Abstract：
PURPOSE:Methylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in endothelial nitric oxide synthase (eNOS) coupling and homocysteine metabolism. The rs1801133 polymorphism of the MTHFR gene affects risk of coronary artery disease. We assessed its influence on 5-year survival of patients with ST-elevation acute myocardial infarction (STEMI). MATERIAL/METHODS:The study group comprised consecutive patients with STEMI. Genotyping was performed with a TaqMan SNP Genotyping Assay using the ABI 7500 Real Time PCR System (Applied Biosystems). The analyzed end-point was all-cause 5-year survival. RESULTS:The study group comprised 637 patients (mean age 62.3 ± 11.9 years; 25.1% females, n=160; 5-year mortality 16.3%, n=104). The percentages of TT, CT and CC genotypes were: 10.8 (n=69), 39.7 (n=253) and 49.45 (n=315), respectively. No significant differences in clinical characteristics were identified between the genotypes (p>0.05 for all parameters). Eleven (15.9%) TT homozygotes, 40 (15.8%) heterozygotes and 53 (16.8%) CC homozygotes died during follow up (p=0.99 log-rank test). TT homozygotes presented only weak and insignificant tendency towards higher mortality rates in subgroups of patients ≤75 years old (15.6 vs. 11.54%, p=0.35) or with intermediate risk according to the GRACE risk score (13.3% vs. 8.76%, p=0.42). CONCLUSIONS:The rs1801133 polymorphism did not show significant association with 5-year survival.
journal_name
Adv Med Scijournal_title
Advances in medical sciencesauthors
Kozieradzka A,Pepinski W,Waszkiewicz E,Olszewska M,Maciorkowska D,Skawronska M,Niemcunowicz-Janica A,Dobrzycki S,Musial WJ,Kaminski KAdoi
10.2478/v10039-012-0010-1subject
Has Abstractpub_date
2012-06-01 00:00:00pages
106-11issue
1eissn
1896-1126issn
1898-4002pii
S1896-1126(14)60117-6journal_volume
57pub_type
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