Regional left ventricular systolic function in humans during off-pump coronary bypass surgery.

abstract：BACKGROUND:Low endothelial shear stress (ESS) promotes the development of atherosclerosis; however, its role in the progression of atherosclerotic plaques and evolution to inflamed high-risk plaques has not been studied. Our hypothesis was that the lowest values of ESS are responsible for the development of high-risk c...

journal_title：Circulation

authors： Chatzizisis YS,Jonas M,Coskun AU,Beigel R,Stone BV,Maynard C,Gerrity RG,Daley W,Rogers C,Edelman ER,Feldman CL,Stone PH

更新日期：2008-02-26 00:00:00

abstract：BACKGROUND:In the past few years, although significant efforts have been made to assess flow distribution during retrograde cerebral perfusion with microspheres, dye, or hydrogen clearance, flow distribution in real time is still undefined. We used MR perfusion imaging to monitor flow distribution in the brain during a...

journal_title：Circulation

authors： Ye J,Ryner LN,Kozlowski P,Yang L,Del Bigio MR,Sun J,Donnelly M,Summers R,Salerno TA,Somorjai RL,Saunders JK,Deslauriers R

更新日期：1998-11-10 00:00:00

abstract：BACKGROUND:The renin-angiotensin system (RAS) is a key player in the progression of heart failure. Angiotensin-(1-7) is thought to modulate the activity of the RAS. Furthermore, this peptide may play a part in the beneficial effects of angiotensin-converting enzyme inhibitors in cardiovascular disease. We assessed the ...

journal_title：Circulation

authors： Loot AE,Roks AJ,Henning RH,Tio RA,Suurmeijer AJ,Boomsma F,van Gilst WH

更新日期：2002-04-02 00:00:00

abstract：BACKGROUND:Peroxisome proliferator-activated receptor gamma (PPARgamma) activators, such as troglitazone (Tro), not only improve insulin resistance but also suppress the neointimal formation after balloon injury. However, the precise mechanisms have not been determined. Angiotensin II (Ang II) plays crucial roles in th...

journal_title：Circulation

authors： Takeda K,Ichiki T,Tokunou T,Funakoshi Y,Iino N,Hirano K,Kanaide H,Takeshita A

更新日期：2000-10-10 00:00:00

abstract：BACKGROUND:Platelet-thrombus formation is a complication of arterial wall deep injury by balloon angioplasty that may lead to acute arterial occlusion and may contribute to restenosis. METHODS AND RESULTS:Because common platelet-inhibitor drugs with a heparin bolus (100 units/kg) may be effective in inhibiting platele...

journal_title：Circulation

authors： Lam JY,Chesebro JH,Steele PM,Heras M,Webster MW,Badimon L,Fuster V

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:An effect of diet in determining blood pressure is suggested by epidemiological studies, but the role of specific nutrients is still unsettled. METHODS AND RESULTS:The relation of various nutritional factors with hypertension was examined prospectively among 30,681 predominantly white US male health profess...

journal_title：Circulation

authors： Ascherio A,Rimm EB,Giovannucci EL,Colditz GA,Rosner B,Willett WC,Sacks F,Stampfer MJ

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:The long-term outcomes of off-pump coronary artery bypass grafting (CABG) are the subject of speculation. Our institution has >15 years of experience performing CABG both off-pump (OPCAB) and on cardiopulmonary bypass (CPB). Our null hypothesis was that there would be no difference in a long-term composite o...

journal_title：Circulation

authors： Kirmani BH,Holmes MV,Muir AD

更新日期：2016-10-25 00:00:00

abstract：:The results of coronary bypass 5-10 years after operation at the Baylor College of Medicine are reported. The late results demonstrate that good relief of symptoms of angina pectoris persisted in 89% of patients at 10 years of follow-up. An overall annual attrition rate of 3% has been fairly constant through 10 years ...

journal_title：Circulation

authors： Lawrie GM,Morris GC Jr

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:We hypothesized that 1) endogenous adenosine released during ischemia conferred an inherent cardioprotection, and 2) a pretreatment dose of adenosine before ischemia would provide additional protection independent of hemodynamic effects. METHODS AND RESULTS:Thirty-six anesthetized New Zealand White rabbits ...

journal_title：Circulation

authors： Toombs CF,McGee S,Johnston WE,Vinten-Johansen J

更新日期：1992-09-01 00:00:00

abstract：:To compare angiographically-determined coronary artery disease in diabetic patients with controls, 1,653 patients coming to cardiac catheterization were reviewed retrospectively to find 37 diabetic and 79 control patients matched for sex, age (+/- 3 years), and risk factors (hypertension, hyperlipidemia, and smoking)....

journal_title：Circulation

authors： Dortimer AC,Shenoy PN,Shiroff RA,Leaman DM,Babb JD,Liedtke AJ,Zelis R

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:Clinical trials have demonstrated that platelet glycoprotein (GP) IIb/IIIa antagonists effectively prevent acute thrombotic events. Orally active GP IIb/IIIa antagonists are essential to evaluate the clinical benefit of long-term treatment. We therefore investigated platelet inhibition by the GP IIb/IIIa ant...

journal_title：Circulation

authors： Müller TH,Weisenberger H,Brickl R,Narjes H,Himmelsbach F,Krause J

更新日期：1997-08-19 00:00:00

abstract：BACKGROUND:Cellular transplantation is emerging as a promising strategy for the treatment of postinfarction ventricular dysfunction. Whether its beneficial effects can be extended to other cardiomyopathies remains an unexplored question. We evaluated the histological and functional effects of simultaneous autologous tr...

journal_title：Circulation

authors： Guarita-Souza LC,Carvalho KA,Woitowicz V,Rebelatto C,Senegaglia A,Hansen P,Miyague N,Francisco JC,Olandoski M,Faria-Neto JR,Brofman P

更新日期：2006-07-04 00:00:00

abstract：BACKGROUND:Adenosine acutely reconnects pulmonary veins (PVs) after radiofrequency application, revealing "dormant conduction" and identifying PVs at risk of reconnection, but the underlying mechanisms are unknown. METHODS AND RESULTS:Canine PV and left-atrial (LA) action potentials were recorded with standard microel...

journal_title：Circulation

authors： Datino T,Macle L,Qi XY,Maguy A,Comtois P,Chartier D,Guerra PG,Arenal A,Fernández-Avilés F,Nattel S

更新日期：2010-03-02 00:00:00

abstract：:The status of radioactive tracer studies in cardiovascular diagnosis is summarized. Planning guidelines are suggested for a hospital nuclear medical service including a central nuclear medical facility and satellite units, and resource criteria are given for professional personnel including training and duties, equipm...

journal_title：Circulation

authors： Adelstein SJ,Jansen C,Wagner HN Jr

更新日期：1975-07-01 00:00:00

abstract：BACKGROUND:The Jun family of activator protein 1 (AP-1) transcription factors (c-Jun, JunB, and JunD) is involved in fundamental biological processes such as proliferation, apoptosis, tumor angiogenesis, and hypertrophy. The role of individual AP-1 transcription factors in the stressed heart is not clear. In the presen...

journal_title：Circulation

authors： Hilfiker-Kleiner D,Hilfiker A,Kaminski K,Schaefer A,Park JK,Michel K,Quint A,Yaniv M,Weitzman JB,Drexler H

更新日期：2005-09-06 00:00:00

abstract：BACKGROUND:Autosomal dominant hypercholesterolemia (ADH) is characterized by elevated low-density lipoprotein cholesterol levels and premature cardiovascular disease. Mutations in the genes encoding for low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB), and proprotein convertase subtilisin/kexin 9 (PCSK9...

journal_title：Circulation

authors： van der Graaf A,Avis HJ,Kusters DM,Vissers MN,Hutten BA,Defesche JC,Huijgen R,Fouchier SW,Wijburg FA,Kastelein JJ,Wiegman A

更新日期：2011-03-22 00:00:00

abstract：BACKGROUND:Several mechanisms have been advanced to explain Mobitz type II atrioventricular block in the ischemically damaged His-Purkinje system. Only recently, however, has an animal model been developed to study this form of conduction defect in vivo and in vitro. METHODS AND RESULTS:Conduction defects were induced...

journal_title：Circulation

authors： Gonzalez MD,Scherlag BJ,Mabo P,Lazzara R

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Demonstration and quantification of site-specific intracoronary administration of compounds has been confined thus far to the experimental animal laboratory. The aim of this study was to describe a scintigraphic method to demonstrate site-specific intracoronary drug delivery in humans. The methods allow on-l...

journal_title：Circulation

authors： Camenzind E,Bakker WH,Reijs A,van Geijlswijk IM,Boersma E,Kutryk MJ,Krenning EP,Roelandt JR,Serruys PW

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:In this study, we both investigated coronary flow velocity in hypertrophic obstructive cardiomyopathy (HOCM) and tested the hypothesis of differing coronary flow reserve (CFR) of coronary arteries perfusing left ventricular regions with nonuniform myocardial hypertrophy by measuring the relative CFR. METHOD...

journal_title：Circulation

authors： Kyriakidis MK,Dernellis JM,Androulakis AE,Kelepeshis GA,Barbetseas J,Anastasakis AN,Trikas AG,Tentolouris CA,Gialafos JE,Toutouzas PK

更新日期：1997-08-05 00:00:00

abstract：BACKGROUND:Intravascular irradiation with beta-emitters has been proposed for inhibition of restenosis in coronary arteries after balloon angioplasty or stent implantation. Previous studies have shown the effectiveness of gamma-radiation to prevent recurrent restenosis, even in the presence of an implanted stent. The l...

journal_title：Circulation

authors： Amols HI,Trichter F,Weinberger J

更新日期：1998-11-10 00:00:00

abstract：:To assess the impact of operative reduction of left ventricular outflow obstruction in hypertrophic cardiomyopathy, measurements of great cardiac vein flow, oxygen and lactate content, left ventricular pressures, and cardiac index were measured at rest and during pacing stress in 20 consecutive patients (13, myotomy-m...

journal_title：Circulation

authors： Cannon RO 3rd,McIntosh CL,Schenke WH,Maron BJ,Bonow RO,Epstein SE

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Fortilin, a recently characterized nuclear antiapoptotic factor structurally distinct from inhibitor of apoptosis proteins (IAPs) and Bcl-2 family member proteins, has been suggested to be involved in cell survival and regulation of apoptosis within the cardiovascular system. In this continued investigation,...

journal_title：Circulation

authors： Tulis DA,Mnjoyan ZH,Schiesser RL,Shelat HS,Evans AJ,Zoldhelyi P,Fujise K

更新日期：2003-01-07 00:00:00

abstract：BACKGROUND:The causes of metabolic syndrome (MS), which may be a precursor of coronary disease, are uncertain. We hypothesize that disturbances in neuroendocrine and cardiac autonomic activity (CAA) contribute to development of MS. We examine reversibility and the power of psychosocial and behavioral factors to explain...

journal_title：Circulation

authors： Brunner EJ,Hemingway H,Walker BR,Page M,Clarke P,Juneja M,Shipley MJ,Kumari M,Andrew R,Seckl JR,Papadopoulos A,Checkley S,Rumley A,Lowe GD,Stansfeld SA,Marmot MG

更新日期：2002-11-19 00:00:00

abstract：:From 1962-1977, 99 patients, mean age 65 +/- 0.5 years (range 60-81 years) underwent valve replacement for severe calcific aortic valve stenosis. Ninety-three percent of the patients were in New York Heart Association functional class III or IV. The aortic valve gradient was 76 +/- 3 mm Hg and the aortic valve area in...

journal_title：Circulation

authors： Murphy ES,Lawson RM,Starr A,Rahimtoola SH

更新日期：1981-08-01 00:00:00

abstract：BACKGROUND:Vascular injury and atherothrombosis involve vessel infiltration by inflammatory leukocytes, migration of medial vascular smooth muscle cells to the intimal layer, and ultimately acute thrombosis. A strategy to simultaneously target these pathological processes has yet to be identified. The secreted protein,...

journal_title：Circulation

authors： Patel S,Huang YW,Reheman A,Pluthero FG,Chaturvedi S,Mukovozov IM,Tole S,Liu GY,Li L,Durocher Y,Ni H,Kahr WH,Robinson LA

更新日期：2012-09-11 00:00:00

abstract：BACKGROUND:Associations of obesity with incidence of heart failure have been observed, but the causality is uncertain. We hypothesized that gastric bypass surgery leads to a lower incidence of heart failure compared with intensive lifestyle modification in obese people. METHODS:We included obese people without previou...

journal_title：Circulation

authors： Sundström J,Bruze G,Ottosson J,Marcus C,Näslund I,Neovius M

更新日期：2017-04-25 00:00:00

abstract：BACKGROUND:Adults with obesity or type 2 diabetes mellitus (T2DM) are at higher risk for stroke and myocardial infarction. Increased carotid intima-media thickness (cIMT) and stiffness are associated with these adverse outcomes. We compared carotid arteries in youth who were lean, were obese, or had T2DM. METHODS AND ...

journal_title：Circulation

authors： Urbina EM,Kimball TR,McCoy CE,Khoury PR,Daniels SR,Dolan LM

更新日期：2009-06-09 00:00:00

abstract：:Thirty patients with triple-vessel coronary artery disease proven by angiography, symptomatic angina and a positive ECG stress test were evaluated with thallium-201 (201TI) scintigraphy. Twenty patients also had aortocoronary saphenous vein bypass surgery; 15 of them had repeat noninvasive evaluation. Seventy percent ...

journal_title：Circulation

authors： Leppo J,Yipintsoi T,Blankstein R,Bontemps R,Freeman LM,Zohman L,Scheuer J

更新日期：1979-04-01 00:00:00

abstract：BACKGROUND:To further evaluate the mechanism of beta-blocker-induced benefits in heart failure, the relationships between bisoprolol-induced hemodynamic effects and survival were studied during the Cardiac Insufficiency BIsoprolol Study (CIBIS). METHODS AND RESULTS:In 557 patients studied, bisoprolol significantly red...

journal_title：Circulation

authors： Lechat P,Escolano S,Golmard JL,Lardoux H,Witchitz S,Henneman JA,Maisch B,Hetzel M,Jaillon P,Boissel JP,Mallet A

更新日期：1997-10-07 00:00:00

abstract：BACKGROUND:Defining the arrhythmogenic substrate is essential for successful ablation of scar-related ventricular tachycardia. The visual characteristics of endocardial ischemic scar have not been described in vivo. The goal of this study was (1) to quantify the visual characteristics of normal tissue, scar border zone...

journal_title：Circulation

authors： Betensky BP,Jauregui M,Campos B,Michele J,Marchlinski FE,Oley L,Wylie B,Robinson D,Gerstenfeld EP

更新日期：2012-10-23 00:00:00