Molecular basis of autosomal dominant hypercholesterolemia: assessment in a large cohort of hypercholesterolemic children.

abstract：BACKGROUND:Left ventricular (LV) reconstruction surgery leads to early improvement in LV function in ischemic cardiomyopathy (ICM) patients. This study was designed to evaluate the impact of mitral valve (MV) repair associated with LV reconstruction on LV function 1-year after surgery in ICM patients assessed by real-t...

journal_title：Circulation

authors： Qin JX,Shiota T,McCarthy PM,Asher CR,Hail M,Agler DA,Popović ZB,Greenberg NL,Smedira NG,Starling RC,Young JB,Thomas JD

更新日期：2003-09-09 00:00:00

abstract：BACKGROUND:To explore roles of endogenous atrial natriuretic peptide (ANP) in blood pressure and volume regulation, we examined the effects of a newly developed ANP antagonist, HS-142-1 (HS) in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. METHODS AND RESULTS:We examined 1) the effects of HS on ANP- or br...

journal_title：Circulation

authors： Hirata Y,Matsuoka H,Suzuki E,Hayakawa H,Sugimoto T,Matsuda Y,Morishita Y,Kangawa K,Minamino N,Matsuo H

更新日期：1993-02-01 00:00:00

abstract：:To determine whether alteration of intrinsic myocardial stiffness is responsible for the reduction of left ventricular filling pressure and volume by nifedipine in patients with impaired baseline ventricular function, we evaluated the hemodynamic responses in 32 patients undergoing diagnostic cardiac catheterization. ...

journal_title：Circulation

authors： Kurnik PB,Courtois MR,Ludbrook PA

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:An association of chronic Chlamydia pneumoniae infection to coronary heart disease has been suggested recently. In a recent study, we demonstrated circulating immune complexes containing chlamydial genus-specific lipopolysaccharide in patients with coronary heart disease. The objective of the present study w...

journal_title：Circulation

authors： Linnanmäki E,Leinonen M,Mattila K,Nieminen MS,Valtonen V,Saikku P

更新日期：1993-04-01 00:00:00

abstract：:Although evidence suggests that primary percutaneous coronary intervention (PCI) is the preferred reperfusion strategy in the majority of patients with ST-segment-elevation myocardial infarction (STEMI), only a minority of patients with STEMI are treated with primary PCI, and of those, only a minority receive the trea...

journal_title：Circulation

authors： Jacobs AK,Antman EM,Ellrodt G,Faxon DP,Gregory T,Mensah GA,Moyer P,Ornato J,Peterson ED,Sadwin L,Smith SC,American Heart Association's Acute Myocardial Infarction Advisory Working Group.

更新日期：2006-05-02 00:00:00

abstract：BACKGROUND:High-density lipoproteins have antidiabetic properties in vitro. Furthermore, elevated high-density lipoprotein levels accompanying a genetic deficiency of cholesteryl ester transfer protein are associated with decreased levels of plasma glucose. We now investigate effects on glucose homeostasis of inhibitin...

journal_title：Circulation

authors： Barter PJ,Rye KA,Tardif JC,Waters DD,Boekholdt SM,Breazna A,Kastelein JJ

更新日期：2011-08-02 00:00:00

abstract：BACKGROUND:Postprandial angina pectoris has been recognized for more than two centuries and can be identified in up to 10% of patients with chronic ischemic heart disease. Redistribution of myocardial blood flow, from a region supplied by a severely stenotic coronary artery to those supplied by less diseased or normal ...

journal_title：Circulation

authors： Baliga RR,Rosen SD,Camici PG,Kooner JS

更新日期：1998-03-31 00:00:00

abstract：:Real-time cross-sectional echocardiographic studies of the main coronary arteries were performed in 20 normal subjects, 12 patients with patent ductus arteriosus and 14 patients with coronary artery fistula in whom the diagnosis was established by angiography. In 12 patients, the coronary artery that formed the fistul...

journal_title：Circulation

authors： Yoshikawa J,Katao H,Yanagihara K,Takagi Y,Okumachi F,Yoshida K,Tomita Y,Fukaya T,Baba K

更新日期：1982-03-01 00:00:00

abstract：BACKGROUND:The individual makeup of atherosclerotic plaque has been identified as a dominant prognostic factor. With the use of an intravascular magnetic resonance (MR) catheter coil, we evaluated the effectiveness of high-resolution MR in the study of the development of atherosclerotic lesions in heritable hyperlipide...

journal_title：Circulation

authors： Zimmermann-Paul GG,Quick HH,Vogt P,von Schulthess GK,Kling D,Debatin JF

更新日期：1999-03-02 00:00:00

abstract：BACKGROUND:Coronary artery bypass surgery (CABG) has been associated with a range of neurological and neuropsychological complications from stroke to cognitive problems such as memory and problem solving disturbance. However, little is known about the impact of percutaneous coronary intervention (PCI) on neuropsycholog...

journal_title：Circulation

authors： Währborg P,Booth JE,Clayton T,Nugara F,Pepper J,Weintraub WS,Sigwart U,Stables RH,SoS Neuropsychology Substudy Investigators.

更新日期：2004-11-30 00:00:00

abstract：BACKGROUND:Although clopidogrel is used to prevent subacute stent thrombosis, its safety and efficacy have not been compared with ticlopidine in a randomized manner in the United States. METHODS AND RESULTS:Patients with successful intracoronary stent implantation were randomly assigned to therapy with ticlopidine or ...

journal_title：Circulation

authors： Taniuchi M,Kurz HI,Lasala JM

更新日期：2001-07-31 00:00:00

abstract：:In a double-blind randomized trial involving five Sydney hospitals and the city ambulance paramedical service, 145 patients with a first evolving myocardial infarction and with onset of pain less than 2.5 (mean 1.9 +/- 0.5 [SD]) hr previously were allocated to intravenous infusion of 100 mg recombinant tissue-type pla...

journal_title：Circulation

authors： O'Rourke M,Baron D,Keogh A,Kelly R,Nelson G,Barnes C,Raftos J,Graham K,Hillman K,Newman H

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND:Although it has been suggested that elevation of CK-MB after percutaneous coronary intervention is associated with adverse clinical outcomes, limited data are available in the setting of coronary bypass grafting. The aim of the present study was to determine the incidence, predictors, and prognostic signific...

journal_title：Circulation

authors： Costa MA,Carere RG,Lichtenstein SV,Foley DP,de Valk V,Lindenboom W,Roose PC,van Geldorp TR,Macaya C,Castanon JL,Fernandez-Avilèz F,Gonzáles JH,Heyer G,Unger F,Serruys PW

更新日期：2001-11-27 00:00:00

abstract：:Nine patients with severe mitral disease were studied before and six months after mitral valve replacement with a three-cusp stented prosthesis using fresh autologous fascia lata tissue. Only patients in whom there was no auscultatory and angiographic evidence of incompetence of the replaced valve were selected for re...

journal_title：Circulation

authors： Taylor SH,Galvin MC,Pakrashi BC,Tulpule AT,Ionescu MI,Whitaker W

更新日期：1975-11-01 00:00:00

abstract：:Background- Cardiovagal baroreflex sensitivity (BRS) declines with age but is favorably modulated by habitual aerobic exercise. We tested the hypothesis that compliance (transducing capacity) of an elastic artery in which baroreceptors are located is associated with these age-exercise interactions. Methods and Results...

journal_title：Circulation

authors： Monahan KD,Tanaka H,Dinenno FA,Seals DR

更新日期：2001-10-02 00:00:00

abstract：BACKGROUND:In the Basel Antiarrhythmic Study of Infarct Survival trial, low-dose amiodarone improved 1-year survival in patients with asymptomatic complex ventricular arrhythmias persisting 2 weeks after myocardial infarction. To assess whether this beneficial effect persisted despite discontinuation of amiodarone afte...

journal_title：Circulation

authors： Pfisterer ME,Kiowski W,Brunner H,Burckhardt D,Burkart F

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:The outcome of aortic valve replacement in patients with severe aortic stenosis, low transvalvular gradient, and severe left ventricular dysfunction is not well known. METHODS AND RESULTS:Between 1985 and 1995, 52 patients with left ventricular ejection fraction (EF) < or =35% and aortic stenosis with trans...

journal_title：Circulation

authors： Connolly HM,Oh JK,Schaff HV,Roger VL,Osborn SL,Hodge DO,Tajik AJ

更新日期：2000-04-25 00:00:00

abstract：BACKGROUND:Proliferation of smooth muscle cells (SMCs) plays an important role in vascular pathobiology, being involved in the development of coronary restenosis and atherosclerosis. The activation of nuclear proto-oncogenes appears to be a final common pathway onto which various mitogenic signals coverage. Accordingly...

journal_title：Circulation

authors： Shi Y,Hutchinson HG,Hall DJ,Zalewski A

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Adenosine acutely reconnects pulmonary veins (PVs) after radiofrequency application, revealing "dormant conduction" and identifying PVs at risk of reconnection, but the underlying mechanisms are unknown. METHODS AND RESULTS:Canine PV and left-atrial (LA) action potentials were recorded with standard microel...

journal_title：Circulation

authors： Datino T,Macle L,Qi XY,Maguy A,Comtois P,Chartier D,Guerra PG,Arenal A,Fernández-Avilés F,Nattel S

更新日期：2010-03-02 00:00:00

abstract：BACKGROUND:We have previously shown major differences in beta-adrenergic and muscarinic modulation of L-type calcium currents (ICa) in newborn and adult rabbit heart. However, little is known about developmental changes in modulation of ICa by phosphodiesterases (PDEs), which also regulate intracellular cAMP concentrat...

journal_title：Circulation

authors： Akita T,Joyner RW,Lu C,Kumar R,Hartzell HC

更新日期：1994-07-01 00:00:00

abstract：:Long-term clinical and laboratory findings in three children who required mitral valve replacement below age four years are reported. In each instance a second valve replacement was necessary approximately 8 1/2 years after the initial one, following a two and one-half fold increase in body weight. Inadequate mitral v...

journal_title：Circulation

authors： Friedman S,Edmunds LH Jr,Cuaso CC

更新日期：1978-05-01 00:00:00

abstract：:This study describes the efficacy of the right gastroepiploic artery (GEA) as graft material for coronary artery bypass grafting (CABG) as assessed by exercise thallium 201 myocardial scintigraphy in eight patients (age, 59.4 +/- 9.35 years [mean +/- SD]) who underwent CABG with the GEA graft in the past 2 years. Plan...

journal_title：Circulation

authors： Kusukawa J,Hirota Y,Kawamura K,Suma H,Takeuchi A,Adachi I,Akagi H

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:Patients with prior atherosclerosis in 1 or more vascular territories (coronary, cerebrovascular, or peripheral arterial) who present with acute coronary syndromes have high cardiovascular risk and may benefit significantly from evidence-based therapies, yet whether these are used consistently is unknown. M...

journal_title：Circulation

authors： Brilakis ES,Hernandez AF,Dai D,Peterson ED,Banerjee S,Fonarow GC,Cannon CP,Bhatt DL

更新日期：2009-08-18 00:00:00

abstract：:Cardiac output and pressure-flow measurements were made in left internal mammary artery-to-left anterior descending coronary artery grafts and left subclavian artery-to-left circumflex coronary artery vein grafts after proximal coronary artery ligation. Similar measurements were also made in left internal mammary arte...

journal_title：Circulation

authors： McCormick JR,Kaneko M,Baue AE,Geha AS

更新日期：1975-08-01 00:00:00

abstract：:The benefit of cholesterol-lowering therapy in the prevention of coronary heart disease (CHD) is well established. The secondary prevention Scandinavian Simvastatin Survival Study (4S) and the primary prevention West of Scotland Coronary Prevention Study (WOSCOPS) demonstrated that lipid lowering with a statin can dra...

journal_title：Circulation

authors： Gotto AM Jr,Grundy SM

更新日期：1999-03-02 00:00:00

abstract：BACKGROUND:Tenascin is a large extracellular matrix glycoprotein generally found in adult tissues undergoing active remodeling such as healing wounds and tumors. To determine the potential role of tenascin-C (TN-C) in the pathophysiology of atherosclerosis, we investigated the pattern of expression of TN-C in human cor...

journal_title：Circulation

authors： Wallner K,Li C,Shah PK,Fishbein MC,Forrester JS,Kaul S,Sharifi BG

更新日期：1999-03-16 00:00:00

abstract：BACKGROUND:Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used to treat cardiogenic shock. However, VA-ECMO might hamper myocardial recovery. The Impella unloads the left ventricle. This study aimed to evaluate whether left ventricular unloading in patients with cardiogenic shock treated wit...

journal_title：Circulation

authors： Schrage B,Becher PM,Bernhardt A,Bezerra H,Blankenberg S,Brunner S,Colson P,Cudemus Deseda G,Dabboura S,Eckner D,Eden M,Eitel I,Frank D,Frey N,Funamoto M,Goßling A,Graf T,Hagl C,Kirchhof P,Kupka D,Landmesser U,Li

更新日期：2020-12-01 00:00:00

abstract：:Absence of continuity between the heart and the pulmonary arteries has the potential for total correction. When the pulmonary arteries are narrow, a palliative first stage systemic-pulmonary arterial anastomosis serves to enlarge the pulmonary arteries so that, with time, they become of adequate caliber for total corr...

journal_title：Circulation

authors： Todd EP,Lindsay WG,Edwards JE

更新日期：1976-11-01 00:00:00

abstract：BACKGROUND:Repeated brief episodes of myocardial ischemia performed by mechanical clamping of a coronary artery "precondition" the heart and reduce infarct size after a subsequent sustained ischemia. It is not known, however, whether spontaneous episodes of transient ischemia caused by formation of platelet thrombi, wh...

journal_title：Circulation

authors： Ovize M,Kloner RA,Hale SL,Przyklenk K

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND:Optimal management of acute pulmonary embolism (PE) requires medical expertise, diagnostic testing, and therapies that may not be available consistently throughout the entire week. We sought to assess whether associations exist between weekday or weekend admission and mortality and length of hospital stay fo...

journal_title：Circulation

authors： Aujesky D,Jiménez D,Mor MK,Geng M,Fine MJ,Ibrahim SA

更新日期：2009-02-24 00:00:00