Treatment of angina pectoris and hypertension with sustained-release calcium channel-blocking drugs.

abstract：BACKGROUND:Chronic Chlamydia pneumoniae and Helicobacter pylori infections could be a risk factor for ischemic heart disease (IHD), possibly by increasing fibrinogen levels. The aim of our study was to evaluate changes in fibrinogen level in patients with IHD and H pylori and/or C pneumoniae positivity randomly assigne...

journal_title：Circulation

authors： Torgano G,Cosentini R,Mandelli C,Perondi R,Blasi F,Bertinieri G,Tien TV,Ceriani G,Tarsia P,Arosio C,Ranzi ML

更新日期：1999-03-30 00:00:00

abstract：:Forty-four patients with acute transmural myocardial infarction underwent cardiac catheterization 4.7 +/- 1.3 hours (+/- SD) after the onset of persistent chest discomfort. Thirty-nine patients had total occlusion of infarct-related vessels; 27 of these 39 had successful intracoronary thrombolysis. Twenty of these 27 ...

journal_title：Circulation

authors： Goldberg S,Urban P,Greenspon A,Berger B,Walinsky P,Muza B,Kusiak V,Maroko PR

更新日期：1983-08-01 00:00:00

abstract：:In 72% of 143 patients undergoing a second coronary bypass grafting, mural or occlusive late thrombosis was observed histologically in 69% of 173 resected grafts. Late thrombosis was particularly prevalent in atherosclerotic grafts (80.2% vs. 40.4% in nonatherosclerotic grafts) and was always noted in 16 grafts with a...

journal_title：Circulation

authors： Solymoss BC,Nadeau P,Millette D,Campeau L

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Recent findings suggest a causative role of infections in the pathogenesis of atherosclerosis. In hypothesizing an association between infectious agents and the development of atherosclerosis, we would expect a correlation to the extent of atherosclerosis. Moreover, this effect could be multiplied by the num...

journal_title：Circulation

authors： Espinola-Klein C,Rupprecht HJ,Blankenberg S,Bickel C,Kopp H,Rippin G,Victor A,Hafner G,Schlumberger W,Meyer J,AtheroGene Investigators.

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Although diabetes is a well-known risk factor of atherosclerotic cardiovascular diseases, the cardiovascular disease risk of glycemia below the current diabetic threshold remains uncertain. METHODS AND RESULTS:A total of 652,901 Korean men aged 30 to 64 years from the Korean National Health Insurance System...

journal_title：Circulation

authors： Sung J,Song YM,Ebrahim S,Lawlor DA

更新日期：2009-02-17 00:00:00

abstract：BACKGROUND:Despite recommendations in the guidelines and consensus documents, there has been no randomized controlled trial evaluating oral anticoagulation (OAC) alone without antiplatelet therapy (APT) in patients with atrial fibrillation and stable coronary artery disease beyond 1 year after coronary stenting. METHO...

journal_title：Circulation

authors： Matsumura-Nakano Y,Shizuta S,Komasa A,Morimoto T,Masuda H,Shiomi H,Goto K,Nakai K,Ogawa H,Kobori A,Kono Y,Kaitani K,Suwa S,Aoyama T,Takahashi M,Sasaki Y,Onishi Y,Mano T,Matsuda M,Motooka M,Tomita H,Inoko M,Wak

更新日期：2019-01-29 00:00:00

abstract：BACKGROUND:Household air pollution is the third largest risk factor for global disease burden, but direct links with cardiovascular disease mortality are limited. This study aimed to evaluate the relationship between household fuel use and cardiovascular disease mortality. METHODS AND RESULTS:The Golestan Cohort Study...

journal_title：Circulation

authors： Mitter SS,Vedanthan R,Islami F,Pourshams A,Khademi H,Kamangar F,Abnet CC,Dawsey SM,Pharoah PD,Brennan P,Fuster V,Boffetta P,Malekzadeh R

更新日期：2016-06-14 00:00:00

abstract：BACKGROUND:Familial polymorphic ventricular tachycardia (FPVT) is characterized by exercise-induced arrhythmias and sudden cardiac death due to missense mutations in the cardiac ryanodine receptor (RyR2), an intracellular Ca2+ release channel required for excitation-contraction coupling in the heart. METHODS AND RESUL...

journal_title：Circulation

authors： Lehnart SE,Wehrens XH,Laitinen PJ,Reiken SR,Deng SX,Cheng Z,Landry DW,Kontula K,Swan H,Marks AR

更新日期：2004-06-29 00:00:00

abstract：BACKGROUND:Matrix metalloproteinase-9 could exhibit an important role in the destabilization of atherosclerotic carotid plaques. We hypothesized that in patients with carotid stenosis, elevated levels of plasma matrix metalloproteinase-9 are associated with ipsilateral stroke or cardiovascular death. METHODS AND RESUL...

journal_title：Circulation

authors： Eldrup N,Grønholdt ML,Sillesen H,Nordestgaard BG

更新日期：2006-10-24 00:00:00

abstract：BACKGROUND:Inflammation and matrix degradation may play a pathogenic role in chronic heart failure (CHF), and therefore, we examined whether thalidomide, a drug with potential immunomodulating and matrix-stabilizing properties, could improve left ventricular (LV) function in patients with CHF secondary to idiopathic di...

journal_title：Circulation

authors： Gullestad L,Ueland T,Fjeld JG,Holt E,Gundersen T,Breivik K,Følling M,Hodt A,Skårdal R,Kjekshus J,Andreassen A,Kjekshus E,Wergeland R,Yndestad A,Frøland SS,Semb AG,Aukrust P

更新日期：2005-11-29 00:00:00

abstract：BACKGROUND:A paucity of literature is available on the effects of age and coronary artery bypass grafting (CABG) on the outcomes of patients undergoing mitral valve (MV) repair versus replacement. METHODS AND RESULTS:A matched study was performed using prospectively collected data from the Emory cardiovascular databas...

journal_title：Circulation

authors： Thourani VH,Weintraub WS,Guyton RA,Jones EL,Williams WH,Elkabbani S,Craver JM

更新日期：2003-07-22 00:00:00

abstract：BACKGROUND:Brugada syndrome (BrS) primarily associates with the loss of sodium channel function. Previous studies showed features consistent with sodium current (INa) deficit in patients carrying desmosomal mutations, diagnosed with arrhythmogenic cardiomyopathy (or arrhythmogenic right ventricular cardiomyopathy). Exp...

journal_title：Circulation

authors： Cerrone M,Lin X,Zhang M,Agullo-Pascual E,Pfenniger A,Chkourko Gusky H,Novelli V,Kim C,Tirasawadichai T,Judge DP,Rothenberg E,Chen HS,Napolitano C,Priori SG,Delmar M

更新日期：2014-03-11 00:00:00

abstract：:Separate effects of perfusion hypothermia, potassium arrest, and procaine arrest were studied in 150 hearts using the isolated rat heart preparation. Aortic flow rate (AFR), coronary flow rate (CFR), and heart rate (HR) were measured before and after ischemic periods of 90 to 300 min. Prior to the ischemic period, the...

journal_title：Circulation

authors： Harlan BJ,Ross D,Macmanus Q,Knight R,Luber J,Starr A

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND:N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, reduces the glycogenolytic rate by inhibiting the alpha-1,6-glucosidase of glycogen-debranching enzyme in the liver, in addition to possessing an antihyperglycemic action by blocking alpha-1,4-glucosidase in the intestine. Because the redu...

journal_title：Circulation

authors： Arai M,Minatoguchi S,Takemura G,Uno Y,Kariya T,Takatsu H,Fujiwara T,Higashioka M,Yoshikuni Y,Fujiwara H

更新日期：1998-04-07 00:00:00

abstract：BACKGROUND:Atherosclerosis is associated with immune responses to oxidized lipoproteins and certain microorganisms, but the role of specific immunity has remained unclear. METHODS AND RESULTS:To study the role of immunity in atherosclerosis, we crossed atherosclerosis-prone apoE(-/-) mice with immunodeficient scid/sci...

journal_title：Circulation

authors： Zhou X,Nicoletti A,Elhage R,Hansson GK

更新日期：2000-12-12 00:00:00

abstract：BACKGROUND:Previous studies have shown that pericytes can differentiate into osteoblasts and form bone. This study investigated whether pericytes can also differentiate into chondrocytes and adipocytes. METHODS AND RESULTS:Reverse transcription-polymerase chain reaction demonstrated that pericytes express mRNA for the...

journal_title：Circulation

authors： Farrington-Rock C,Crofts NJ,Doherty MJ,Ashton BA,Griffin-Jones C,Canfield AE

更新日期：2004-10-12 00:00:00

abstract：BACKGROUND:Brain natriuretic peptide (BNP) and N-terminal (NT)-proBNP have recently emerged as promising parameters for risk assessment in acute pulmonary embolism (PE). However, their positive predictive value is low, and the prognostic implications of NT-proBNP or troponin elevation alone are questionable. METHODS A...

journal_title：Circulation

authors： Binder L,Pieske B,Olschewski M,Geibel A,Klostermann B,Reiner C,Konstantinides S

更新日期：2005-09-13 00:00:00

abstract：:In previous studies from this laboratory, we found that approximately 30% of women with chest pain and normal coronary arteries demonstrated either a decrease in or a failure to increase radionuclide ejection fraction during exercise. To examine the hypothesis that this apparent abnormality in left ventricular functio...

journal_title：Circulation

authors： Higginbotham MB,Morris KG,Coleman RE,Cobb FR

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:The incidence, determinants, and outcome of postoperative atrial fibrillation (AF) after surgery for mitral regurgitation (MR) are poorly defined but may have important implications for timing of mitral valve surgery. METHODS AND RESULTS:In 762 patients in sinus rhythm with no AF history undergoing MR surgi...

journal_title：Circulation

authors： Kernis SJ,Nkomo VT,Messika-Zeitoun D,Gersh BJ,Sundt TM 3rd,Ballman KV,Scott CG,Schaff HV,Enriquez-Sarano M

更新日期：2004-10-19 00:00:00

abstract：BACKGROUND:The timing of onset of angina before myocardial infarction in relation to outcome is unknown. METHODS AND RESULTS:We prospectively determined the importance of the time of onset of preinfarction angina in relation to 30-day outcomes in the TIMI-9B study from standardized forms. Of the 3002 patients entered ...

journal_title：Circulation

authors： Kloner RA,Shook T,Antman EM,Cannon CP,Przyklenk K,Yoo K,McCabe CH,Braunwald E

更新日期：1998-03-24 00:00:00

abstract：:In rats, atrial natriuretic factor (ANF) reduces sympathetic nerve activity (SNA) reflexively by sensitizing cardiac mechanoreceptors with inhibitory vagal afferents. We performed three series of experiments in 26 normal young men to document whether ANF inhibits SNA in humans and if so, to determine potential mechani...

journal_title：Circulation

authors： Floras JS

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:Coxsackievirus-induced myocarditis can be a serious cause of heart failure. In the absence of a specific antiviral therapy, modulating the host immune response may be protective. Interferons (IFNs)-alpha and -beta perform a fundamental role in innate and adaptive antiviral responses, thereby presenting as ca...

journal_title：Circulation

authors： Deonarain R,Cerullo D,Fuse K,Liu PP,Fish EN

更新日期：2004-12-07 00:00:00

abstract：:Proarrhythmic effects of flecainide acetate have been reported during exercise, but the mechanism for the arrhythmogenic interaction between flecainide and exercise is unknown. We hypothesized that the sinus tachycardia of exercise may enhance flecainide-induced conduction slowing by increasing use-dependent sodium ch...

journal_title：Circulation

authors： Ranger S,Talajic M,Lemery R,Roy D,Nattel S

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:In patients with atrial fibrillation, intracardiac atrial defibrillation causes discomfort. An easily applicable, short-acting analgesic and anxiolytic drug would increase acceptability of this new treatment mode. METHODS AND RESULTS:In a double-blind, placebo-controlled manner, the effect of intranasal but...

journal_title：Circulation

authors： Timmermans C,Rodriguez LM,Ayers GM,Lambert H,Smeets JL,Vlaeyen JW,Albert A,Wellens HJ

更新日期：1999-04-13 00:00:00

abstract：BACKGROUND:A growing body of evidence from animal studies supports the hypothesis that oxidative stress-mediated mechanisms play a central role in early atherogenesis. In contrast, clinical trials with antioxidant vitamins have not produced consistent results in humans with established atherosclerosis. METHODS AND RES...

journal_title：Circulation

authors： Cyrus T,Yao Y,Rokach J,Tang LX,Praticò D

更新日期：2003-02-04 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP) may have proatherogenic but also vasoprotective properties. We tested the hypothesis that the configuration of CRP (pentameric, or native [nCRP], versus monomeric, or modified [mCRP]) determines these different characteristics in an in vivo model. METHODS AND RESULTS:We investigated...

journal_title：Circulation

authors： Schwedler SB,Amann K,Wernicke K,Krebs A,Nauck M,Wanner C,Potempa LA,Galle J

更新日期：2005-08-16 00:00:00

abstract：BACKGROUND:Previous studies suggest that management of ambulatory hemodynamics may improve outcomes in chronic heart failure. We conducted a prospective, observational, first-in-human study of a physician-directed patient self-management system targeting left atrial pressure. METHODS AND RESULTS:Forty patients with re...

journal_title：Circulation

authors： Ritzema J,Troughton R,Melton I,Crozier I,Doughty R,Krum H,Walton A,Adamson P,Kar S,Shah PK,Richards M,Eigler NL,Whiting JS,Haas GJ,Heywood JT,Frampton CM,Abraham WT,Hemodynamically Guided Home Self-Therapy in Severe Hea

更新日期：2010-03-09 00:00:00

abstract：:Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with an increasingly recognized heterogeneity in pathophysiology. Exercise intolerance is the hallmark of HFpEF and appears to be caused by both cardiac and peripheral abnormalities in the arterial tree and skeletal muscle. Mitochondrial abno...

journal_title：Circulation

authors： Kumar AA,Kelly DP,Chirinos JA

更新日期：2019-03-12 00:00:00

abstract：BACKGROUND:Transplantation of ex vivo expanded circulating endothelial progenitor cells (EPCs) from peripheral blood mononuclear cells improves the neovascularization after critical ischemia. However, the origin of the endothelial progenitor lineage and its characteristics have not yet been clearly defined. Therefore, ...

journal_title：Circulation

authors： Urbich C,Heeschen C,Aicher A,Dernbach E,Zeiher AM,Dimmeler S

更新日期：2003-11-18 00:00:00

abstract：:Minoxidil, a potent predominant arterial dilator, improves hemodynamics over the short term in patients with heart failure. In random double-blind fashion 17 patients with chronic left heart failure were given minoxidil (nine patients) or placebo (eight patients) in addition to digoxin and diuretics for 3 months. Card...

journal_title：Circulation

authors： Franciosa JA,Jordan RA,Wilen MM,Leddy CL

更新日期：1984-07-01 00:00:00