Microsomal prostaglandin e2 synthase-1 modulates the response to vascular injury.

abstract：BACKGROUND:Left ventricular (LV) mechanical dyssynchrony (LVMD) has emerged as a therapeutic target using cardiac resynchronization therapy (CRT) in selected patients with chronic heart failure. Current methods used to evaluate LVMD are technically difficult and do not assess LVMD of the whole LV simultaneously. We dev...

journal_title：Circulation

authors： Kapetanakis S,Kearney MT,Siva A,Gall N,Cooklin M,Monaghan MJ

更新日期：2005-08-16 00:00:00

abstract：BACKGROUND:The reason for the delay in onset of the electrophysiological effects and antiarrhythmic efficacy of amiodarone is not clear. The relation between the development of the electrophysiological effects of amiodarone and its myocardial concentration is unknown. We therefore examined the time course of developmen...

journal_title：Circulation

authors： Nanas JN,Mason JW

更新日期：1995-01-15 00:00:00

abstract：:Knowledge of the potential gradient field created by defibrillation electrodes is important for the understanding and improvement of defibrillation. To obtain this knowledge by direct measurements, potentials were recorded from 60 epicardial, eight septal, and 36 right ventricular transmural electrodes in six open-che...

journal_title：Circulation

authors： Chen PS,Wolf PD,Claydon FJ,Dixon EG,Vidaillet HJ Jr,Danieley ND,Pilkington TC,Ideker RE

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:Inflammation and matrix degradation may play a pathogenic role in chronic heart failure (CHF), and therefore, we examined whether thalidomide, a drug with potential immunomodulating and matrix-stabilizing properties, could improve left ventricular (LV) function in patients with CHF secondary to idiopathic di...

journal_title：Circulation

authors： Gullestad L,Ueland T,Fjeld JG,Holt E,Gundersen T,Breivik K,Følling M,Hodt A,Skårdal R,Kjekshus J,Andreassen A,Kjekshus E,Wergeland R,Yndestad A,Frøland SS,Semb AG,Aukrust P

更新日期：2005-11-29 00:00:00

abstract：BACKGROUND:We sought to separately examine the effects of either weight loss or diets varying in protein content and glycemic index without further changes in body weight on cardiovascular risk factors within the Diet, Obesity, and Genes study (DiOGenes). METHODS AND RESULTS:DiOGenes is a pan-European controlled dieta...

journal_title：Circulation

authors： Gögebakan O,Kohl A,Osterhoff MA,van Baak MA,Jebb SA,Papadaki A,Martinez JA,Handjieva-Darlenska T,Hlavaty P,Weickert MO,Holst C,Saris WH,Astrup A,Pfeiffer AF,DiOGenes.

更新日期：2011-12-20 00:00:00

abstract：:In this study, we tested the hypothesis that the neural control of circulation in humans undergoes continuous but in part predictable changes throughout the day and night. Dynamic 24-hour recordings were obtained in two groups of ambulant subjects. In 18 hospitalized patients free to move, direct high-fidelity arteria...

journal_title：Circulation

authors： Furlan R,Guzzetti S,Crivellaro W,Dassi S,Tinelli M,Baselli G,Cerutti S,Lombardi F,Pagani M,Malliani A

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:Postmortem-derived findings support the common beliefs that lipid-rich coronary plaques with a thin, fibrous cap are prone to rupture and that rupture and superimposed thrombosis are the primary mechanisms causing acute coronary syndromes. In vivo imaging with intracoronary techniques may disclose difference...

journal_title：Circulation

authors： de Feyter PJ,Ozaki Y,Baptista J,Escaned J,Di Mario C,de Jaegere PP,Serruys PW,Roelandt JR

更新日期：1995-09-15 00:00:00

abstract：BACKGROUND:Development and validation of novel imaging modalities to assess the composition of human atherosclerotic plaques will improve the understanding of atheroma evolution and could facilitate evaluation of therapeutic strategies for plaque modification. Surface MRI can characterize tissue content of carotid but ...

journal_title：Circulation

authors： Larose E,Yeghiazarians Y,Libby P,Yucel EK,Aikawa M,Kacher DF,Aikawa E,Kinlay S,Schoen FJ,Selwyn AP,Ganz P

更新日期：2005-10-11 00:00:00

abstract：BACKGROUND:Drug-eluting stents have shown promising antirestenotic effects in clinical trials. Non-stent-based local delivery of antiproliferative drugs may offer additional flexibility and also reach vessel areas beyond the immediate stent coverage. The aim of the present study was to evaluate a novel method of local ...

journal_title：Circulation

authors： Scheller B,Speck U,Abramjuk C,Bernhardt U,Böhm M,Nickenig G

更新日期：2004-08-17 00:00:00

abstract：BACKGROUND:Flavone-8-acetic acid (FAA; [Flavonoid]), an adjuvant antitumor drug, inhibits ristocetin-induced aggregation of human platelets. The effect of FAA on platelet-dependent thrombosis was studied in vivo in the porcine carotid artery after deep arterial injury by balloon angioplasty. METHODS AND RESULTS:(111)I...

journal_title：Circulation

authors： Mruk JS,Webster MW,Heras M,Reid JM,Grill DE,Chesebro JH

更新日期：2000-01-25 00:00:00

abstract：:We made continuous electrocardiographic recordings on magnetic tape during 15 episodes of ischemia in five patients with variant angina to determine the characteristics of the QRS changes. Orthogonal leads were used and the electrocardiograms were analyzed visually and by digital computer. Changes were quantified by s...

journal_title：Circulation

authors： Barnhill JE,Wikswo JP Jr,Dawson AK,Gundersen S,Robertson RM,Robertson D,Virmani R,Smith RF

更新日期：1985-05-01 00:00:00

abstract：:Lidocaine is a commonly used antiarrhythmic drug that causes use-dependent blockade of sodium channels in vitro and reduces conduction velocity in vitro and in vivo. According to the modulated receptor hypothesis of antiarrhythmic drug action, lidocaine has a low affinity for rested sodium channels but a high affinity...

journal_title：Circulation

authors： Davis J,Matsubara T,Scheinman MM,Katzung B,Hondeghem LH

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:Brain natriuretic peptide (BNP), as a cardiac hormone, is expressed together with atrial natriuretic peptide (ANP) in the ventricles in congestive heart failure. However, the ventricular expression of BNP in hypertrophic cardiomyopathy (HCM) with normal systolic function is still unclear. METHODS AND RESULT...

journal_title：Circulation

authors： Hasegawa K,Fujiwara H,Doyama K,Miyamae M,Fujiwara T,Suga S,Mukoyama M,Nakao K,Imura H,Sasayama S

更新日期：1993-08-01 00:00:00

abstract：:Contracture and collapse often complicate dissection and excision of blood vessels for grafting. Subsequent forceful redilatation and leak checking with cold saline almost always lead to partial or total denudation of endothelium, which increases the risk of early occlusion by thrombi or late occlusion by fibrocellula...

journal_title：Circulation

authors： Haudenschild C,Gould KE,Quist WC,LoGerfo FW

更新日期：1981-08-01 00:00:00

abstract：BACKGROUND:To simplify extensive primary repair of the thoracic aorta in acute type A aortic dissection, we developed the open triple-branched stent graft placement technique. The early results of this new technique are reported. METHODS AND RESULTS:Between June 2008 and November 2009, 30 patients with acute Stanford ...

journal_title：Circulation

authors： Chen LW,Dai XF,Lu L,Zhang GC,Cao H

更新日期：2010-10-05 00:00:00

abstract：BACKGROUND:Excessive proliferation and apoptosis resistance of pulmonary artery smooth muscle cells (PASMCs) are key mechanisms of pulmonary arterial hypertension (PAH). Despite the multiple combination therapy, a considerable number of patients develop severe pulmonary hypertension (PH) because of the lack of diagnost...

journal_title：Circulation

authors： Kikuchi N,Satoh K,Kurosawa R,Yaoita N,Elias-Al-Mamun M,Siddique MAH,Omura J,Satoh T,Nogi M,Sunamura S,Miyata S,Saito Y,Hoshikawa Y,Okada Y,Shimokawa H

更新日期：2018-08-07 00:00:00

abstract：BACKGROUND:Subclinical inflammation is associated with an increased risk of heart failure and with adverse prognosis in patients with established heart failure. Yet, treatments specifically directed at reducing inflammation in patients with heart failure have not yet shown improved clinical outcomes. We tested the hypo...

journal_title：Circulation

authors： Everett BM,Cornel JH,Lainscak M,Anker SD,Abbate A,Thuren T,Libby P,Glynn RJ,Ridker PM

更新日期：2019-03-05 00:00:00

abstract：BACKGROUND:A family history of coronary heart disease (CHD) is an independent risk factor for cardiovascular events. However, the mechanisms underlying this susceptibility have not been fully elucidated. We hypothesized that an important mediator of the familial predisposition to CHD is subclinical atherosclerosis, whi...

journal_title：Circulation

authors： Wang TJ,Nam BH,D'Agostino RB,Wolf PA,Lloyd-Jones DM,MacRae CA,Wilson PW,Polak JF,O'Donnell CJ

更新日期：2003-08-05 00:00:00

abstract：BACKGROUND:Patients with a non-ST-elevation acute coronary syndrome and prior CABG are at high risk of a recurrent ischemic event despite aspirin therapy. This trial investigated the potential benefit of secondary prevention with warfarin. METHODS AND RESULTS:In a double-blind randomized trial, 135 patients with unsta...

journal_title：Circulation

authors： Huynh T,Théroux P,Bogaty P,Nasmith J,Solymoss S

更新日期：2001-06-26 00:00:00

abstract：:The indications for biventricular versus left ventricular mechanical circulatory support as a bridge to cardiac transplantation are not well established. In this study, 27 potential heart transplant candidates who were in imminent risk of dying before donor heart procurement were implanted with Thoratec prosthetic ven...

journal_title：Circulation

authors： Farrar DJ,Hill JD,Gray LA Jr,Galbraith TA,Chow E,Hershon JJ

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Roux-en-Y gastric bypass (RYGB) reduces body weight and cardiovascular mortality in morbidly obese patients. Glucagon-like peptide-1 (GLP-1) seems to mediate the metabolic benefits of RYGB partly in a weight loss-independent manner. The present study investigated in rats and patients whether obesity-induced ...

journal_title：Circulation

authors： Osto E,Doytcheva P,Corteville C,Bueter M,Dörig C,Stivala S,Buhmann H,Colin S,Rohrer L,Hasballa R,Tailleux A,Wolfrum C,Tona F,Manz J,Vetter D,Spliethoff K,Vanhoutte PM,Landmesser U,Pattou F,Staels B,Matter CM,Lut

更新日期：2015-03-10 00:00:00

abstract：BACKGROUND:Alterations in the balance of matrix metalloproteinases (MMPs) and their specific tissue inhibitors (TIMPs) are involved in left ventricular (LV) remodeling. Whether their expression is related to interstitial fibrosis or LV dysfunction in patients with chronic pressure overload-induced LV hypertrophy, howev...

journal_title：Circulation

authors： Heymans S,Schroen B,Vermeersch P,Milting H,Gao F,Kassner A,Gillijns H,Herijgers P,Flameng W,Carmeliet P,Van de Werf F,Pinto YM,Janssens S

更新日期：2005-08-23 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells (MSCs) are bone marrow stromal cells that are in phase 1 clinical studies of cellular cardiomyoplasty. However, the electrophysiological effects of MSC transplantation have not been studied. Although improvement of ventricular function would represent a positive outcome of MSC transpla...

journal_title：Circulation

authors： Chang MG,Tung L,Sekar RB,Chang CY,Cysyk J,Dong P,Marbán E,Abraham MR

更新日期：2006-04-18 00:00:00

abstract：BACKGROUND:Pharmacological evidence has implicated ATP-sensitive K(+) (K(ATP)) channels as the effectors of cardioprotection, but the relative roles of mitochondrial (mitoK(ATP)) and sarcolemmal (surfaceK(ATP)) channels remain controversial. METHODS AND RESULTS:We examined the effects of the K(ATP) channel blocker HMR...

journal_title：Circulation

authors： Sato T,Sasaki N,Seharaseyon J,O'Rourke B,Marbán E

更新日期：2000-05-23 00:00:00

abstract：:Sustained-release diltiazem (D-SR) and sustained-release verapamil (V-SR) when given twice a day have been successfully used to treat both essential hypertension and angina pectoris. Review of available studies indicates that 120 to 180 mg D-SR twice a day and 240 mg V-SR once or twice a day can lower diastolic pressu...

journal_title：Circulation

authors： Klein MD,Weiner DA

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:Increased carotid intimal-medial thickness (IMT) and coronary artery calcification (CAC) are used as 2 markers of early atherosclerosis. Our objectives were to assess whether increased IMT and CAC are related and to determine the relationship between cardiovascular risk factors and carotid IMT in young adult...

journal_title：Circulation

authors： Davis PH,Dawson JD,Mahoney LT,Lauer RM

更新日期：1999-08-24 00:00:00

abstract：:To determine if acute lung rejection after heart-lung transplantation can be detected noninvasively with indium-111-labeled (111In) lymphocytes, we studied 33 allogeneic and 18 isogeneic heterotopic heart-lung transplants in rats. Twenty-four hours after injection of isogeneic splenic 111In-lymphocytes (75 +/- 2 micro...

journal_title：Circulation

authors： Arai H,Yuda T,Goodgold HM,deMello DE,Hendershott L,Pennington DG

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Aspirin is effective for the primary prevention of cardiovascular events, but it remains unclear for which subgroups of individuals aspirin is beneficial. We assessed the cost-effectiveness of aspirin separately for men and women of different ages with various levels of cardiovascular disease risk. METHODS ...

journal_title：Circulation

authors： Greving JP,Buskens E,Koffijberg H,Algra A

更新日期：2008-06-03 00:00:00

abstract：:The relationship between fasting plasma cholesterol and triglyceride concentrations and the frequency and extensiveness of coronary artery disease (CAD) was studied in 496 subjects evaluated for chest pain by coronary arteriography at The Methodist Hospital. One hundred six of the patients had no CAD while 390 had 25%...

journal_title：Circulation

authors： Gotto AM,Gorry GA,Thompson JR,Cole JS,Trost R,Yeshurun D,DeBakey ME

更新日期：1977-11-01 00:00:00

abstract：BACKGROUND:Despite intensive investigation, how DNA methylation influences endothelial function remains poorly understood. We used methyl-CpG-binding domain protein 2 (MBD2), an interpreter for DNA methylome-encoded information, to dissect the impact of DNA methylation on endothelial function in both physiological and ...

journal_title：Circulation

authors： Rao X,Zhong J,Zhang S,Zhang Y,Yu Q,Yang P,Wang MH,Fulton DJ,Shi H,Dong Z,Wang D,Wang CY

更新日期：2011-06-28 00:00:00