Autoregulation of cardiac output by passive elastic characteristics of the vascular capacitance system.

abstract：:We evaluated the effects of selective activation of H1 receptors on coronary hemodynamics in 16 patients divided into two groups: group A, 11 patients with atypical angina or valvular heart disease and normal coronary arteries, and group B, five patients with spontaneous angina, four of whom had significant (greater t...

journal_title：Circulation

authors： Vigorito C,Poto S,Picotti GB,Triggiani M,Marone G

更新日期：1986-06-01 00:00:00

abstract：:We studied the inferior vena cava (IVC) as an index of right-heart function in 111 patients. A two-dimensional echocardiographic sector was used to visualize the IVC, and its M-mode cursor was used to generate a time-motion record of the IVC size and pulsation. Normal subjects had a small presystolic A wave (less than...

journal_title：Circulation

authors： Mintz GS,Kotler MN,Parry WR,Iskandrian AS,Kane SA

更新日期：1981-11-01 00:00:00

abstract：BACKGROUND:Biological pacemakers (BPM) implanted in canine left bundle branch function competitively with electronic pacemakers (EPM). We hypothesized that BPM engineered with the use of mE324A mutant murine HCN2 (mHCN2) genes would improve function over mHCN2 and that BPM/EPM tandems confer advantage over either appro...

journal_title：Circulation

authors： Bucchi A,Plotnikov AN,Shlapakova I,Danilo P Jr,Kryukova Y,Qu J,Lu Z,Liu H,Pan Z,Potapova I,KenKnight B,Girouard S,Cohen IS,Brink PR,Robinson RB,Rosen MR

更新日期：2006-09-05 00:00:00

abstract：BACKGROUND:Poststroke angiogenesis contributes to long-term recovery after stroke. Signal transducer and activator of transcription-3 (Stat3) is a key regulator for various inflammatory signals and angiogenesis. It was the aim of this study to determine its function in poststroke outcome. METHODS AND RESULTS:We genera...

journal_title：Circulation

authors： Hoffmann CJ,Harms U,Rex A,Szulzewsky F,Wolf SA,Grittner U,Lättig-Tünnemann G,Sendtner M,Kettenmann H,Dirnagl U,Endres M,Harms C

更新日期：2015-05-19 00:00:00

abstract：BACKGROUND:The purpose of this study was to describe a new technique for catheter ablation of left lateral accessory pathways (APs) by radiofrequency energy applied at the epicardium through the coronary sinus wall using a unipolar configuration. METHODS AND RESULTS:In an overall group of 212 patients with left latera...

journal_title：Circulation

authors： Haissaguerre M,Gaita F,Fischer B,Egloff P,Lemetayer P,Warin JF

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:The balance between apoptosis and proliferation of vascular smooth muscle cells (VSMCs) is believed to contribute to the vascular remodeling process. Cyclic AMP response element-binding protein (CREB) is a critical transcription factor for the survival of neuronal cells and T lymphocytes. However, the role o...

journal_title：Circulation

authors： Tokunou T,Shibata R,Kai H,Ichiki T,Morisaki T,Fukuyama K,Ono H,Iino N,Masuda S,Shimokawa H,Egashira K,Imaizumi T,Takeshita A

更新日期：2003-09-09 00:00:00

abstract：BACKGROUND:Percutaneous transluminal coronary angioplasty (PTCA) is a widely used and important method of reperfusing coronary arteries. However, it is also associated with serious complications such as acute reocclusion and accelerated restenosis. The factors as well as the mechanisms involved in PTCA-associated compl...

journal_title：Circulation

authors： Brezinski DA,Nesto RW,Serhan CN

更新日期：1992-07-01 00:00:00

abstract：:Ultrasonic tissue characterization is a new area of investigation in the field of cardiac ultrasound. The amplitude and frequency of the ultrasound signal are normally altered as the signal penetrates through tissue. It is assumed that the amplitude distribution and frequency shift of diseased or edematous tissue are ...

journal_title：Circulation

authors： Schnittger I,Vieli A,Heiserman JE,Director BA,Billingham ME,Ellis SG,Kernoff RS,Takamoto T,Popp RL

更新日期：1985-07-01 00:00:00

abstract：:Eighteen of 388 patients with chronic bundle branch block, studied electrophysiologically and followed prospectively, had H-V intervals of 80 msec or greater. Five patients were functional class I, five class II, seven class III, and one class IV. Follow-up ranged from 103 to 1919 days (mean 711 +/- 118). Three patien...

journal_title：Circulation

authors： Dhingra RC,Denes P,Wu D,Wyndham CR,Amat-y-Leon F,Towne WD,Rosen KM

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND:Oxidative stress has been implicated in vascular injury and atherogenesis, and antioxidant treatment has shown favorable results in preclinical studies. Despite this, antioxidant therapy has failed to show benefit in clinical trials. Failure of antioxidants in clinical trials may be partly because such thera...

journal_title：Circulation

authors： Chyu KY,Babbidge SM,Zhao X,Dandillaya R,Rietveld AG,Yano J,Dimayuga P,Cercek B,Shah PK

更新日期：2004-05-25 00:00:00

abstract：BACKGROUND:Chagas heart disease is a frequent cause of morbidity and mortality in Latin America. Echocardiography provides useful diagnostic and prognostic information and is an important tool in the management of patients with Chagas disease. METHODS AND RESULTS:A search for relevant publications was obtained from ME...

journal_title：Circulation

authors： Acquatella H

更新日期：2007-03-06 00:00:00

abstract：BACKGROUND:Short-term hibernating myocardium is characterized by a decrease in contractile function in proportion to the reduced myocardial blood flow. Myocardial creatine phosphate content, initially decreased during the first minutes of ischemia, returns to near-control values, the ischemia-induced net lactate produc...

journal_title：Circulation

authors： Schulz R,Rose J,Martin C,Brodde OE,Heusch G

更新日期：1993-08-01 00:00:00

abstract：:Oral flecainide acetate was administered to 34 patients with documented symptomatic paroxysmal supraventricular tachycardia (PSVT) with a double-blind, placebo-controlled, 8-week crossover trial design. PSVT was defined as a regular tachycardia of at least 120 beats/min without evidence of atrioventricular dissociatio...

journal_title：Circulation

authors： Henthorn RW,Waldo AL,Anderson JL,Gilbert EM,Alpert BL,Bhandari AK,Hawkinson RW,Pritchett EL

更新日期：1991-01-01 00:00:00

abstract：:Coronary occlusion in the dog results in irreversible myocardial cell injury which develops first in subendocardial areas of severe ischemica and subsequently spreads into mid and subepicardial areas of moderate ischemia. The effect of propranolol on this progression of ischemic injury was evaluated. Three groups of d...

journal_title：Circulation

authors： Rasmussen MM,Reimer KA,Kloner RA,Jennings RB

更新日期：1977-11-01 00:00:00

abstract：:Over the last 20 years, operative mortality has decreased and late survival has improved for patients with chronic stable angina who have coronary artery bypass surgery. However, this favorable trend may not continue because the operation is now extended to elderly and high-risk patients. The most powerful predictors ...

journal_title：Circulation

authors： Gersh BJ,Califf RM,Loop FD,Akins CW,Pryor DB,Takaro TC

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND:Sharing of patient-level clinical trial data has been widely endorsed. Little is known about how extensively these data have been used for cardiometabolic diseases. We sought to evaluate the availability and use of shared data from cardiometabolic clinical trials. METHODS:We extracted data from ClinicalStud...

journal_title：Circulation

authors： Vaduganathan M,Nagarur A,Qamar A,Patel RB,Navar AM,Peterson ED,Bhatt DL,Fonarow GC,Yancy CW,Butler J

更新日期：2018-02-27 00:00:00

abstract：:Our experimental studies since 1972 show that the heart is preserved best during cardiopulmonary bypass when it is in the beating, nonworking state. Results after mitral valve replacement (MVR) from 1968 to 1974 using various techniques of cardiac preservation were compared. In group I were 47 patients (1968 to 1972) ...

journal_title：Circulation

authors： Maloney JV Jr,Cooper N,Mulder DG,Buckberg GD

更新日期：1975-08-01 00:00:00

abstract：BACKGROUND:Defining the arrhythmogenic substrate is essential for successful ablation of scar-related ventricular tachycardia. The visual characteristics of endocardial ischemic scar have not been described in vivo. The goal of this study was (1) to quantify the visual characteristics of normal tissue, scar border zone...

journal_title：Circulation

authors： Betensky BP,Jauregui M,Campos B,Michele J,Marchlinski FE,Oley L,Wylie B,Robinson D,Gerstenfeld EP

更新日期：2012-10-23 00:00:00

abstract：BACKGROUND:The concept of natriuretic peptide guidance has been extensively studied in patients with chronic heart failure (HF), with only limited success. The effect of NT-proBNP (N-terminal probrain natriuretic peptide)-guided therapy in patients with acute decompensated HF using a relative NT-proBNP target has not b...

journal_title：Circulation

authors： Stienen S,Salah K,Moons AH,Bakx AL,van Pol P,Kortz RAM,Ferreira JP,Marques I,Schroeder-Tanka JM,Keijer JT,Bayés-Genis A,Tijssen JGP,Pinto YM,Kok WE

更新日期：2018-04-17 00:00:00

abstract：BACKGROUND:Bias in studies of preventive medications can occur when healthier patients are more likely to initiate and adhere to therapy than less healthy patients. We sought evidence of this bias by examining associations between statin exposure and various outcomes that should not be causally affected by statin expos...

journal_title：Circulation

authors： Dormuth CR,Patrick AR,Shrank WH,Wright JM,Glynn RJ,Sutherland J,Brookhart MA

更新日期：2009-04-21 00:00:00

abstract：BACKGROUND:The hypoxia-inducible transcription factor (HIF) subunits are destabilized via the O(2)-dependent prolyl hydroxylase domain proteins (PHD1, PHD2, and PHD3). We investigated whether inhibition of PHDs via upregulating HIF might promote postischemic neovascularization. METHODS AND RESULTS:Mice with right femo...

journal_title：Circulation

authors： Loinard C,Ginouvès A,Vilar J,Cochain C,Zouggari Y,Recalde A,Duriez M,Lévy BI,Pouysségur J,Berra E,Silvestre JS

更新日期：2009-07-07 00:00:00

abstract：BACKGROUND:In cardiac arrest, use of percutaneous cardiopulmonary bypass support (PCPS) may lead to left ventricular loading, with deleterious effects on the myocardium, and is often accompanied by an increase in pulmonary artery pressure. The present study was designed to assess the potential of artificially induced p...

journal_title：Circulation

authors： Scholz KH,Figulla HR,Schröder T,Hering JP,Bock H,Ferrari M,Kreuzer H,Hellige G

更新日期：1995-05-15 00:00:00

abstract：:Ventricular tachycardia is unusual in infancy. Three infants are described in whom this arrhythmia was documented by electrophysiologic studies. The ability to start and terminate this rhythm by critically timed premature ventricular stimulation suggests a reentrant mechanism. All three patients have remained free of ...

journal_title：Circulation

authors： Gaum WE,Schwartz DC,Kaplan S

更新日期：1980-08-01 00:00:00

abstract：:Inherited thoracic aortopathies denote a group of congenital conditions that predispose to disease of the thoracic aorta. Aortic wall weakness and abnormal aortic hemodynamic profiles predispose these patients to dilatation of the thoracic aorta, which is generally silent but can precipitate aortic dissection or ruptu...

journal_title：Circulation

authors： Fletcher AJ,Syed MBJ,Aitman TJ,Newby DE,Walker NL

更新日期：2020-05-12 00:00:00

abstract：BACKGROUND:Cystathionine γ-lyase (CSE) produces H2S via enzymatic conversion of L-cysteine and plays a critical role in cardiovascular homeostasis. We investigated the effects of genetic modulation of CSE and exogenous H2S therapy in the setting of pressure overload-induced heart failure. METHODS AND RESULTS:Transvers...

journal_title：Circulation

authors： Kondo K,Bhushan S,King AL,Prabhu SD,Hamid T,Koenig S,Murohara T,Predmore BL,Gojon G Sr,Gojon G Jr,Wang R,Karusula N,Nicholson CK,Calvert JW,Lefer DJ

更新日期：2013-03-12 00:00:00

abstract：BACKGROUND:Inhaled nitric oxide (NO) is a potent and selective pulmonary vasodilator, which induces cGMP synthesis by activating soluble guanylate cyclase (sGC) in ventilated lung regions. Carbon monoxide (CO) has also been proposed to influence smooth muscle tone via activation of sGC. We examined whether direct stimu...

journal_title：Circulation

authors： Evgenov OV,Ichinose F,Evgenov NV,Gnoth MJ,Falkowski GE,Chang Y,Bloch KD,Zapol WM

更新日期：2004-10-12 00:00:00

abstract：:A case of progressive pulmonary hypertension in a child with a small ventricular septal defect is presented. Natural history studies have indicated that children with small ventricular septal defects can be followed conservatively. This case represents a contradiction to that rule and suggests that further study must ...

journal_title：Circulation

authors： Bisset GS 3rd,Hirschfeld SS

更新日期：1983-02-01 00:00:00

abstract：:Patients with idiopathic hypertrophic subaortic stenosis (IHSS) have supernormal left ventricular systolic function at rest. Septal myotomy/myectomy reduces outflow obstruction and symptoms. However, it has been proposed that operation causes myocardial damage, with consequent reduction in left ventricular function an...

journal_title：Circulation

authors： Borer JS,Bacharach SL,Green MV,Kent KM,Rosing DR,Seides SF,Morrow AG,Epstein SE

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND:Restenosis after initial, successful percutaneous transluminal coronary angioplasty (PTCA) is due to fibrocellular proliferation. METHODS AND RESULTS:The present study focused on the nature of fibrocellular tissue in humans by use of immunocytochemical techniques. Four hearts (five coronary arteries) were i...

journal_title：Circulation

authors： Ueda M,Becker AE,Tsukada T,Numano F,Fujimoto T

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Blood clotting activation is an important component of the inflammatory response; the outbursts of unstable angina are usually associated with increased thrombin formation and coronary mural thrombosis. METHODS AND RESULTS:To investigate 1) whether monocyte activation is responsible for the enhanced thrombi...

journal_title：Circulation

authors： Serneri GG,Abbate R,Gori AM,Attanasio M,Martini F,Giusti B,Dabizzi P,Poggesi L,Modesti PA,Trotta F

更新日期：1992-09-01 00:00:00