Abstract:
:The acute coronary hemodynamic and metabolic effects of intravenous dipyridamole were studied in 13 patients. Total left ventricular (LV), anterior (supplied by the left anterior descending coronary artery) and inferior (supplied by circumflex and right coronary arteries) regional flows and metabolic responses were assessed from the coronary sinus and great cardiac vein. Perfusion to LV regions was classified as potentially "normal" or "abnormal," based on coronary angiographic findings. Before dipyridamole, coronary flow, LV oxygen delivery and lactate extraction in both the normal and abnormal regions were similar. Within 1 minute after injection of 20 mg of dipyridamole by i.v. bolus, total coronary flow increased 51% (p less than 0.05). Fifteen minutes after injection the flow increase persisted. Flow decreased to approximately control level by 20 minutes. The major component of this increased total coronary flow resulted from increased flow in normal regions (75% at 1 minute, p less than 0.05). Mean regional LV oxygen delivery and lactate extraction were not changed significantly in either normal or abnormal regions. However, lactate production occurred more often after dipyridamole in abnormal regions. These results suggest that during dipyridamole-induced hyperemia, regional coronary flow and metabolic responses depend upon the status of the arteries supplying the LV region. Regional differences in flow and metabolism occur independent of major changes in heart rate and aortic and LV pressures.
journal_name
Circulationjournal_title
Circulationauthors
Feldman RL,Nichols WW,Pepine CJ,Conti CRdoi
10.1161/01.cir.64.2.333subject
Has Abstractpub_date
1981-08-01 00:00:00pages
333-44issue
2eissn
0009-7322issn
1524-4539journal_volume
64pub_type
杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:During heart development, the ventricular activation sequence changes from a base-to-apex to an apex-to-base pattern. We investigated the possibility of impulse propagation through remnants of atrioventricular (AV) connections in quail hearts. METHODS AND RESULTS:In 86 hearts (group A, HH30-34, n=15; group ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.106.658807
更新日期:2007-01-02 00:00:00
abstract:BACKGROUND:The estrogen receptor-alpha (ER-alpha) IVS1-401 polymorphism identifies a group of women (approximately 20%) who have augmented effects of hormone replacement therapy (HRT) on levels of HDL cholesterol. This study sought to determine if this augmentation extends to HRT regulation of E-selectin and C-reactive...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.0000016173.98826.88
更新日期:2002-04-23 00:00:00
abstract:BACKGROUND:We recently demonstrated that phospholipase C (PLC)-delta1 activity in cultured skin fibroblasts obtained from patients with coronary spastic angina (CSA) is enhanced. We tested the hypothesis that structural abnormality in PLC-delta1 isoform is a cause of the enhanced activity. METHODS AND RESULTS:Sequence...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000014613.36469.3f
更新日期:2002-04-30 00:00:00
abstract:BACKGROUND:We investigated the feasibility and efficacy of polyethylenimine (PEI) based human vascular endothelial growth factor-165 (hVEGF165) gene transfer into human skeletal myoblasts (HSM) for cell based delivery to the infarcted myocardium. METHODS AND RESULTS:Based on optimized transfection procedure using enha...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.106.680124
更新日期:2007-09-11 00:00:00
abstract:BACKGROUND:Mitral regurgitation (MR) generally accompanies inferobasal myocardial infarction (MI), with leaflet tethering by displaced papillary muscles. Mitral regurgitation is also reported with anteroapical MI without global dilatation or inferior wall motion abnormalities. We hypothesized that anteroapical MI exten...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.110.977843
更新日期:2011-04-12 00:00:00
abstract:BACKGROUND:Visceral adiposity is generally considered to play a key role in the metabolic syndrome, including hypertension. The purpose of this study was to evaluate cross-sectionally whether visceral adiposity is associated with prevalence of hypertension independent of other adipose depots and fasting plasma insulin....
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000087597.59169.8D
更新日期:2003-10-07 00:00:00
abstract:BACKGROUND:Coxsackieviruses B (CBVs) are dominant causative agents in myocarditis and are associated with pathogenesis is some cases of dilated cardiomyopathy, a clinical entity with a poor survival without heart transplantation. METHODS AND RESULTS:In vitro, the antiviral agent WIN 54 954 was shown to inhibit replica...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.94.9.2254
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:Second trimester routine ultrasound evaluation of the fetal heart by means of the four-chamber view has been proposed for prenatal detection of cardiac anomalies. The aim of this study was to evaluate the efficacy of this procedure. METHODS AND RESULTS:A prospective follow-up study on 6922 scanned fetuses w...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.94.1.67
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:Increased common carotid artery intima-media thickness (CCA-IMT) is a marker of early atherosclerosis. Low-grade inflammation is associated with the pathogenesis of atherosclerosis. Low-grade inflammation and increased CCA-IMT are observed in end-stage renal disease (ESRD). Oxidative stress is involved in ur...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000035250.66458.67
更新日期:2002-10-22 00:00:00
abstract::After a change in cardiac output, the magnitude of potential blood volume redistribution was investigated in 10 dogs anesthetized with chloralose. All of the venous return was pumped into a reservoir, using servocontrolled pumps to maintain fixed superior and inferior vena cava pressures. The cardiac output was set at...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.81.1.360
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF) is the most common sustained arrhythmia; however, little is known about patients in a primary care setting from high-, middle-, and low-income countries. METHODS AND RESULTS:This prospective registry enrolled patients presenting to an emergency department with AF at 164 sites in 46 ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.113.005451
更新日期:2014-04-15 00:00:00
abstract::This study analyzes the response to overdrive suppression of junctional pacemakers (JP) and correlates it with symptoms in 21 patients. Junctional rhythm (JR) was seen in 5 patients with intact A-V conduction, and in 16 with complete heart block, the JPs were located proximal to or within the His bundle (BH). Junction...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.57.5.880
更新日期:1978-05-01 00:00:00
abstract:BACKGROUND:Although prospective studies, systematic reviews, and meta-analyses have documented an association between depression and increased morbidity and mortality in a variety of cardiac populations, depression has not yet achieved formal recognition as a risk factor for poor prognosis in patients with acute corona...
journal_title:Circulation
pub_type: 杂志文章,meta分析,评审
doi:10.1161/CIR.0000000000000019
更新日期:2014-03-25 00:00:00
abstract::Mitochondria have emerged as a central factor in the pathogenesis and progression of heart failure, and other cardiovascular diseases, as well, but no therapies are available to treat mitochondrial dysfunction. The National Heart, Lung, and Blood Institute convened a group of leading experts in heart failure, cardiova...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/CIRCULATIONAHA.119.040551
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:It was the aim of this study to assess the long-term effects of physical exercise and low-fat diet on the progression of coronary artery disease. At the beginning of the study, 113 male patients with coronary artery disease were randomized to an intervention group (n=56) or a control group (n=57); 90 patient...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.96.8.2534
更新日期:1997-10-21 00:00:00
abstract:BACKGROUND:Physical forces, such as pressure and flow, are well known to affect vascular function in the coronary circulation. Increases in shear stress produce vasodilation in coronary arterioles in vitro, and constant-flow preparations suggest a role for shear stress-induced vasodilation during adjustments to metabol...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.100.14.1555
更新日期:1999-10-05 00:00:00
abstract:BACKGROUND:Cell-mediated autoimmunity has been strongly implicated in the pathogenesis of viral myocarditis. METHODS AND RESULTS:Using a murine model of acute myocarditis caused by coxsackievirus B3, we analyzed the phenotypes and morphology of the infiltrating cells in the hearts by immunofluorescence and electron mi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.84.2.788
更新日期:1991-08-01 00:00:00
abstract:BACKGROUND:Inhaled nitric oxide (iNO) has been used to assess the vasodilator capacity of the pulmonary vascular bed in children with congenital heart disease and elevated pulmonary vascular resistance. Inhaled iloprost is a pulmonary vasodilator for the long-term treatment of pulmonary hypertension (PHT). Because thes...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.103.4.544
更新日期:2001-01-30 00:00:00
abstract:BACKGROUND:The relations of insulin sensitivity (IS) to hypertension incidence may vary according to baseline age, body mass index (BMI), and blood pressure (BP). METHODS AND RESULTS:We investigated the relations of IS (insulin sensitivity index, ISI(0,120)) to 4-year incidence of hypertension and BP progression in 19...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.105.535039
更新日期:2005-09-20 00:00:00
abstract:BACKGROUND:Vasodilatory shock is a potentially lethal complication of severe disease in critically ill patients. Currently, catecholamines are the most widely used vasopressor agents to support blood pressure, but loss of catecholamine pressor effects is a well-known clinical dilemma. Arginine vasopressin (AVP) has rec...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.CIR.0000066692.71008.BB
更新日期:2003-05-13 00:00:00
abstract::A patient is described in whom a large congenital aneurysm or diverticulum of the right atrium caused repeated attacks of supraventricular arrhythmia and a strikingly reduced cardiac output. The aneurysm, which contained a large thrombus, was demonstrated by preoperative angiographic examinations. At the time of opera...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.38.1.124
更新日期:1968-07-01 00:00:00
abstract:BACKGROUND:Molecular targeted chemotherapies have been shown to significantly improve the outcomes of patients who have cancer, but they often cause cardiovascular side effects that limit their use and impair patients' quality of life. Cardiac dysfunction induced by these therapies, especially trastuzumab, shows a dist...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.118.037357
更新日期:2019-05-21 00:00:00
abstract::Coronary heart disease (CHD) remains a leading cause of morbidity and mortality in the United States, despite our better understanding of the pathobiology of atherosclerosis, our knowledge of risk factors, the widespread availability of inexpensive cholesterol screening, and the availability of effective and well-tole...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc3901.096665
更新日期:2001-10-02 00:00:00
abstract::To compare acute effects of nitroglycerin (0.8 mg sublingually), nifedipine (5 ng/kg/min i.v.) and metoprolol (0.15 mg/kg i.v.) on normal, ischemic and scarred myocardial segments in man, we performed simultaneous hemodynamic and radionuclide measurements of left ventricular functions. Sixteen patients with isolated l...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.67.2.291
更新日期:1983-02-01 00:00:00
abstract::Our experimental studies since 1972 show that the heart is preserved best during cardiopulmonary bypass when it is in the beating, nonworking state. Results after mitral valve replacement (MVR) from 1968 to 1974 using various techniques of cardiac preservation were compared. In group I were 47 patients (1968 to 1972) ...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1975-08-01 00:00:00
abstract:BACKGROUND:Thrombus formation within a coronary vessel is the acute precipitating event in most acute coronary syndromes. Recently, constitutive nitric oxide synthase (cNOS) has been identified in human platelets, and platelet-derived nitric oxide has been shown to inhibit platelet recruitment after aggregation. Howeve...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.98.15.1481
更新日期:1998-10-13 00:00:00
abstract:BACKGROUND:approximately half of patients with heart failure die suddenly as a result of ventricular arrhythmias. Although abnormal Ca(2+) release from the sarcoplasmic reticulum through ryanodine receptors (RyR2) has been linked to arrhythmogenesis, the molecular mechanisms triggering release of arrhythmogenic Ca(2+) ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.110.982298
更新日期:2010-12-21 00:00:00
abstract:BACKGROUND:We investigated the association between trainees performing supervised operations and late outcomes of patients undergoing cardiac surgery. METHODS AND RESULTS:Data were prospectively collected on patients who underwent coronary artery bypass graft surgery, aortic valve replacement, or a combination of thes...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.107.756379
更新日期:2008-09-30 00:00:00
abstract:BACKGROUND:The relationship between autonomic activation and the mechanisms of paroxysmal atrial fibrillation remains unclear. METHODS AND RESULTS:We implanted a pacemaker and a radio transmitter in 7 dogs (group 1). After baseline recording, we paced the left atrium at 20 Hz for 1 week and then monitored left stellat...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.108.776203
更新日期:2008-08-26 00:00:00
abstract::Common conditions predisposing to atherosclerosis, such as hypercholesterolemia, hypertension, diabetes, and smoking, are associated with endothelial dysfunction. Endothelial function has largely been assessed as endothelium-dependent vasomotion, at least in part based on the assumption that impaired endothelium-depen...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/01.CIR.0000129501.88485.1f
更新日期:2004-06-01 00:00:00