between total antioxidant status of unstimulated whole saliva, patients' ages, oral hygiene status and dental caries. MATERIAL AND METHODS:The study involved 120 non-smokers. Mean age of the study subjects was 18.40 ± 1.7...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-012-0015-9
更新日期：2012-06-01 00:00:00
abstract：PURPOSE:Arterial hypertension (aHT) is the leading risk factor for morbidity and mortality worldwide. Blood pressure (BP) deviation at rest is well defined and accompanies risk for cardiovascular events and cardiovascular mortality. A growing body of evidence emphasises that an exaggerated blood pressure response (EBPR...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：10.1016/j.advms.2016.11.010
更新日期：2017-09-01 00:00:00
