Abstract:
BACKGROUND:The role of intracellular calcium (Ca(i)) in defibrillation and vulnerability is unclear. METHODS AND RESULTS:We simultaneously mapped epicardial membrane potential and Ca(i) during shock on T-wave episodes (n=104) and attempted defibrillation episodes (n=173) in 17 Langendorff-perfused rabbit ventricles. Unsuccessful and type B successful defibrillation shocks were followed by heterogeneous distribution of Ca(i), including regions of low Ca(i) surrounded by elevated Ca(i) ("Ca(i) sinkholes") 31+/-12 ms after shock. The first postshock activation then originated from the Ca(i) sinkhole 53+/-14 ms after the shock. No sinkholes were present in type A successful defibrillation. A Ca(i) sinkhole also was present 39+/-32 ms after a shock on T that induced ventricular fibrillation, followed 22+/-15 ms later by propagated wave fronts that arose from the same site. This wave propagated to form a spiral wave and initiated ventricular fibrillation. Thapsigargin and ryanodine significantly decreased the upper limit of vulnerability and defibrillation threshold. We studied an additional 7 rabbits after left ventricular endocardial cryoablation, resulting in a thin layer of surviving epicardium. Ca(i) sinkholes occurred 31+/-12 ms after the shock, followed in 19+/-7 ms by first postshock activation in 63 episodes of unsuccessful defibrillation. At the Ca(i) sinkhole, the rise of Ca(i) preceded the rise of epicardial membrane potential in 5 episodes. CONCLUSIONS:There is a heterogeneous postshock distribution of Ca(i). The first postshock activation always occurs from a Ca(i) sinkhole. The Ca(i) prefluorescence at the first postshock early site suggests that reverse excitation-contraction coupling might be responsible for the initiation of postshock activations that lead to ventricular fibrillation.
journal_name
Circulationjournal_title
Circulationauthors
Hwang GS,Hayashi H,Tang L,Ogawa M,Hernandez H,Tan AY,Li H,Karagueuzian HS,Weiss JN,Lin SF,Chen PSdoi
10.1161/CIRCULATIONAHA.106.630509subject
Has Abstractpub_date
2006-12-12 00:00:00pages
2595-603issue
24eissn
0009-7322issn
1524-4539pii
CIRCULATIONAHA.106.630509journal_volume
114pub_type
杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:The influence of changes in heart rate on myocardial contractility (the force-frequency effect) differs under various experimental conditions, including the anesthetized versus the conscious state. METHODS AND RESULTS:To assess the influence of beta-adrenergic stimulation on force-frequency effects on myoca...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.86.2.572
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:The renin-angiotensin system regulates blood pressure through its effects on vascular tone, renal hemodynamics, and renal sodium and fluid balance. METHODS AND RESULTS:Using data from a large population-based sample of 1488 siblings having a mean age of 14.8 years and belonging to the youngest generation of...
journal_title:Circulation
pub_type: 评论,杂志文章
doi:10.1161/01.cir.97.18.1773
更新日期:1998-05-12 00:00:00
abstract:BACKGROUND:Recent data from this laboratory indicate that pretreatment with adenosine can protect the heart against infarction via A1-receptors, but because of systemic hypotension, adenosine had to be given into the coronary circulation. METHODS AND RESULTS:In this study, we tested whether the protection could be ach...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.85.2.659
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:There are few studies of cardiac autonomic nervous activity (CANA) in patients with congenital heart disease. Methods and Results-We evaluated CANA in 54 patients after closure of an atrial/ventricular septal defect (group A), 54 patients after successful right ventricular outflow tract reconstruction (RVOTR...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.22.2732
更新日期:2000-11-28 00:00:00
abstract:BACKGROUND:Mitral leaflet extension (MLE) combined with septal myectomy is a new surgical approach to treat hypertrophic obstructive cardiomyopathy (HOCM) and an enlarged mitral leaflet area. The study presents the long-term clinical results and outcome of this technique. METHODS AND RESULTS:MLE entails grafting a glu...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.CIR.0000092912.57140.14
更新日期:2003-10-28 00:00:00
abstract:BACKGROUND:Cardiotoxicity is a leading cause for drug attrition during pharmaceutical development and has resulted in numerous preventable patient deaths. Incidents of adverse cardiac drug reactions are more common in patients with preexisting heart disease than the general population. Here we generated a library of hu...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.113.001883
更新日期:2013-04-23 00:00:00
abstract:BACKGROUND:Percutaneous transluminal coronary angioplasty of the infarct-related artery in stable survivors of acute myocardial infarction is often performed, even in patients without any symptoms or residual ischemia. Despite the lack of randomized studies, it is widely believed that this intervention will improve the...
journal_title:Circulation
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1161/01.CIR.0000087605.09362.0E
更新日期:2003-09-16 00:00:00
abstract::Of 1,801 patients in the 1985-1986 Percutaneous Transluminal Coronary Angioplasty (PTCA) Registry, 122 (6.8%) had periprocedural occlusion (4.9% in the catheterization laboratory, 1.9% outside the laboratory). Baseline patient factors independently associated with increased occlusion rates included triple-vessel disea...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.82.3.739
更新日期:1990-09-01 00:00:00
abstract::This study explored the association between sodium excretion and blood pressure (BP). A new method was used to minimize the measurement error introduced by the large intrinsic variability of 24-hour sodium excretion. The ratio of intra- to interindividual variation was used to estimate the number of measurements neede...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.62.1.97
更新日期:1980-07-01 00:00:00
abstract::To investigate whether a fixed external reference system should be used to most accurately describe regional left ventricular wall motion, we used vectors to analyze a simple model of ventricular contraction. If measured in a fixed external reference system, motion of implanted radiopaque midwall markers may contain t...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.65.7.1518
更新日期:1982-06-01 00:00:00
abstract:BACKGROUND:Patients with primary amyloidosis (AL type) have a poor prognosis, in part due to frequent cardiac involvement. Although intracardiac thrombus has been reported in anecdotal cases, neither its frequency nor its role in causing mortality is known. Furthermore, the clinical and echocardiographic variables that...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.107.697763
更新日期:2007-11-20 00:00:00
abstract:BACKGROUND:Although phase 2 reentry is said to be responsible for initiation of ventricular tachycardia (VT) in Brugada syndrome, information about the activation sequence during VT is limited. METHODS AND RESULTS:We developed an experimental Brugada syndrome model using a canine isolated right ventricular preparation...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000105762.94855.46
更新日期:2004-01-06 00:00:00
abstract:BACKGROUND:Bartonella species are the only known bacterial pathogens causing vasculoproliferative disorders in humans (bacillary angiomatosis [BA]). Cellular and bacterial pathogenetic mechanisms underlying the induction of BA are largely unknown. METHODS AND RESULTS:Activation of hypoxia-inducible factor-1 (HIF-1), t...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000155608.07691.B7
更新日期:2005-03-01 00:00:00
abstract::This two-part article provides an overview of the global burden of atherothrombotic cardiovascular disease. Part I initially discusses the epidemiologic transition which has resulted in a decrease in deaths in childhood due to infections, with a concomitant increase in cardiovascular and other chronic diseases; and th...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/hc4601.099487
更新日期:2001-11-27 00:00:00
abstract:BACKGROUND:In the Basel Antiarrhythmic Study of Infarct Survival trial, low-dose amiodarone improved 1-year survival in patients with asymptomatic complex ventricular arrhythmias persisting 2 weeks after myocardial infarction. To assess whether this beneficial effect persisted despite discontinuation of amiodarone afte...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.87.2.309
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:High-pressure distension during harvesting damages the saphenous vein (SV) and may contribute to subsequent coronary artery bypass graft (CABG) occlusion. Application of vasodilator agents to the SV during harvesting may reduce the need for high-pressure distension and improve graft quality. We tested the ef...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.92.9.31
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to describe the long-term event-free survival patterns of patients with significant coronary artery disease treated medically versus patterns of those treated surgically and to evaluate the factors associated with improved event-free survival. METHODS AND RESULTS:We studied the...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Oral anticoagulation (OAC) therapy is effective in atrial fibrillation but requires vigilance to maintain the international normalized ratio in the therapeutic range. This report examines how differences in time in therapeutic range (TTR) between centers and between countries affect the outcomes of OAC thera...
journal_title:Circulation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/CIRCULATIONAHA.107.750000
更新日期:2008-11-11 00:00:00
abstract:BACKGROUND:Tumor necrosis factor-alpha (TNF-alpha) and interleukin 1 (IL-1) are proximal inflammatory cytokines that stimulate expression of adhesion molecules and induce synthesis of other proinflammatory cytokines. In addition, TNF-alpha and IL-1 influence vascular smooth muscle cell migration and proliferation in vi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.14.1697
更新日期:2000-10-03 00:00:00
abstract::Originally described by Japanese authors in the 1990s, Takotsubo syndrome (TTS) generally presents as an acute myocardial infarction characterized by severe left ventricular dysfunction. TTS, however, differs from an acute coronary syndrome because patients have generally a normal coronary angiogram and left ventricul...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/CIRCULATIONAHA.116.027121
更新日期:2017-06-13 00:00:00
abstract:BACKGROUND:An effect of diet in determining blood pressure is suggested by epidemiological studies, but the role of specific nutrients is still unsettled. METHODS AND RESULTS:The relation of various nutritional factors with hypertension was examined prospectively among 30,681 predominantly white US male health profess...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.86.5.1475
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Optimal management of acute pulmonary embolism (PE) requires medical expertise, diagnostic testing, and therapies that may not be available consistently throughout the entire week. We sought to assess whether associations exist between weekday or weekend admission and mortality and length of hospital stay fo...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.108.824292
更新日期:2009-02-24 00:00:00
abstract::Valve-related complications after Björk-Shiley mitral valve implantation (n = 475), aortic valve implantation (n = 424), or mitral-aortic valve implantation (n = 119) were compared with those after St. Jude Medical mitral valve replacement (n = 173), aortic valve replacement (n = 152), or mitral-aortic valve replaceme...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1983-09-01 00:00:00
abstract:BACKGROUND:Chlamydia pneumoniae (Cp) has been demonstrated in arteries and abdominal aortic aneurysms (AAAs). However, the validity of the methods used is questioned, and antibiotic treatment trials have thus far shown disappointing results. Nevertheless, antibodies against the Cp outer membrane proteins (OMPs) have be...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000127772.58427.7E
更新日期:2004-05-04 00:00:00
abstract:BACKGROUND:It is unclear whether increased left ventricular (LV) mass in overweight individuals is related to their adiposity or to greater fat-free mass (FFM). METHODS AND RESULTS:We compared echocardiographic LV mass to FFM and adipose body mass by bioelectric impedance and to anthropometric measurements in 3107 Ame...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.98.23.2538
更新日期:1998-12-08 00:00:00
abstract:BACKGROUND:Transplantation of ex vivo expanded circulating endothelial progenitor cells (EPCs) from peripheral blood mononuclear cells improves the neovascularization after critical ischemia. However, the origin of the endothelial progenitor lineage and its characteristics have not yet been clearly defined. Therefore, ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000096483.29777.50
更新日期:2003-11-18 00:00:00
abstract:BACKGROUND:Research published in Circulation has shown that cardiac mortality is highest during December and January. We investigated whether some of this spike could be ascribed to the Christmas/New Year's holidays rather than to climatic factors. METHODS AND RESULTS:We fitted a locally weighted polynomial regression...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/01.CIR.0000151424.02045.F7
更新日期:2004-12-21 00:00:00
abstract::Three patients with total anomalous pulmonary venous drainage (TAPVD) into the innominate vein were studied by using M-mode and pulsed Doppler echocardiography. An abnormal continuous flow towards the transducer in a suprasternal notch position detected by pulsed Doppler echocardiography in the left hemithorax leftwar...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.61.4.841
更新日期:1980-04-01 00:00:00
abstract:BACKGROUND:Whether reperfusion can cause necrosis of previously viable myocytes (lethal reperfusion injury) remains controversial. Numerous studies examined the ability of various agents to prevent or limit reperfusion injury, but the results were contradictory. In a single-canine-heart model of ischemia-reperfusion, w...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.91.12.2989
更新日期:1995-06-15 00:00:00
abstract:BACKGROUND:Adrenomedullin (AM) is a vasodilating peptide involved in the regulation of circulatory homeostasis and in the pathophysiology of certain cardiovascular diseases. To determine the extent to which chronic AM overproduction affects circulatory physiology under normal and pathological conditions, we used a prep...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.101.19.2309
更新日期:2000-05-16 00:00:00