Increased preferential absorption in human atherosclerotic plaque with oral beta carotene. Implications for laser endarterectomy.

Abstract:

:Patients undergoing carotid endarterectomy were pretreated with low-dose, oral beta carotene to determine whether the carotenoid content of plaque could be increased in vivo. Beta carotene-treated patients had a 50-fold increase in their plaque beta carotene level from 0.066 to 3.3 micrograms beta carotene/g plaque. Microscopy and microspectrophotometry demonstrated that plaque from beta carotene-treated patients had higher carotenoid levels and higher absorption (450-500 nm) compared with control specimens, but normal media was unaffected. This demonstration of increased preferential absorption by plaque suggests that selective ablation of atherosclerotic plaque may be enhanced by pretreating patients with oral beta carotene.

journal_name

Circulation

journal_title

Circulation

authors

Prince MR,LaMuraglia GM,MacNichol EF Jr

doi

10.1161/01.cir.78.2.338

subject

Has Abstract

pub_date

1988-08-01 00:00:00

pages

338-44

issue

2

eissn

0009-7322

issn

1524-4539

journal_volume

78

pub_type

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