Transfer of CD4(+) T cells aggravates atherosclerosis in immunodeficient apolipoprotein E knockout mice.

Abstract:

BACKGROUND:Atherosclerosis is associated with immune responses to oxidized lipoproteins and certain microorganisms, but the role of specific immunity has remained unclear. METHODS AND RESULTS:To study the role of immunity in atherosclerosis, we crossed atherosclerosis-prone apoE(-/-) mice with immunodeficient scid/scid mice. The offspring showed a 73% reduction in aortic fatty streak lesions when compared with immunocompetent apoE(-/-) mice. Transfer of CD4(+) T cells from apoE(-/-) to immunodeficient apoE(-/-)/scid/scid mice increased lesions by 164%. This was associated with the infiltration of transferred T cells into lesions, increased circulating interferon-gamma levels, and increased I-A expression in lesions. CONCLUSIONS:CD4(+) T cells carry disease-promoting immunity in atherosclerosis.

journal_name

Circulation

journal_title

Circulation

authors

Zhou X,Nicoletti A,Elhage R,Hansson GK

doi

10.1161/01.cir.102.24.2919

subject

Has Abstract

pub_date

2000-12-12 00:00:00

pages

2919-22

issue

24

eissn

0009-7322

issn

1524-4539

journal_volume

102

pub_type

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