Abstract：
:Lung cancer causes an estimated 1.6 million deaths each year, being the leading cause of cancer-related deaths in the world. Late diagnosis and, in some cases, the high aggressiveness of the tumour result in low overall five-year survival rates of 12% among men and 7% among women. The cure is most likely in early-stage disease. The poor outcomes of treatment in lung cancer resulting from the fact that most cases are diagnosed in the advanced stage of the disease justify the implementation of an optimal lung cancer prevention in the form of smoking cessation and screening programmes that would offer a chance to detect early stages of the disease, while fitting within specific economic constraints. The National Lung Screening Trial (NLST) - the largest and most expensive randomised, clinical trial in the USA demonstrated a 20% mortality rate reduction in patients who had undergone chest low-dose computed tomography (LDCT) screening, as compared to patients screened with a conventional chest X-ray. Results of the NLST enabled the implementation of lung cancer screening programme among highrisk patients in the USA and parts of China. In 2017, recommendations of the European Society of Thoracic Surgeons also strongly recommend an implementation of a screening programme in the EU. Further studies of improved lung cancer risk assessment scores and of effective molecular markers should intensify in order to reduce all potential harms to the high-risk group and to increase cost-effectiveness of the screening.
journal_name
Adv Med Scijournal_title
Advances in medical sciencesauthors
Ostrowski M,Marjański T,Rzyman Wdoi
10.1016/j.advms.2017.12.002subject
Has Abstractpub_date
2018-09-01 00:00:00pages
230-236issue
2eissn
1896-1126issn
1898-4002pii
S1896-1126(17)30083-4journal_volume
63pub_type
杂志文章,评审abstract：PURPOSE:The aim of this study was to check the pro-apoptotic mechanism of prosthetic reconstruction on epithelial cells of the oral mucosa. PATIENTS AND METHODS:The research was carried out on the saliva of healthy patients using prostheses. The sample swabs were stained using the May-Grünwald-Giemsa method and proces...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2019.12.010
更新日期：2020-03-01 00:00:00
abstract：PURPOSE:The purpose of this study was to test the influence of a barbituric acid derivative acting as a catalyst and small amounts of pyrolytic silica in acrylic resins on color stability, solubility and sorption of a composite. MATERIALS AND METHODS:A series of two-component powder/liquid resin systems were prepared....
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2017.04.006
更新日期：2017-09-01 00:00:00
abstract：PURPOSE:Cerebral metastases develop in 10-30% of patients with breast cancer (BC) and in around 3.3 to 4% of patients with ovarian cancer (OC). The aim of the multicenter study is to investigate the correlation between the expression of estrogen alpha receptors (ERα), progesterone receptors (PR), human epidermal growth...
journal_title：Advances in medical sciences
pub_type： 杂志文章,多中心研究
doi：10.1016/j.advms.2018.12.007
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:Caries, a social ailment, is one of the diseases of civilization of the 20th century. In Poland, the incidence rate of caries is very high both in the young and adults. The major etiological factors of caries are: improper oral hygiene, diet based on carbohydrate-rich and highly processed food products, neglect...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
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abstract：PURPOSE:The aim of this study was to determine the antimicrobial resistance and the occurrence of virulence determinants among glycopeptide-resistant enterococci (GRE) isolated in 2007-2009 from patients hospitalized in southwestern Poland. MATERIAL AND METHODS:The minimal inhibitory concentrations (MICs) of antibioti...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-011-0022-2
更新日期：2011-01-01 00:00:00
abstract：PURPOSE:To investigate the synergistic effects of nerve growth factor (NGF), ciliary neurotrophic factor (CNTF) and glia cell line-derived neurotrophic factor (GDNF) on survival and growth of sensory neurons and motoneurons, as well as on the functional recovery following sciatic nerve injury in rats. METHODS:Experime...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-010-0020-9
更新日期：2010-01-01 00:00:00
abstract：:Apelin is an endogenous peptide, which is expressed in a vast board of organs such as the brain, placenta, heart, lungs, kidneys, pancreas, testis, prostate and adipose tissues. The apelin receptor, called angiotensin-like-receptor 1 (APJ), is also expressed in the brain, spleen, placenta, heart, liver, intestine, pro...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
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更新日期：2020-03-01 00:00:00
abstract：:Hepatitis C virus (HCV) infection is a common problem. Combined treatment with interferon and ribavirin improved treatment efficacy, but still high percentage of infected patients has not reached virus elimination. It was found that HCV infection course, but also treatment efficacy among other things can depend on pat...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：10.2478/v10039-009-0002-y
更新日期：2009-01-01 00:00:00
abstract：PURPOSE:To assess the prognostic significance of clinicopathological factors, especially histological parameters of new Jass classification, following sphincter-sparing total mesorectal excision (TME) for high-risk rectal cancer. MATERIAL AND METHODS:Forty-five consecutive patients treated with curative intent in 1998...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:The aim of the study was to establish whether preoperative serum levels of HE4 and CA125 could be a good predictor for lymphadenectomy in the early stage of endometrioid adenocarcinoma of the uterus. MATERIAL AND METHODS:Preoperative serum HE4 and CA125 were measured in 78 postmenopausal patients treated surgi...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2015.07.010
更新日期：2016-03-01 00:00:00
abstract：:Adhesive molecules are responsible for the cell-cell interaction and the surrounding intercellular environment creating normal tissue architecture. The role of adhesion proteins in cancer refers to angiogenesis, loss of tissue continuity, and deprivation of intercellular contact with the extracellular matrix, promotin...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：10.1016/j.advms.2019.08.003
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:Sarcoidosis affected lungs detected in more than 90% of patients. The relationship between different stages of pulmonary sarcoidosis and pulmonary function tests (PFT) as well as bronchoalveolar lavage fluid (BALF) cells can be established. Geographic and ethnic factors are known to be linked to the specific ch...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-008-0014-z
更新日期：2008-01-01 00:00:00
abstract：PURPOSE:Promoter hypermethylation and reduced expression of many genes have been found in gastric cancer. DNA methyltransferases are enzymes potentially affecting promoter hypermethylation. MATERIAL AND METHODS:We analyzed proteins expression of DNA methyltransferase 1 and 3b by immunohistochemistry in 47 surgically r...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2014.10.002
更新日期：2015-03-01 00:00:00
abstract：UNLABELLED:Factors believed to affect masticatory efficiency include loss of postcanine teeth, bite force, severity of malocclusion, occlusal contact area, body size and oral motor function. THE AIM:to record if there is relationship between masticatory efficiency and the state of dentition at patients whose occlusion...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:HCV chronic infection still presents a very serious epidemiological and clinical problem. Apart from its cytopathic effect on liver parenchyma, its detrimental effect on lipid and carbohydrate metabolism has recently been emphasized. The aim of the study was to assess lipid and carbohydrate parameters in childr...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-011-0048-5
更新日期：2011-01-01 00:00:00
abstract：PURPOSE:In a retrospective analysis of the prevalence of KRAS mutations in patients with advanced non-small cell lung cancer (NSCLC), we detected a unique and not earlier described case of a double combination of mutations at codons 12 and 13 of the KRAS gene in a patient with lung adenocarcinoma. MATERIAL/METHODS:To ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-012-0080-0
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:Glaucoma is one of the most important reason causes of the blindness, associated with retinal ganglion cells (RGC) death. This process is not fully understood, however apoptosis due to hypoxia is one of the most important processes leading to RGC death. Glaucomatous optic neuropathy is characterized by remodeli...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2015.07.007
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:The question of whether or not non-sporadic breast malignancies have different immunohistochemical features than sporadic malignancies has not been investigated previously. Consequently, the purpose of this study was to compare the expression of E-cadherin (EC) in breast cancer patients with positive and negati...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-008-0007-y
更新日期：2008-01-01 00:00:00
abstract：PURPOSE:Cardiogenic shock (CS) is a severe complication of acute coronary syndromes (ACS). Intra-aortic balloon pump (IABP) is considered important mechanical therapy for acute CS. We aimed to analyze the natural history and possible prognostic factors in patients with CS complicating ACS. PATIENTS/METHODS:All 126 pat...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2013.12.003
更新日期：2014-09-01 00:00:00
abstract：:We present 21 studies of cases of lung cancer in patients with situs inversus totalis (SIT) published worldwide. The first case was described in 1952. Thirteen patients were from Japan, 4 from Eastern Europe, including 2 Polish cases from the authors` center (Department of Thoracic Surgery, Pomeranian Medical Universi...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：10.2478/v10039-012-0083-x
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:Vascular endothelial growth factor is an important factor in promoting angiogenesis in malignant processes, matrix metalloproteinase-9 in the degradation of extracellular matrix, which enhances metastasis, and tissue inhibitor of metalloproteinase-1 is its inhibitor. The aim of this study was to investigate the...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2018.07.002
更新日期：2019-03-01 00:00:00
abstract：PURPOSE:The aim of the research was to investigate correlation between strain on the spine, work place and years spent in work. MATERIAL AND METHODS:Research was carried out on a group of 937 nurses working in health care units in the Warsaw district area. The study was conducted using the method of diagnostic survey ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:Arterial hypertension (aHT) is the leading risk factor for morbidity and mortality worldwide. Blood pressure (BP) deviation at rest is well defined and accompanies risk for cardiovascular events and cardiovascular mortality. A growing body of evidence emphasises that an exaggerated blood pressure response (EBPR...
journal_title：Advances in medical sciences
pub_type： 杂志文章,评审
doi：10.1016/j.advms.2016.11.010
更新日期：2017-09-01 00:00:00
abstract：PURPOSE:NT-proBNP and BNP concentrations in CHF correlate with NYHA class and LVEE Little research has been conducted to compare the clinical performance of these two natriuretic peptides in heterogeneous CHF population. Purpose: to evaluate and compare the clinical performance of NT-proBNP and BNP in heterogeneous gro...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:Desmin regulates function of mitochondria, T-tubular system and cytosolic Ca(2+) transients. We investigated whether desmin remodeling correlates with diastolic dysfunction and whether progressive desmin abnormalities are accompanied by increasing diastolic dysfunction stages. PATIENTS AND METHODS:Eighty five ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.1016/j.advms.2015.01.009
更新日期：2015-03-01 00:00:00
abstract：PURPOSE:Urinary incontinence is a disease due to which women have suffered for many centuries. But there is some optimistic side to the problem, too; such illnesses can be treated and prevented. The aim of the work was to evaluate the frequency of occurring such cases among women and to evaluate the chosen risk factors...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:The data concerning the relation between subclinical hypothyroidism (SH) and the risk of cardiovascular disease are divergent. We aimed to assess myocardial perfusion in contrast-enhanced echocardiography and intima-media thickness (IMT) in patients with SH. MATERIAL/METHODS:Forty females with SH without sympt...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-012-0068-9
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:C-kit positive interstitial cells of Cajal (ICCs) play an important role in the regulation of the smooth muscle motility, acting as pacemakers to provide the slow wave activity in various organs. Recent studies have shown that c-kit positive ICCs are widely distributed in the urinary tract of animals and humans...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/ams-2013-0002
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:Behaviour of the vein thrombus is determined by the activity ratio of coagulation factors to factors of fibrinolytic system. The aim of the study is to evaluate activity of some coagulation and fibrinolytic factors in the vein thrombus. MATERIAL AND METHODS:The activity of platelets aggregating factors, tissue...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:To characterize the interaction between tiagabine (TGB) and valproate (VPA)--two antiepileptic drugs in the mouse pentylenetetrazole (PTZ)-induced clonic seizure model, type I isobolographic analysis for non-parallel dose-response relationship curves (DRRCs) was used. MATERIAL AND METHODS:Clonic seizures were ...
journal_title：Advances in medical sciences
pub_type： 杂志文章
doi：10.2478/v10039-009-0006-7
更新日期：2009-01-01 00:00:00
