Abstract：
PURPOSE:The aim of this study was to check the pro-apoptotic mechanism of prosthetic reconstruction on epithelial cells of the oral mucosa. PATIENTS AND METHODS:The research was carried out on the saliva of healthy patients using prostheses. The sample swabs were stained using the May-Grünwald-Giemsa method and processed by immunohistochemistry for nuclear factor kappa B (NF-κB; p65) and caspase-3. Western blots were used to detect caspase-3, NF-κB, p53 and COX-2 expression. RESULTS:We found an increased expression of caspase-3, NF-κB and p53 in the oral epithelial cells of patients using prosthetic restorations compared to the subjects from the control group. No differences in COX-2 expression were found between the groups. The strongest immunoreactivity and expression of caspase-3, NF-κB and p53 were observed in patients using full prosthesis for less than two years. CONCLUSIONS:The results of the conducted research indicate that prosthetic restorations may affect the process of apoptosis of oral mucosa epithelial cells. Lack of difference in expression of COX-2 in the saliva of the studied patients suggests that apoptosis is not caused by inflammatory factors.
journal_name
Adv Med Scijournal_title
Advances in medical sciencesauthors
Domian N,Surażyński A,Szarmach J,Piotrowska Ż,Kasacka Idoi
10.1016/j.advms.2019.12.010subject
Has Abstractpub_date
2020-03-01 00:00:00pages
134-140issue
1eissn
1896-1126issn
1898-4002pii
S1896-1126(19)30027-6journal_volume
65pub_type
杂志文章abstract：PURPOSE:The aim of this prospective randomized trial was to assess the influence of the sequence of pulmonary vessel ligation, during anatomic resection, on long term survival in patients with NSCLC. MATERIAL/METHODS:This prospective randomized study included 385 patients treated surgically with lobectomy or pneumonec...
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pub_type： 杂志文章,随机对照试验
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