Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure.

abstract：:A 28-year-old female undergoing elective total hip replacement experienced an anaphylactic reaction to succinylcholine. Hemodynamics, plasma histamine and catecholamines were measured. The tachycardia experienced during the reaction appeared to be secondary to the sympathoadrenal response rather than a direct chronotr...

journal_title：Circulation

authors： Moss J,Fahmy NR,Sunder N,Beaven MA

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Insulin modulates sympathetic vasoconstriction, but the mechanisms underlying this effect are not completely elucidated. We have recently investigated the insulin effect on the alpha 1- and alpha 2-adrenergic vasoconstriction pathway, where it is still conflicting with the possible insulin influence on the b...

journal_title：Circulation

authors： Lembo G,Iaccarino G,Vecchione C,Rendina V,Parrella L,Trimarco B

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Extracorporeal circulation with circuits coated with surface-bound heparin has allowed reduced levels of systemic heparinization. Clinical benefits have included reduced postoperative bleeding and less homologous blood usage. However, the effects on the hemostatic and fibrinolytic systems have remained in pa...

journal_title：Circulation

authors： Ovrum E,Brosstad F,Am Holen E,Tangen G,Abdelnoor M

更新日期：1995-11-01 00:00:00

abstract：:Coronary artery bypass surgery with or without aneurysmectomy has been used to treat patients with angiographically defined left ventricular aneurysm. To evaluate whether surgery benefits such patients, we analyzed the data from 1131 patients who were enrolled in the registry of the Coronary Artery Surgery Study. Four...

journal_title：Circulation

authors： Faxon DP,Myers WO,McCabe CH,Davis KB,Schaff HV,Wilson JW,Ryan TJ

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:Radiofrequency ablation of the atrioventricular node and permanent pacing are used for symptomatic relief in patients with medically refractory atrial fibrillation. In this study, meta-analysis was used to clarify clinical outcomes and survival after ablation and pacing therapy using data from the published ...

journal_title：Circulation

authors： Wood MA,Brown-Mahoney C,Kay GN,Ellenbogen KA

更新日期：2000-03-14 00:00:00

abstract：BACKGROUND:Matrix metalloproteinase-9 could exhibit an important role in the destabilization of atherosclerotic carotid plaques. We hypothesized that in patients with carotid stenosis, elevated levels of plasma matrix metalloproteinase-9 are associated with ipsilateral stroke or cardiovascular death. METHODS AND RESUL...

journal_title：Circulation

authors： Eldrup N,Grønholdt ML,Sillesen H,Nordestgaard BG

更新日期：2006-10-24 00:00:00

abstract：:To determine whether real-time two-dimensional echocardiography (2-D echo) can estimate the extent of myocardial involvement in patients with acute myocardial infarction (MI), regional wall motion on serial short-axis 2-D echo recordings was analyzed and the summed scores were compared with estimates of infarct involv...

journal_title：Circulation

authors： Nixon JV,Narahara KA,Smitherman TC

更新日期：1980-12-01 00:00:00

abstract：BACKGROUND:Postmortem-derived findings support the common beliefs that lipid-rich coronary plaques with a thin, fibrous cap are prone to rupture and that rupture and superimposed thrombosis are the primary mechanisms causing acute coronary syndromes. In vivo imaging with intracoronary techniques may disclose difference...

journal_title：Circulation

authors： de Feyter PJ,Ozaki Y,Baptista J,Escaned J,Di Mario C,de Jaegere PP,Serruys PW,Roelandt JR

更新日期：1995-09-15 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) is the leading cause of death in the United States and is responsible for 17% of national health expenditures. As the population ages, these costs are expected to increase substantially. METHODS AND RESULTS:To prepare for future cardiovascular care needs, the American Heart Asso...

journal_title：Circulation

authors： Heidenreich PA,Trogdon JG,Khavjou OA,Butler J,Dracup K,Ezekowitz MD,Finkelstein EA,Hong Y,Johnston SC,Khera A,Lloyd-Jones DM,Nelson SA,Nichol G,Orenstein D,Wilson PW,Woo YJ,American Heart Association Advocacy Coordinating

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Although global ischemia induces troponin I (TnI) degradation, regional ischemia does not. We hypothesized that this disparity is related to preload-induced proteolysis, which varies as a function of the amount of myocardium at risk of ischemia. METHODS AND RESULTS:Isolated rat hearts were buffer-perfused a...

journal_title：Circulation

authors： Feng J,Schaus BJ,Fallavollita JA,Lee TC,Canty JM Jr

更新日期：2001-04-24 00:00:00

abstract：BACKGROUND:Although implantable cardioverter-defibrillator (ICD) therapy reduces mortality in moderately symptomatic heart failure patients with an ejection fraction

journal_title：Circulation

authors： Levy WC,Lee KL,Hellkamp AS,Poole JE,Mozaffarian D,Linker DT,Maggioni AP,Anand I,Poole-Wilson PA,Fishbein DP,Johnson G,Anderson J,Mark DB,Bardy GH

更新日期：2009-09-08 00:00:00

abstract：BACKGROUND:The aim of the present study was to evaluate dynamic changes in aortic regurgitant (AR) orifice area with the use of calibrated electromagnetic (EM) flowmeters and to validate a color Doppler flow convergence (FC) method for evaluating effective AR orifice area and regurgitant volume. METHODS AND RESULTS:In...

journal_title：Circulation

authors： Shiota T,Jones M,Yamada I,Heinrich RS,Ishii M,Sinclair B,Holcomb S,Yoganathan AP,Sahn DJ

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:Cardiac resynchronization therapy for heart failure with left bundle branch block reduces left ventricular (LV) conduction delay, contraction asynchrony, and LV end-systolic volume ("reverse remodeling"). Up to one third of patients do not improve, and the electric requirements for reverse remodeling are unc...

journal_title：Circulation

authors： Sweeney MO,van Bommel RJ,Schalij MJ,Borleffs CJ,Hellkamp AS,Bax JJ

更新日期：2010-02-09 00:00:00

abstract：BACKGROUND:One or more brief episodes of coronary artery occlusion protect or "precondition" the myocardium perfused by that artery from a subsequent episode of sustained ischemia. We sought to determine whether ischemic preconditioning protects only those myocytes subjected to brief coronary occlusion or whether brief...

journal_title：Circulation

authors： Przyklenk K,Bauer B,Ovize M,Kloner RA,Whittaker P

更新日期：1993-03-01 00:00:00

abstract：:These types of studies lay the foundation for understanding the human apolipoproteins at the genetic level. In addition, through a few specific examples, we have already shown evidence at the DNA level that lesions in apolipoprotein genes can play a role in human atherosclerosis. This work is in its infancy, but we ho...

journal_title：Circulation

authors： Breslow JL

更新日期：1984-06-01 00:00:00

abstract：BACKGROUND:Statins are effective in the primary prevention of atherosclerotic cardiovascular disease. The 2013 American College of Cardiology/American Heart Association (ACC/AHA) guideline expands recommended statin use, but its cost-effectiveness has not been compared with other guidelines. METHODS:We used the Cardio...

journal_title：Circulation

authors： Heller DJ,Coxson PG,Penko J,Pletcher MJ,Goldman L,Odden MC,Kazi DS,Bibbins-Domingo K

更新日期：2017-09-19 00:00:00

abstract：BACKGROUND:The diagnosis of infective endocarditis (IE) in prosthetic valves and intracardiac devices is challenging because both the modified Duke criteria (DC) and echocardiography have limitations in this population. The added value of (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET)/computed ...

journal_title：Circulation

authors： Pizzi MN,Roque A,Fernández-Hidalgo N,Cuéllar-Calabria H,Ferreira-González I,Gonzàlez-Alujas MT,Oristrell G,Gracia-Sánchez L,González JJ,Rodríguez-Palomares J,Galiñanes M,Maisterra-Santos O,Garcia-Dorado D,Castell-Conesa J,Alm

更新日期：2015-09-22 00:00:00

abstract：BACKGROUND:Impaired endothelium-dependent vasodilation is an early sign of atherosclerosis in hypercholesterolemic patients. We hypothesized that lipid-lowering therapy can improve endothelial function and that this effect is mainly mediated by increased bioavailability of nitric oxide (NO). METHODS AND RESULTS:In a r...

journal_title：Circulation

authors： John S,Schlaich M,Langenfeld M,Weihprecht H,Schmitz G,Weidinger G,Schmieder RE

更新日期：1998-07-21 00:00:00

abstract：:Exit block from a parasystolic focus is recognized when automatic discharges fail to become manifest during the excitable phase of the ventricular cycle. In the present study, an apparently complete exit block and a persistently concealed ventricular parasystole (VP) resulted from an exit refractory period (ExRP) long...

journal_title：Circulation

authors： Nau GJ,Aldariz AE,Acunzo RS,Chiale PA,Elizari MV,Rosenbaum MB

更新日期：1981-07-01 00:00:00

abstract：BACKGROUND:The effect of human immunodeficiency virus (HIV) on the development of peripheral artery disease (PAD) remains unclear. We investigated whether HIV infection is associated with an increased risk of PAD after adjustment for traditional atherosclerotic risk factors in a large cohort of HIV-infected (HIV+) and ...

journal_title：Circulation

authors： Beckman JA,Duncan MS,Alcorn CW,So-Armah K,Butt AA,Goetz MB,Tindle HA,Sico JJ,Tracy RP,Justice AC,Freiberg MS

更新日期：2018-07-17 00:00:00

abstract：BACKGROUND:The treatment of unstable angina targets the specific pathophysiological thrombotic process at the site of the active culprit lesion. In unstable angina due to a restenotic lesion, smooth muscle cell proliferation and increased vasoreactivity may play a more important role than thrombus formation. Therefore,...

journal_title：Circulation

authors： Doucet S,Malekianpour M,Théroux P,Bilodeau L,Côté G,de Guise P,Dupuis J,Joyal M,Gosselin G,Tanguay JF,Juneau M,Harel F,Nattel S,Tardif JC,Lespérance J

更新日期：2000-03-07 00:00:00

abstract：BACKGROUND:Several centers favor replacing a diseased native heart valve with a tissue rather than a mechanical prosthesis, even in younger adult patients. However, long-term data supporting this approach are lacking. We examined the survival implications of selecting a tissue versus a mechanical prosthesis at initial ...

journal_title：Circulation

authors： Ruel M,Chan V,Bédard P,Kulik A,Ressler L,Lam BK,Rubens FD,Goldstein W,Hendry PJ,Masters RG,Mesana TG

更新日期：2007-09-11 00:00:00

abstract：:This essay reviews the founding and early history of the Council on Clinical Cardiology of the American Heart Association (AHA), the largest of the AHA's 14 councils. Based on archival research, it stresses the factors that led to the council's formation and shaped its agenda. The council was established in the contex...

journal_title：Circulation

authors： Fye WB

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Impaired endothelium-dependent NO-mediated vasodilation is a key feature of essential hypertension and may precede the increase in blood pressure. We investigated whether transport of the NO precursor L-arginine is related to decreased endothelial function. METHODS AND RESULTS:Radiotracer kinetics ([3H]L-ar...

journal_title：Circulation

authors： Schlaich MP,Parnell MM,Ahlers BA,Finch S,Marshall T,Zhang WZ,Kaye DM

更新日期：2004-12-14 00:00:00

abstract：BACKGROUND:Currently, only anecdotal information exists on the presentation and outcome of coronary arterial injury after ablation procedures. METHODS AND RESULTS:Four patients who sustained coronary artery injury of a cohort of patients undergoing 4655 consecutive ablation procedures (0.09%) are described. The patien...

journal_title：Circulation

authors： Roberts-Thomson KC,Steven D,Seiler J,Inada K,Koplan BA,Tedrow UB,Epstein LM,Stevenson WG

更新日期：2009-10-13 00:00:00

abstract：BACKGROUND:Aortic valve-preserving procedures have resulted in excellent outcomes in selected patients, particularly those with normal aortic valve leaflets and dilated aortic roots. However, several congenital heart lesions are associated with abnormal aortic valve leaflets. The long-term results of aortic valve repai...

journal_title：Circulation

authors： Rao V,Van Arsdell GS,David TE,Azakie A,Williams WG

更新日期：2000-11-07 00:00:00

abstract：BACKGROUND:The future risk of myocardial infarction is commonly assessed using cardiovascular risk scores, coronary artery calcium score, or coronary artery stenosis severity. We assessed whether noncalcified low-attenuation plaque burden on coronary CT angiography (CCTA) might be a better predictor of the future risk ...

journal_title：Circulation

authors： Williams MC,Kwiecinski J,Doris M,McElhinney P,D'Souza MS,Cadet S,Adamson PD,Moss AJ,Alam S,Hunter A,Shah ASV,Mills NL,Pawade T,Wang C,Weir McCall J,Bonnici-Mallia M,Murrills C,Roditi G,van Beek EJR,Shaw LJ,Nicol E

更新日期：2020-05-05 00:00:00

abstract：BACKGROUND:Few studies have examined the association of race and outcomes after coronary artery bypass graft (CABG) surgery while controlling for both patient and hospital effects. METHODS AND RESULTS:We retrospectively analyzed data on a cohort of 566,785 white and 24,354 black Medicare beneficiaries 65 years old and...

journal_title：Circulation

authors： Konety SH,Vaughan Sarrazin MS,Rosenthal GE

更新日期：2005-03-15 00:00:00

abstract：BACKGROUND:Previous studies have shown that pericytes can differentiate into osteoblasts and form bone. This study investigated whether pericytes can also differentiate into chondrocytes and adipocytes. METHODS AND RESULTS:Reverse transcription-polymerase chain reaction demonstrated that pericytes express mRNA for the...

journal_title：Circulation

authors： Farrington-Rock C,Crofts NJ,Doherty MJ,Ashton BA,Griffin-Jones C,Canfield AE

更新日期：2004-10-12 00:00:00

abstract：BACKGROUND:Controversy exists as to whether off-pump CABG with local occlusion results in clinically significant myocardial ischemia during the occlusion period. This study was undertaken to delineate the effects of transient local coronary artery occlusion on regional systolic function. METHODS AND RESULTS:Eight cons...

journal_title：Circulation

authors： Brown PM Jr,Kim VB,Boyer BJ,Lust RM,Chitwood WR Jr,Elbeery JR

更新日期：1999-11-09 00:00:00