Prognostic implications of myocardial perfusion single-photon emission computed tomography in the elderly.

abstract：BACKGROUND:This multicenter trial was conducted to determine the efficacy and safety of pimobendan, an inotropic agent with calcium-sensitizing properties and activity as a phosphodiesterase inhibitor, in patients with heart failure. METHODS AND RESULTS:One hundred ninety-eight ambulatory patients with symptoms of mod...

journal_title：Circulation

authors： Kubo SH,Gollub S,Bourge R,Rahko P,Cobb F,Jessup M,Brozena S,Brodsky M,Kirlin P,Shanes J

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:Bradycardia and sinus node dysfunction are common causes of early postoperative morbidity in orthotopic heart transplant recipients and frequently require the use of chronotropic drugs or permanent pacemakers. Several causes have been postulated, including surgical trauma to the sinus node and its blood supp...

journal_title：Circulation

authors： Rothman SA,Jeevanandam V,Combs WG,Furukawa S,Hsia HH,Eisen HJ,Buxton AE,Miller JM

更新日期：1996-11-01 00:00:00

abstract：:The Beta-Blocker Heart Attack Trial was a multicenter, randomized, double-blind, placebo-controlled trial of propranolol therapy in 3837 men and women with acute myocardial infarction. The patients began their treatment 5-21 days after hospital admission (mean 13.8 days). During an average follow-up of 25 months, ther...

journal_title：Circulation

authors： Goldstein S

更新日期：1983-06-01 00:00:00

abstract：BACKGROUND:Household air pollution is the third largest risk factor for global disease burden, but direct links with cardiovascular disease mortality are limited. This study aimed to evaluate the relationship between household fuel use and cardiovascular disease mortality. METHODS AND RESULTS:The Golestan Cohort Study...

journal_title：Circulation

authors： Mitter SS,Vedanthan R,Islami F,Pourshams A,Khademi H,Kamangar F,Abnet CC,Dawsey SM,Pharoah PD,Brennan P,Fuster V,Boffetta P,Malekzadeh R

更新日期：2016-06-14 00:00:00

abstract：BACKGROUND:Blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) has been used to measure T2* changes in skeletal muscle tissue of healthy volunteers. The BOLD effect is assumed to primarily reflect changes in blood oxygenation at the tissue level. We compared the calf muscle BOLD response of patien...

journal_title：Circulation

authors： Ledermann HP,Schulte AC,Heidecker HG,Aschwanden M,Jäger KA,Scheffler K,Steinbrich W,Bilecen D

更新日期：2006-06-27 00:00:00

abstract：:Two-dimensional echocardiographic findings in a group of 24 patients with atrial septal defects were correlated with findings obtained by cardiac catheterization and M-mode echocardiography. The prevalence of mitral prolapse was 95% by two-dimensional echocardiography and 59% by angiography in patients with secundum a...

journal_title：Circulation

authors： Lieppe W,Scallion R,Behar VS,Kisslo JA

更新日期：1977-09-01 00:00:00

abstract：BACKGROUND:In an open-label blinded study, we compared intracoronary and transendocardial CD34(+) cell transplantation in patients with nonischemic dilated cardiomyopathy. METHODS AND RESULTS:Of the 40 patients with dilated cardiomyopathy, 20 were randomized to receive intracoronary injection and 20 received transendo...

journal_title：Circulation

authors： Vrtovec B,Poglajen G,Lezaic L,Sever M,Socan A,Domanovic D,Cernelc P,Torre-Amione G,Haddad F,Wu JC

更新日期：2013-09-10 00:00:00

abstract：BACKGROUND:Bias in studies of preventive medications can occur when healthier patients are more likely to initiate and adhere to therapy than less healthy patients. We sought evidence of this bias by examining associations between statin exposure and various outcomes that should not be causally affected by statin expos...

journal_title：Circulation

authors： Dormuth CR,Patrick AR,Shrank WH,Wright JM,Glynn RJ,Sutherland J,Brookhart MA

更新日期：2009-04-21 00:00:00

abstract：:Certain clinical and morphologic observations are described in 27 patients with severe isolated angina pectoris of either the stable (five patients) or the unstable form (22 patients). Twenty-four patients died during or shortly after cardiac operations designed to relieve angina pectoris and three died during cardiac...

journal_title：Circulation

authors： Roberts WC

更新日期：1976-09-01 00:00:00

abstract：BACKGROUND:Visceral adiposity is generally considered to play a key role in the metabolic syndrome, including hypertension. The purpose of this study was to evaluate cross-sectionally whether visceral adiposity is associated with prevalence of hypertension independent of other adipose depots and fasting plasma insulin....

journal_title：Circulation

authors： Hayashi T,Boyko EJ,Leonetti DL,McNeely MJ,Newell-Morris L,Kahn SE,Fujimoto WY

更新日期：2003-10-07 00:00:00

abstract：BACKGROUND:Postprandial hyperglycemia may be a risk factor for cardiovascular disease. We compared the effects of two insulin secretagogues, repaglinide and glyburide, known to have different efficacy on postprandial hyperglycemia, on carotid intima-media thickness (CIMT) and markers of systemic vascular inflammation i...

journal_title：Circulation

authors： Esposito K,Giugliano D,Nappo F,Marfella R,Campanian Postprandial Hyperglycemia Study Group.

更新日期：2004-07-13 00:00:00

abstract：BACKGROUND:The Bleeding Academic Research Consortium (BARC) has recently proposed a unified definition of bleeding in patients receiving antithrombotic therapy. We investigated the relationship between bleeding events as defined by BARC and 1-year mortality in patients undergoing percutaneous coronary intervention (PCI...

journal_title：Circulation

authors： Ndrepepa G,Schuster T,Hadamitzky M,Byrne RA,Mehilli J,Neumann FJ,Richardt G,Schulz S,Laugwitz KL,Massberg S,Schömig A,Kastrati A

更新日期：2012-03-20 00:00:00

abstract：BACKGROUND:Reperfusion of acutely infarcted myocardium may be beneficial in limiting infarct expansion and ventricular remodeling even if established after the time that salvage of ischemic myocardium is possible. METHODS AND RESULTS:To examine the permanency, time course, and mechanism of this effect of late reperfus...

journal_title：Circulation

authors： Boyle MP,Weisman HF

更新日期：1993-12-01 00:00:00

abstract：:In vitro experiments on precontracted canine coronary arteries were performed to study the direct relaxant effects of molsidomine (MOLS) and its active metabolite, SIN-1, and to determine if there is a relationship between effect and cGMP level elevations. The effects of MOLS and SIN-1 were compared with those of a cl...

journal_title：Circulation

authors： Rinaldi G,Cingolani H

更新日期：1983-12-01 00:00:00

abstract：BACKGROUND:Recognition of the complex pathophysiology of heart failure and its high mortality has emphasized the need for prognostic markers that can be used in clinical assessment as well as in the design of mortality trials. Data from the Department of Veterans Affairs Cooperative Vasodilator-Heart Failure Trials (V-...

journal_title：Circulation

authors： Cohn JN,Johnson GR,Shabetai R,Loeb H,Tristani F,Rector T,Smith R,Fletcher R

更新日期：1993-06-01 00:00:00

abstract：:The cause and associated pathophysiology of precordial ST-segment depression (ST decreases) during acute inferior myocardial infarction (IMI) are controversial. To investigate this problem, electrocardiographic findings in 48 consecutive patients with acute IMI were prospectively compared with results of coronary angi...

journal_title：Circulation

authors： Gibson RS,Crampton RS,Watson DD,Taylor GJ,Carabello BA,Holt ND,Beller GA

更新日期：1982-10-01 00:00:00

abstract：BACKGROUND:Enzymatic, nonoxidative modification transforms LDL to an atherogenic molecule (E-LDL) that activates complement and macrophages and is present in early atherosclerotic lesions. METHODS AND RESULTS:We report on the atherogenic effects of E-LDL on human vascular smooth muscle cells (SMC). E-LDL accumulated i...

journal_title：Circulation

authors： Klouche M,Rose-John S,Schmiedt W,Bhakdi S

更新日期：2000-04-18 00:00:00

abstract：BACKGROUND:Both a vascular endothelial cytochrome P450 (CYP450) product of arachidonic acid metabolism and the potassium ion (K(+)) have been identified as endothelium-derived hyperpolarizing factors (EDHFs) in animal vascular tissues. We studied the relative importance of EDHF, nitric oxide (NO), and prostacyclin (PGI...

journal_title：Circulation

authors： Coats P,Johnston F,MacDonald J,McMurray JJ,Hillier C

更新日期：2001-03-27 00:00:00

abstract：BACKGROUND:Previous experimental studies have shown that nitric oxide (NO) modulates cardiac function by an abbreviation of systolic contraction and an enhancement of diastolic relaxation. However, the response to NO donors of patients with severe pressure-overload hypertrophy and diastolic dysfunction is unknown. MET...

journal_title：Circulation

authors： Matter CM,Mandinov L,Kaufmann PA,Vassalli G,Jiang Z,Hess OM

更新日期：1999-05-11 00:00:00

abstract：:Two patients with supraventricular parasystole (one atrioventricular and one auricular) are reported. In both patients, reentrant extrasystoles appeared to occur as the result of Mobitz type I second-degree entrance block. We believe that when a sinus impulse fell soon after the absolute refractory period of the pathw...

journal_title：Circulation

authors： Kinoshita S,Nakagawa K,Kato N,Nishino T,Tanabe Y

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:In this study, we both investigated coronary flow velocity in hypertrophic obstructive cardiomyopathy (HOCM) and tested the hypothesis of differing coronary flow reserve (CFR) of coronary arteries perfusing left ventricular regions with nonuniform myocardial hypertrophy by measuring the relative CFR. METHOD...

journal_title：Circulation

authors： Kyriakidis MK,Dernellis JM,Androulakis AE,Kelepeshis GA,Barbetseas J,Anastasakis AN,Trikas AG,Tentolouris CA,Gialafos JE,Toutouzas PK

更新日期：1997-08-05 00:00:00

abstract：:Isovolumic relaxation time (IVRT) and events of early transmitral flow measured by Doppler echocardiography were validated against the time constant of left ventricular relaxation (tau) in open-chest dogs. During increased inotropy (by isoproterenol infusion) at constant preload, enhancement of relaxation was indicate...

journal_title：Circulation

authors： Myreng Y,Smiseth OA

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Pharmacogenetic-guided dosing of warfarin is a promising application of "personalized medicine" but has not been adequately tested in randomized trials. METHODS AND RESULTS:Consenting patients (n=206) being initiated on warfarin were randomized to pharmacogenetic-guided or standard dosing. Buccal swab DNA w...

journal_title：Circulation

authors： Anderson JL,Horne BD,Stevens SM,Grove AS,Barton S,Nicholas ZP,Kahn SF,May HT,Samuelson KM,Muhlestein JB,Carlquist JF,Couma-Gen Investigators.

更新日期：2007-11-27 00:00:00

abstract：BACKGROUND:A warm-water bath (WWB) or sauna bath (SB) has generally been considered inappropriate for patients with severe congestive heart failure (CHF). However, a comprehensive investigation of the hemodynamic effects of thermal vasodilation in CHF has not been previously undertaken. METHODS AND RESULTS:To investig...

journal_title：Circulation

authors： Tei C,Horikiri Y,Park JC,Jeong JW,Chang KS,Toyama Y,Tanaka N

更新日期：1995-05-15 00:00:00

abstract：BACKGROUND:The accumulation of macrophage-derived foam cells in atherosclerotic lesions correlates with increased local release of matrix-degrading metalloproteinases (MMPs) and a thin fibrous cap. The activity of these enzymes is controlled by specific tissue inhibitors of metalloproteinases (TIMPs). METHODS AND RESU...

journal_title：Circulation

authors： Moreau M,Brocheriou I,Petit L,Ninio E,Chapman MJ,Rouis M

更新日期：1999-01-26 00:00:00

abstract：BACKGROUND:The use of balloon coarctation angioplasty instead of surgery as treatment for unoperated coarctation of the aorta is controversial. The efficacy and complications of the two procedures have not been studied before in a prospective fashion. METHODS AND RESULTS:Thirty-six patients were prospectively randomiz...

journal_title：Circulation

authors： Shaddy RE,Boucek MM,Sturtevant JE,Ruttenberg HD,Jaffe RB,Tani LY,Judd VE,Veasy LG,McGough EC,Orsmond GS

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:NO has been advocated as an adjunct to cardioplegia solutions. However, NO undergoes a rapid biradical reaction with superoxide anions to produce peroxynitrite (ONOO(-)). ONOO(-) in crystalloid cardioplegia solution induces injury to coronary endothelium and to systolic function after cardioplegia and reperf...

journal_title：Circulation

authors： Nakamura M,Thourani VH,Ronson RS,Velez DA,Ma XL,Katzmark S,Robinson J,Schmarkey LS,Zhao ZQ,Wang NP,Guyton RA,Vinten-Johansen J

更新日期：2000-11-07 00:00:00

abstract：BACKGROUND:Out-of-hospital cardiac arrest (OHCA) is a major public health problem. We sought to describe changes in 1-month survival after OHCA in patients given cardiopulmonary resuscitation (CPR) during the last 14 years in Sweden. METHODS AND RESULTS:All patients experiencing OHCA in whom CPR was attempted between ...

journal_title：Circulation

authors： Hollenberg J,Herlitz J,Lindqvist J,Riva G,Bohm K,Rosenqvist M,Svensson L

更新日期：2008-07-22 00:00:00

abstract：BACKGROUND:Z-Val-Ala-Asp(OMe)-CH2F (ZVAD-fmk), a tripeptide inhibitor of the caspase interleukin-1beta-converting enzyme family of cysteine proteases, may reduce myocardial reperfusion injury in vivo by attenuating cardiomyocyte apoptosis within the ischemic area at risk. METHODS AND RESULTS:Sprague-Dawley rats were s...

journal_title：Circulation

authors： Yaoita H,Ogawa K,Maehara K,Maruyama Y

更新日期：1998-01-27 00:00:00

abstract：BACKGROUND:The impact of abdominal arterial calcific deposits on the prediction of cardiovascular disease (CVD) over a long follow-up interval deserves greater scrutiny. METHODS AND RESULTS:Lateral lumbar radiographs were studied as a predictor of incident coronary heart disease (CHD), CVD, and CVD mortality in 1049 m...

journal_title：Circulation

authors： Wilson PW,Kauppila LI,O'Donnell CJ,Kiel DP,Hannan M,Polak JM,Cupples LA

更新日期：2001-03-20 00:00:00