Adenoviral gene transfer of fortilin attenuates neointima formation through suppression of vascular smooth muscle cell proliferation and migration.

abstract：:To study the variability of the fraction of CPK released from the infarcted heart which enters the serum (serum entry ratio, or SER) with size and model of infarction, nine dogs underwent homogeneous infarctions (LAD ligation) of varying sizes, and 10 dogs underwent scattered infarctions (left coronary embolization). ...

journal_title：Circulation

authors： Cairns JA,Missirlis E,Fallen EL

更新日期：1978-12-01 00:00:00

abstract：BACKGROUND:Patients with prior atherosclerosis in 1 or more vascular territories (coronary, cerebrovascular, or peripheral arterial) who present with acute coronary syndromes have high cardiovascular risk and may benefit significantly from evidence-based therapies, yet whether these are used consistently is unknown. M...

journal_title：Circulation

authors： Brilakis ES,Hernandez AF,Dai D,Peterson ED,Banerjee S,Fonarow GC,Cannon CP,Bhatt DL

更新日期：2009-08-18 00:00:00

abstract：BACKGROUND:The alpha1-adrenergic receptors (alpha1-ARs) play a key role in cardiovascular homeostasis. However, the functional role of alpha1-AR subtypes in vivo is still unclear. The aim of this study was to evaluate the cardiovascular influences of alpha1b-AR. METHODS AND RESULTS:In transgenic mice lacking alpha1-AR...

journal_title：Circulation

authors： Vecchione C,Fratta L,Rizzoni D,Notte A,Poulet R,Porteri E,Frati G,Guelfi D,Trimarco V,Mulvany MJ,Agabiti-Rosei E,Trimarco B,Cotecchia S,Lembo G

更新日期：2002-04-09 00:00:00

abstract：:The predictive value of the myocardial scintigraphy with 99mTc-pyrophosphate was studied in 100 patients admitted to the coronary care unit with suspected acute myocardial infarction. None of the 21 patients with normal scintigrams had acute myocardial infraction by other criteria. Fifty-five percent of patients with ...

journal_title：Circulation

authors： Holman BL,Chisholm RJ,Braunwald E

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND:Factors leading differentially to the development of isolated diastolic (IDH), systolic-diastolic (SDH), and isolated systolic (ISH) hypertension are poorly understood. We examined the relations of blood pressure (BP) and clinical risk factors to the new onset of the 3 forms of hypertension. METHODS AND RES...

journal_title：Circulation

authors： Franklin SS,Pio JR,Wong ND,Larson MG,Leip EP,Vasan RS,Levy D

更新日期：2005-03-08 00:00:00

abstract：BACKGROUND:Hypoxia from birth in immature rabbits increases the tolerance of isolated hearts to ischemia compared with age-matched normoxic rabbits. We determined whether this increased tolerance to ischemia was due to an alteration in the ATP-sensitive potassium (KATP) channel and whether increased KATP channel activa...

journal_title：Circulation

authors： Baker JE,Curry BD,Olinger GN,Gross GJ

更新日期：1997-03-04 00:00:00

abstract：:Composite graft replacement of the ascending aorta and aortic valve was performed in 78 patients over an 8 1/2-year period. Degenerative lesions of the aortic root in Marfan's syndrome (annuloaortic ectasia) was the indication for operation in 56 cases; the other 22 patients had other causes of aortic root dilatation ...

journal_title：Circulation

authors： Donaldson RM,Ross DN

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND:In vivo gene transfer into injured arteries may provide a new means to facilitate molecular understanding of and to treat the intractable fibroproliferative arterial diseases. Selection of an optimal molecule to be transferred will be a key to successful gene therapy in the future. We tested the hypothesis t...

journal_title：Circulation

authors： Ueno H,Haruno A,Morisaki N,Furuya M,Kangawa K,Takeshita A,Saito Y

更新日期：1997-10-07 00:00:00

abstract：:The disparate effects of social determinants of health on cardiovascular health status and health care have been extensively documented by epidemiology. Yet, very little attention has been paid to how understanding and addressing social determinants of health might improve the quality of clinical interactions, especia...

journal_title：Circulation

authors： Kressin NR,Chapman SE,Magnani JW

更新日期：2016-06-14 00:00:00

abstract：BACKGROUND:The goal of this study was to assess the clinical value of stress myocardial perfusion scintigraphy (MPS) in elderly patients (> or =75 years of age). METHODS AND RESULTS:We followed up 5200 elderly patients (41% exercise) after dual-isotope MPS over 2.8+/-1.7 years (362 cardiac deaths [CDs], 7.0%, 2.6%/y) ...

journal_title：Circulation

authors： Hachamovitch R,Kang X,Amanullah AM,Abidov A,Hayes SW,Friedman JD,Cohen I,Thomson LE,Germano G,Berman DS

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:In heart failure, sarcoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA2a) activity is decreased, resulting in abnormal calcium handling and contractile dysfunction. We have previously shown that increasing SERCA2a expression by gene transfer improves ventricular function in a rat model of heart failure created b...

journal_title：Circulation

authors： del Monte F,Williams E,Lebeche D,Schmidt U,Rosenzweig A,Gwathmey JK,Lewandowski ED,Hajjar RJ

更新日期：2001-09-18 00:00:00

abstract：BACKGROUND:Prolonged survival of xenografted neonatal cardiomyocytes was achieved by blocking the CD28/B7 costimulatory pathway via CTLA4-Ig gene transfer. We examined the long-term survival of xenografted neonatal cardiomyocytes by adenovirus-mediated CTLA4-Ig expression and transient CD40 blockade with anti-CD40L mon...

journal_title：Circulation

authors： Li TS,Ito H,Kajiwara K,Hamano K

更新日期：2003-10-07 00:00:00

abstract：BACKGROUND:Heart failure treatment depends partly on the underlying cause of the disease. We evaluated cardiovascular magnetic resonance (CMR) for the problem of differentiating dilated cardiomyopathy (DCM) from left ventricular (LV) dysfunction caused by coronary artery disease (CAD). METHODS AND RESULTS:Late gadolin...

journal_title：Circulation

authors： McCrohon JA,Moon JC,Prasad SK,McKenna WJ,Lorenz CH,Coats AJ,Pennell DJ

更新日期：2003-07-08 00:00:00

abstract：BACKGROUND:Endothelin (ET), a coronary vasoconstrictor, mediates its activity through the specific receptors ET-A and ET-B, which may demonstrate different activity under pathophysiological conditions. Thoracic inferior vena cava constriction (TIVCC) is an experimental model of congestive heart failure that is characte...

journal_title：Circulation

authors： Cannan CR,Burnett JC Jr,Lerman A

更新日期：1996-02-15 00:00:00

abstract：:Patients undergoing carotid endarterectomy were pretreated with low-dose, oral beta carotene to determine whether the carotenoid content of plaque could be increased in vivo. Beta carotene-treated patients had a 50-fold increase in their plaque beta carotene level from 0.066 to 3.3 micrograms beta carotene/g plaque. M...

journal_title：Circulation

authors： Prince MR,LaMuraglia GM,MacNichol EF Jr

更新日期：1988-08-01 00:00:00

abstract：:Twenty-one patients with documented coronary atherosclerotic heart disease were studied to determine the effect of high dose oral isosorbide dinitrate (ISDN) on heart rate, blood pressure, and exercise time until angina pectoris. Patients were tested in two phases, initially with 0.4 mg of sublingual nitroglycerin and...

journal_title：Circulation

authors： Danahy DT,Burwell DT,Aronow WS,Prakash R

更新日期：1977-02-01 00:00:00

abstract：BACKGROUND:Whether the benefit in quality of life (QOL) after percutaneous coronary intervention depends on the severity of the stenosis as determined by fractional flow reserve (FFR) remains unknown. This study sought to investigate the relationship between FFR values and improvement in QOL. METHODS:From the FAME 1 a...

journal_title：Circulation

authors： Nishi T,Piroth Z,De Bruyne B,Jagic N,Möbius-Winkler S,Kobayashi Y,Derimay F,Fournier S,Barbato E,Tonino P,Jüni P,Pijls NHJ,Fearon WF

更新日期：2018-10-23 00:00:00

abstract：BACKGROUND:The age association of cardiovascular disease may be in part because its metabolic risk factors tend to rise with age. Few studies have analyzed age associations of multiple metabolic risks in the same population, especially in nationally representative samples. We examined worldwide variations in the age as...

journal_title：Circulation

authors： Singh GM,Danaei G,Pelizzari PM,Lin JK,Cowan MJ,Stevens GA,Farzadfar F,Khang YH,Lu Y,Riley LM,Lim SS,Ezzati M

更新日期：2012-05-08 00:00:00

abstract：BACKGROUND:Depressive symptoms have been associated with increased risk of coronary artery disease and poor prognosis among patients with existing coronary artery disease, but whether depressive symptoms specifically influence atherosclerotic progression among such patients is uncertain. METHODS AND RESULTS:The Post-C...

journal_title：Circulation

authors： Wellenius GA,Mukamal KJ,Kulshreshtha A,Asonganyi S,Mittleman MA

更新日期：2008-05-06 00:00:00

abstract：:Experimental studies of animals have previously demonstrated the validity of [1-11C]acetate as a tracer of oxidative metabolism for use with positron emission tomography. The present study was undertaken to define in normal human volunteers the relation between myocardial clearance kinetics of [1-11C]acetate, and the ...

journal_title：Circulation

authors： Armbrecht JJ,Buxton DB,Brunken RC,Phelps ME,Schelbert HR

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:Fat inflammation may play an important role in comorbidities associated with obesity such as atherosclerosis. METHODS AND RESULTS:To first establish feasibility of fat transplantation, epididymal fat pads were harvested from wild-type C57BL/6J mice and transplanted into leptin-deficient (Lep(ob/ob)) mice. F...

journal_title：Circulation

authors： Ohman MK,Shen Y,Obimba CI,Wright AP,Warnock M,Lawrence DA,Eitzman DT

更新日期：2008-02-12 00:00:00

abstract：BACKGROUND:Ischemia reperfusion injury (IRI) predisposes to the formation of donor-specific antibodies, a factor contributing to chronic rejection and late allograft loss. METHODS:We describe a mechanism underlying the correlative association between IRI and donor-specific antibodies by using humanized models and pati...

journal_title：Circulation

authors： Liu L,Fang C,Fu W,Jiang B,Li G,Qin L,Rosenbluth J,Gong G,Xie CB,Yoo P,Tellides G,Pober JS,Jane-Wit D

更新日期：2020-02-11 00:00:00

abstract：:Numerous criteria for the diagnosis of inferior wall myocardial infarction by electrocardiogram (ECG) and vectorcardiogram (VCG) have been published, but they have not been subjected to a systematic, independent evaluation. Accordingly, we studied 146 patients undergoing cardiac catheterization; 63 were normal and 83 ...

journal_title：Circulation

authors： Hurd HP 2nd,Starling MR,Crawford MH,Dlabal PW,O'Rourke RA

更新日期：1981-05-01 00:00:00

abstract：BACKGROUND:Oxidative stress activates endothelial innate immunity and disrupts endothelial functions, including endothelial nitric oxide synthase-derived nitric oxide bioavailability. Here, we postulated that oxidative stress induces sterol regulatory element-binding protein 2 (SREBP2) and microRNA-92a (miR-92a), which...

journal_title：Circulation

authors： Chen Z,Wen L,Martin M,Hsu CY,Fang L,Lin FM,Lin TY,Geary MJ,Geary GG,Zhao Y,Johnson DA,Chen JW,Lin SJ,Chien S,Huang HD,Miller YI,Huang PH,Shyy JY

更新日期：2015-03-03 00:00:00

abstract：BACKGROUND:Preconditioning the heart before an ischemic insult has been shown to protect against contractile dysfunction, arrhythmias, and infarction. Pharmacological studies have suggested that fibroblast growth factor-2 (FGF2) is involved in cardioprotection. However, because of the number of FGFs expressed in the he...

journal_title：Circulation

authors： House SL,Bolte C,Zhou M,Doetschman T,Klevitsky R,Newman G,Schultz Jel J

更新日期：2003-12-23 00:00:00

abstract：BACKGROUND:The Washington Radiation for In-Stent Restenosis Trial for long lesions (Long WRIST) was designed to determine the safety and efficacy of vascular brachytherapy for the treatment of diffuse in-stent restenosis. METHODS AND RESULTS:A total of 120 patients with diffuse in-stent restenosis in native coronary a...

journal_title：Circulation

authors： Waksman R,Cheneau E,Ajani AE,White RL,Pinnow E,Torguson R,Deible R,Satler LF,Pichard AD,Kent KM,Teirstein PS,Lindsay J,Washington Radiation for In-Stent Restenosis Trial for Long Lesions Studies.

更新日期：2003-04-08 00:00:00

abstract：:Scanning and transmission electron microscopic studies were made of: 1) 15 glutaraldehyde-treated porcine valvular heterografts that had been implanted in patients for periods of time ranging from 2 days to 76 months; 2) unimplanted, commercially processed porcine aortic valves; and 3) unprocessed porcine aortic valve...

journal_title：Circulation

authors： Ferrans VJ,Spray TL,Billingham ME,Roberts WC

更新日期：1978-09-01 00:00:00

abstract：:A clinical study was conducted to evaluate the efficacy and safety of percutaneous coronary excimer laser angioplasty in 60 patients with coronary artery disease. Forty-nine patients had stable exertional angina, and 11 patients had unstable angina despite medical therapy. A novel 1.4-mm diameter catheter with 20 quar...

journal_title：Circulation

authors： Karsch KR,Haase KK,Voelker W,Baumbach A,Mauser M,Seipel L

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:Plaque rupture with subsequent thrombosis is recognized as the underlying pathophysiology of most acute coronary syndromes and stroke. Thus, direct thrombus visualization may be beneficial for both diagnosis and guidance of therapy. We sought to test the feasibility of direct imaging of acute and subacute th...

journal_title：Circulation

authors： Botnar RM,Perez AS,Witte S,Wiethoff AJ,Laredo J,Hamilton J,Quist W,Parsons EC Jr,Vaidya A,Kolodziej A,Barrett JA,Graham PB,Weisskoff RM,Manning WJ,Johnstone MT

更新日期：2004-04-27 00:00:00

abstract：BACKGROUND:Contrast agents can cause a reduction in renal function that may be due to the generation of reactive oxygen species. Conflicting evidence suggests that administration of the antioxidant acetylcysteine prevents this renal impairment. The action of other antioxidant agents has not been investigated. METHODS ...

journal_title：Circulation

authors： Spargias K,Alexopoulos E,Kyrzopoulos S,Iokovis P,Greenwood DC,Manginas A,Voudris V,Pavlides G,Buller CE,Kremastinos D,Cokkinos DV

更新日期：2004-11-02 00:00:00