Influence of the pericardium and ventricular interdependence on left ventricular diastolic and systolic function in patients with heart failure.


:The pericardium, because of the nature of its pressure-volume relation, can influence left ventricular diastolic and systolic pump function. During an acute increase in heart size that results in the stretching of the pericardium, the elastic properties of the pericardium restrict further cardiac dilatation and curtail the ability of the ventricles to increase stroke volume. In addition, the pericardium enhances the degree to which increments in right ventricular volume would alter left ventricular diastolic distensibility. Ventricular interdependence is enhanced as a direct consequence of pericardial elastic properties. During the heightened venous return associated with marked muscular work, we found evidence of pericardial constraint in 31 of 61 patients with heart failure of varying severity and diverse etiology. The occurrence of pericardial constraint, which was characterized by stroke volume becoming invariant and an equivalent rise in right atrial and pulmonary capillary wedge pressures as work load was raised during incremental upright exercise, was independent of the degree to which maximum oxygen consumption was reduced or, equivalently, the severity of heart failure. In contrast, when pericardial constraint was not apparent during our exercise protocol, stroke volume did not become invariant, and the increments in pulmonary capillary wedge pressure were two- to threefold that of right atrial pressure. Thus, the pericardium can have a substantial role in determining the limits to left ventricular diastolic and systolic function.






Janicki JS


Has Abstract


1990-02-01 00:00:00




2 Suppl








  • Regional wave travel and reflections along the human aorta: a study with six simultaneous micromanometric pressures.

    abstract::The human aorta and its terminal branches were investigated in normal subjects during elective cardiac catheterization to evaluate regional wave travel and arterial wave reflections. A specially designed catheter with six micromanometers equally spaced at 10 cm intervals was positioned with the tip sensor in the dista...


    pub_type: 杂志文章


    authors: Latham RD,Westerhof N,Sipkema P,Rubal BJ,Reuderink P,Murgo JP

    更新日期:1985-12-01 00:00:00

  • Selective serotonin reuptake inhibitors and myocardial infarction.

    abstract:BACKGROUND:Depression is an independent risk factor for myocardial infarction (MI). Selective serotonin reuptake inhibitors (SSRIs) may reduce this risk through attenuation of serotonin-mediated platelet activation in addition to treatment of depression itself. METHODS AND RESULTS:case-control study of first MI in smo...


    pub_type: 杂志文章


    authors: Sauer WH,Berlin JA,Kimmel SE

    更新日期:2001-10-16 00:00:00

  • S100B expression modulates left ventricular remodeling after myocardial infarction in mice.

    abstract:BACKGROUND:S100B, a 20-kDa, Ca2+-binding dimer, is a putative intrinsic negative regulator of myocardial hypertrophy expressed after myocardial infarction. S100B-overexpressing transgenic (TG) and S100B-knockout (KO) mice have been generated to assess the consequences of S100B expression and altered hypertrophy after i...


    pub_type: 杂志文章


    authors: Tsoporis JN,Marks A,Haddad A,Dawood F,Liu PP,Parker TG

    更新日期:2005-02-08 00:00:00

  • Physiological effects of adenoviral gene transfer of sarcoplasmic reticulum calcium ATPase in isolated rat myocytes.

    abstract:BACKGROUND:In myocardial cells, relaxation is governed primarily by the sarcoplasmic reticulum (SR) Ca(2+)-ATPase transporting enzyme, which regulates Ca2+ sequestration into the SR. Human and experimental cardiomyopathies are associated with reduced SR Ca(2+)-ATPase activity. METHODS AND RESULTS:To modify intracellul...


    pub_type: 杂志文章


    authors: Hajjar RJ,Kang JX,Gwathmey JK,Rosenzweig A

    更新日期:1997-01-21 00:00:00

  • Postinfarction gene therapy against transforming growth factor-beta signal modulates infarct tissue dynamics and attenuates left ventricular remodeling and heart failure.

    abstract:BACKGROUND:Fibrosis and progressive failure are prominent pathophysiological features of hearts after myocardial infarction (MI). We examined the effects of inhibiting transforming growth factor-beta (TGF-beta) signaling on post-MI cardiac fibrosis and ventricular remodeling and function. METHODS AND RESULTS:MI was in...


    pub_type: 杂志文章


    authors: Okada H,Takemura G,Kosai K,Li Y,Takahashi T,Esaki M,Yuge K,Miyata S,Maruyama R,Mikami A,Minatoguchi S,Fujiwara T,Fujiwara H

    更新日期:2005-05-17 00:00:00

  • Endoventricular remodeling of left ventricular aneurysm. Functional, clinical, and electrophysiological results.

    abstract:BACKGROUND:Recent advances in surgical techniques for the repair of left ventricular aneurysms (LVAs) include the use of an endoventricular patch to exclude the aneurysm cavity. This technique has replaced conventional linear plication of the aneurysm. The endoventricular patch technique remodels the left ventricular c...


    pub_type: 杂志文章


    authors: Grossi EA,Chinitz LA,Galloway AC,Delianides J,Schwartz DS,McLoughlin DE,Keller N,Kronzon I,Spencer FC,Colvin SB

    更新日期:1995-11-01 00:00:00

  • Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes.

    abstract:BACKGROUND:Titin is a giant elastic protein that spans the half-sarcomere from Z-disk to M-band. It acts as a molecular spring and mechanosensor and has been linked to striated muscle disease. The pathways that govern titin-dependent cardiac growth and contribute to disease are diverse and difficult to dissect. METHOD...


    pub_type: 杂志文章


    authors: Radke MH,Polack C,Methawasin M,Fink C,Granzier HL,Gotthardt M

    更新日期:2019-04-09 00:00:00

  • Myocardial strain analysis in acute coronary occlusion: a tool to assess myocardial viability and reperfusion.

    abstract:BACKGROUND:This study proposes 2 new echocardiographic indices with potential application in acute coronary artery occlusion to differentiate between viable and necrotic myocardium and to identify reperfusion. We investigated whether the ratio between systolic lengthening and combined late and postsystolic shortening (...


    pub_type: 杂志文章


    authors: Lyseggen E,Skulstad H,Helle-Valle T,Vartdal T,Urheim S,Rabben SI,Opdahl A,Ihlen H,Smiseth OA

    更新日期:2005-12-20 00:00:00

  • Arterial neovascularization and inflammation in vulnerable patients: early and late signs of symptomatic atherosclerosis.

    abstract:BACKGROUND:Atherosclerosis is complicated by cardiovascular events such as myocardial infarction, stroke, or peripheral arterial occlusive disease. Inflammation and pathological neovascularization are thought to precipitate plaque rupture or erosion, both causes of arterial thrombosis and cardiovascular events. We test...


    pub_type: 杂志文章


    authors: Fleiner M,Kummer M,Mirlacher M,Sauter G,Cathomas G,Krapf R,Biedermann BC

    更新日期:2004-11-02 00:00:00

  • Adenosine alters glucose use during ischemia and reperfusion in isolated rat hearts.

    abstract:BACKGROUND:Adenosine possesses marked cardioprotective properties, but the mechanisms for this beneficial effect are unclear. The objective of this study was to determine the effect of adenosine given before ischemia or at reperfusion on mechanical function, glucose oxidation, glycolysis, and metabolite levels in isola...


    pub_type: 杂志文章


    authors: Finegan BA,Lopaschuk GD,Coulson CS,Clanachan AS

    更新日期:1993-03-01 00:00:00

  • Platelets, thromboembolism and mitral valve prolapse.

    abstract::Cerebral and retinal ischemic events have been described in mitral valve prolapse. To determine whether platelets play a part in the pathogenesis of thromboembolism we studied 29 patients with mitral valve prolapse, including nine (group I) with thromboembolism (cerebral, retinal and deep venous), eight (group II) wit...


    pub_type: 杂志文章


    authors: Walsh PN,Kansu TA,Corbett JJ,Savion PJ,Goldburgh WP,Schatz NJ

    更新日期:1981-03-01 00:00:00

  • Left ventricular outflow tract obstruction after mitral valve repair. Results of the sliding leaflet technique.

    abstract:BACKGROUND:Left ventricular outflow tract obstruction (LVOTO) occurs in 4% to 5% of patients after prosthetic ring mitral valve repair. Major anatomic factors incriminated in the genesis of LVOTO include degenerative mitral valve insufficiency with excess leaflet tissue, nondilated left ventricular cavity, and narrow m...


    pub_type: 杂志文章


    authors: Jebara VA,Mihaileanu S,Acar C,Brizard C,Grare P,Latremouille C,Chauvaud S,Fabiani JN,Deloche A,Carpentier A

    更新日期:1993-11-01 00:00:00

  • Intravital microscopy on atherosclerosis in apolipoprotein e-deficient mice establishes microvessels as major entry pathways for leukocytes to advanced lesions.

    abstract:BACKGROUND:There has been considerable speculation about the role of lesion microvessels in the accumulation of leukocytes in atherosclerosis. However, direct study of microvascular recruitment of leukocytes in lesions has not been performed, and the quantitative role for this route of entry is unclear. METHODS AND RE...


    pub_type: 杂志文章


    authors: Eriksson EE

    更新日期:2011-11-08 00:00:00

  • Rigid ring fixation of the mitral annulus does not impair left ventricular systolic function in the normal canine heart.

    abstract:BACKGROUND:Previous studies suggest that rigid fixation of the mitral annulus with an annuloplasty ring may impair left ventricular (LV) systolic performance. We used load-insensitive indexes of global and regional LV contractile mechanics to test the hypothesis that rigid fixation of the mitral annulus alters LV systo...


    pub_type: 杂志文章


    authors: Rayhill SC,Castro LJ,Nizyporuk MA,Ingels NB Jr,Daughters GT,Derby GC,Tye TL,Bolger AF,Miller DC

    更新日期:1992-11-01 00:00:00

  • Results of Prevention of REStenosis with Tranilast and its Outcomes (PRESTO) trial.

    abstract:BACKGROUND:Restenosis after percutaneous coronary intervention (PCI) is a major problem affecting 15% to 30% of patients after stent placement. No oral agent has shown a beneficial effect on restenosis or on associated major adverse cardiovascular events. In limited trials, the oral agent tranilast has been shown to de...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Holmes DR Jr,Savage M,LaBlanche JM,Grip L,Serruys PW,Fitzgerald P,Fischman D,Goldberg S,Brinker JA,Zeiher AM,Shapiro LM,Willerson J,Davis BR,Ferguson JJ,Popma J,King SB 3rd,Lincoff AM,Tcheng JE,Chan R,Granett JR,P

    更新日期:2002-09-03 00:00:00

  • Relation of plasma lipoprotein(a) to infarct artery patency in survivors of myocardial infarction.

    abstract:BACKGROUND:In the minutes to days after myocardial infarction, endogenous lysis of an occlusive coronary arterial thrombus occurs in most subjects. Compared with those in whom thrombolysis does not occur, those with antegrade flow in the infarct artery have improved left ventricular performance, less left ventricular d...


    pub_type: 杂志文章


    authors: Moliterno DJ,Lange RA,Meidell RS,Willard JE,Leffert CC,Gerard RD,Boerwinkle E,Hobbs HH,Hillis LD

    更新日期:1993-09-01 00:00:00

  • L-4F, an apolipoprotein A-1 mimetic, restores nitric oxide and superoxide anion balance in low-density lipoprotein-treated endothelial cells.

    abstract:BACKGROUND:Low-density lipoprotein (LDL) impairs endothelial cell function by uncoupling endothelial nitric oxide synthase (eNOS) activity, which allows superoxide anion (O2*-)) to be generated rather than nitric oxide (*NO). Recent reports indicate that apolipoprotein (apo) A-1 mimetics inhibit the development of athe...


    pub_type: 杂志文章


    authors: Ou Z,Ou J,Ackerman AW,Oldham KT,Pritchard KA Jr

    更新日期:2003-03-25 00:00:00

  • Syncope while driving: clinical characteristics, causes, and prognosis.

    abstract:BACKGROUND:The risk of syncope occurring while driving has obvious implications for personal and public safety. We aimed to define the clinical characteristics, causes, and prognosis of syncope while driving. METHODS AND RESULTS:In this case-control study of consecutive patients evaluated for syncope from 1996 through...


    pub_type: 杂志文章


    authors: Sorajja D,Nesbitt GC,Hodge DO,Low PA,Hammill SC,Gersh BJ,Shen WK

    更新日期:2009-09-15 00:00:00

  • Myocardial inotropic responses to aggregating platelets and modulation by the endocardium.

    abstract::Ventricular mural thrombi complicate many cardiac diseases. The endocardial endothelium can modulate the mechanical performance of subjacent myocardium and mediate responses to certain physiopharmacologic agents. We studied the effects of aggregating platelets on the contractile performance of isolated cardiac muscle....


    pub_type: 杂志文章


    authors: Shah AM,Meulemans AL,Brutsaert DL

    更新日期:1989-06-01 00:00:00

  • Mechanism of ST elevation and ventricular arrhythmias in an experimental Brugada syndrome model.

    abstract:BACKGROUND:Although phase 2 reentry is said to be responsible for initiation of ventricular tachycardia (VT) in Brugada syndrome, information about the activation sequence during VT is limited. METHODS AND RESULTS:We developed an experimental Brugada syndrome model using a canine isolated right ventricular preparation...


    pub_type: 杂志文章


    authors: Kimura M,Kobayashi T,Owada S,Ashikaga K,Higuma T,Sasaki S,Iwasa A,Motomura S,Okumura K

    更新日期:2004-01-06 00:00:00

  • Transfer of CD4(+) T cells aggravates atherosclerosis in immunodeficient apolipoprotein E knockout mice.

    abstract:BACKGROUND:Atherosclerosis is associated with immune responses to oxidized lipoproteins and certain microorganisms, but the role of specific immunity has remained unclear. METHODS AND RESULTS:To study the role of immunity in atherosclerosis, we crossed atherosclerosis-prone apoE(-/-) mice with immunodeficient scid/sci...


    pub_type: 杂志文章


    authors: Zhou X,Nicoletti A,Elhage R,Hansson GK

    更新日期:2000-12-12 00:00:00

  • Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe-/- Mice.

    abstract:BACKGROUND:Altered composition of the gut microbiota is involved in both the onset and progression of obesity and diabetes mellitus. However, the link between gut microbiota and obesity-related cardiovascular complications has not been explored. The present study was designed to investigate the role of Akkermansia muci...


    pub_type: 杂志文章


    authors: Li J,Lin S,Vanhoutte PM,Woo CW,Xu A

    更新日期:2016-06-14 00:00:00

  • Risk of thromboembolic events after percutaneous left atrial radiofrequency ablation of atrial fibrillation.

    abstract:BACKGROUND:In patients with atrial fibrillation (AF), the risk of thromboembolic events (TEs) is variable and is influenced by the presence and number of comorbid conditions. The effect of percutaneous left atrial radiofrequency ablation (LARFA) of AF on the risk of TEs is unclear. METHODS AND RESULTS:LARFA was perfor...


    pub_type: 杂志文章


    authors: Oral H,Chugh A,Ozaydin M,Good E,Fortino J,Sankaran S,Reich S,Igic P,Elmouchi D,Tschopp D,Wimmer A,Dey S,Crawford T,Pelosi F Jr,Jongnarangsin K,Bogun F,Morady F

    更新日期:2006-08-22 00:00:00

  • Impaired modulation of sympathetic excitability by nitric oxide after long-term administration of organic nitrates in pigs.

    abstract:BACKGROUND:Endogenous nitric oxide (NO) reduces sympathetic vasoconstriction by attenuating neuronal excitability in the brain stem and inhibition of postganglionic neurotransmission. We studied whether this modulation of sympathetic circulatory control by NO may be altered during chronic administration of NO donor dru...


    pub_type: 杂志文章


    authors: Zanzinger J,Czachurski J,Seller H

    更新日期:1998-06-16 00:00:00

  • Blood flow and vasoactive drug effects in internal mammary and venous bypass grafts.

    abstract::Cardiac output and pressure-flow measurements were made in left internal mammary artery-to-left anterior descending coronary artery grafts and left subclavian artery-to-left circumflex coronary artery vein grafts after proximal coronary artery ligation. Similar measurements were also made in left internal mammary arte...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: McCormick JR,Kaneko M,Baue AE,Geha AS

    更新日期:1975-08-01 00:00:00

  • Household Fuel Use and Cardiovascular Disease Mortality: Golestan Cohort Study.

    abstract:BACKGROUND:Household air pollution is the third largest risk factor for global disease burden, but direct links with cardiovascular disease mortality are limited. This study aimed to evaluate the relationship between household fuel use and cardiovascular disease mortality. METHODS AND RESULTS:The Golestan Cohort Study...


    pub_type: 杂志文章


    authors: Mitter SS,Vedanthan R,Islami F,Pourshams A,Khademi H,Kamangar F,Abnet CC,Dawsey SM,Pharoah PD,Brennan P,Fuster V,Boffetta P,Malekzadeh R

    更新日期:2016-06-14 00:00:00

  • Chronic variant of myocarditis associated with hepatitis C virus infection.

    abstract:BACKGROUND:Although molecular biological studies suggest a pathogenic link between enterovirus infection and dilated cardiomyopathy (DCM), the frequency of detection of enteroviral RNA is not consistently high in myocardial tissue from patients with DCM. A recent study has suggested that hepatitis C virus (HCV) may als...


    pub_type: 杂志文章


    authors: Okabe M,Fukuda K,Arakawa K,Kikuchi M

    更新日期:1997-07-01 00:00:00

  • Angiotensin AT1 receptor inhibition. Effects on hypertrophic remodeling and ACE expression in rats with pressure-overload hypertrophy due to ascending aortic stenosis.

    abstract:BACKGROUND:We tested the hypothesis that long-term administration of the specific angiotensin II subtype 1 (AT1)-receptor blocker BMS-186295 will regress hypertrophy and modify left ventricular angiotensin converting enzyme (ACE) expression in rats with ascending aortic stenosis. METHODS AND RESULTS:Six weeks after su...


    pub_type: 杂志文章


    authors: Weinberg EO,Lee MA,Weigner M,Lindpaintner K,Bishop SP,Benedict CR,Ho KK,Douglas PS,Chafizadeh E,Lorell BH

    更新日期:1997-03-18 00:00:00

  • Introduction to the Analysis of Survival Data in the Presence of Competing Risks.

    abstract::Competing risks occur frequently in the analysis of survival data. A competing risk is an event whose occurrence precludes the occurrence of the primary event of interest. In a study examining time to death attributable to cardiovascular causes, death attributable to noncardiovascular causes is a competing risk. When ...


    pub_type: 杂志文章


    authors: Austin PC,Lee DS,Fine JP

    更新日期:2016-02-09 00:00:00

  • Macrophage microRNA-155 promotes cardiac hypertrophy and failure.

    abstract:BACKGROUND:Cardiac hypertrophy and subsequent heart failure triggered by chronic hypertension represent major challenges for cardiovascular research. Beyond neurohormonal and myocyte signaling pathways, growing evidence suggests inflammatory signaling pathways as therapeutically targetable contributors to this process....


    pub_type: 杂志文章


    authors: Heymans S,Corsten MF,Verhesen W,Carai P,van Leeuwen RE,Custers K,Peters T,Hazebroek M,Stöger L,Wijnands E,Janssen BJ,Creemers EE,Pinto YM,Grimm D,Schürmann N,Vigorito E,Thum T,Stassen F,Yin X,Mayr M,de Windt LJ,

    更新日期:2013-09-24 00:00:00