Propranolol therapy in patients with acute myocardial infarction: the Beta-Blocker Heart Attack Trial.

abstract：BACKGROUND:Arterial relaxation is largely regulated by endothelial nitric oxide (NO). Its diminished activity has been associated with incipient atherosclerosis. We investigated the endothelium-dependent relaxation of aorta in apolipoprotein E-knockout (apoE-KO) mice exposed to single or repeated Chlamydia pneumoniae i...

journal_title：Circulation

authors： Liuba P,Karnani P,Pesonen E,Paakkari I,Forslid A,Johansson L,Persson K,Wadström T,Laurini R

更新日期：2000-08-29 00:00:00

abstract：BACKGROUND:Interferons (IFNs) play an important role in antiviral defense and have therapeutic potential in coxsackievirus heart disease. However, little is known about the relative contributions of type I and type II IFN signaling in coxsackievirus B3 (CVB3) infection or their role in the cardioselective nature of CVB...

journal_title：Circulation

authors： Wessely R,Klingel K,Knowlton KU,Kandolf R

更新日期：2001-02-06 00:00:00

abstract：BACKGROUND:Cardiac myosin-binding protein C (cMyBP-C) is a sarcomeric protein that dynamically regulates thick-filament structure and function. In constitutive cMyBP-C knockout (cMyBP-C(-/-)) mice, loss of cMyBP-C has been linked to left ventricular dilation, cardiac hypertrophy, and systolic and diastolic dysfunction,...

journal_title：Circulation

authors： Chen PP,Patel JR,Powers PA,Fitzsimons DP,Moss RL

更新日期：2012-09-04 00:00:00

abstract：:To estimate the effect of distance between the electrode and the signal source on the amplitude of the His bundle electrogram (HBE) recorded during open heart surgery, a specially designed probe, containing six pairs of closely spaced (1 mm) electrodes was placed on the endocardial surface of the right atrium such tha...

journal_title：Circulation

authors： Dick M 2nd,Krongrad E,Antar RE,Ross S,Bowman FO Jr,Malm JR,Hoffman BF

更新日期：1976-02-01 00:00:00

abstract：BACKGROUND:To evaluate the effect of plasminogen activator inhibitor type 1 (PAI-1) levels on the clearance of total tissue plasminogen activator (TPA) antigen, we studied the clearance of active TPA and TPA/PAI-1 complex in subjects with low (181+/-109 pmol/L; n=7) and high (1166+/-322 pmol/L; n=4) baseline active PAI...

journal_title：Circulation

authors： Chandler WL,Alessi MC,Aillaud MF,Henderson P,Vague P,Juhan-Vague I

更新日期：1997-08-05 00:00:00

abstract：BACKGROUND:This study was performed to report causes of death or graft loss and to identify possible pretransplant risk factors for death or graft loss in infants after heart transplantation. METHODS AND RESULTS:Pretransplant risk factors were compared for 153 infants registered for heart transplantation within 90 day...

journal_title：Circulation

authors： Chinnock RE,Larsen RL,Emery JR,Bailey LL

更新日期：1995-11-01 00:00:00

abstract：:The dynamics between mitral anulus motion, and, thus, motion of the base of the heart, and filling of the left atrium and ventricle were studied by Doppler echocardiography in 12 normal subjects and 28 patients with dilated cardiomyopathy. The normal motion of the mitral anulus is associated with two phases of inflow ...

journal_title：Circulation

authors： Keren G,Sonnenblick EH,LeJemtel TH

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Left ventricular (LV) mass is an important predictor of heart failure and cardiovascular mortality, yet determinants of LV mass are incompletely understood. Pulmonary hyperinflation in chronic obstructive pulmonary disease (COPD) may contribute to changes in intrathoracic pressure that increase LV wall stres...

journal_title：Circulation

authors： Smith BM,Kawut SM,Bluemke DA,Basner RC,Gomes AS,Hoffman E,Kalhan R,Lima JA,Liu CY,Michos ED,Prince MR,Rabbani L,Rabinowitz D,Shimbo D,Shea S,Barr RG

更新日期：2013-04-09 00:00:00

abstract：:This study describes the efficacy of the right gastroepiploic artery (GEA) as graft material for coronary artery bypass grafting (CABG) as assessed by exercise thallium 201 myocardial scintigraphy in eight patients (age, 59.4 +/- 9.35 years [mean +/- SD]) who underwent CABG with the GEA graft in the past 2 years. Plan...

journal_title：Circulation

authors： Kusukawa J,Hirota Y,Kawamura K,Suma H,Takeuchi A,Adachi I,Akagi H

更新日期：1989-09-01 00:00:00

abstract：:This essay reviews the founding and early history of the Council on Clinical Cardiology of the American Heart Association (AHA), the largest of the AHA's 14 councils. Based on archival research, it stresses the factors that led to the council's formation and shaped its agenda. The council was established in the contex...

journal_title：Circulation

authors： Fye WB

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Despite recommendations in the guidelines and consensus documents, there has been no randomized controlled trial evaluating oral anticoagulation (OAC) alone without antiplatelet therapy (APT) in patients with atrial fibrillation and stable coronary artery disease beyond 1 year after coronary stenting. METHO...

journal_title：Circulation

authors： Matsumura-Nakano Y,Shizuta S,Komasa A,Morimoto T,Masuda H,Shiomi H,Goto K,Nakai K,Ogawa H,Kobori A,Kono Y,Kaitani K,Suwa S,Aoyama T,Takahashi M,Sasaki Y,Onishi Y,Mano T,Matsuda M,Motooka M,Tomita H,Inoko M,Wak

更新日期：2019-01-29 00:00:00

abstract：:A clinical study was conducted to evaluate the efficacy and safety of percutaneous coronary excimer laser angioplasty in 60 patients with coronary artery disease. Forty-nine patients had stable exertional angina, and 11 patients had unstable angina despite medical therapy. A novel 1.4-mm diameter catheter with 20 quar...

journal_title：Circulation

authors： Karsch KR,Haase KK,Voelker W,Baumbach A,Mauser M,Seipel L

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:Weight loss in obese insulin-resistant but not in insulin-sensitive persons reduces coronary heart disease risk. To what extent changes in gene expression are related to atherosclerosis and cardiovascular function is unknown. METHODS AND RESULTS:We studied the effect of diet restriction-induced weight loss ...

journal_title：Circulation

authors： Verreth W,De Keyzer D,Pelat M,Verhamme P,Ganame J,Bielicki JK,Mertens A,Quarck R,Benhabilès N,Marguerie G,Mackness B,Mackness M,Ninio E,Herregods MC,Balligand JL,Holvoet P

更新日期：2004-11-16 00:00:00

abstract：BACKGROUND:Alfieri edge-to-edge mitral repair has been used clinically with ring annuloplasty to correct ischemic mitral regurgitation (IMR), but its efficacy without concomitant ring annuloplasty has not been described in this setting. METHODS:Seventeen sheep underwent implantation of 9 radiopaque markers on the left...

journal_title：Circulation

authors： Timek TA,Nielsen SL,Lai DT,Tibayan FA,Liang D,Rodriguez F,Daughters GT,Ingels NB Jr,Miller DC

更新日期：2003-09-09 00:00:00

abstract：BACKGROUND:Severe obesity can result in proteinuria and progressive glomerulosclerosis in humans and experimental animals. The associated renal disease is ameliorated by weight reduction and/or blockade of the renin-angiotensin system. Various growth factors, cytokines, and lipid mediators are implicated in the pathoge...

journal_title：Circulation

authors： Xu ZG,Lanting L,Vaziri ND,Li Z,Sepassi L,Rodriguez-Iturbe B,Natarajan R

更新日期：2005-04-19 00:00:00

abstract：BACKGROUND:Long-term implantable left ventricular assist devices (LVADs) are increasingly used as a bridge to cardiac transplantation and may be used as long-term therapy for end-stage heart failure. After insertion of an LVAD, patients frequently become ambulatory. Sensors contained within these devices can measure th...

journal_title：Circulation

authors： Foray A,Williams D,Reemtsma K,Oz M,Mancini D

更新日期：1996-11-01 00:00:00

abstract：:Systemic, renal and splanchnic hemodynamics, intravascular volume, circulating catecholamine levels and plasma renin activity were compared in 39 patients with borderline hypertension and 28 normotensive subjects, who were less than 5% (n = 42, lean patients) or more than 40% overweight (n = 25, obese patients). Lean ...

journal_title：Circulation

authors： Messerli FH,Ventura HO,Reisin E,Dreslinski GR,Dunn FG,MacPhee AA,Frohlich ED

更新日期：1982-07-01 00:00:00

abstract：BACKGROUND:A complete understanding of fluid mechanics in Fontan physiology includes knowledge of the caval contributions to right (RPA) and left (LPA) pulmonary arterial blood flow, total systemic venous return, and relative blood flow to each lung. METHODS AND RESULTS:Ten Fontan patients underwent cine MRI. Three ci...

journal_title：Circulation

authors： Fogel MA,Weinberg PM,Rychik J,Hubbard A,Jacobs M,Spray TL,Haselgrove J

更新日期：1999-03-09 00:00:00

abstract：BACKGROUND:The mechanisms responsible for the association between advanced age and atherosclerotic diseases are not clear. Because atherosclerosis develops in response to local endothelial injuries, we investigated the effect of aging on vascular healing and reendothelialization. METHODS AND RESULTS:Endothelium denuda...

journal_title：Circulation

authors： Gennaro G,Ménard C,Michaud SE,Rivard A

更新日期：2003-01-21 00:00:00

abstract：:Depression is commonly present in patients with coronary heart disease (CHD) and is independently associated with increased cardiovascular morbidity and mortality. Screening tests for depressive symptoms should be applied to identify patients who may require further assessment and treatment. This multispecialty consen...

journal_title：Circulation

authors： Lichtman JH,Bigger JT Jr,Blumenthal JA,Frasure-Smith N,Kaufmann PG,Lespérance F,Mark DB,Sheps DS,Taylor CB,Froelicher ES,American Heart Association Prevention Committee of the Council on Cardiovascular Nursing.,American Heart Assoc

更新日期：2008-10-21 00:00:00

abstract：BACKGROUND:The mechanism through which ischemic preconditioning causes cardioprotection is unknown. The present study investigated the role of stunning in preconditioning. METHODS AND RESULTS:We studied three different protocols of preconditioning: two cycles of 2-minute ischemia separated by 5-minute reperfusion (2'P...

journal_title：Circulation

authors： Miura T,Goto M,Urabe K,Endoh A,Shimamoto K,Iimura O

更新日期：1991-12-01 00:00:00

abstract：:Fibrinopeptide A, platelet factor 4, beta-thromboglobulin, thromboxane B2, and 6-keto-prostaglandin F1 alpha were estimated by radioimmunoassay on venous plasma samples taken within 48 hr of admission from 16 consecutive patients with unstable angina and 15 patients with stable angina matched for clinical variables. T...

journal_title：Circulation

authors： Théroux P,Latour JG,Léger-Gauthier C,De Lara J

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Administration of aprotinin during extracorporeal circulation reduces blood loss and improves platelet function. METHODS AND RESULTS:To evaluate the protective effect of aprotinin on platelets, 50 patients undergoing cardiopulmonary bypass were randomized before surgery to one of three groups. Seventeen pat...

journal_title：Circulation

authors： Mohr R,Goor DA,Lusky A,Lavee J

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Spectral analysis of heart rate (HR) variability (HRV) requires, as a rule, some level of stationarity and, as a result, is inadequate to quantify biological transients. A time-/frequency-domain method (TF) was developed to obtain an instant spectral power (SP) of HRV during tilt. METHODS AND RESULTS:HR was...

journal_title：Circulation

authors： Jasson S,Médigue C,Maison-Blanche P,Montano N,Meyer L,Vermeiren C,Mansier P,Coumel P,Malliani A,Swynghedauw B

更新日期：1997-11-18 00:00:00

abstract：:Echocardiographic and hemodynamic data were measured in closed-chest dogs during graded cardiac tamponade (pericardial pressure 5, 10, and 15 mm Hg) before and after production of diffuse ischemic left ventricular dysfunction. Left ventricular dysfunction was produced by intracoronary injection of nonradioactive micro...

journal_title：Circulation

authors： Hoit BD,Gabel M,Fowler NO

更新日期：1990-10-01 00:00:00

abstract：:Background: In ISCHEMIA, an initial invasive strategy did not significantly reduce rates of cardiovascular events or all-cause mortality compared with a conservative strategy in patients with stable ischemic heart disease and moderate/severe myocardial ischemia. The most frequent component of composite cardiovascular ...

journal_title：Circulation

authors： Chaitman BR,Alexander KP,Cyr DD,Berger JS,Reynolds HR,Bangalore S,Boden WE,Lopes RD,Demkow M,Perna GP,Riezebos RK,McFalls EO,Banerjee S,Bagai A,Gosselin G,O'Brien SM,Rockhold FW,Waters DD,Thygesen KA,Stone GW,Whit

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND:Cardiotoxicity is a leading cause for drug attrition during pharmaceutical development and has resulted in numerous preventable patient deaths. Incidents of adverse cardiac drug reactions are more common in patients with preexisting heart disease than the general population. Here we generated a library of hu...

journal_title：Circulation

authors： Liang P,Lan F,Lee AS,Gong T,Sanchez-Freire V,Wang Y,Diecke S,Sallam K,Knowles JW,Wang PJ,Nguyen PK,Bers DM,Robbins RC,Wu JC

更新日期：2013-04-23 00:00:00

abstract：BACKGROUND:Albumin microbubbles that are used for contrast echocardiography persist within the myocardial microcirculation after ischemia/reperfusion (I-R). The mechanism responsible for this phenomenon is unknown. METHODS AND RESULTS:Intravital microscopy of the microcirculation of exteriorized cremaster muscle was p...

journal_title：Circulation

authors： Lindner JR,Coggins MP,Kaul S,Klibanov AL,Brandenburger GH,Ley K

更新日期：2000-02-15 00:00:00

abstract：BACKGROUND:Endogenous nitric oxide (NO) reduces sympathetic vasoconstriction by attenuating neuronal excitability in the brain stem and inhibition of postganglionic neurotransmission. We studied whether this modulation of sympathetic circulatory control by NO may be altered during chronic administration of NO donor dru...

journal_title：Circulation

authors： Zanzinger J,Czachurski J,Seller H

更新日期：1998-06-16 00:00:00

abstract：:Serial sections of the conduction system (CS) were performed in two patients with recurrent tachyarrhythmias. Case 1, a 34-year-old female who had dual atrioventricular (AV) nodal pathways with recurrent paroxysmal supraventricular tachycardia, committed suicide. Autopsy revealed an abnormally formed atrial septum wit...

journal_title：Circulation

authors： Bharati S,Bauernfiend R,Scheinman M,Massie B,Cheitlin M,Denes P,Wu D,Lev M,Rosen KM

更新日期：1979-03-01 00:00:00