Sustained hemodynamic and antianginal effect of high dose oral isosorbide dinitrate.

abstract：BACKGROUND:Titin is a giant elastic protein that spans the half-sarcomere from Z-disk to M-band. It acts as a molecular spring and mechanosensor and has been linked to striated muscle disease. The pathways that govern titin-dependent cardiac growth and contribute to disease are diverse and difficult to dissect. METHOD...

journal_title：Circulation

authors： Radke MH,Polack C,Methawasin M,Fink C,Granzier HL,Gotthardt M

更新日期：2019-04-09 00:00:00

abstract：:For patients with stenotic native valves, the modified Bernoulli equation (delta P = 4V2) may be applied to Doppler-measured transvalvular velocities to yield an accurate estimate of transvalvular gradients. Although it would be useful if the same approach could be used for those with stenotic prosthetic valves, no pr...

journal_title：Circulation

authors： Wilkins GT,Gillam LD,Kritzer GL,Levine RA,Palacios IF,Weyman AE

更新日期：1986-10-01 00:00:00

abstract：BACKGROUND:Ischemic preconditioning attenuates the effects of subsequent sustained ischemia by a mechanism involving adenosine and G proteins in several species. Adenosine is not involved in ischemic preconditioning of rat hearts, the mechanisms of which are poorly understood. METHODS AND RESULTS:Reduction of isometri...

journal_title：Circulation

authors： Hu K,Nattel S

更新日期：1995-10-15 00:00:00

abstract：BACKGROUND:There is compelling experimental evidence that autologous skeletal muscle (SM) cell transplantation improves postinfarction cardiac function. This study assessed whether this benefit is still manifested in the clinically relevant setting of a treatment by ACE inhibitors. METHODS AND RESULTS:A myocardial inf...

journal_title：Circulation

authors： Pouzet B,Ghostine S,Vilquin JT,Garcin I,Scorsin M,Hagège AA,Duboc D,Schwartz K,Menasché P

更新日期：2001-09-18 00:00:00

abstract：:Total anomalous pulmonary venous connection (TAPVC) is a rare cardiac congenital abnormality which usually results in death in infancy or early childhood. We describe a 52-year-old man with TAPVC and severe calcific pulmonic stenosis. Both diagnoses were suspected clinically and from the chest X-ray. Cardiac catheteri...

journal_title：Circulation

authors： Pastore JO,Akins CW,Zir LM,Buckley MJ,Dinsmore RE

更新日期：1977-01-01 00:00:00

abstract：:Calcification of valvular bioprostheses in children is a major problem that has stimulated extensive research in our laboratory. In previous reports, we have shown that the rate of calcification could be reduced by decreasing the phosphate content in the tissue or by blocking calcification binding sites with Mg++ and/...

journal_title：Circulation

authors： Carpentier A,Nashef A,Carpentier S,Ahmed A,Goussef N

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:Many epidemiological studies have evaluated whether different alcoholic beverages protect against cardiovascular disease. We performed a meta-analysis of 26 studies on the relationship between wine or beer consumption and vascular risk. Methods and Results- General variance-based method and fitting models we...

journal_title：Circulation

authors： Di Castelnuovo A,Rotondo S,Iacoviello L,Donati MB,De Gaetano G

更新日期：2002-06-18 00:00:00

abstract：:Between July 1980 and November 1982, there were 935 coronary angioplasties attempted at Emory University Hospital. Of these patients, 20 developed acute occlusion. Of these 20, 19 presented within 3 hr of surgery or within 3 hr after stopping a continuous heparin infusion. Five patients required emergency surgery, but...

journal_title：Circulation

authors： Hollman J,Gruentzig AR,Douglas JS Jr,King SB 3rd,Ischinger T,Meier B

更新日期：1983-10-01 00:00:00

abstract：BACKGROUND:The ability of echocardiographic dyssynchrony to predict response to cardiac resynchronization therapy (CRT) has been unclear. METHODS AND RESULTS:A prospective, longitudinal study was designed with predefined dyssynchrony indexes and outcome variables to test the hypothesis that baseline dyssynchrony is as...

journal_title：Circulation

authors： Gorcsan J 3rd,Oyenuga O,Habib PJ,Tanaka H,Adelstein EC,Hara H,McNamara DM,Saba S

更新日期：2010-11-09 00:00:00

abstract：:A Y-shaped lesion in the right atrium allows induction of atrial flutter in dogs. We recorded the activation sequence during this tachycardia from 96 endocardial bipolar electrodes using intracavitary electrode arrays during 12 separate episodes in three isolated perfused hearts. In each case a reentrant impulse circu...

journal_title：Circulation

authors： Frame LH,Page RL,Boyden PA,Fenoglio JJ Jr,Hoffman BF

更新日期：1987-11-01 00:00:00

abstract：:Phasic blood flow recorded in five unobstructed dog aortocoronary bypass grafts to the left coronary artery was similar to that of normal coronary arteries, with a high diastolic-to-systolic flow ratio which averaged 2.7 +/- 0.4. With an average of 52 +/- 7% and 72 +/- 6% stenosis in the coronary artery distal to the ...

journal_title：Circulation

authors： Folts JD,Kahn DR,Bittar N,Rowe GG

更新日期：1975-08-01 00:00:00

abstract：BACKGROUND:Intracoronary radiotherapy (brachytherapy) has been proposed as treatment option for in-stent restenosis. Long-term results of brachytherapy with regard to vascular integrity and vasomotor responsiveness are unknown. The purpose of the present study was to determine the vasomotor response after brachytherapy...

journal_title：Circulation

authors： Togni M,Windecker S,Wenaweser P,Tueller D,Kaisaier A,Maier W,Meier B,Hess OM

更新日期：2004-07-13 00:00:00

abstract：BACKGROUND:There is no consensus on how, when, or at what intensity exercise should be performed after heart transplantation (HTx). We have recently shown that high-intensity interval training (HIT) is safe, well tolerated, and efficacious in the maintenance state after HTx, but studies have not investigated HIT effect...

journal_title：Circulation

authors： Nytrøen K,Rolid K,Andreassen AK,Yardley M,Gude E,Dahle DO,Bjørkelund E,Relbo Authen A,Grov I,Philip Wigh J,Have Dall C,Gustafsson F,Karason K,Gullestad L

更新日期：2019-05-07 00:00:00

abstract：BACKGROUND:Cellular electrophysiological alterations may contribute to arrhythmogenesis in cardiac hypertrophy. An L-like current occurs in left ventricular myocytes (LVMs) isolated from the hypertrophied heart of old spontaneously hypertensive rats (SHR). Factors that influence L occurrence during development of cardi...

journal_title：Circulation

authors： Cerbai E,Barbieri M,Mugelli A

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Although acute rheumatic fever (ARF) and its sequel, rheumatic heart disease (RHD), continue to cause a large burden of morbidity and mortality in disadvantaged populations, most studies investigating the effectiveness of control programs date from the 1950s. A control program, including a disease register, ...

journal_title：Circulation

authors： Lawrence JG,Carapetis JR,Griffiths K,Edwards K,Condon JR

更新日期：2013-07-30 00:00:00

abstract：:The existence of a brain renin-angiotensin system (RAS) as one of various tissue RASs is now firmly established. Angiotensin-containing pathways within brain areas involved in central blood pressure regulation have been described. Evidence from biochemical, neurophysiologic, pharmacologic, and most recently, molecular...

journal_title：Circulation

authors： Unger T,Badoer E,Ganten D,Lang RE,Rettig R

更新日期：1988-06-01 00:00:00

abstract：:Exit block from a parasystolic focus is recognized when automatic discharges fail to become manifest during the excitable phase of the ventricular cycle. In the present study, an apparently complete exit block and a persistently concealed ventricular parasystole (VP) resulted from an exit refractory period (ExRP) long...

journal_title：Circulation

authors： Nau GJ,Aldariz AE,Acunzo RS,Chiale PA,Elizari MV,Rosenbaum MB

更新日期：1981-07-01 00:00:00

abstract：:Considerable variability was observed among recruitment sources and centers in the proportion of first protocol visits proceeding to entry. Some of the reasons for these differences are explored. Several characteristics of the participants were also analyzed to determine whether significant variability existed among r...

journal_title：Circulation

authors： Hunninghake DB,Knoke J,LaDouceur M,Peterson F

更新日期：1982-12-01 00:00:00

abstract：BACKGROUND:Digoxin is commonly prescribed in symptomatic paroxysmal atrial fibrillation (AF) but has never been evaluated in this condition. METHODS AND RESULTS:From a multicenter registry, 43 representative patients with frequent symptomatic AF episodes were recruited into a randomized, double-blind crossover compari...

journal_title：Circulation

authors： Murgatroyd FD,Gibson SM,Baiyan X,O'Nunain S,Poloniecki JD,Ward DE,Malik M,Camm AJ

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Coronary irradiation is a new concept to reduce restenosis. We evaluated the feasibility and safety of intracoronary irradiation with a balloon catheter filled with (188)Re, a liquid, high-energy beta-emitter. METHODS AND RESULTS:Irradiation with 15 Gy at 0.5-mm tissue depth was performed in 28 lesions afte...

journal_title：Circulation

authors： Höher M,Wöhrle J,Wohlfrom M,Hanke H,Voisard R,Osterhues HH,Kochs M,Reske SN,Hombach V,Kotzerke J

更新日期：2000-05-23 00:00:00

abstract：BACKGROUND:Aortic counterpulsation has been observed to reduce the rate of reocclusion of the infarct-related artery after patency has been restored during acute myocardial infarction in observational studies. To evaluate the benefit-to-risk ratio of aortic counterpulsation during the early phase of myocardial infarcti...

journal_title：Circulation

authors： Ohman EM,George BS,White CJ,Kern MJ,Gurbel PA,Freedman RJ,Lundergan C,Hartmann JR,Talley JD,Frey MJ

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:We reported that HDL loses its antiinflammatory properties during acute influenza A infection in mice, and we hypothesized that these changes might be associated with increased trafficking of macrophages into the artery wall. The present study tested this hypothesis. METHODS AND RESULTS:D-4F, an apolipoprot...

journal_title：Circulation

authors： Van Lenten BJ,Wagner AC,Anantharamaiah GM,Garber DW,Fishbein MC,Adhikary L,Nayak DP,Hama S,Navab M,Fogelman AM

更新日期：2002-08-27 00:00:00

abstract：BACKGROUND:Endogenous adenosine can protect the overloaded heart against the development of hypertrophy and heart failure, but the contribution of A(1) receptors (A(1)R) and A(3) receptors (A(3)R) is not known. METHODS AND RESULTS:To test the hypothesis that A(1)R and A(3)R can protect the heart against systolic overl...

journal_title：Circulation

authors： Lu Z,Fassett J,Xu X,Hu X,Zhu G,French J,Zhang P,Schnermann J,Bache RJ,Chen Y

更新日期：2008-10-21 00:00:00

abstract：BACKGROUND:The impact of mitral regurgitation (MR) on elderly patients (> or = 70 years) undergoing isolated aortic valve replacement (AVR) is not clearly defined. This study investigates the long-term effects of preoperative, moderate MR on survival and functional outcome in elderly AVR patients. METHODS AND RESULTS:...

journal_title：Circulation

authors： Barreiro CJ,Patel ND,Fitton TP,Williams JA,Bonde PN,Chan V,Alejo DE,Gott VL,Baumgartner WA

更新日期：2005-08-30 00:00:00

abstract：BACKGROUND:A line of block in the right atrium (RA) between the venae cavae is necessary to obtain classic atrial flutter (AFL). We tested the hypothesis that the location of that line of block would determine whether the AFL reentrant circuit would be due to single-loop reentry or figure-of-8 reentry. METHODS AND RES...

journal_title：Circulation

authors： Tomita Y,Matsuo K,Sahadevan J,Khrestian CM,Waldo AL

更新日期：2001-02-20 00:00:00

abstract：BACKGROUND:Bartonella species are the only known bacterial pathogens causing vasculoproliferative disorders in humans (bacillary angiomatosis [BA]). Cellular and bacterial pathogenetic mechanisms underlying the induction of BA are largely unknown. METHODS AND RESULTS:Activation of hypoxia-inducible factor-1 (HIF-1), t...

journal_title：Circulation

authors： Kempf VA,Lebiedziejewski M,Alitalo K,Wälzlein JH,Ehehalt U,Fiebig J,Huber S,Schütt B,Sander CA,Müller S,Grassl G,Yazdi AS,Brehm B,Autenrieth IB

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Our purpose was to use multislice MRI for detection of reversible myocardial ischemia and assessment of the effect of revascularization on tissue perfusion in patients with coronary artery disease. METHODS AND RESULTS:Eleven patients with single-vessel proximal left anterior descending coronary artery disea...

journal_title：Circulation

authors： Lauerma K,Virtanen KS,Sipilä LM,Hekali P,Aronen HJ

更新日期：1997-11-04 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP), a well-recognized marker of atherosclerosis, has recently been suggested to have a direct proinflammatory effect. The constitutive expression of low levels of CRP in normal plasma suggests the likelihood that a natural factor exists to neutralize the effect of CRP. This factor(s) ha...

journal_title：Circulation

authors： Wadham C,Albanese N,Roberts J,Wang L,Bagley CJ,Gamble JR,Rye KA,Barter PJ,Vadas MA,Xia P

更新日期：2004-05-04 00:00:00

abstract：BACKGROUND:The aim of this study was to determine whether antianginal medications affect the prognostic value of pharmacological stress echocardiography. METHODS AND RESULTS:From the EPIC-EDIC Data Bank, 7333 patients (5452 men; age; 59+/-10 years) underwent pharmacological stress echocardiography with either high-dos...

journal_title：Circulation

authors： Sicari R,Cortigiani L,Bigi R,Landi P,Raciti M,Picano E,Echo-Persantine International Cooperative (EPIC) Study Group.,Echo-Dobutamine International Cooperative (EDIC) Study Group.

更新日期：2004-05-25 00:00:00

abstract：BACKGROUND:Modeling of human arrhythmias with induced pluripotent stem cell-derived cardiomyocytes has focused on single-cell phenotypes. However, arrhythmias are the emergent properties of cells assembled into tissues, and the impact of inherited arrhythmia mutations on tissue-level properties of human heart tissue ha...

journal_title：Circulation

authors： Park SJ,Zhang D,Qi Y,Li Y,Lee KY,Bezzerides VJ,Yang P,Xia S,Kim SL,Liu X,Lu F,Pasqualini FS,Campbell PH,Geva J,Roberts AE,Kleber AG,Abrams DJ,Pu WT,Parker KK

更新日期：2019-07-30 00:00:00