Cell adhesion molecules in endometrial cancer - A systematic review.

Abstract:

:Adhesive molecules are responsible for the cell-cell interaction and the surrounding intercellular environment creating normal tissue architecture. The role of adhesion proteins in cancer refers to angiogenesis, loss of tissue continuity, and deprivation of intercellular contact with the extracellular matrix, promoting the spread of cancer through the formation of metastases. The integrity of the epithelium is disturbed - with disturbances in the whole mechanism of cell connections, thanks to which cancer cells infiltrate surrounding tissues, and move to lymphatic and blood vessels. Adhesive molecules are divided into five main families: cadherin, catenins, integrins, the immunoglobulin superfamily and non-classical adhesion molecules. In the present review we describe the role of all five families of adhesive molecules in endometrial cancer.

journal_name

Adv Med Sci

authors

Lewczuk Ł,Pryczynicz A,Guzińska-Ustymowicz K

doi

10.1016/j.advms.2019.08.003

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

423-429

issue

2

eissn

1896-1126

issn

1898-4002

pii

S1896-1126(18)30431-0

journal_volume

64

pub_type

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