Transfer of CD4(+) T cells aggravates atherosclerosis in immunodeficient apolipoprotein E knockout mice.


BACKGROUND:Atherosclerosis is associated with immune responses to oxidized lipoproteins and certain microorganisms, but the role of specific immunity has remained unclear. METHODS AND RESULTS:To study the role of immunity in atherosclerosis, we crossed atherosclerosis-prone apoE(-/-) mice with immunodeficient scid/scid mice. The offspring showed a 73% reduction in aortic fatty streak lesions when compared with immunocompetent apoE(-/-) mice. Transfer of CD4(+) T cells from apoE(-/-) to immunodeficient apoE(-/-)/scid/scid mice increased lesions by 164%. This was associated with the infiltration of transferred T cells into lesions, increased circulating interferon-gamma levels, and increased I-A expression in lesions. CONCLUSIONS:CD4(+) T cells carry disease-promoting immunity in atherosclerosis.






Zhou X,Nicoletti A,Elhage R,Hansson GK




Has Abstract


2000-12-12 00:00:00












  • The Safety and Efficacy of Aspirin Discontinuation on a Background of a P2Y12 Inhibitor in Patients After Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Dual antiplatelet therapy with aspirin and a P2Y12 inhibitor has been shown to reduce the risk of major adverse cardiovascular events (MACE) compared with aspirin alone after percutaneous coronary intervention (PCI) or acute coronary syndrome but with increased risk of bleeding. The safety of discontinuing a...


    pub_type: 杂志文章


    authors: O'Donoghue ML,Murphy SA,Sabatine MS

    更新日期:2020-08-11 00:00:00

  • Increased diastolic chamber stiffness during demand ischemia: response to quick length change differentiates rigor-activated from calcium-activated tension.

    abstract:BACKGROUND:Increased diastolic chamber stiffness (increased DCS) during angina (demand ischemia) has been postulated to be generated by increased diastolic myocyte calcium concentration. METHODS AND RESULTS:We reproduced demand ischemia in isolated isovolumically contracting red-cell-perfused rabbit hearts by imposing...


    pub_type: 杂志文章


    authors: Varma N,Eberli FR,Apstein CS

    更新日期:2000-05-09 00:00:00

  • Generic, simple risk stratification model for heart valve surgery.

    abstract:BACKGROUND:Heart valve surgery has an associated in-hospital mortality rate of 4% to 8%. This study aims to develop a simple risk model to predict the risk of in-hospital mortality for patients undergoing heart valve surgery to provide information to patients and clinicians and to facilitate institutional comparisons. ...


    pub_type: 杂志文章


    authors: Ambler G,Omar RZ,Royston P,Kinsman R,Keogh BE,Taylor KM

    更新日期:2005-07-12 00:00:00

  • QT dispersion as an attribute of T-loop morphology.

    abstract:BACKGROUND:The suggestion that increased QT dispersion (QTD) is due to increased differences in local action potential durations within the myocardium is wanting. An alternative explanation was sought by relating QTD to vectorcardiographic T-loop morphology. METHODS AND RESULTS:The T loop is characterized by its ampli...


    pub_type: 杂志文章


    authors: Kors JA,van Herpen G,van Bemmel JH

    更新日期:1999-03-23 00:00:00

  • Coronary revascularization in diabetic patients: a comparison of the randomized and observational components of the Aypass Angioplasty Revascularization Investigation (BARI).

    abstract:BACKGROUND:Patients with treated diabetes in the randomized-trial segment of the Bypass Angioplasty Revascularization Investigation (BARI) who were randomized to initial revascularization with PTCA had significantly worse 5-year survival than patients assigned to CABG. This treatment difference was not seen among diabe...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Detre KM,Guo P,Holubkov R,Califf RM,Sopko G,Bach R,Brooks MM,Bourassa MG,Shemin RJ,Rosen AD,Krone RJ,Frye RL,Feit F

    更新日期:1999-02-09 00:00:00

  • Significance of ventricular arrhythmias initiated by programmed ventricular stimulation: the importance of the type of ventricular arrhythmia induced and the number of premature stimuli required.

    abstract::An increasing number of premature ventricular stimuli are being used during programmed stimulation of the heart in the investigation of patients with documented or suspected ventricular arrhythmias. To analyze the significance of the different types of ventricular arrhythmias that are initiated, we evaluated in a pros...


    pub_type: 杂志文章


    authors: Brugada P,Green M,Abdollah H,Wellens HJ

    更新日期:1984-01-01 00:00:00

  • Transplantation for idiopathic pulmonary arterial hypertension: improvement in the lung allocation score era.

    abstract:BACKGROUND:Lung transplantation and heart-lung transplantation represent surgical options for treatment of medically refractory idiopathic pulmonary arterial hypertension. The effect of the lung allocation score on wait-list and transplantation outcomes in patients with idiopathic pulmonary arterial hypertension is poo...


    pub_type: 杂志文章


    authors: Schaffer JM,Singh SK,Joyce DL,Reitz BA,Robbins RC,Zamanian RT,Mallidi HR

    更新日期:2013-06-25 00:00:00

  • Coronary flow velocity pattern immediately after percutaneous coronary intervention as a predictor of complications and in-hospital survival after acute myocardial infarction.

    abstract:BACKGROUND:Recently, it was reported that the degree of microvascular injury and left ventricular functional recovery during the chronic period can be predicted after treatment of the infarct-related artery based on the coronary flow velocity (CFV) pattern assessed using a Doppler guidewire. The aim of this prospective...


    pub_type: 临床试验,杂志文章


    authors: Yamamuro A,Akasaka T,Tamita K,Yamabe K,Katayama M,Takagi T,Morioka S

    更新日期:2002-12-10 00:00:00

  • Impact of angiographic complete revascularization after drug-eluting stent implantation or coronary artery bypass graft surgery for multivessel coronary artery disease.

    abstract:BACKGROUND:This study sought to evaluate the clinical impact of angiographic complete revascularization (CR) after drug-eluting stent implantation or coronary artery bypass graft surgery for multivessel coronary disease. METHODS AND RESULTS:A total of 1914 consecutive patients with multivessel coronary disease undergo...


    pub_type: 杂志文章


    authors: Kim YH,Park DW,Lee JY,Kim WJ,Yun SC,Ahn JM,Song HG,Oh JH,Park JS,Kang SJ,Lee SW,Lee CW,Park SW,Park SJ

    更新日期:2011-05-31 00:00:00

  • Effect of activation of the H1 receptor on coronary hemodynamics in man.

    abstract::We evaluated the effects of selective activation of H1 receptors on coronary hemodynamics in 16 patients divided into two groups: group A, 11 patients with atypical angina or valvular heart disease and normal coronary arteries, and group B, five patients with spontaneous angina, four of whom had significant (greater t...


    pub_type: 杂志文章


    authors: Vigorito C,Poto S,Picotti GB,Triggiani M,Marone G

    更新日期:1986-06-01 00:00:00

  • Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.

    abstract::We have previously shown that a brief episode of ischemia slows the rate of ATP depletion during subsequent ischemic episodes. Additionally, intermittent reperfusion may be beneficial to the myocardium by washing out catabolites that have accumulated during ischemia. Thus, we proposed that multiple brief ischemic epis...


    pub_type: 杂志文章


    authors: Murry CE,Jennings RB,Reimer KA

    更新日期:1986-11-01 00:00:00

  • Dynamic aspects of acute mitral regurgitation: effects of ventricular volume, pressure and contractility on the effective regurgitant orifice area.

    abstract::The dynamics of acute mitral regurgitation were studied in six open-chest dogs in whom a portion of the anterior leaflet was excised. Phasic mitral and aortic flows were measured electromagnetically and left ventricular filling volume, regurgitant volume (RV) and forward stroke volume (SV) were calculated. The systoli...


    pub_type: 杂志文章


    authors: Yoran C,Yellin EL,Becker RM,Gabbay S,Frater RW,Sonnenblick EH

    更新日期:1979-07-01 00:00:00

  • Participation of tyrosine phosphorylation in cytoskeletal reorganization, alpha(IIb)beta(3) integrin receptor activation, and aspirin-insensitive mechanisms of thrombin-stimulated human platelets.

    abstract:BACKGROUND:Fibrinogen binding to the active conformation of the alpha(IIb)beta(3) integrin receptor (glycoprotein IIb/IIIa) and cytoskeletal reorganization are important events in platelet function. Tyrosine phosphorylation of platelet proteins plays an essential role in platelet signal transduction pathways. We studie...


    pub_type: 杂志文章


    authors: Santos MT,Moscardó A,Vallés J,Martínez M,Piñón M,Aznar J,Broekman MJ,Marcus AJ

    更新日期:2000-10-17 00:00:00

  • Coronary anatomy and prognosis after myocardial infarction in patients 60 years of age and younger.

    abstract::Two hundred twenty-nine hospital survivors of acute myocardial infarction (MI) age 60 years or younger underwent coronary arteriography a median of 2 weeks after infarction and were followed a median of 24 months (range 6-62 months). For 62%, MI was the first presentation of coronary disease and 75% were in clinical K...


    pub_type: 杂志文章


    authors: Roubin GS,Harris PJ,Bernstein L,Kelly DT

    更新日期:1983-04-01 00:00:00

  • Primary outcomes for resuscitation science studies: a consensus statement from the American Heart Association.

    abstract:BACKGROUND AND PURPOSE:The guidelines presented in this consensus statement are intended to serve researchers, clinicians, reviewers, and regulators in the selection of the most appropriate primary outcome for a clinical trial of cardiac arrest therapies. The American Heart Association guidelines for the treatment of c...


    pub_type: 杂志文章,实务指引


    authors: Becker LB,Aufderheide TP,Geocadin RG,Callaway CW,Lazar RM,Donnino MW,Nadkarni VM,Abella BS,Adrie C,Berg RA,Merchant RM,O'Connor RE,Meltzer DO,Holm MB,Longstreth WT,Halperin HR,American Heart Association Emergency Cardiova

    更新日期:2011-11-08 00:00:00

  • Vasopressor response to angiotensin II infusion in patients with chronic heart failure receiving beta-blockers.

    abstract:BACKGROUND:A synergistic interaction between the angiotensin II (Ang II) type 1 receptor and alpha1-adrenergic receptors has been described. We hypothesized that the nonselective beta-antagonist carvedilol, through its alpha1-adrenergic blocking properties, may modulate vascular reactivity to Ang II in patients with ch...


    pub_type: 临床试验,杂志文章


    authors: Vittorio TJ,Lang CC,Katz SD,Packer M,Mancini DM,Jorde UP

    更新日期:2003-01-21 00:00:00

  • Acute hemodynamic effects of captopril in children with a congestive or restrictive cardiomyopathy.

    abstract::The acute hemodynamic effects of captopril were evaluated at cardiac catheterization in 16 children (age, 0.3-18 years) with cardiomyopathy. Twelve children had congestive cardiomyopathy, whereas four had restrictive cardiomyopathy. Hemodynamic measurements were obtained 30 and 60 minutes after the oral administration...


    pub_type: 临床试验,杂志文章


    authors: Bengur AR,Beekman RH,Rocchini AP,Crowley DC,Schork MA,Rosenthal A

    更新日期:1991-02-01 00:00:00

  • Regional variation in the incidence and outcomes of in-hospital cardiac arrest in the United States.

    abstract:BACKGROUND:Regional variation in the incidence and outcomes of in-hospital cardiac arrest (IHCA) is not well studied and may have important health and policy implications. METHODS AND RESULTS:We used the 2003 to 2011 Nationwide Inpatient Sample databases to identify patients≥18 years of age who underwent cardiopulmona...


    pub_type: 杂志文章


    authors: Kolte D,Khera S,Aronow WS,Palaniswamy C,Mujib M,Ahn C,Iwai S,Jain D,Sule S,Ahmed A,Cooper HA,Frishman WH,Bhatt DL,Panza JA,Fonarow GC

    更新日期:2015-04-21 00:00:00

  • Can adenosine 5'-triphosphate be used to select treatment in severe vasovagal syndrome?

    abstract:BACKGROUND:Selection of treatment in vasovagal syndrome should be guided by the mechanism of symptoms. This study determined whether a simple drug test may assess one mechanism. METHODS AND RESULTS:To identify patients at risk of severe cardioinhibitory response of vagal origin, we infused 20 mg ATP into 316 patients ...


    pub_type: 杂志文章


    authors: Flammang D,Church T,Waynberger M,Chassing A,Antiel M

    更新日期:1997-08-19 00:00:00

  • Should a fixed external reference system be used to analyze left ventricular wall motion?

    abstract::To investigate whether a fixed external reference system should be used to most accurately describe regional left ventricular wall motion, we used vectors to analyze a simple model of ventricular contraction. If measured in a fixed external reference system, motion of implanted radiopaque midwall markers may contain t...


    pub_type: 杂志文章


    authors: Clayton PD,Jeppson GM,Klausner SC

    更新日期:1982-06-01 00:00:00

  • Intraoperative recording of the His bundle electrogram in man. An assessment of its precision.

    abstract::To estimate the effect of distance between the electrode and the signal source on the amplitude of the His bundle electrogram (HBE) recorded during open heart surgery, a specially designed probe, containing six pairs of closely spaced (1 mm) electrodes was placed on the endocardial surface of the right atrium such tha...


    pub_type: 杂志文章


    authors: Dick M 2nd,Krongrad E,Antar RE,Ross S,Bowman FO Jr,Malm JR,Hoffman BF

    更新日期:1976-02-01 00:00:00

  • Effects of neuronal nitric oxide synthase on human coronary artery diameter and blood flow in vivo.

    abstract:BACKGROUND:Nitric oxide (NO)-mediated local regulation of vascular tone is considered to involve endothelial NO synthase (eNOS). However, we recently reported that human forearm basal microvascular tone in vivo is tonically regulated by neuronal NO synthase (nNOS), in contrast to an acetylcholine-stimulated reduction i...


    pub_type: 杂志文章


    authors: Seddon M,Melikian N,Dworakowski R,Shabeeh H,Jiang B,Byrne J,Casadei B,Chowienczyk P,Shah AM

    更新日期:2009-05-26 00:00:00

  • The epidemiology of plasma high-density lipoprotein cholesterol levels. The Lipid Research Clinics Program Prevalence Study. Summary.

    abstract::Correlates of high-density lipoprotein (HDL) cholesterol levels were studied in 4756 white males and females ages 20-59 years examined during a population survey conducted by 10 North American Lipid Research Clinics. Multivariable analysis was used to assess the relation of social, demographic, physical and behavioral...


    pub_type: 杂志文章


    authors: Heiss G,Johnson NJ,Reiland S,Davis CE,Tyroler HA

    更新日期:1980-11-01 00:00:00

  • Effect of baseline or changes in adrenergic activity on clinical outcomes in the beta-blocker evaluation of survival trial.

    abstract:BACKGROUND:Adrenergic activation is thought to be an important determinant of outcome in subjects with chronic heart failure (CHF), but baseline or serial changes in adrenergic activity have not been previously investigated in a large patient sample treated with a powerful antiadrenergic agent. METHODS AND RESULTS:Sys...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Bristow MR,Krause-Steinrauf H,Nuzzo R,Liang CS,Lindenfeld J,Lowes BD,Hattler B,Abraham WT,Olson L,Krueger S,Thaneemit-Chen S,Hare JM,Loeb HS,Domanski MJ,Eichhorn EJ,Zelis R,Lavori P

    更新日期:2004-09-14 00:00:00

  • Randomized crossover comparison of DDDR versus VDD pacing after atrioventricular junction ablation for prevention of atrial fibrillation. The atrial pacing peri-ablation for paroxysmal atrial fibrillation (PA (3)) study investigators.

    abstract:BACKGROUND:Some clinical data suggest that atrial-based pacing prevents paroxysmal atrial fibrillation (AF). This study tested the hypothesis that DDDR pacing compared with VDD pacing prevents AF after atrioventricular (AV) junction ablation. METHODS AND RESULTS:Patients were randomized to DDDR pacing (n=33) or to VDD...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gillis AM,Connolly SJ,Lacombe P,Philippon F,Dubuc M,Kerr CR,Yee R,Rose MS,Newman D,Kavanagh KM,Gardner MJ,Kus T,Wyse DG

    更新日期:2000-08-15 00:00:00

  • Comparative effects of nitroglycerin, nifedipine and metoprolol on regional left ventricular function in patients with one-vessel coronary disease.

    abstract::To compare acute effects of nitroglycerin (0.8 mg sublingually), nifedipine (5 ng/kg/min i.v.) and metoprolol (0.15 mg/kg i.v.) on normal, ischemic and scarred myocardial segments in man, we performed simultaneous hemodynamic and radionuclide measurements of left ventricular functions. Sixteen patients with isolated l...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Pfisterer M,Glaus L,Burkart F

    更新日期:1983-02-01 00:00:00

  • Epidemiology and cause-specific outcome of hypertrophic cardiomyopathy in children: findings from the Pediatric Cardiomyopathy Registry.

    abstract:BACKGROUND:Current information on the epidemiology and outcomes of hypertrophic cardiomyopathy (HCM) in children is limited by disease diversity and small case series. METHODS AND RESULTS:The Pediatric Cardiomyopathy Registry has collected prospective and retrospective data on children diagnosed with HCM since 1990. W...


    pub_type: 杂志文章


    authors: Colan SD,Lipshultz SE,Lowe AM,Sleeper LA,Messere J,Cox GF,Lurie PR,Orav EJ,Towbin JA

    更新日期:2007-02-13 00:00:00

  • Mitochondrial Dysfunction in Heart Failure With Preserved Ejection Fraction.

    abstract::Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with an increasingly recognized heterogeneity in pathophysiology. Exercise intolerance is the hallmark of HFpEF and appears to be caused by both cardiac and peripheral abnormalities in the arterial tree and skeletal muscle. Mitochondrial abno...


    pub_type: 杂志文章,评审


    authors: Kumar AA,Kelly DP,Chirinos JA

    更新日期:2019-03-12 00:00:00

  • Vein graft stenosis and the heparin responsiveness of human vascular smooth muscle cells.

    abstract:BACKGROUND:Vascular smooth muscle cell (VMSC) proliferation is an essential component of myointimal hyperplasia, which is implicated in the failure of 30% to 50% of vascular interventions, such as coronary angioplasty and peripheral vein grafting. We have shown that cells derived from stenotic lesions in infrainguinal ...


    pub_type: 杂志文章


    authors: Refson JS,Schachter M,Patel MK,Hughes AD,Munro E,Chan P,Wolfe JH,Sever PS

    更新日期:1998-06-30 00:00:00

  • Apoptosis induced by inhibition of cyclic AMP response element-binding protein in vascular smooth muscle cells.

    abstract:BACKGROUND:The balance between apoptosis and proliferation of vascular smooth muscle cells (VSMCs) is believed to contribute to the vascular remodeling process. Cyclic AMP response element-binding protein (CREB) is a critical transcription factor for the survival of neuronal cells and T lymphocytes. However, the role o...


    pub_type: 杂志文章


    authors: Tokunou T,Shibata R,Kai H,Ichiki T,Morisaki T,Fukuyama K,Ono H,Iino N,Masuda S,Shimokawa H,Egashira K,Imaizumi T,Takeshita A

    更新日期:2003-09-09 00:00:00