Abstract:
:Although evidence suggests that primary percutaneous coronary intervention (PCI) is the preferred reperfusion strategy in the majority of patients with ST-segment-elevation myocardial infarction (STEMI), only a minority of patients with STEMI are treated with primary PCI, and of those, only a minority receive the treatment within the recommended 90 minutes after entry into the medical system. Market research conducted by the American Heart Association revealed that those involved in the care of patients with STEMI recognize the multiple barriers that prevent the prompt delivery of primary PCI and agree that it is necessary to develop systems or centers of care that will allow STEMI patients to benefit from primary PCI. The American Heart Association will convene a group of stakeholders (representing the interests of patients, physicians, emergency medical systems, community hospitals, tertiary hospitals, and payers) and quality-of-care and outcomes experts to identify the gaps between the existing and ideal delivery of care for STEMI patients, as well as the requisite policy implications. Working within a framework of guiding principles, the group will recommend strategies to increase the number of STEMI patients with timely access to primary PCI.
journal_name
Circulationjournal_title
Circulationauthors
Jacobs AK,Antman EM,Ellrodt G,Faxon DP,Gregory T,Mensah GA,Moyer P,Ornato J,Peterson ED,Sadwin L,Smith SC,American Heart Association's Acute Myocardial Infarction Advisory Working Group.doi
10.1161/CIRCULATIONAHA.106.174477subject
Has Abstractpub_date
2006-05-02 00:00:00pages
2152-63issue
17eissn
0009-7322issn
1524-4539pii
CIRCULATIONAHA.106.174477journal_volume
113pub_type
杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:The most troublesome complication of acute pericarditis is recurrent episodes of pericardial inflammation, occurring in 15% to 32% of cases. The cause of the recurrence is usually unknown, although in some cases it may be traced to viral infection or may be a consequence of coronary artery bypass grafting. T...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/01.cir.97.21.2183
更新日期:1998-06-02 00:00:00
abstract:BACKGROUND:Platelet-thrombus formation is a complication of arterial wall deep injury by balloon angioplasty that may lead to acute arterial occlusion and may contribute to restenosis. METHODS AND RESULTS:Because common platelet-inhibitor drugs with a heparin bolus (100 units/kg) may be effective in inhibiting platele...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.84.2.814
更新日期:1991-08-01 00:00:00
abstract:BACKGROUND:Recognition of rates and causes of hard, patient-centered outcomes of death and cerebrovascular events (CVEs) after heart rhythm disorder management (HRDM) procedures is an essential step for the development of quality improvement programs in electrophysiology laboratories. Our primary aim was to assess and ...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.117.030523
更新日期:2018-01-02 00:00:00
abstract:BACKGROUND:Recent data highlight a vital link between well-performed cardiopulmonary resuscitation (CPR) and survival after cardiac arrest; however, the quality of CPR as actually performed by trained healthcare providers is largely unknown. We sought to measure in-hospital chest compression rates and to determine comp...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/01.CIR.0000153811.84257.59
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:Cardiopulmonary bypass (CPB) induces an inflammatory reaction that activates neutrophils and releases free radicals in tissue. Ischemia-reperfusion further aggravates inflammation. Hemofiltration (HF) could potentially remove inflammatory mediators and reduce injury. This study assessed the effect of continu...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1998-11-10 00:00:00
abstract:BACKGROUND:The Lewis-F344 rat cardiac transplantation model produces cardiac allografts with chronic rejection characterized by arteriosclerotic lesions composed of macrophages and smooth muscle cells. Modulation of the inflammatory response with a diet deficient in essential fatty acids protects against the developmen...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.92.3.457
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:Fixed-dose unmonitored treatment with dabigatran etexilate is effective and has a favorable safety profile in the prevention of stroke in atrial fibrillation patients compared with warfarin. We hypothesized that genetic variants could contribute to interindividual variability in blood concentrations of the a...
journal_title:Circulation
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCULATIONAHA.112.001233
更新日期:2013-04-02 00:00:00
abstract:BACKGROUND:Hemodynamic stability after Norwood palliation often requires manipulation of pulmonary vascular resistance to alter the pulmonary-to-systemic blood flow ratio (Qp:Qs). Qp:Qs is often estimated from arterial saturation (SaO2), a practice based on 2 untested assumptions: constant systemic arteriovenous O2 dif...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.103.22.2699
更新日期:2001-06-05 00:00:00
abstract:BACKGROUND:Previous studies have demonstrated that synchronized coronary venous retroperfusion (SRP) can restore blood flow to the ischemic myocardium, resulting in infarct size reduction and improvement of the left ventricular function. Despite the nutritive blood flow achieved by SRP being relatively limited, SRP has...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.88.5.2370
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:We developed autologous prosthetic implants by simple and safe in-body tissue architecture technology. We present the first report on the development of autologous valved conduit with the sinus of Valsalva (BIOVALVE) by using this unique technology and its subsequent implantation in the pulmonary valves in a...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.109.922211
更新日期:2010-09-14 00:00:00
abstract:BACKGROUND:A mortality follow-up of 12,866 men was conducted 16 years after randomization to special intervention (SI) or usual care (UC) groups of the Multiple Risk Factor Intervention Trial to assess the long-term effect of cardiovascular risk factor intervention on coronary heart disease (CHD), cardiovascular death ...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.94.5.946
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:The role of intracellular calcium (Ca(i)) in defibrillation and vulnerability is unclear. METHODS AND RESULTS:We simultaneously mapped epicardial membrane potential and Ca(i) during shock on T-wave episodes (n=104) and attempted defibrillation episodes (n=173) in 17 Langendorff-perfused rabbit ventricles. U...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.106.630509
更新日期:2006-12-12 00:00:00
abstract:BACKGROUND:Orally administered heparin (OHEP) is unreliable because of poor absorption. Sodium N-(8[2-hydroxybenzoyl]amino) caprylate (SNAC) is an amido acid that facilitates the gastrointestinal absorption of heparin. We evaluated the effectiveness of OHEP combined with SNAC (OHEP/SNAC) in the treatment of deep-vein t...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.101.22.2658
更新日期:2000-06-06 00:00:00
abstract:BACKGROUND:Endothelial integrity is essential for maintaining vascular homeostasis, and endothelial denudation results in neointimal thickening. Balloon-expandable endovascular stents provide a luminal scaffolding within atherosclerotic arteries with minimal direct contact between balloon and endothelium. We wondered w...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.94.11.2909
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:Fortilin, a recently characterized nuclear antiapoptotic factor structurally distinct from inhibitor of apoptosis proteins (IAPs) and Bcl-2 family member proteins, has been suggested to be involved in cell survival and regulation of apoptosis within the cardiovascular system. In this continued investigation,...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000047675.86603.eb
更新日期:2003-01-07 00:00:00
abstract:BACKGROUND:The age association of cardiovascular disease may be in part because its metabolic risk factors tend to rise with age. Few studies have analyzed age associations of multiple metabolic risks in the same population, especially in nationally representative samples. We examined worldwide variations in the age as...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.111.058834
更新日期:2012-05-08 00:00:00
abstract:BACKGROUND:Familial polymorphic ventricular tachycardia (FPVT) is characterized by exercise-induced arrhythmias and sudden cardiac death due to missense mutations in the cardiac ryanodine receptor (RyR2), an intracellular Ca2+ release channel required for excitation-contraction coupling in the heart. METHODS AND RESUL...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000132472.98675.EC
更新日期:2004-06-29 00:00:00
abstract:BACKGROUND:Alpha-linolenic acid may protect against cardiovascular disease. We examined the association between adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction (MI) in a population-based case-control study in Costa Rica. METHODS AND RESULTS:The 482 case patients with a first nonfatal acute...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000058165.81208.C6
更新日期:2003-04-01 00:00:00
abstract::Little is known of the functional capacity of coronary collaterals in humans without occlusive coronary artery disease. We, therefore, measured peripheral coronary pressure (PCP) and retrograde flow (RF) from coronary arteries at aortic valve replacement in seven patients without occlusive coronary artery disease. Usi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.51.1.118
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to determine the minimum hematocrit (Hct) supporting cerebral oxygenation over the range clinically relevant cardiopulmonary bypass (CPB) temperatures in dogs. The effect of hemodilution on cerebral blood flow (CBF), cerebral metabolic rate (CMRO2), and cerebral oxygen delivery ...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1998-11-10 00:00:00
abstract:BACKGROUND:MicroRNAs (miRs) participate in many cardiac pathophysiological processes, including ischemia/reperfusion (I/R)-induced cardiac injury. Recently, we and others observed that miR-494 was downregulated in murine I/R-injured and human infarcted hearts. However, the functional consequence of miR-494 in response ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.110.964684
更新日期:2010-09-28 00:00:00
abstract::Reperfusion of the previously ischemic myocardium is associated with the production of oxygen free radicals and their metabolites, which contribute to the ultimate extent of irreversible myocardial injury. The relative importance of polymorphonuclear leukocytes vs intracellular-derived oxygen metabolites has remained ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.73.5.1077
更新日期:1986-05-01 00:00:00
abstract:BACKGROUND:The effect of the increasing prevalence of obesity on blood pressure (BP) secular trends is unclear. We analyzed BP and body mass index secular trends between 1998 and 2006 in children and adolescents of the Seychelles, a rapidly developing island state in the African region. METHODS AND RESULTS:School-base...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.108.796276
更新日期:2009-02-03 00:00:00
abstract::To estimate the effect of distance between the electrode and the signal source on the amplitude of the His bundle electrogram (HBE) recorded during open heart surgery, a specially designed probe, containing six pairs of closely spaced (1 mm) electrodes was placed on the endocardial surface of the right atrium such tha...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.53.2.224
更新日期:1976-02-01 00:00:00
abstract:BACKGROUND:Proposed advantages to the Ross procedure included presumed increased freedom from reoperation and simpler reoperation for pulmonary conduit replacement if needed. It is increasingly apparent, however, that reoperations are frequent after the Ross procedure and that when required, they may be more complex th...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.109.897538
更新日期:2010-09-21 00:00:00
abstract::The significance of the direction of the ST-segment shifts on the 12-lead electrocardiogram was evaluated in 82 consecutive patients with unstable angina. Eighteen patients with ST-segment elevation (group I) were compared with 64 patients with ST-segment depression (group II). There was no difference between group I ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.51.6.1015
更新日期:1975-06-01 00:00:00
abstract::Two hundred forty-five patients with variant angina were followed for an average of 80.5 months (range, 36-184 months). Survival rate at 1, 3, 5, and 10 years was 98%, 97%, 97%, and 93%, respectively. Survival rate without myocardial infarction at 1, 3, 5, and 10 years was 86%, 85%, 83%, and 81%, respectively. By univ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.78.1.1
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND:Previous studies suggest that the antifibrillatory action of class I and III drugs is due to prolongation of the atrial wavelength. The aim of the present study was to directly evaluate the electrophysiological action of antifibrillatory drugs in a goat model of chronic atrial fibrillation (AF). METHODS AND...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.2.260
更新日期:2000-07-11 00:00:00
abstract:BACKGROUND:The treatment of unstable angina targets the specific pathophysiological thrombotic process at the site of the active culprit lesion. In unstable angina due to a restenotic lesion, smooth muscle cell proliferation and increased vasoreactivity may play a more important role than thrombus formation. Therefore,...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.101.9.955
更新日期:2000-03-07 00:00:00
abstract:BACKGROUND:In patients with neurogenic orthostatic hypotension (NOH), the availability of the sympathetic neurotransmitter norepinephrine (NE) in the synaptic cleft is insufficient to maintain blood pressure while in the standing posture. METHODS AND RESULTS:We determined the effect of oral administration of the synth...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.CIR.0000083721.49847.D7
更新日期:2003-08-12 00:00:00