Differences in beta-adrenergic neuroeffector mechanisms in ischemic versus idiopathic dilated cardiomyopathy.

abstract：BACKGROUND:During ischemia, the intracellular calcium and inorganic phosphate (P(i)) concentrations rise and pH falls. We investigated the effects of these changes on force development in donor and failing human hearts to determine if altered contractile protein composition during heart failure changes the myocardial r...

journal_title：Circulation

authors： van Der Velden J,Klein LJ,Zaremba R,Boontje NM,Huybregts MA,Stooker W,Eijsman L,de Jong JW,Visser CA,Visser FC,Stienen GJ

更新日期：2001-09-04 00:00:00

abstract：BACKGROUND:While previous clinical studies have shown a possible beneficial effect of the reperfusion performed at a relatively late phase of acute myocardial infarction ("late reperfusion") in preventing left ventricular enlargement, the mechanism has not been clarified. METHODS AND RESULTS:Of 89 patients with an ini...

journal_title：Circulation

authors： Hirayama A,Adachi T,Asada S,Mishima M,Nanto S,Kusuoka H,Yamamoto K,Matsumura Y,Hori M,Inoue M

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:The mechanistic target of rapamycin (mTOR) comprises 2 structurally distinct multiprotein complexes, mTOR complexes 1 and 2 (mTORC1 and mTORC2). Deregulation of mTOR signaling occurs during and contributes to the severity of myocardial damage from ischemic heart disease. However, the relative roles of mTORC1...

journal_title：Circulation

authors： Völkers M,Konstandin MH,Doroudgar S,Toko H,Quijada P,Din S,Joyo A,Ornelas L,Samse K,Thuerauf DJ,Gude N,Glembotski CC,Sussman MA

更新日期：2013-11-05 00:00:00

abstract：BACKGROUND:Increasingly, the diagnostic codes from administrative claims data are being used as clinical outcomes. METHODS AND RESULTS:Data from the Cardiovascular Health Study (CHS) were used to compare event rates and risk factor associations between adjudicated hospitalized cardiovascular events and claims-based me...

journal_title：Circulation

authors： Psaty BM,Delaney JA,Arnold AM,Curtis LH,Fitzpatrick AL,Heckbert SR,McKnight B,Ives D,Gottdiener JS,Kuller LH,Longstreth WT Jr

更新日期：2016-01-12 00:00:00

abstract：BACKGROUND:The characteristics of transmembrane potential (TMP) at the core of functional reentry in the atrium are not well understood. METHODS AND RESULTS:In protocol 1 (11 dogs), isolated perfused canine right atria were mapped from the endocardial surface while simultaneous TMPs were recorded from the epicardial s...

journal_title：Circulation

authors： Athill CA,Ikeda T,Kim YH,Wu TJ,Fishbein MC,Karagueuzian HS,Chen PS

更新日期：1998-10-13 00:00:00

abstract：BACKGROUND:Central aortic pressures and waveform convey important information about cardiovascular status, but direct measurements are invasive. Peripheral pressures can be measured noninvasively, and although they often differ substantially from central pressures, they may be mathematically transformed to approximate ...

journal_title：Circulation

authors： Chen CH,Nevo E,Fetics B,Pak PH,Yin FC,Maughan WL,Kass DA

更新日期：1997-04-01 00:00:00

abstract：:One of the noninvasive methods of evaluating left ventricular performance is the measurement of left ventricular systolic time intervals (LVSTI). However, noninvasive measurement of right ventricular systole by this technique has been unreliable because of the inability to accurately time the onset of right ventricula...

journal_title：Circulation

authors： Hirschfeld S,Meyer R,Schwartz DC,Korfhagen J,Kaplan S

更新日期：1975-02-01 00:00:00

abstract：:The movements of the mitral, tricuspid and aortic valves have been recorded echocardiographically and related to the first heart sound (S1) in patients with various hemodynamic and conduction abnormalities. Closure of the mitral and tricuspid valves has been studied with respect to the corresponding atrioventricular p...

journal_title：Circulation

authors： Mills PG,Chamusco RF,Moos S,Craige E

更新日期：1976-12-01 00:00:00

abstract：BACKGROUND:Recent data suggest that the Berlin Heart EXCOR Pediatric ventricular assist device is superior to extracorporeal membrane oxygenation for bridge to heart transplantation. Published data are limited to 1 in 4 children who received the device as part of the US clinical trial. We analyzed outcomes for all US c...

journal_title：Circulation

authors： Almond CS,Morales DL,Blackstone EH,Turrentine MW,Imamura M,Massicotte MP,Jordan LC,Devaney EJ,Ravishankar C,Kanter KR,Holman W,Kroslowitz R,Tjossem C,Thuita L,Cohen GA,Buchholz H,St Louis JD,Nguyen K,Niebler RA,Walt

更新日期：2013-04-23 00:00:00

abstract：:The purpose of this study was to examine high density lipoprotein cholesterol (HDL-C) levels in a sample of community-living women and men who consumed 1 drink of alcohol/day or less. Self-reports of alcohol consumption and clinical assessments of plasma lipid and lipoprotein levels were obtained twice, at 12 months a...

journal_title：Circulation

authors： Weidner G,Connor SL,Chesney MA,Burns JW,Connor WE,Matarazzo JD,Mendell NR

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Research published in Circulation has shown that cardiac mortality is highest during December and January. We investigated whether some of this spike could be ascribed to the Christmas/New Year's holidays rather than to climatic factors. METHODS AND RESULTS:We fitted a locally weighted polynomial regression...

journal_title：Circulation

authors： Phillips DP,Jarvinen JR,Abramson IS,Phillips RR

更新日期：2004-12-21 00:00:00

abstract：BACKGROUND:Together with pulmonary veins, many extrapulmonary vein areas may be the source of initiation and maintenance of atrial fibrillation. The left atrial appendage (LAA) is an underestimated site of initiation of atrial fibrillation. Here, we report the prevalence of triggers from the LAA and the best strategy f...

journal_title：Circulation

authors： Di Biase L,Burkhardt JD,Mohanty P,Sanchez J,Mohanty S,Horton R,Gallinghouse GJ,Bailey SM,Zagrodzky JD,Santangeli P,Hao S,Hongo R,Beheiry S,Themistoclakis S,Bonso A,Rossillo A,Corrado A,Raviele A,Al-Ahmad A,Wang P,

更新日期：2010-07-13 00:00:00

abstract：BACKGROUND:Aging is associated with increased cardiovascular risk and endothelial dysfunction. Since exercise can improve endothelium-dependent vasodilation, in the present study we tested whether long-term physical activity could prevent aging-related endothelial dysfunction. METHODS AND RESULTS:In 12 young and elder...

journal_title：Circulation

authors： Taddei S,Galetta F,Virdis A,Ghiadoni L,Salvetti G,Franzoni F,Giusti C,Salvetti A

更新日期：2000-06-27 00:00:00

abstract：:The human aorta and its terminal branches were investigated in normal subjects during elective cardiac catheterization to evaluate regional wave travel and arterial wave reflections. A specially designed catheter with six micromanometers equally spaced at 10 cm intervals was positioned with the tip sensor in the dista...

journal_title：Circulation

authors： Latham RD,Westerhof N,Sipkema P,Rubal BJ,Reuderink P,Murgo JP

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:Ventricular tachyarrhythmias are the major clinical manifestation of arrhythmogenic right ventricular disease. Although antiarrhythmic therapy has been widely advocated, there is only limited information available on the efficacy of antiarrhythmic drugs in these patients. METHODS AND RESULTS:The short- and ...

journal_title：Circulation

authors： Wichter T,Borggrefe M,Haverkamp W,Chen X,Breithardt G

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Ultrafast computed tomography (CT), by acquiring images of the proximal coronary arteries, detects coronary calcifications and has been demonstrated to be highly sensitive for the detection of coronary artery disease in many small studies. The aim of this study was to determine the relationship between ultra...

journal_title：Circulation

authors： Budoff MJ,Georgiou D,Brody A,Agatston AS,Kennedy J,Wolfkiel C,Stanford W,Shields P,Lewis RJ,Janowitz WR,Rich S,Brundage BH

更新日期：1996-03-01 00:00:00

abstract：:A transient form of hypertrophic cardiomyopathy has been previously described in infants of diabetic mothers (IDMs). The purpose of this study was to determine the incidence, natural history and pathologic features of this cardiomyopathy in symptomatic and asymptomatic IDMs. We studied 47 IDMs for evidence of cardiomy...

journal_title：Circulation

authors： Gutgesell HP,Speer ME,Rosenberg HS

更新日期：1980-02-01 00:00:00

abstract：BACKGROUND:Hypercholesterolemia causes an upregulation of vascular angiotensin II type 1 (AT1) receptor expression in cell culture and animal models. The presented studies were undertaken to examine AT1 receptor overexpression in hypercholesterolemic men and therapeutic interventions thereof by HMG CoA reductase inhibi...

journal_title：Circulation

authors： Nickenig G,Bäumer AT,Temur Y,Kebben D,Jockenhövel F,Böhm M

更新日期：1999-11-23 00:00:00

abstract：BACKGROUND:Recent studies suggest that the oxygen-sensing pathway consisting of transcription factor hypoxia-inducible factor and prolyl hydroxylase domain proteins (PHDs) plays a critical role in glucose metabolism. However, the role of adipocyte PHD in the development of obesity has not been clarified. We examined wh...

journal_title：Circulation

authors： Matsuura H,Ichiki T,Inoue E,Nomura M,Miyazaki R,Hashimoto T,Ikeda J,Takayanagi R,Fong GH,Sunagawa K

更新日期：2013-05-28 00:00:00

abstract：:Relationships between enzyme estimates (EE) and histologic measurements of infarct size (HIS) were analyzed in 14 conscious dogs with permanent occlusion of the circumflex coronary artery. EE were derived from serial CPK, CPK-MM, CPK-MB, and CPK-BB. Estimates were obtained using methods of Shell et al., Norris et al.,...

journal_title：Circulation

authors： Roe CR,Cobb FR,Starmer CF

更新日期：1977-03-01 00:00:00

abstract：:The prognostic value of abnormalities on the electrocardiogram (ECG) present 1 year after initial myocardial infarction (MI) is examined in relation to reinfarction and coronary death throughout 32 years (mean, 10.1 years) of follow-up in the Framingham Heart Study. Resting 12-lead ECGs were available in 251 survivors...

journal_title：Circulation

authors： Wong ND,Levy D,Kannel WB

更新日期：1990-03-01 00:00:00

abstract：:Data from 981 patients evaluated for ischemic heart disease with coronary angiography were reviewed to identify variables predictive of sudden death and duration from onset of symptoms to death. During the period of follow-up, 113 patients died. Of these deaths, 99 were classified as cardiovascular. Forty percent occu...

journal_title：Circulation

authors： Oberman A,Ray M,Turner ME,Barnes G,Grooms C

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND:Thioredoxin 2 (Trx2) is a key mitochondrial protein that regulates cellular redox and survival by suppressing mitochondrial reactive oxygen species generation and by inhibiting apoptosis stress kinase-1 (ASK1)-dependent apoptotic signaling. To date, the role of the mitochondrial Trx2 system in heart failure ...

journal_title：Circulation

authors： Huang Q,Zhou HJ,Zhang H,Huang Y,Hinojosa-Kirschenbaum F,Fan P,Yao L,Belardinelli L,Tellides G,Giordano FJ,Budas GR,Min W

更新日期：2015-03-24 00:00:00

abstract：BACKGROUND:CD4+CD28null T cells are present in increased numbers in the peripheral blood of patients with acute coronary syndrome (ACS) compared with patients with chronic stable angina (CSA). The triggers of activation and expansion of these cells to date remain unclear. METHODS AND RESULTS:Twenty-one patients with A...

journal_title：Circulation

authors： Zal B,Kaski JC,Arno G,Akiyu JP,Xu Q,Cole D,Whelan M,Russell N,Madrigal JA,Dodi IA,Baboonian C

更新日期：2004-03-16 00:00:00

abstract：BACKGROUND:Bone marrow-derived cells have been shown to contribute to endothelial replacement after vascular injury. In vitro culture of peripheral blood mononuclear cells produces cells with phenotypic characteristics of endothelium. To test the hypothesis that delivery of autologous culture-modified mononuclear cells...

journal_title：Circulation

authors： Gulati R,Jevremovic D,Peterson TE,Witt TA,Kleppe LS,Mueske CS,Lerman A,Vile RG,Simari RD

更新日期：2003-09-23 00:00:00

abstract：BACKGROUND:Ten percent to 20% of potential cardiac donors with brain injury and no previous cardiac history have myocardial dysfunction. We assessed components of the beta-receptor-G-protein-adenylyl cyclase complex as well as the contractile response in 10 explanted acutely failing human hearts (donor heart dysfunctio...

journal_title：Circulation

authors： White M,Wiechmann RJ,Roden RL,Hagan MB,Wollmering MM,Port JD,Hammond E,Abraham WT,Wolfel EE,Lindenfeld J

更新日期：1995-10-15 00:00:00

abstract：BACKGROUND:We hypothesized that cytomegalovirus (CMV) may contribute to the vasculopathy observed in cardiac allograft recipients by impairing the endothelial nitric oxide synthase pathway. We focused on asymmetric dimethylarginine (ADMA, the endogenous inhibitor of nitric oxide synthase) as a potential mediator of the...

journal_title：Circulation

authors： Weis M,Kledal TN,Lin KY,Panchal SN,Gao SZ,Valantine HA,Mocarski ES,Cooke JP

更新日期：2004-02-03 00:00:00

abstract：BACKGROUND:Matrix metalloproteinase-9 could exhibit an important role in the destabilization of atherosclerotic carotid plaques. We hypothesized that in patients with carotid stenosis, elevated levels of plasma matrix metalloproteinase-9 are associated with ipsilateral stroke or cardiovascular death. METHODS AND RESUL...

journal_title：Circulation

authors： Eldrup N,Grønholdt ML,Sillesen H,Nordestgaard BG

更新日期：2006-10-24 00:00:00

abstract：BACKGROUND:We postulated that the variability of the phase shift between blood pressure and heart rate fluctuation near the frequency of 0.10 Hz might be useful in assessing autonomic circulatory control. METHODS AND RESULTS:We tested this hypothesis in 4 groups of subjects: 28 young, healthy individuals; 13 elderly h...

journal_title：Circulation

authors： Halámek J,Kára T,Jurák P,Soucek M,Francis DP,Davies LC,Shen WK,Coats AJ,Novák M,Nováková Z,Panovský R,Toman J,Sumbera J,Somers VK

更新日期：2003-07-22 00:00:00

abstract：BACKGROUND:Venous thromboembolism can be a presenting symptom of cancer, but the association between lower limb arterial thrombosis and cancer is unknown. We therefore examined cancer risk and prognosis of cancer in patients with lower limb arterial thrombosis. METHODS:Using nationwide population-based Danish medical ...

journal_title：Circulation

authors： Sundbøll J,Veres K,Horváth-Puhó E,Adelborg K,Sørensen HT

更新日期：2018-08-14 00:00:00