Ultrastructure of Hancock porcine valvular heterografts. Pre- and post-implantation changes.

Abstract:

:Scanning and transmission electron microscopic studies were made of: 1) 15 glutaraldehyde-treated porcine valvular heterografts that had been implanted in patients for periods of time ranging from 2 days to 76 months; 2) unimplanted, commercially processed porcine aortic valves; and 3) unprocessed porcine aortic valves. Unimplanted, commercially processed valves showed loss of endothelium and acid mucopolysaccharides. Short-term (< 2 months) post-implantation changes consisted of insudation of plasma proteins, penetration of erythrocytes into surface crevices, formation of a thin surface layer of fibrin, and deposition of macrophages, giant cells and a few platelets. Longer term (> 2 months) changes consisted of progressive disruption of collagen, erosion of valvular surfaces, formation of aggregates of platelets, and accumulation of lipid. The surfaces of the leaflets did not become covered with endothelium or with a fibrous sheath. It is concluded that progressive breakdown of collagen is a critical factor in determining the long-term durability of glutaraldehyde-treated porcine valvular heterografts.

journal_name

Circulation

journal_title

Circulation

authors

Ferrans VJ,Spray TL,Billingham ME,Roberts WC

subject

Has Abstract

pub_date

1978-09-01 00:00:00

pages

I10-8

issue

3 Pt 2

eissn

0009-7322

issn

1524-4539

journal_volume

58

pub_type

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