Abstract:
BACKGROUND:Coronary artery bypass surgery (CABG) has been associated with a range of neurological and neuropsychological complications from stroke to cognitive problems such as memory and problem solving disturbance. However, little is known about the impact of percutaneous coronary intervention (PCI) on neuropsychological outcome. METHODS AND RESULTS:In the Stent or Surgery Trial (SoS), 988 patients were randomized in equal proportions between PCI supported by stent implantation and CABG. As a substudy of this trial, we undertook an evaluation of neurological and neuropsychological outcomes after intervention. A clinical examination and neuropsychological assessment consisting of 5 tests (Digit Span Forwards and Backwards, Visual Reproduction, Bourdon, and Block Design) were performed at baseline and 6 and 12 months after the procedure. A total of 145 patients were included in the substudy analysis: 77 in the PCI group and 68 in the CABG group. One patient in the PCI arm had a stroke. There was no significant difference between treatment groups at 6 and 12 months for any of the 5 tests. The mean change from baseline was also similar in both groups. CONCLUSIONS:We were not able to demonstrate an important and significant difference in neuropsychological outcome in patients treated with different revascularization strategies. This important finding needs to be examined in further research.
journal_name
Circulationjournal_title
Circulationauthors
Währborg P,Booth JE,Clayton T,Nugara F,Pepper J,Weintraub WS,Sigwart U,Stables RH,SoS Neuropsychology Substudy Investigators.doi
10.1161/01.CIR.0000148366.80443.2Bsubject
Has Abstractpub_date
2004-11-30 00:00:00pages
3411-7issue
22eissn
0009-7322issn
1524-4539pii
01.CIR.0000148366.80443.2Bjournal_volume
110pub_type
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