Central arterial compliance is associated with age- and habitual exercise-related differences in cardiovagal baroreflex sensitivity.

abstract：BACKGROUND:Inbred mouse strains C57BL/6J (B6) and C3H/HeJ (C3H) exhibit marked differences in atherosclerosis susceptibility. We sought to determine whether the difference in atherosclerosis susceptibility resides at the level of arterial walls. METHODS AND RESULTS:Thoracic aortic segments from 8-week-old female B6 an...

journal_title：Circulation

authors： Pei H,Wang Y,Miyoshi T,Zhang Z,Matsumoto AH,Helm GA,Tellides G,Shi W

更新日期：2006-11-28 00:00:00

abstract：:Novel compounds that induce or inhibit platelet aggregation and constrict or dilate blood vessels were recently discovered. These compounds are all derivatives of arachidonic acid and include prostaglandin endoperoxides, thromboxane A2, prostaglandin E2, prostaglandin D2 and prostacyclin. Thromboxane A2 (TxA2) could b...

journal_title：Circulation

authors： Smith JB,Araki H,Lefer AM

更新日期：1980-12-01 00:00:00

abstract：BACKGROUND:Exercise echocardiography (digital cine-loop technique) and 201Tl single-photon emission computed tomography (SPECT) were performed simultaneously in 292 patients being evaluated for coronary artery disease. METHODS AND RESULTS:Pretreadmill and posttreadmill echocardiographic images of diagnostic quality we...

journal_title：Circulation

authors： Quiñones MA,Verani MS,Haichin RM,Mahmarian JJ,Suarez J,Zoghbi WA

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:It has been proposed that bone marrow-derived cells infiltrate the neointima, where they differentiate into smooth muscle (SM) cells; however, technical limitations have hindered clear identification of the lineages of bone marrow-derived "SM cell-like" cells. METHODS AND RESULTS:Using a specific antibody a...

journal_title：Circulation

authors： Iwata H,Manabe I,Fujiu K,Yamamoto T,Takeda N,Eguchi K,Furuya A,Kuro-o M,Sata M,Nagai R

更新日期：2010-11-16 00:00:00

abstract：BACKGROUND:Various measures of arterial stiffness and wave reflection have been proposed as cardiovascular risk markers. Prior studies have not assessed relations of a comprehensive panel of stiffness measures to prognosis in the community. METHODS AND RESULTS:We used proportional hazards models to analyze first-onset...

journal_title：Circulation

authors： Mitchell GF,Hwang SJ,Vasan RS,Larson MG,Pencina MJ,Hamburg NM,Vita JA,Levy D,Benjamin EJ

更新日期：2010-02-02 00:00:00

abstract：BACKGROUND:Aerobic power declines with age. The degree to which this decline is reversible remains unclear. In a 30-year longitudinal follow-up study, the cardiovascular adaptations to exercise training in 5 middle-aged men previously trained in 1966 were evaluated to assess the degree to which the age-associated decli...

journal_title：Circulation

authors： McGuire DK,Levine BD,Williamson JW,Snell PG,Blomqvist CG,Saltin B,Mitchell JH

更新日期：2001-09-18 00:00:00

abstract：BACKGROUND:As part of the Worcester Heart Attack Study, a community-wide study examining changes over time in the incidence and long-term case-fatality rates of greater Worcester, Mass, residents hospitalized with confirmed acute myocardial infarction (AMI), we investigated the hypothesis that census tract-level socioe...

journal_title：Circulation

authors： Tonne C,Schwartz J,Mittleman M,Melly S,Suh H,Goldberg R

更新日期：2005-06-14 00:00:00

abstract：BACKGROUND:Functional benefit in heart failure due to idiopathic dilated cardiomyopathy has been observed after beta-blockade, but improvement in survival has not been established in a large-scale randomized trial. This was the main objective of the Cardiac Insufficiency Bisoprolol Study (CIBIS). METHODS AND RESULTS:S...

journal_title：Circulation

authors：

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:We have demonstrated that myocardial acceleration during isovolumic contraction (IVA) is a sensitive index of right ventricular contractile function. In this study, we assessed the usefulness of IVA to measure left ventricular (LV) contractile function and force-frequency relationships in an experimental pre...

journal_title：Circulation

authors： Vogel M,Cheung MM,Li J,Kristiansen SB,Schmidt MR,White PA,Sorensen K,Redington AN

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Severe obesity can result in proteinuria and progressive glomerulosclerosis in humans and experimental animals. The associated renal disease is ameliorated by weight reduction and/or blockade of the renin-angiotensin system. Various growth factors, cytokines, and lipid mediators are implicated in the pathoge...

journal_title：Circulation

authors： Xu ZG,Lanting L,Vaziri ND,Li Z,Sepassi L,Rodriguez-Iturbe B,Natarajan R

更新日期：2005-04-19 00:00:00

abstract：:BACKGROUND-Catecholamine-induced apoptosis is mediated by activation of the beta-adrenergic signaling pathway. We tested the hypothesis that beta(1)- and beta(2)-adrenergic receptor (AR) subtypes differentially affect apoptosis in adult rat ventricular myocytes in vitro. METHODS AND RESULTS-Myocytes were first exposed...

journal_title：Circulation

authors： Zaugg M,Xu W,Lucchinetti E,Shafiq SA,Jamali NZ,Siddiqui MA

更新日期：2000-07-18 00:00:00

abstract：BACKGROUND:Women have a higher operative mortality (OM) after coronary artery bypass graft (CABG) surgery than men. Suggested contributing factors have included women's increased age, advanced disease, comorbidities, and smaller body surface area (BSA). It is unclear whether women's increased risk factors fully account...

journal_title：Circulation

authors： Blankstein R,Ward RP,Arnsdorf M,Jones B,Lou YB,Pine M

更新日期：2005-08-30 00:00:00

abstract：:Between January 1, 1970, and December 31, 1974, 2981 patients underwent coronary arteriography. Twelve acute coronary dissections or embolizations occurred, an incidence of 0.4%. The incidences of acute occlusions for the Sones and Judkins techniques were 0.19% (4/2077 studies) and 0.88% (8/940), respectively. No inst...

journal_title：Circulation

authors： Guss SB,Zir LM,Garrison HB,Daggett WM,Block PC,Dinsmore RE

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND:Comprehensive data based on single-beat analysis of the ventricular activation sequence during sinus rhythm in infarcted hearts are currently not available. It was the aim of our study (1) to measure and analyze these activation sequences on the epicardial surface of the right and left ventricles and on the ...

journal_title：Circulation

authors： Hatala R,Savard P,Tremblay G,Pagé P,Cardinal R,Molin F,Kus T,Nadeau R

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Peripheral arterial disease (PAD) is associated with significant morbidity and mortality and is an important marker of subclinical coronary heart disease. However, estimates of PAD prevalence in the general US population have varied widely. METHODS AND RESULTS:We analyzed data from 2174 participants aged 40...

journal_title：Circulation

authors： Selvin E,Erlinger TP

更新日期：2004-08-10 00:00:00

abstract：:In three newborn infants with infradiaphragmatic total anomalous pulmonary venous connection, the common pulmonary vein was visualized with two-dimensional echocardiography and validated with saline contrast injections. The transducer was placed in the subcostal region in a sagittal body plane so as to image the desce...

journal_title：Circulation

authors： Snider AR,Silverman NH,Turley K,Ebert PA

更新日期：1982-11-01 00:00:00

abstract：:Body surface isochrone mapping was performed in 36 normal subjects and in 85 patients with previous myocardial infarction. Eighty-seven unipolar electrocardiograms distributed over the anterior chest and the back were recorded simultaneously. For each lead, activation time was measured as the time from the onset of QR...

journal_title：Circulation

authors： Ikeda K,Kubota I,Igarashi A,Yamaki M,Tsuiki K,Yasui S

更新日期：1985-10-01 00:00:00

abstract：:We evaluated the effects of selective activation of H1 receptors on coronary hemodynamics in 16 patients divided into two groups: group A, 11 patients with atypical angina or valvular heart disease and normal coronary arteries, and group B, five patients with spontaneous angina, four of whom had significant (greater t...

journal_title：Circulation

authors： Vigorito C,Poto S,Picotti GB,Triggiani M,Marone G

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND:Ventricular tachyarrhythmias are the major clinical manifestation of arrhythmogenic right ventricular disease. Although antiarrhythmic therapy has been widely advocated, there is only limited information available on the efficacy of antiarrhythmic drugs in these patients. METHODS AND RESULTS:The short- and ...

journal_title：Circulation

authors： Wichter T,Borggrefe M,Haverkamp W,Chen X,Breithardt G

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Defining the arrhythmogenic substrate is essential for successful ablation of scar-related ventricular tachycardia. The visual characteristics of endocardial ischemic scar have not been described in vivo. The goal of this study was (1) to quantify the visual characteristics of normal tissue, scar border zone...

journal_title：Circulation

authors： Betensky BP,Jauregui M,Campos B,Michele J,Marchlinski FE,Oley L,Wylie B,Robinson D,Gerstenfeld EP

更新日期：2012-10-23 00:00:00

abstract：:The electrophysiologic mechanisms for the initiation and termination of re-entrant ventricular arrhythmias (RVA) were critically analyzed in dogs 3-7 days following ligation of the anterior descending coronary artery, utilizing direct recordings of the re-entrant pathway (RP) from the epicardial surface of the infarct...

journal_title：Circulation

authors： El-Sherif N,Hope RR,Scherlag BJ,Lazzara R

更新日期：1977-05-01 00:00:00

abstract：BACKGROUND:Cardiac troponin and B-type natriuretic peptide (BNP) concentrations are associated with adverse cardiovascular outcome in primary prevention populations. Whether statin therapy modifies this association is poorly understood. METHODS AND RESULTS:We measured high-sensitivity cardiac troponin I (hsTnI) in 12 ...

journal_title：Circulation

authors： Everett BM,Zeller T,Glynn RJ,Ridker PM,Blankenberg S

更新日期：2015-05-26 00:00:00

abstract：:Coronary artery bypass grafts, angioplasty, and thrombolysis are beneficial procedures for patients with coronary artery disease. However, these procedures can fail by mechanisms related to interactions between platelets and the damaged arterial wall. An experimental model for studying some of the mechanisms of platel...

journal_title：Circulation

authors： Folts J

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Inhibition of fibrinolysis attributable to elevated concentrations of plasminogen activator inhibitor type 1 (PAI-1) in blood is associated with insulin resistance, hyperinsulinemia, and type 2 diabetes mellitus. Because we have shown that insulin can stimulate PAI-1 synthesis in vivo and because accelerated...

journal_title：Circulation

authors： Sobel BE,Woodcock-Mitchell J,Schneider DJ,Holt RE,Marutsuka K,Gold H

更新日期：1998-06-09 00:00:00

abstract：:The Persantine-Aspirin Reinfarction Study (PARIS) was a randomized, controlled, double-blind study of dipyridamole (Persantine) and aspirin in secondary prevention of coronary heart disease. Two thousand twenty-six men and women with myocardial infarction (MI) documented by electrocardiographic findings, clinical hist...

journal_title：Circulation

authors：

更新日期：1980-09-01 00:00:00

abstract：BACKGROUND:Coxsackievirus-induced myocarditis can be a serious cause of heart failure. In the absence of a specific antiviral therapy, modulating the host immune response may be protective. Interferons (IFNs)-alpha and -beta perform a fundamental role in innate and adaptive antiviral responses, thereby presenting as ca...

journal_title：Circulation

authors： Deonarain R,Cerullo D,Fuse K,Liu PP,Fish EN

更新日期：2004-12-07 00:00:00

abstract：:A prospective electrocardiographic study was designed to establish baseline values for electrocardiographic measurements, with specific reference to the QT interval during infancy, and to test the "QT hypothesis" for the sudden infant death syndrome (SIDS). In this ongoing study, ECGs are recorded on the fourth day of...

journal_title：Circulation

authors： Schwartz PJ,Montemerlo M,Facchini M,Salice P,Rosti D,Poggio G,Giorgetti R

更新日期：1982-09-01 00:00:00

abstract：:Recent studies have shown that blood flow during closed-chest cardiopulmonary resuscitation (CPR) results primarily from generalized changes in intrathoracic pressure rather than direct compression of the heart. Since ascending aortic and right atrial pressures rise and fall synchronously and to comparable levels duri...

journal_title：Circulation

authors： Ditchey RV,Winkler JV,Rhodes CA

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND:AMP-activated protein kinase (AMPK) is a stress-activated protein kinase that works as a metabolic sensor of cellular ATP levels. Here, we investigated whether AMPK signaling has a role in the regulation of the angiotensin II (Ang II)-induced proliferation signal in rat vascular smooth muscle cells (VSMCs). ...

journal_title：Circulation

authors： Nagata D,Takeda R,Sata M,Satonaka H,Suzuki E,Nagano T,Hirata Y

更新日期：2004-07-27 00:00:00

abstract：BACKGROUND:Adipocyte-derived hormones may represent a mechanism linking insulin resistance to cardiovascular disease. In the present study, we evaluated the direct effects of resistin, a novel adipocyte-derived hormone, on endothelial activation. METHODS AND RESULTS:Endothelial cells (ECs) were incubated with human re...

journal_title：Circulation

authors： Verma S,Li SH,Wang CH,Fedak PW,Li RK,Weisel RD,Mickle DA

更新日期：2003-08-12 00:00:00