Prospective observations in patients with chronic bundle branch block and marked H-V prolongation.

abstract：BACKGROUND:A robotic catheter navigation system has been developed that provides a significant degree of freedom of catheter movement. This study examines the feasibility of synchronizing this robotic navigation system with electroanatomic mapping and 3-dimensional computed tomography imaging to perform view-synchroniz...

journal_title：Circulation

authors： Reddy VY,Neuzil P,Malchano ZJ,Vijaykumar R,Cury R,Abbara S,Weichet J,McPherson CD,Ruskin JN

更新日期：2007-05-29 00:00:00

abstract：BACKGROUND:The heart contains a variety of morphologically distinct nerve terminals known to influence cardiac function. Little is known about the distribution, morphology, and neurochemistry of these terminals in the human heart. METHODS AND RESULTS:We examined the entire endocardial and epicardial surfaces of infant...

journal_title：Circulation

authors： Marron K,Wharton J,Sheppard MN,Fagan D,Royston D,Kuhn DM,de Leval MR,Whitehead BF,Anderson RH,Polak JM

更新日期：1995-10-15 00:00:00

abstract：BACKGROUND:AMP-activated protein kinase (AMPK) is a stress-activated protein kinase that works as a metabolic sensor of cellular ATP levels. Here, we investigated whether AMPK signaling has a role in the regulation of the angiotensin II (Ang II)-induced proliferation signal in rat vascular smooth muscle cells (VSMCs). ...

journal_title：Circulation

authors： Nagata D,Takeda R,Sata M,Satonaka H,Suzuki E,Nagano T,Hirata Y

更新日期：2004-07-27 00:00:00

abstract：:We used Doppler echocardiography to quantitate the changes in intracardiac blood flow velocities and right and left ventricular stroke volumes in 80 normal human fetuses from 19 to 40 weeks gestation. Blood flow velocity spectra across the aortic, pulmonary, tricuspid, and mitral valves were digitized to obtain peak v...

journal_title：Circulation

authors： Kenny JF,Plappert T,Doubilet P,Saltzman DH,Cartier M,Zollars L,Leatherman GF,St John Sutton MG

更新日期：1986-12-01 00:00:00

abstract：BACKGROUND:Although the use of physical signs for the diagnosis of ventricular tachycardia (VT) was described in the early 1900s, their value in this role has never been systematically assessed. METHODS AND RESULTS:Using a blinded, randomized protocol, we examined the ability of 26 clinicians to detect ventriculoatria...

journal_title：Circulation

authors： Garratt CJ,Griffith MJ,Young G,Curzen N,Brecker S,Rickards AF,Camm AJ

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Heart rate reduction should benefit patients with chronic stable angina by improving myocardial perfusion and reducing myocardial oxygen demand. This study evaluated the antianginal and antiischemic effects of ivabradine, a new heart rate-lowering agent that acts specifically on the sinoatrial node. METHODS...

journal_title：Circulation

authors： Borer JS,Fox K,Jaillon P,Lerebours G,Ivabradine Investigators Group.

更新日期：2003-02-18 00:00:00

abstract：BACKGROUND:Influenza infection is a serious event for patients with heart failure (HF). Little knowledge exists about the association between influenza vaccination and outcome in patients with HF. This study sought to determine whether influenza vaccination is associated with improved long-term survival in patients wit...

journal_title：Circulation

authors： Modin D,Jørgensen ME,Gislason G,Jensen JS,Køber L,Claggett B,Hegde SM,Solomon SD,Torp-Pedersen C,Biering-Sørensen T

更新日期：2019-01-29 00:00:00

abstract：BACKGROUND:Cardiac myosin-binding protein C (cMyBP-C) is a sarcomeric protein that dynamically regulates thick-filament structure and function. In constitutive cMyBP-C knockout (cMyBP-C(-/-)) mice, loss of cMyBP-C has been linked to left ventricular dilation, cardiac hypertrophy, and systolic and diastolic dysfunction,...

journal_title：Circulation

authors： Chen PP,Patel JR,Powers PA,Fitzsimons DP,Moss RL

更新日期：2012-09-04 00:00:00

abstract：BACKGROUND:Cardiac effects of hypertension include increased left ventricular (LV) mass and LV hypertrophy, as well as increased left atrial size, a predictor of stroke and atrial fibrillation. Although literature on reduction of LV mass with antihypertensive therapy is extensive, little information is available on eff...

journal_title：Circulation

authors： Gottdiener JS,Reda DJ,Williams DW,Materson BJ,Cushman W,Anderson RJ

更新日期：1998-07-14 00:00:00

abstract：BACKGROUND:Among patients with documented stable coronary artery disease and in whom no revascularization was performed, we compared the respective values of angiographic diameter stenosis (DS) and fractional flow reserve (FFR) in predicting natural history. METHODS:The present analysis included the 607 patients from ...

journal_title：Circulation

authors： Ciccarelli G,Barbato E,Toth GG,Gahl B,Xaplanteris P,Fournier S,Milkas A,Bartunek J,Vanderheyden M,Pijls N,Tonino P,Fearon WF,Jüni P,De Bruyne B

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:Convincing evidence suggests that atherosclerosis is an inflammatory disease. The inflammatory response is an important determinant of atherosclerotic plaque instability. Therefore, we investigated the prognostic impact of key inflammatory players, namely the inflammatory marker C-reactive protein (CRP) and ...

journal_title：Circulation

authors： Heeschen C,Dimmeler S,Hamm CW,Fichtlscherer S,Boersma E,Simoons ML,Zeiher AM,CAPTURE Study Investigators.

更新日期：2003-04-29 00:00:00

abstract：BACKGROUND:ACE inhibitors exert both acute and chronic beneficial effects on cardiac function (eg, remodeling, diastolic dysfunction) in experimental studies and in patients. They inhibit the formation of angiotensin II as well as the degradation of endogenous bradykinin. We recently reported that bradykinin induces se...

journal_title：Circulation

authors： Anning PB,Grocott-Mason RM,Lewis MJ,Shah AM

更新日期：1995-11-01 00:00:00

abstract：:The term "linking" has been used specifically to describe the mechanism for perpetuation of functional anterograde bundle branch block: namely, repetitive transseptal retrograde concealed penetration by impulses propagating along the contralateral bundle. We present selected examples that demonstrate tht linking-type ...

journal_title：Circulation

authors： Lehmann MH,Denker S,Mahmud R,Addas A,Akhtar M

更新日期：1985-02-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine the minimum hematocrit (Hct) supporting cerebral oxygenation over the range clinically relevant cardiopulmonary bypass (CPB) temperatures in dogs. The effect of hemodilution on cerebral blood flow (CBF), cerebral metabolic rate (CMRO2), and cerebral oxygen delivery ...

journal_title：Circulation

authors： Cook DJ,Orszulak TA,Daly RC

更新日期：1998-11-10 00:00:00

abstract：:The effects of abrupt withdrawal or continuation of beta-blockade therapy during acute myocardial infarction were evaluated in 326 patients participating in the Multicenter Investigation of the Limitation of Infarct Size (MILIS). Thirty-nine patients previously receiving a beta-blocker and randomly selected for withdr...

journal_title：Circulation

authors： Croft CH,Rude RE,Gustafson N,Stone PH,Poole WK,Roberts R,Strauss HW,Raabe DS Jr,Thomas LJ,Jaffe AS

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND:Patients with advanced heart failure have bioenergetic abnormalities of skeletal muscle metabolism during exercise. Using 31P magnetic resonance spectroscopy, we sought to determine whether skeletal metabolic responses to exercise are normalized by orthotopic cardiac transplantation. METHODS AND RESULTS:Fou...

journal_title：Circulation

authors： Stratton JR,Kemp GJ,Daly RC,Yacoub M,Rajagopalan B

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:Despite successful surgical correction, morbidity of patients with coarctation of the aorta is increased. It is well known that these patients have impaired elastic properties of the prestenotic arteries. To find out whether these abnormalities are primarily present or develop later, we studied 17 newborns b...

journal_title：Circulation

authors： Vogt M,Kühn A,Baumgartner D,Baumgartner C,Busch R,Kostolny M,Hess J

更新日期：2005-06-21 00:00:00

abstract：BACKGROUND:Although hepatocyte growth factor (HGF), a novel angiogenic growth factor, plays an important role in angiogenesis, regulation of local HGF production under hypoxia has not yet been clarified in vascular smooth muscle cells (VSMC) and endothelial cells (EC). Thus, we have studied the role of HGF in hypoxia-i...

journal_title：Circulation

authors： Hayashi S,Morishita R,Nakamura S,Yamamoto K,Moriguchi A,Nagano T,Taiji M,Noguchi H,Matsumoto K,Nakamura T,Higaki J,Ogihara T

更新日期：1999-11-09 00:00:00

abstract：BACKGROUND:Surviving cells in the postinfarction border zone are subjected to intense fluctuations of their microenvironment. Recently, border zone cardiomyocytes have been specifically implicated in cardiac regeneration. Here, we defined their unique transcriptional and regulatory properties, and comprehensively valid...

journal_title：Circulation

authors： van Duijvenboden K,de Bakker DEM,Man JCK,Janssen R,Günthel M,Hill MC,Hooijkaas IB,van der Made I,van der Kraak PH,Vink A,Creemers EE,Martin JF,Barnett P,Bakkers J,Christoffels VM

更新日期：2019-09-09 00:00:00

abstract：:We determined the pharmacokinetics, efficacy and therapeutic plasma concentration of encainide, a new antiarrhythmic drug that affects His-Purkinje conduction but not ventricular refractoriness. Nine patients with frequent and complex premature ventricular complexes were studied in a 3-day double-blind protocol. Each ...

journal_title：Circulation

authors： Winkle RA,Peters F,Kates RE,Tucker C,Harrison DC

更新日期：1981-08-01 00:00:00

abstract：BACKGROUND:To examine the effect of plasminogen activator therapy on vascular permeability, we used a modified rabbit mesenteric model of extravascular tissue accumulation of radiolabeled albumin. METHODS AND RESULTS:Albumin deposition was measured after saline, tissue-type plasminogen activator (t-PA; 0.86 mg/kg for ...

journal_title：Circulation

authors： Rudd MA,Johnstone MT,Rabbani LE,George D,Ware JA,Loscalzo J

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:The residual Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery (SYNTAX) Score is an objective measure of the degree and complexity of residual stenosis after percutaneous coronary intervention (PCI). METHODS AND RESULTS:In the randomized PCI cohort of the SYNTAX Trial (n=903)...

journal_title：Circulation

authors： Farooq V,Serruys PW,Bourantas CV,Zhang Y,Muramatsu T,Feldman T,Holmes DR,Mack M,Morice MC,Ståhle E,Colombo A,de Vries T,Morel MA,Dawkins KD,Kappetein AP,Mohr FW

更新日期：2013-07-09 00:00:00

abstract：BACKGROUND:Morbidity and mortality after conventional repair of thoracoabdominal aneurysms remain high. Alternative techniques have been proposed and are the subject of this report. METHODS AND RESULTS:Endovascular grafts that have a means of incorporating the visceral vessels into the aortic repair were divided into ...

journal_title：Circulation

authors： Greenberg RK,Lytle B

更新日期：2008-04-29 00:00:00

abstract：:Background: In ISCHEMIA, an initial invasive strategy did not significantly reduce rates of cardiovascular events or all-cause mortality compared with a conservative strategy in patients with stable ischemic heart disease and moderate/severe myocardial ischemia. The most frequent component of composite cardiovascular ...

journal_title：Circulation

authors： Chaitman BR,Alexander KP,Cyr DD,Berger JS,Reynolds HR,Bangalore S,Boden WE,Lopes RD,Demkow M,Perna GP,Riezebos RK,McFalls EO,Banerjee S,Bagai A,Gosselin G,O'Brien SM,Rockhold FW,Waters DD,Thygesen KA,Stone GW,Whit

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND:Although black cardiac patients receive fewer revascularization procedures than whites, it is unclear whether this has a detrimental impact on outcomes. The objective of our study was to compare 6-month functional status and angina outcomes among blacks and whites with documented coronary disease and to asse...

journal_title：Circulation

authors： Kaul P,Lytle BL,Spertus JA,DeLong ER,Peterson ED

更新日期：2005-03-15 00:00:00

abstract：:A prospective electrocardiographic study was designed to establish baseline values for electrocardiographic measurements, with specific reference to the QT interval during infancy, and to test the "QT hypothesis" for the sudden infant death syndrome (SIDS). In this ongoing study, ECGs are recorded on the fourth day of...

journal_title：Circulation

authors： Schwartz PJ,Montemerlo M,Facchini M,Salice P,Rosti D,Poggio G,Giorgetti R

更新日期：1982-09-01 00:00:00

abstract：BACKGROUND:Ischemia reperfusion injury (IRI) predisposes to the formation of donor-specific antibodies, a factor contributing to chronic rejection and late allograft loss. METHODS:We describe a mechanism underlying the correlative association between IRI and donor-specific antibodies by using humanized models and pati...

journal_title：Circulation

authors： Liu L,Fang C,Fu W,Jiang B,Li G,Qin L,Rosenbluth J,Gong G,Xie CB,Yoo P,Tellides G,Pober JS,Jane-Wit D

更新日期：2020-02-11 00:00:00

abstract：BACKGROUND:Antiplatelet agents presently used in the secondary prevention of cardiovascular disease fail to prevent the majority of cases of recurrent stroke and systemic embolization. An evaluation of the efficacy of new agents is hampered by a lack of in vivo models in humans. Asymptomatic cerebral embolic signals (E...

journal_title：Circulation

authors： Molloy J,Martin JF,Baskerville PA,Fraser SC,Markus HS

更新日期：1998-10-06 00:00:00

abstract：:To compare acute effects of nitroglycerin (0.8 mg sublingually), nifedipine (5 ng/kg/min i.v.) and metoprolol (0.15 mg/kg i.v.) on normal, ischemic and scarred myocardial segments in man, we performed simultaneous hemodynamic and radionuclide measurements of left ventricular functions. Sixteen patients with isolated l...

journal_title：Circulation

authors： Pfisterer M,Glaus L,Burkart F

更新日期：1983-02-01 00:00:00

abstract：:In a porcine preparation of cardiac arrest, we demonstrated that there is a marked paradox of venous acidemia and arterial alkalemia. This paradox is related to decreased clearance of CO2 from the lungs when pulmonary blood flow is critically reduced. Accordingly, increased venous PCO2 rather than metabolic acidosis d...

journal_title：Circulation

authors： Grundler W,Weil MH,Rackow EC

更新日期：1986-11-01 00:00:00