Abstract:
BACKGROUND:Resetting has been used to characterize reentrant circuits causing clinical tachycardias. METHODS AND RESULTS:To determine the mechanisms of resetting, sustained ventricular tachycardia was induced in dogs with 4-day-old myocardial infarctions by programmed stimulation. Premature stimulation was accomplished from multiple regions within reentrant circuits; resetting curves were constructed and compared with activation maps. Monotonically increasing responses, or a "mixed" response (increasing portion preceded by a flat portion), occurred. All reentrant circuits had a fully excitable gap. Interval-dependent conduction delay and concealed retrograde penetration led to increased resetting response curves. CONCLUSIONS:Multiple mechanisms revealed by mapping cause resetting of reentrant circuits.
journal_name
Circulationjournal_title
Circulationauthors
Hanna MS,Coromilas J,Josephson ME,Wit AL,Peters NSdoi
10.1161/01.cir.103.8.1148subject
Has Abstractpub_date
2001-02-27 00:00:00pages
1148-56issue
8eissn
0009-7322issn
1524-4539journal_volume
103pub_type
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