Abstract:
BACKGROUND:The maternal circulatory system and hormone balance both change dynamically during pregnancy, delivery, and the postpartum period. Although atrial natriuretic peptides and brain natriuretic peptides produced in the heart control circulatory homeostasis through their common receptor, NPR1, the physiologic and pathophysiologic roles of endogenous atrial natriuretic peptide/brain natriuretic peptide in the perinatal period are not fully understood. METHODS:To clarify the physiologic and pathophysiologic roles of the endogenous atrial natriuretic peptide/brain natriuretic peptide-NPR1 system during the perinatal period, the phenotype of female wild-type and conventional or tissue-specific Npr1-knockout mice during the perinatal period was examined, especially focusing on maternal heart weight, blood pressure, and cardiac function. RESULTS:In wild-type mice, lactation but not pregnancy induced reversible cardiac hypertrophy accompanied by increases in fetal cardiac gene mRNAs and ERK1/2 (extracellular signaling-regulated kinase) phosphorylation. Npr1-knockout mice exhibited significantly higher plasma aldosterone level than did wild-type mice, severe cardiac hypertrophy accompanied by fibrosis, and left ventricular dysfunction in the lactation period. Npr1-knockout mice showed a high mortality rate over consecutive pregnancy-lactation cycles. In the hearts of Npr1-knockout mice during or after the lactation period, an increase in interleukin-6 mRNA expression, phosphorylation of signal transducer and activator of transcription 3, and activation of the calcineurin-nuclear factor of the activated T cells pathway were observed. Pharmacologic inhibition of the mineralocorticoid receptor or neuron-specific deletion of the mineralocorticoid receptor gene significantly ameliorated cardiac hypertrophy in lactating Npr1-knockout mice. Anti-interleukin-6 receptor antibody administration tended to reduce cardiac hypertrophy in lactating Npr1-knockout mice. CONCLUSIONS:These results suggest that the characteristics of lactation-induced cardiac hypertrophy in wild-type mice are different from exercise-induced cardiac hypertrophy, and that the endogenous atrial natriuretic peptide/brain natriuretic peptide-NPR1 system plays an important role in protecting the maternal heart from interleukin-6-induced inflammation and remodeling in the lactation period, a condition mimicking peripartum cardiomyopathy.
journal_name
Circulationjournal_title
Circulationauthors
Otani K,Tokudome T,Kamiya CA,Mao Y,Nishimura H,Hasegawa T,Arai Y,Kaneko M,Shioi G,Ishida J,Fukamizu A,Osaki T,Nagai-Okatani C,Minamino N,Ensho T,Hino J,Murata S,Takegami M,Nishimura K,Kishimoto I,Miyazato M,Haradoi
10.1161/CIRCULATIONAHA.119.039761subject
Has Abstractpub_date
2020-02-18 00:00:00pages
571-588issue
7eissn
0009-7322issn
1524-4539journal_volume
141pub_type
杂志文章相关文献
CIRCULATION文献大全abstract::For estimating left ventricular mass (LVM), ECG criteria for left ventricular hypertrophy (LVH) were selected from conventional 12-lead ECGs, orthogonal three-lead ECGs, and multiple-dipole ECGs (MDECG). The three cardiograms were recorded in 139 patients for whom the degree of LVH was independently determined from bi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.60.6.1350
更新日期:1979-12-01 00:00:00
abstract:BACKGROUND:Lipoprotein(a) [Lp(a)] may play a causal role in atherosclerosis. PCSK9 (proprotein convertase subtilisin/kexin 9) inhibitors have been shown to significantly reduce plasma Lp(a) concentration. However, the relationship between Lp(a) levels, PCSK9 inhibition, and cardiovascular risk reduction remains undefin...
journal_title:Circulation
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCULATIONAHA.118.037184
更新日期:2019-03-19 00:00:00
abstract:BACKGROUND:Extrahepatic tissues have long been considered critical contributors of cholesterol to nascent HDL particles in the reverse cholesterol transport pathway, in which ABCA1 plays the crucial role. Recent studies, however, including both overexpression and deletion of ABCA1 selectively in the liver, have highlig...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.106.621433
更新日期:2006-09-19 00:00:00
abstract:BACKGROUND:Paraplegia continues to complicate thoracoabdominal aortic interventions. The elusive mechanism of spinal cord ischemia-reperfusion injury has delayed the development of pharmacological adjuncts. Microglia, the resident macrophages of the central nervous system, can have pathological responses after a variet...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.112.000024
更新日期:2013-09-10 00:00:00
abstract:BACKGROUND:During the 1980s, mortality from coronary artery disease (CAD) decreased markedly in the United States. This raises the question of whether a parallel decrease occurred in excess mortality due to CAD in patients undergoing surgical correction of valvular regurgitation. METHODS AND RESULTS:Survival of 752 pa...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1998-11-10 00:00:00
abstract:BACKGROUND:To examine the influence active-play video gaming (also referred to as exergaming, exertainment, and active gaming) might have on improving health-related skills, enhancing self-esteem and self-efficacy, promoting social support, and ultimately motivating positive changes in health behaviors, the American He...
journal_title:Circulation
pub_type:
doi:10.1161/CIR.0b013e318219661d
更新日期:2011-05-31 00:00:00
abstract:BACKGROUND:The role of angiotensin II receptor subtypes was investigated in focal brain ischemia induced by middle cerebral artery (MCA) occlusion. METHODS AND RESULTS:In Agtr2+ (wild-type) mice, MCA occlusion induced focal ischemia of approximately 20% to 30% of the total area in coronal section of the brain. The isc...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000138848.58269.80
更新日期:2004-08-17 00:00:00
abstract:BACKGROUND:Right ventricular free wall (RVFW) ischemia impairs global RV performance and may result in acute hemodynamic compromise. However, RV function and hemodynamic performance typically improve spontaneously over time. This study was designed to determine whether reperfusion facilitates recovery of function in th...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.90.3.1398
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:The outcome of patients with corrected transposition of the great arteries (CTGA) is variably affected by associated intracardiac defects, tricuspid valve competence, and systemic right ventricular (RV) function. The relative importance of these factors in long-term outcome has not been evaluated. METHODS A...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.98.10.997
更新日期:1998-09-08 00:00:00
abstract:BACKGROUND:Associations of obesity with incidence of heart failure have been observed, but the causality is uncertain. We hypothesized that gastric bypass surgery leads to a lower incidence of heart failure compared with intensive lifestyle modification in obese people. METHODS:We included obese people without previou...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.116.025629
更新日期:2017-04-25 00:00:00
abstract:BACKGROUND:Congestive heart failure (CHF) is characterized by enhanced immune activation, and immune-mediated mechanisms may play a pathogenic role in this disorder. Based on the immunomodulatory effects of intravenous immunoglobulin (IVIG), we hypothesized that IVIG could downregulate inflammatory responses in CHF pat...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.103.2.220
更新日期:2001-01-16 00:00:00
abstract:BACKGROUND:Human endothelial and vascular smooth muscle cells synthesize prostanoids. Several of these have been implicated in the physiological and pathophysiological regulation of vascular tone; however, there is no direct evidence that human blood vessels synthesize sufficient prostanoid to alter vessel tone. METHO...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.92.8.2113
更新日期:1995-10-15 00:00:00
abstract:BACKGROUND:CD4+CD28null T cells are present in increased numbers in the peripheral blood of patients with acute coronary syndrome (ACS) compared with patients with chronic stable angina (CSA). The triggers of activation and expansion of these cells to date remain unclear. METHODS AND RESULTS:Twenty-one patients with A...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000118476.29352.2A
更新日期:2004-03-16 00:00:00
abstract:BACKGROUND:We have previously shown that hydrogen peroxide stimulates endothelial [Ca(2+)](i) oscillations. This study was performed to determine whether posthypoxic reoxygenation stimulates [Ca(2+)](i) oscillations in vascular endothelial cells. METHODS AND RESULTS:Hypoxia (glucose-free 95% N(2)/5% CO(2) bicarbonate ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.20.2541
更新日期:2000-11-14 00:00:00
abstract::R-wave synchronous equilbrium radionuclide angiography (RNA) is a noninvasive method that provides time-activity curve count information proportional to ventricular volumes and is used for relative volume comparisons within the left or right ventricle to derive the ejection fraction. Comparison of the ventricular coun...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.62.5.1089
更新日期:1980-11-01 00:00:00
abstract:BACKGROUND:Coronary heart disease (CHD) is the leading cause of morbidity and mortality in persons with type 2 diabetes mellitus (T2DM). Electron-beam computed tomography (EBCT) detects coronary artery calcium (CAC), a marker of atherosclerotic plaque. Few studies have described EBCT-defined CHD among ethnic minorities...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000146377.15057.CC
更新日期:2004-11-02 00:00:00
abstract::The first stage of a repair of pulmonary atresia with intact ventricular septum (type I) was attempted in a 2-day-old infant. At surgery, decompression of the hypertensive small right ventricle was followed by a sudden loss of myocardial contractility and death. Postmortem examination revealed a fistula with a large o...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.65.4.805
更新日期:1982-04-01 00:00:00
abstract:BACKGROUND:In a correlative functional/histopathologic study, we investigated the regional deformation characteristics of both chronic nontransmural and transmural infarctions before and after a dobutamine challenge. METHODS AND RESULTS:After stenosing copper-coated stent implantation to produce circumflex artery endo...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000050146.66577.4b
更新日期:2003-02-18 00:00:00
abstract::Knowledge of the potential gradient field created by defibrillation electrodes is important for the understanding and improvement of defibrillation. To obtain this knowledge by direct measurements, potentials were recorded from 60 epicardial, eight septal, and 36 right ventricular transmural electrodes in six open-che...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.74.3.626
更新日期:1986-09-01 00:00:00
abstract:BACKGROUND:Platelet aggregation plays a critical role in myocardial infarction and stroke; however, the role of platelet secretion in atherosclerotic vascular disease is poorly understood. Therefore, we examined the hypothesis that platelet dense-granule secretion modulates thrombosis, inflammation, and atherosclerotic...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.108.845461
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Pulse pressure (PP) increases with age as a result of arterial stiffening and is a powerful predictor of cardiovascular disease. Type 1 diabetes is associated with excessive cardiovascular mortality and increased arterial stiffness. We examined whether the age-related blood pressure changes in type 1 diabeti...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000139903.29522.8D
更新日期:2004-08-31 00:00:00
abstract::The antiarrhythmic efficacy and safety of oral flecainide acetate and quinidine sulfate were compared in a double-blind, 16-center parallel trial involving 280 patients with chronic premature ventricular complexes (PVCs). Eighty-five percent of the flecainide patients had at least 80% suppression of PVCs, vs 57% of th...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.67.5.1117
更新日期:1983-05-01 00:00:00
abstract:BACKGROUND:Dysregulation of adipocyte-derived bioactive molecules plays an important role in the development of atherosclerosis. We previously reported that adiponectin, an adipocyte-specific plasma protein, accumulated in the injured artery from the plasma and suppressed endothelial inflammatory response and vascular ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000042707.50032.19
更新日期:2002-11-26 00:00:00
abstract::The predictive value of the myocardial scintigraphy with 99mTc-pyrophosphate was studied in 100 patients admitted to the coronary care unit with suspected acute myocardial infarction. None of the 21 patients with normal scintigrams had acute myocardial infraction by other criteria. Fifty-five percent of patients with ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.57.2.320
更新日期:1978-02-01 00:00:00
abstract:BACKGROUND:The effect of human immunodeficiency virus (HIV) on the development of peripheral artery disease (PAD) remains unclear. We investigated whether HIV infection is associated with an increased risk of PAD after adjustment for traditional atherosclerotic risk factors in a large cohort of HIV-infected (HIV+) and ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.117.032647
更新日期:2018-07-17 00:00:00
abstract:BACKGROUND:Pregnant women with congenital heart disease (CHD) are susceptible to cardiovascular, obstetric, and offspring complications. In women with CHD, cardiac dysfunction may compromise uteroplacental flow and contribute to the increased incidence of obstetric and offspring events. METHODS AND RESULTS:We performe...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.113.002810
更新日期:2013-12-03 00:00:00
abstract:BACKGROUND:We previously demonstrated that ischemic postconditioning decreases creatine kinase release, a surrogate marker for infarct size, in patients with acute myocardial infarction. Our objective was to determine whether ischemic postconditioning could afford (1) a persistent infarct size limitation and (2) an imp...
journal_title:Circulation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/CIRCULATIONAHA.107.729780
更新日期:2008-02-26 00:00:00
abstract:BACKGROUND:It has been suggested that intracellular Ca2+ overload in cardiac myocytes leads to the development of diabetic cardiomyopathy. Troglitazone, an insulin-sensitizing agent, is a promising therapeutic agent for diabetes and has been shown to prevent diabetes-induced myocardial changes. To elucidate the underly...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.99.22.2942
更新日期:1999-06-08 00:00:00
abstract::The pericardium, because of the nature of its pressure-volume relation, can influence left ventricular diastolic and systolic pump function. During an acute increase in heart size that results in the stretching of the pericardium, the elastic properties of the pericardium restrict further cardiac dilatation and curtai...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND:Clinical trials have demonstrated that platelet glycoprotein (GP) IIb/IIIa antagonists effectively prevent acute thrombotic events. Orally active GP IIb/IIIa antagonists are essential to evaluate the clinical benefit of long-term treatment. We therefore investigated platelet inhibition by the GP IIb/IIIa ant...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.96.4.1130
更新日期:1997-08-19 00:00:00