Abstract:
:The pericardium, because of the nature of its pressure-volume relation, can influence left ventricular diastolic and systolic pump function. During an acute increase in heart size that results in the stretching of the pericardium, the elastic properties of the pericardium restrict further cardiac dilatation and curtail the ability of the ventricles to increase stroke volume. In addition, the pericardium enhances the degree to which increments in right ventricular volume would alter left ventricular diastolic distensibility. Ventricular interdependence is enhanced as a direct consequence of pericardial elastic properties. During the heightened venous return associated with marked muscular work, we found evidence of pericardial constraint in 31 of 61 patients with heart failure of varying severity and diverse etiology. The occurrence of pericardial constraint, which was characterized by stroke volume becoming invariant and an equivalent rise in right atrial and pulmonary capillary wedge pressures as work load was raised during incremental upright exercise, was independent of the degree to which maximum oxygen consumption was reduced or, equivalently, the severity of heart failure. In contrast, when pericardial constraint was not apparent during our exercise protocol, stroke volume did not become invariant, and the increments in pulmonary capillary wedge pressure were two- to threefold that of right atrial pressure. Thus, the pericardium can have a substantial role in determining the limits to left ventricular diastolic and systolic function.
journal_name
Circulationjournal_title
Circulationauthors
Janicki JSsubject
Has Abstractpub_date
1990-02-01 00:00:00pages
III15-20issue
2 Suppleissn
0009-7322issn
1524-4539journal_volume
81pub_type
杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:The effect of effective refractory period (ERP) shortening on the vulnerability and characteristics of induced functional reentry in the ventricle remain poorly defined. We hypothesized that ERP shortening increases ventricular vulnerability to reentry and accelerates its rate, as is the case in the atrium. ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.99.5.704
更新日期:1999-02-09 00:00:00
abstract::Cerebral and retinal ischemic events have been described in mitral valve prolapse. To determine whether platelets play a part in the pathogenesis of thromboembolism we studied 29 patients with mitral valve prolapse, including nine (group I) with thromboembolism (cerebral, retinal and deep venous), eight (group II) wit...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.63.3.552
更新日期:1981-03-01 00:00:00
abstract:BACKGROUND:Older coronary patients are at high risk of cardiac disability. Exercise conditioning programs have been demonstrated to improve functional capacity, particularly in younger coronary patients. In this study, the effects of aerobic conditioning on submaximal and maximal indicators of exercise performance were...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.88.2.572
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:The role of infections and inflammation in the pathophysiology of coronary heart disease is emerging. We studied the independent and joint effects of these 2 components on coronary risk. METHODS AND RESULTS:We measured baseline levels of C-reactive protein (CRP) and antibodies to adenovirus, enterovirus, cy...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.101.3.252
更新日期:2000-01-25 00:00:00
abstract:BACKGROUND:Whether knowledge of genetic risk for coronary heart disease (CHD) affects health-related outcomes is unknown. We investigated whether incorporating a genetic risk score (GRS) in CHD risk estimates lowers low-density lipoprotein cholesterol (LDL-C) levels. METHODS AND RESULTS:Participants (n=203, 45-65 year...
journal_title:Circulation
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCULATIONAHA.115.020109
更新日期:2016-03-22 00:00:00
abstract:BACKGROUND:Although LDL cholesterol (LDL-C) is generally accepted to be a major risk factor for progression of atherosclerosis, the traditional measurement of LDL-C includes measurement of IDL. Little is known about the relationship between IDL and progression of atherosclerosis. Therefore, we investigated the associat...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.95.8.2022
更新日期:1997-04-15 00:00:00
abstract:BACKGROUND:Atherosclerosis is a multifactorial disease in which inflammatory processes play an important role. Inflammation underlies lesion evolution at all stages, from establishment to plaque rupture and thrombosis. Costimulatory molecules of the tumor necrosis factor superfamily such as CD40/CD40L and OX40/OX40L ha...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.107.699173
更新日期:2008-03-11 00:00:00
abstract:BACKGROUND:The outcome of patients with corrected transposition of the great arteries (CTGA) is variably affected by associated intracardiac defects, tricuspid valve competence, and systemic right ventricular (RV) function. The relative importance of these factors in long-term outcome has not been evaluated. METHODS A...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.98.10.997
更新日期:1998-09-08 00:00:00
abstract:BACKGROUND:The site of cannulation for repair of ascending aortic dissection remains controversial. We present our experience with ascending aortic cannulation for acute aortic dissection type A. METHODS AND RESULTS:From January 1988 to September 2007, we operated on 242 patients for acute aortic dissection type A. Me...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.108.844480
更新日期:2009-09-15 00:00:00
abstract:BACKGROUND:Two types of ischemia, pacing-induced and coronary occlusion-induced, have different effects on left ventricular diastolic properties. During pacing-induced ischemia, the diastolic pressure-volume relation is said to shift upward, whereas during coronary occlusion, it is said to shift rightward or downward. ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.91.9.2423
更新日期:1995-05-01 00:00:00
abstract::The importance of pulmonary artery size and the value of a standardized pulmonary artery index (PAI) in predicting outcome after Fontan's repair have previously been reported and questioned. We retrospectively reviewed 29 patients undergoing modified Fontan repair at The Children's Hospital of Philadelphia to examine ...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1989-09-01 00:00:00
abstract::From January 1968 to June 1975 tricuspid regurgitation was encountered in 238 patients of a total of 1074 patients undergoing operations on the mitral valve. During this time tricuspid annuloplasty (TA) was performed in 137 patients and the tricuspid valve was replaced (TVR) in 101 patients. Comparison of hospital mor...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1976-12-01 00:00:00
abstract::Patients with congestive heart failure have a high incidence of sudden cardiac death that is attributed to ventricular arrhythmias. The mortality rate in a group of patients with class III and IV heart failure is about 40% per year, and half of the deaths are sudden. Half of the patients with New York Heart Associatio...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:
更新日期:1987-05-01 00:00:00
abstract:BACKGROUND:We have demonstrated that brain natriuretic peptide (BNP) is a cardiac hormone predominantly synthesized in and secreted from the ventricle. We have also reported that, compared with atrial natriuretic peptide (ANP), the plasma concentration of BNP is increased to a greater degree in patients with congestive...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.92.6.1558
更新日期:1995-09-15 00:00:00
abstract::All physicians increasingly will encounter patients who have implanted cardioverter-defibrillators (ICDs) for protection from ventricular arrhythmias. This advisory provides a concise summary relevant to the assessment and management of patients with ICDs, including those who present to primary care or emergency depar...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/01.CIR.0000149716.03295.7C
更新日期:2004-12-21 00:00:00
abstract:BACKGROUND:Elevated asymmetrical dimethylarginine (ADMA) is a novel risk factor for atherosclerosis that may impair endothelial function by interfering with endothelial nitric oxide synthesis. To gain insight into the effects of ADMA on systemic endothelial function, we examined the association between ADMA and brachia...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.107.690016
更新日期:2007-09-18 00:00:00
abstract:BACKGROUND:Hypercholesterolemia is associated with endothelial dysfunction. On the basis of the hypothesis that high plasma cholesterol per se may be a sufficient stimulus to upregulate endothelial adhesiveness and that this phenomenon might be reversible, soluble endothelial leukocyte adhesion molecules (sELAMs) were ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.5.1381
更新日期:1997-09-02 00:00:00
abstract:BACKGROUND:Development of surgical therapy for aortic aneurysms and dissections has led to treatment of the life-threatening cardiovascular complications associated with Marfan syndrome. The present study determines the effect of surgical therapy on the life expectancy of patients with Marfan syndrome and the clinical ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.91.3.728
更新日期:1995-02-01 00:00:00
abstract::The existence of a brain renin-angiotensin system (RAS) as one of various tissue RASs is now firmly established. Angiotensin-containing pathways within brain areas involved in central blood pressure regulation have been described. Evidence from biochemical, neurophysiologic, pharmacologic, and most recently, molecular...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND:The role of structural heart disease and sodium channel dysfunction in the induction of electrical instability in Brugada syndrome is still debated. METHODS AND RESULTS:We studied 18 consecutive patients (15 males, 3 females; mean age 42.0+/-12.4 years) with clinical phenotype of Brugada syndrome and normal...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.105.520999
更新日期:2005-12-13 00:00:00
abstract:BACKGROUND:We have reported that myocardial ischemia increases nitric oxide (NO) production. Several lines of evidence suggest that NO reduces myocardial contraction. Therefore, we tested whether endogenous NO decreases the inotropic response of the ischemic myocardium and whether endogenous NO is beneficial in the met...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.93.2.356
更新日期:1996-01-15 00:00:00
abstract:BACKGROUND:Lifetime risk for atherosclerotic cardiovascular disease (CVD) has not previously been estimated, and the effect of risk factor burden on lifetime risk is unknown. METHODS AND RESULTS:We included all Framingham Heart Study participants who were free of CVD (myocardial infarction, coronary insufficiency, ang...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.105.548206
更新日期:2006-02-14 00:00:00
abstract::This investigation was designed to assess the potential use of laser coronary angioplasty as an intraoperative adjunct in the surgical treatment of ischemic heart disease. Among 17 postmortem hearts, simulated laser coronary angioplasty was performed at 53 sites with a No. 4F guiding catheter and 240 micron (200 micro...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1985-09-01 00:00:00
abstract::Intermittent restoration of coronary flow during ischemia reduced myocardial damage and improved recovery of function. The mechanisms of the protective effects of intermittent perfusion were investigated in isolated rat hearts. Ventricular function was assessed as the product of developed pressure (left ventricular sy...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.82.2.536
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND:The potential biological significance of hydrogen sulfide (H(2)S) has attracted growing interest in recent years. The aim of this study was to characterize a novel, water-soluble, slow-releasing H(2)S compound [morpholin-4-ium 4 methoxyphenyl(morpholino) phosphinodithioate (GYY4137)] and evaluate its use as ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.107.753467
更新日期:2008-05-06 00:00:00
abstract:BACKGROUND:In patients with atrial fibrillation (AF), the risk of thromboembolic events (TEs) is variable and is influenced by the presence and number of comorbid conditions. The effect of percutaneous left atrial radiofrequency ablation (LARFA) of AF on the risk of TEs is unclear. METHODS AND RESULTS:LARFA was perfor...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.106.641225
更新日期:2006-08-22 00:00:00
abstract:BACKGROUND:Marfan syndrome (MFS) is caused by mutations in the fibrillin-1 gene and dysregulation of transforming growth factor-beta (TGF-beta). Recent evidence suggests that losartan, an angiotensin II type 1 blocker that blunts TGF-beta activation, may be an effective treatment for MFS. We hypothesized that dysregula...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.108.841981
更新日期:2009-08-11 00:00:00
abstract::Two-dimensional echocardiography can provide serial cross-sectional images of the left ventricular cavity. We examined whether such serial images from steady-state ejecting hearts would allow three-dimensional reconstruction and accurate volume estimation without major geometric assumptions. Cross-circulated, paced do...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.60.2.320
更新日期:1979-08-01 00:00:00
abstract:BACKGROUND:The rate-corrected QT interval (QTc) is heritable, and the discovery of quantitative trait loci that influence the QTc would be an important step in identifying the genes responsible for life-threatening arrhythmias in the general population. We studied 66 pairs of unselected normal dizygotic (DZ) twin subje...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.99.24.3161
更新日期:1999-06-22 00:00:00
abstract:BACKGROUND:The purpose of this study was to determine the influence of clinical characteristics on shock occurrence and survival in 241 patients with implantable cardioverter-defibrillator (ICD) therapy. METHODS AND RESULTS:Two hundred forty-one consecutive patients underwent ICD implantation between November 1982 and...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.87.6.1880
更新日期:1993-06-01 00:00:00