Abrupt withdrawal of beta-blockade therapy in patients with myocardial infarction: effects on infarct size, left ventricular function, and hospital course.

abstract：:Premature opening of the pulmonary valve (opening independent of atrial or ventricular systole) was originally described in a case of sinus of Valsalva rupture into the right atrium. Since that time we have observed five additional cases in which the pulmonary valve opened prematurely. Entities encountered included: 1...

journal_title：Circulation

authors： Wann LS,Weyman AE,Dillon JC,Feigenbaum H

更新日期：1977-01-01 00:00:00

abstract：:We studied the inferior vena cava (IVC) as an index of right-heart function in 111 patients. A two-dimensional echocardiographic sector was used to visualize the IVC, and its M-mode cursor was used to generate a time-motion record of the IVC size and pulsation. Normal subjects had a small presystolic A wave (less than...

journal_title：Circulation

authors： Mintz GS,Kotler MN,Parry WR,Iskandrian AS,Kane SA

更新日期：1981-11-01 00:00:00

abstract：BACKGROUND:Therapy with racemic compounds produces effects that can be attributed to both (S)- and (R)-enantiomers. Here we have tested the hypothesis that an enantiomer-enantiomer interaction would modulate the effects of treatment with a racemate, the antiarrhythmic propafenone. Previous studies have shown that while...

journal_title：Circulation

authors： Kroemer HK,Fromm MF,Bühl K,Terefe H,Blaschke G,Eichelbaum M

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:The incidence of syncope exhibits a daily pattern with more occurrences in the morning, possibly as a result of influences from the endogenous circadian system and/or the daily pattern of behavioral/emotional stimuli. This study tested the hypothesis that the circadian system modulates cardiovascular respons...

journal_title：Circulation

authors： Hu K,Scheer FA,Laker M,Smales C,Shea SA

更新日期：2011-03-08 00:00:00

abstract：BACKGROUND:Postprandial angina pectoris has been recognized for more than two centuries and can be identified in up to 10% of patients with chronic ischemic heart disease. Redistribution of myocardial blood flow, from a region supplied by a severely stenotic coronary artery to those supplied by less diseased or normal ...

journal_title：Circulation

authors： Baliga RR,Rosen SD,Camici PG,Kooner JS

更新日期：1998-03-31 00:00:00

abstract：:Electrophysiologic studies were performed in 28 patients with documented atrioventricular (AV) nodal reentrant supraventricular tachycardia (SVT) to investigate the presence of AV nodal tissue situated between the tachycardia circuit and both the atrium (upper common pathway, UCP) and the His bundle (lower common path...

journal_title：Circulation

authors： Miller JM,Rosenthal ME,Vassallo JA,Josephson ME

更新日期：1987-05-01 00:00:00

abstract：:Digitalis has been shown to improve the impaired ventricular function associated with coronary artery disease as well as to increase myocardial oxygen consumption and produce coronary vasoconstriction. To elucidate the net result of these contrasting effects, six patients with coronary artery disease and left ventricu...

journal_title：Circulation

authors： Vogel R,Kirch D,LeFree M,Frischknecht J,Steele P

更新日期：1977-09-01 00:00:00

abstract：:In a double-blind randomized trial involving five Sydney hospitals and the city ambulance paramedical service, 145 patients with a first evolving myocardial infarction and with onset of pain less than 2.5 (mean 1.9 +/- 0.5 [SD]) hr previously were allocated to intravenous infusion of 100 mg recombinant tissue-type pla...

journal_title：Circulation

authors： O'Rourke M,Baron D,Keogh A,Kelly R,Nelson G,Barnes C,Raftos J,Graham K,Hillman K,Newman H

更新日期：1988-06-01 00:00:00

abstract：:Digoxin, in a common clinical dose and at a low serum level, brought out severe manifestations of sinus node dysfunction in a patient who had previously undergone successful mitral valve replacement. This report presents the results of extensive clinical and electrophysiologic studies of this patient before and after ...

journal_title：Circulation

authors： Margolis JR,Strauss HC,Miller HC,Gilbert M,Wallace AG

更新日期：1975-07-01 00:00:00

abstract：BACKGROUND:Ibutilide is an action potential-prolonging antiarrhythmic currently in clinical trials. The drug shares structural similarities with E-4031 and dofetilide, specific blockers of the rapidly activating delayed rectifier K+ current (IKr). However, previous in vitro studies in guinea pig myocytes have indicated...

journal_title：Circulation

authors： Yang T,Snyders DJ,Roden DM

更新日期：1995-03-15 00:00:00

abstract：:The Academic Research Consortium (ARC)-2 initiative revisited the clinical and angiographic end point definitions in coronary device trials, proposed in 2007, to make them more suitable for use in clinical trials that include increasingly complex lesion and patient populations and incorporate novel devices such as bio...

journal_title：Circulation

authors： Garcia-Garcia HM,McFadden EP,Farb A,Mehran R,Stone GW,Spertus J,Onuma Y,Morel MA,van Es GA,Zuckerman B,Fearon WF,Taggart D,Kappetein AP,Krucoff MW,Vranckx P,Windecker S,Cutlip D,Serruys PW,Academic Research Consortium

更新日期：2018-06-12 00:00:00

abstract：BACKGROUND:Microsomal (m) prostaglandin (PG) E₂ synthase (S)-1 catalyzes the formation of PGE₂ from PGH₂, a cyclooxygenase product that is derived from arachidonic acid. Previous studies in mice suggest that targeting mPGES-1 may be less likely to cause hypertension or thrombosis than cyclooxygenase-2-selective inhibit...

journal_title：Circulation

authors： Wang M,Ihida-Stansbury K,Kothapalli D,Tamby MC,Yu Z,Chen L,Grant G,Cheng Y,Lawson JA,Assoian RK,Jones PL,Fitzgerald GA

更新日期：2011-02-15 00:00:00

abstract：:The electron microscopic structure of heart muscle and the ultrastructural basis of cardiac contraction have been reviewed. The relation between muscle length and developed tension has been explained in terms of the structure of the sarcomere, which is the basic unit of contraction. Using the derived length-tension cu...

journal_title：Circulation

authors： Sonnenblick EH

更新日期：1968-07-01 00:00:00

abstract：:Although coronary thrombus overlying a disrupted atherosclerotic plaque has long been considered the hallmark and the primary therapeutic target for acute myocardial infarction (MI), multiple other mechanisms are now known to cause or contribute to MI. It is further recognized that an MI is just one of many types of a...

journal_title：Circulation

authors： DeFilippis AP,Chapman AR,Mills NL,de Lemos JA,Arbab-Zadeh A,Newby LK,Morrow DA

更新日期：2019-11-12 00:00:00

abstract：:Resting left ventricular (LV) function was evaluated in 22 patients with permanent ventricular pacemakers. LV ejection fraction and volume indexes were determined by gated blood pool scintigraphy at ventricular pacing rates of 50-100 beats/min. In patients with a normal heart size, increases in pacing rates resulted i...

journal_title：Circulation

authors： Narahara KA,Blettel ML

更新日期：1983-02-01 00:00:00

abstract：BACKGROUND:Myocardial perfusion reflects the macro- and microvascular coronary circulation. Recent quantitation developments using cardiovascular magnetic resonance perfusion permit automated measurement clinically. We explored the prognostic significance of stress myocardial blood flow (MBF) and myocardial perfusion r...

journal_title：Circulation

authors： Knott KD,Seraphim A,Augusto JB,Xue H,Chacko L,Aung N,Petersen SE,Cooper JA,Manisty C,Bhuva AN,Kotecha T,Bourantas CV,Davies RH,Brown LAE,Plein S,Fontana M,Kellman P,Moon JC

更新日期：2020-04-21 00:00:00

abstract：BACKGROUND:Coronary artery bypass surgery (CABG) has been associated with a range of neurological and neuropsychological complications from stroke to cognitive problems such as memory and problem solving disturbance. However, little is known about the impact of percutaneous coronary intervention (PCI) on neuropsycholog...

journal_title：Circulation

authors： Währborg P,Booth JE,Clayton T,Nugara F,Pepper J,Weintraub WS,Sigwart U,Stables RH,SoS Neuropsychology Substudy Investigators.

更新日期：2004-11-30 00:00:00

abstract：BACKGROUND:Adenosine possesses marked cardioprotective properties, but the mechanisms for this beneficial effect are unclear. The objective of this study was to determine the effect of adenosine given before ischemia or at reperfusion on mechanical function, glucose oxidation, glycolysis, and metabolite levels in isola...

journal_title：Circulation

authors： Finegan BA,Lopaschuk GD,Coulson CS,Clanachan AS

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Patients with congenital heart disease (CHD) and heterotaxy show high postsurgical morbidity/mortality, with some developing respiratory complications. Although this finding is often attributed to the CHD, airway clearance and left-right patterning both require motile cilia function. Thus, airway ciliary dys...

journal_title：Circulation

authors： Nakhleh N,Francis R,Giese RA,Tian X,Li Y,Zariwala MA,Yagi H,Khalifa O,Kureshi S,Chatterjee B,Sabol SL,Swisher M,Connelly PS,Daniels MP,Srinivasan A,Kuehl K,Kravitz N,Burns K,Sami I,Omran H,Barmada M,Olivier K,

更新日期：2012-05-08 00:00:00

abstract：BACKGROUND:The endocrine-disrupting chemical bisphenol A (BPA) is widely used in food and beverage packaging. Higher urinary BPA concentrations were cross-sectionally associated with heart disease in National Health and Nutrition Examination Survey (NHANES) 2003-2004 and NHANES 2005-2006, independent of traditional ris...

journal_title：Circulation

authors： Melzer D,Osborne NJ,Henley WE,Cipelli R,Young A,Money C,McCormack P,Luben R,Khaw KT,Wareham NJ,Galloway TS

更新日期：2012-03-27 00:00:00

abstract：:Ten patients with the long QT syndrome and recurrent syncope and/or cardiac arrest caused by ventricular arrhythmias underwent left stellate (one patient) or left cervicothoracic sympathectomy (nine patients) after failing to respond to high-dose beta-blocker therapy. The syndrome was familial in four and idiopathic i...

journal_title：Circulation

authors： Bhandari AK,Scheinman MM,Morady F,Svinarich J,Mason J,Winkle R

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:Disintegrin metalloproteinases (ADAMs) may contribute to structural cardiac remodeling by altering cell-surface matrix receptors (integrins) and activating potent biomolecules. We compared expression of ADAMs, their endogenous inhibitor tissue inhibitor of metalloproteinases (TIMP)-3, and integrins in human ...

journal_title：Circulation

authors： Fedak PW,Moravec CS,McCarthy PM,Altamentova SM,Wong AP,Skrtic M,Verma S,Weisel RD,Li RK

更新日期：2006-01-17 00:00:00

abstract：:To study the variability of the fraction of CPK released from the infarcted heart which enters the serum (serum entry ratio, or SER) with size and model of infarction, nine dogs underwent homogeneous infarctions (LAD ligation) of varying sizes, and 10 dogs underwent scattered infarctions (left coronary embolization). ...

journal_title：Circulation

authors： Cairns JA,Missirlis E,Fallen EL

更新日期：1978-12-01 00:00:00

abstract：BACKGROUND:Accumulating evidence suggests that several subsets of regulatory T cells that actively mediate immunologic tolerance play crucial roles in atherogenesis. Recently, orally administered anti-CD3 monoclonal antibody has been shown as an inducer of novel regulatory T cells expressing latency-associated peptide ...

journal_title：Circulation

authors： Sasaki N,Yamashita T,Takeda M,Shinohara M,Nakajima K,Tawa H,Usui T,Hirata K

更新日期：2009-11-17 00:00:00

abstract：BACKGROUND:Brain natriuretic peptide is a novel natriuretic peptide that is secreted predominantly from the ventricles, and its plasma levels have been shown to be markedly increased in patients with chronic congestive heart failure. This study was designed to examine the plasma levels of brain natriuretic peptide as w...

journal_title：Circulation

authors： Morita E,Yasue H,Yoshimura M,Ogawa H,Jougasaki M,Matsumura T,Mukoyama M,Nakao K

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:We hypothesized that a simple, unmeasured posterior annuloplasty technique (two thirds of a 27-mm Duran ring) offered advantages of standardization and ease of insertion. METHODS AND RESULTS:A consecutive series of all patients (n = 418; median age, 67 years) having mitral valve repair performed by two surg...

journal_title：Circulation

authors： Odell JA,Schaff HV,Orszulak TA

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Conventional x-ray angiography frequently underestimates the true burden of atherosclerosis. Although intravascular ultrasound allows for imaging of coronary plaque, this invasive technique is inappropriate for screening or serial examinations. We therefore sought to develop a noninvasive free-breathing MR t...

journal_title：Circulation

authors： Botnar RM,Stuber M,Kissinger KV,Kim WY,Spuentrup E,Manning WJ

更新日期：2000-11-21 00:00:00

abstract：BACKGROUND:Patients with diabetes mellitus (DM) are at high risk of developing congestive heart failure (CHF). However, the relationships between glucose levels and CHF in people with or without a history of DM have not been well characterized. METHODS AND RESULTS:We evaluated the associations between fasting plasma g...

journal_title：Circulation

authors： Held C,Gerstein HC,Yusuf S,Zhao F,Hilbrich L,Anderson C,Sleight P,Teo K,ONTARGET\/TRANSCEND Investigators.

更新日期：2007-03-20 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is a life-threatening disease, characterized by vascular smooth muscle cell hyperproliferation. The calcium/calmodulin-dependent phosphodiesterase 1 (PDE1) may play a major role in vascular smooth muscle cell proliferation. METHODS AND RESULTS:We investigated the expres...

journal_title：Circulation

authors： Schermuly RT,Pullamsetti SS,Kwapiszewska G,Dumitrascu R,Tian X,Weissmann N,Ghofrani HA,Kaulen C,Dunkern T,Schudt C,Voswinckel R,Zhou J,Samidurai A,Klepetko W,Paddenberg R,Kummer W,Seeger W,Grimminger F

更新日期：2007-05-01 00:00:00

abstract：:Correlates of high-density lipoprotein (HDL) cholesterol levels were studied in 4756 white males and females ages 20-59 years examined during a population survey conducted by 10 North American Lipid Research Clinics. Multivariable analysis was used to assess the relation of social, demographic, physical and behavioral...

journal_title：Circulation

authors： Heiss G,Johnson NJ,Reiland S,Davis CE,Tyroler HA

更新日期：1980-11-01 00:00:00