Linkage analysis and long QT syndrome. Using genetics to study cardiovascular disease.

abstract：BACKGROUND:The physiological assessment of angiographically intermediate-severity stenoses remains problematic. Functional measurements of poststenotic intracoronary Doppler coronary flow reserve can be performed in humans but have not been correlated with hyperemic myocardial perfusion imaging or angiographic data in ...

journal_title：Circulation

authors： Miller DD,Donohue TJ,Younis LT,Bach RG,Aguirre FV,Wittry MD,Goodgold HM,Chaitman BR,Kern MJ

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Platelet-thrombus formation is a complication of arterial wall deep injury by balloon angioplasty that may lead to acute arterial occlusion and may contribute to restenosis. METHODS AND RESULTS:Because common platelet-inhibitor drugs with a heparin bolus (100 units/kg) may be effective in inhibiting platele...

journal_title：Circulation

authors： Lam JY,Chesebro JH,Steele PM,Heras M,Webster MW,Badimon L,Fuster V

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:Serum paraoxonase (PON1), an enzyme carried on HDL, inhibits LDL oxidation, and in human population studies, low PON1 activity is associated with atherosclerosis. In addition, PON1 knockout mice are more susceptible to lipoprotein oxidation and atherosclerosis. To evaluate whether PON1 protects against ather...

journal_title：Circulation

authors： Tward A,Xia YR,Wang XP,Shi YS,Park C,Castellani LW,Lusis AJ,Shih DM

更新日期：2002-07-23 00:00:00

abstract：:To assess the effects of moderate potassium cardioplegia (37 mEq/l KCl) on the severity of myocardial ischemia during arrest and on post arrest ventricular function, 32 isolated, isovolumic feline hearts were studied before, during and 1 hour after ischemic arrest. Normothermia (37 degrees C) was maintained in the rem...

journal_title：Circulation

authors： Schaff HV,Dombroff R,Flaherty JT,Bulkley BH,Hutchins GM,Goldman RA,Gott VL

更新日期：1978-08-01 00:00:00

abstract：BACKGROUND:Observational studies suggest that there are differences in adherence to antihypertensive medications in different classes. Our objective was to quantify the association between antihypertensive drug class and adherence in clinical settings. METHODS AND RESULTS:Studies were identified through a systematic s...

journal_title：Circulation

authors： Kronish IM,Woodward M,Sergie Z,Ogedegbe G,Falzon L,Mann DM

更新日期：2011-04-19 00:00:00

abstract：BACKGROUND:In subjects of all ages, those who weigh the most often have the highest blood pressure. Thus, in epidemiological studies, weight is the most important correlate of blood pressure. Using the data from the Medical College of Virginia Twin Study, we asked these questions: 1) Do the same genetic paths that regu...

journal_title：Circulation

authors： Schieken RM,Mosteller M,Goble MM,Moskowitz WB,Hewitt JK,Eaves LJ,Nance WE

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:There is an inverse relationship between HDL cholesterol and coronary heart disease. Experimental studies have indicated that HDL cholesterol may exert an antiatherogenic effect by inducing regression of atherosclerotic plaques and by turning lipid-rich plaques into more fibrotic lesions. In this prospective...

journal_title：Circulation

authors： Johnsen SH,Mathiesen EB,Fosse E,Joakimsen O,Stensland-Bugge E,Njølstad I,Arnesen E

更新日期：2005-07-26 00:00:00

abstract：BACKGROUND:The role of structural heart disease and sodium channel dysfunction in the induction of electrical instability in Brugada syndrome is still debated. METHODS AND RESULTS:We studied 18 consecutive patients (15 males, 3 females; mean age 42.0+/-12.4 years) with clinical phenotype of Brugada syndrome and normal...

journal_title：Circulation

authors： Frustaci A,Priori SG,Pieroni M,Chimenti C,Napolitano C,Rivolta I,Sanna T,Bellocci F,Russo MA

更新日期：2005-12-13 00:00:00

abstract：BACKGROUND:Recent studies of beta-adrenergic receptor (beta-AR) subtype signaling in in vitro preparations have raised doubts as to whether the cAMP/protein kinase A (PKA) signaling is activated in the same manner in response to beta2-AR versus beta1-AR stimulation. METHODS AND RESULTS:The present study compared, in t...

journal_title：Circulation

authors： Kuschel M,Zhou YY,Spurgeon HA,Bartel S,Karczewski P,Zhang SJ,Krause EG,Lakatta EG,Xiao RP

更新日期：1999-05-11 00:00:00

abstract：BACKGROUND:After regular coronary balloon angioplasty, it would be helpful to identify those patients who have a low cardiac event rate. Coronary angiography alone is not sensitive enough for that purpose, but it has been suggested that the combination of optimal angiographic and optimal functional results indicates a ...

journal_title：Circulation

authors： Bech GJ,Pijls NH,De Bruyne B,Peels KH,Michels HR,Bonnier HJ,Koolen JJ

更新日期：1999-02-23 00:00:00

abstract：BACKGROUND:We report the single-institution, long-term results of 358 patients with simple transposition of the great arteries surviving >30 days after a Mustard (n=226, 1965 to 1980) or Senning (n=132, 1978 to 1992) procedure. METHODS AND RESULTS:Outcome measures included late death, reintervention, ECG and ambulator...

journal_title：Circulation

authors： Sarkar D,Bull C,Yates R,Wright D,Cullen S,Gewillig M,Clayton R,Tunstill A,Deanfield J

更新日期：1999-11-09 00:00:00

abstract：BACKGROUND:Congestive heart failure (CHF) patients with central sleep apnea (CHF-CSA) have elevated plasma norepinephrine (NE) compared with CHF patients without apnea (CHF-N). Patients with CHF-CSA also demonstrate higher mean pulmonary artery pressure (PAP), which is suggestive of worse cardiac function. Whether CSA ...

journal_title：Circulation

authors： Mansfield D,Kaye DM,Brunner La Rocca H,Solin P,Esler MD,Naughton MT

更新日期：2003-03-18 00:00:00

abstract：BACKGROUND:Decreased renal function has been found to be an independent risk factor for cardiovascular outcomes in patients with chronic heart failure (CHF) with markedly reduced left ventricular ejection fraction (LVEF). The aim of this analysis was to evaluate the prognostic importance of renal function in a broader ...

journal_title：Circulation

authors： Hillege HL,Nitsch D,Pfeffer MA,Swedberg K,McMurray JJ,Yusuf S,Granger CB,Michelson EL,Ostergren J,Cornel JH,de Zeeuw D,Pocock S,van Veldhuisen DJ,Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity

更新日期：2006-02-07 00:00:00

abstract：BACKGROUND:Mutations in sarcomere protein, PRKAG2, LAMP2, alpha-galactosidase A (GLA), and several mitochondrial genes can cause rare familial cardiomyopathies, but their contribution to increased left ventricular wall thickness (LVWT) in the community is unknown. METHODS AND RESULTS:We studied 1862 unrelated particip...

journal_title：Circulation

authors： Morita H,Larson MG,Barr SC,Vasan RS,O'Donnell CJ,Hirschhorn JN,Levy D,Corey D,Seidman CE,Seidman JG,Benjamin EJ

更新日期：2006-06-13 00:00:00

abstract：BACKGROUND:Whether catheter ablation (CA) is superior to amiodarone (AMIO) for the treatment of persistent atrial fibrillation (AF) in patients with heart failure is unknown. METHODS AND RESULTS:This was an open-label, randomized, parallel-group, multicenter study. Patients with persistent AF, dual-chamber implantable...

journal_title：Circulation

authors： Di Biase L,Mohanty P,Mohanty S,Santangeli P,Trivedi C,Lakkireddy D,Reddy M,Jais P,Themistoclakis S,Dello Russo A,Casella M,Pelargonio G,Narducci ML,Schweikert R,Neuzil P,Sanchez J,Horton R,Beheiry S,Hongo R,Hao S,

更新日期：2016-04-26 00:00:00

abstract：BACKGROUND:We previously found in a pig coronary balloon injury model that vitamins C and E as well as probucol had beneficial effects on the vessel response to injury measured by morphometry These effects correlated with an inhibition in the ability to oxidize LDLs ex vivo, suggesting that the morphological response w...

journal_title：Circulation

authors： Nunes GL,Robinson K,Kalynych A,King SB 3rd,Sgoutas DS,Berk BC

更新日期：1997-11-18 00:00:00

abstract：BACKGROUND:We have developed a new measure of myocardial viability, the water-perfusable tissue index (PTI), which is calculated from transmission, C15O, and H2(15)O positron emission tomography (PET) data sets. It is defined as the proportion of the total anatomical tissue within a given region of interest (ROI) that ...

journal_title：Circulation

authors： Yamamoto Y,de Silva R,Rhodes CG,Araujo LI,Iida H,Rechavia E,Nihoyannopoulos P,Hackett D,Galassi AR,Taylor CJ

更新日期：1992-07-01 00:00:00

abstract：:Graft failure occurs in a sizeable proportion of coronary artery bypass conduits. We herein review relevant current evidence to give an overview of the incidence, pathophysiology, and clinical consequences of this multifactorial phenomenon. Thrombosis, endothelial dysfunction, vasospasm, and oxidative stress are diffe...

journal_title：Circulation

authors： Gaudino M,Antoniades C,Benedetto U,Deb S,Di Franco A,Di Giammarco G,Fremes S,Glineur D,Grau J,He GW,Marinelli D,Ohmes LB,Patrono C,Puskas J,Tranbaugh R,Girardi LN,Taggart DP,ATLANTIC (Arterial Grafting International Con

更新日期：2017-10-31 00:00:00

abstract：BACKGROUND:Bone marrow implantation (BMI) was shown to enhance angiogenesis in a rat ischemic heart model. This preclinical study using a swine model was designed to test the safety and therapeutic effectiveness of BMI. METHODS AND RESULTS:BM-derived mononuclear cells (BM-MNCs) were injected into a zone made ischemic ...

journal_title：Circulation

authors： Kamihata H,Matsubara H,Nishiue T,Fujiyama S,Tsutsumi Y,Ozono R,Masaki H,Mori Y,Iba O,Tateishi E,Kosaki A,Shintani S,Murohara T,Imaizumi T,Iwasaka T

更新日期：2001-08-28 00:00:00

abstract：BACKGROUND:To examine the effect of plasminogen activator therapy on vascular permeability, we used a modified rabbit mesenteric model of extravascular tissue accumulation of radiolabeled albumin. METHODS AND RESULTS:Albumin deposition was measured after saline, tissue-type plasminogen activator (t-PA; 0.86 mg/kg for ...

journal_title：Circulation

authors： Rudd MA,Johnstone MT,Rabbani LE,George D,Ware JA,Loscalzo J

更新日期：1991-12-01 00:00:00

abstract：:We quantitated the growth patterns of the normal fetal heart and the right and left ventricles from postmortem hearts obtained from 55 spontaneously aborted human fetuses from the completion of cardiogenesis to term. Fetal gestational age was assessed by menstrual history of the mother, crown-rump length, head circumf...

journal_title：Circulation

authors： St John Sutton MG,Raichlen JS,Reichek N,Huff DS

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:Elevated levels of high-sensitivity C-reactive protein (hsCRP) are associated with higher risk of adverse outcomes in patients at risk for or with established coronary artery disease. Retrospective analyses suggest that this risk may be modified with statin therapy. However, a role for hsCRP in monitoring th...

journal_title：Circulation

authors： Morrow DA,de Lemos JA,Sabatine MS,Wiviott SD,Blazing MA,Shui A,Rifai N,Califf RM,Braunwald E

更新日期：2006-07-25 00:00:00

abstract：BACKGROUND:Relieving the inhibition of sarcoplasmic reticular function by phospholamban is a major target of beta-adrenergic stimulation. Chronic beta-adrenergic receptor activity has been suggested to be detrimental, on the basis of transgenic overexpression of the receptor or its signaling effectors. However, it is n...

journal_title：Circulation

authors： Dash R,Kadambi V,Schmidt AG,Tepe NM,Biniakiewicz D,Gerst MJ,Canning AM,Abraham WT,Hoit BD,Liggett SB,Lorenz JN,Dorn GW 2nd,Kranias EG

更新日期：2001-02-13 00:00:00

abstract：BACKGROUND:Prosthetic valve thrombosis during pregnancy is life-threatening for mother and fetus, and the treatment of this complication is unclear. Cardiac surgery in pregnancy is associated with very high maternal and fetal mortality and morbidity. Thrombolytic therapy has rarely been used in these patients. The aim ...

journal_title：Circulation

authors： Özkan M,Çakal B,Karakoyun S,Gürsoy OM,Çevik C,Kalçık M,Oğuz AE,Gündüz S,Astarcioglu MA,Aykan AÇ,Bayram Z,Biteker M,Kaynak E,Kahveci G,Duran NE,Yıldız M

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:The production of left ventricular (LV) restoring forces generated during contraction, which are responsible for diastolic suction, is dependent on end-systolic volume (ESV) and systolic transmural and 3D deformation. We tested the hypothesis that acute coronary occlusion would result in loss of forces that ...

journal_title：Circulation

authors： Bell SP,Fabian J,Watkins MW,LeWinter MM

更新日期：1997-10-07 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells (MSCs) are bone marrow stromal cells that are in phase 1 clinical studies of cellular cardiomyoplasty. However, the electrophysiological effects of MSC transplantation have not been studied. Although improvement of ventricular function would represent a positive outcome of MSC transpla...

journal_title：Circulation

authors： Chang MG,Tung L,Sekar RB,Chang CY,Cysyk J,Dong P,Marbán E,Abraham MR

更新日期：2006-04-18 00:00:00

abstract：BACKGROUND:Left atrial macroreentrant tachycardia (LAMRT) has not been characterized in detail. METHODS AND RESULTS:Twenty-eight patients with LAMRT, including 4 patients with ablated typical atrial flutter (AFL), underwent electroanatomic mapping of the left atrium (LA) between February 1999 and October 2001. LA maps...

journal_title：Circulation

authors： Ouyang F,Ernst S,Vogtmann T,Goya M,Volkmer M,Schaumann A,Bänsch D,Antz M,Kuck KH

更新日期：2002-04-23 00:00:00

abstract：BACKGROUND:A prospective regional study was conducted to identify factors associated with in-hospital mortality among patients undergoing isolated coronary artery bypass graft surgery (CABG). A prediction rule was developed and validated based on the data collected. METHODS AND RESULTS:Data from 3,055 patients were co...

journal_title：Circulation

authors： O'Connor GT,Plume SK,Olmstead EM,Coffin LH,Morton JR,Maloney CT,Nowicki ER,Levy DG,Tryzelaar JF,Hernandez F

更新日期：1992-06-01 00:00:00

abstract：:All physicians increasingly will encounter patients who have implanted cardioverter-defibrillators (ICDs) for protection from ventricular arrhythmias. This advisory provides a concise summary relevant to the assessment and management of patients with ICDs, including those who present to primary care or emergency depar...

journal_title：Circulation

authors： Stevenson WG,Chaitman BR,Ellenbogen KA,Epstein AE,Gross WL,Hayes DL,Strickberger SA,Sweeney MO,Subcommittee on Electrocardiography and Arrhythmias of the American Heart Association Council on Clinical Cardiology.,Heart Rhythm Society.

更新日期：2004-12-21 00:00:00

abstract：BACKGROUND:In patients with symptoms of heart failure, elevations in B-type natriuretic peptide (BNP) accurately identify ventricular dysfunction. However, BNP levels are not specific for ventricular dysfunction in patients who do not have overt symptoms of heart failure, suggesting that other cardiac processes such as...

journal_title：Circulation

authors： Bibbins-Domingo K,Ansari M,Schiller NB,Massie B,Whooley MA

更新日期：2003-12-16 00:00:00