Abstract:
BACKGROUND:Recognition of rates and causes of hard, patient-centered outcomes of death and cerebrovascular events (CVEs) after heart rhythm disorder management (HRDM) procedures is an essential step for the development of quality improvement programs in electrophysiology laboratories. Our primary aim was to assess and characterize death and CVEs (stroke or transient ischemic attack) after HRDM procedures over a 17-year period. METHODS:We performed a retrospective cohort study of all patients undergoing HRDM procedures between January 2000 and November 2016 at the Mayo Clinic. Patients from all 3 tertiary academic centers (Rochester, Phoenix, and Jacksonville) were included in the study. All in-hospital deaths and CVEs after HRDM procedures were identified and were further characterized as directly or indirectly related to the HRDM procedure. Subgroup analysis of death and CVE rates was performed for ablation, device implantation, electrophysiology study, lead extraction, and defibrillation threshold testing procedures. RESULTS:A total of 48 913 patients (age, 65.7±6.6 years; 64% male) who underwent a total of 62 065 HRDM procedures were included in the study. The overall mortality and CVE rates in the cohort were 0.36% (95% confidence interval [CI], 0.31-0.42) and 0.12% (95% CI, 0.09-0.16), respectively. Patients undergoing lead extraction had the highest overall mortality rate at 1.9% (95% CI, 1.34-2.61) and CVE rate at 0.62% (95% CI, 0.32-1.07). Among patients undergoing HRDM procedures, 48% of deaths directly related to the HDRM procedure were among patients undergoing device implantation procedures. Overall, cardiac tamponade was the most frequent direct cause of death (40%), and infection was the most common indirect cause of death (29%). The overall 30-day mortality rate was 0.76%, with the highest being in lead extraction procedures (3.08%), followed by device implantation procedures (0.94%). CONCLUSIONS:Half of the deaths directly related to an HRDM procedure were among the patients undergoing device implantation procedures, with cardiac tamponade being the most common cause of death. This highlights the importance of the development of protocols for the quick identification and management of cardiac tamponade even in procedures typically believed to be lower risk such as device implantation.
journal_name
Circulationjournal_title
Circulationauthors
Lee JZ,Ling J,Diehl NN,Hodge DO,Padmanabhan D,Killu AM,Madhavan M,Noseworthy PA,Kapa S,McLeod CJ,Cha YM,Deshmukh AJ,Srivathsan K,Kusumoto FM,Shen WK,Friedman PA,Munger TM,Asirvatham SJ,Packer DL,Mulpuru SKdoi
10.1161/CIRCULATIONAHA.117.030523subject
Has Abstractpub_date
2018-01-02 00:00:00pages
24-33issue
1eissn
0009-7322issn
1524-4539pii
CIRCULATIONAHA.117.030523journal_volume
137pub_type
杂志文章,多中心研究相关文献
CIRCULATION文献大全abstract::We studied the effects of experimentally induced emotional stress (mental arithmetic) on different hemodynamic parameters, catecholamine levels, and serum and platelet function tests in 25 postinfarction patients and in 10 apparently healthy, age-matched control subjects. Mental stress (10 minutes) induced significant...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND:Mitral regurgitation (MR) due to mitral valve prolapse (MVP) is often treatable by surgical repair. However, the very long-term (>10-year) durability of repair in both anterior leaflet prolapse (AL-MVP) and posterior leaflet prolapse (PL-MVP) is unknown. METHODS AND RESULTS:In 917 patients (aged 65+/-13 yea...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/hc37t1.094903
更新日期:2001-09-18 00:00:00
abstract:BACKGROUND:Coronary heart disease (CHD) is the leading cause of morbidity and mortality in persons with type 2 diabetes mellitus (T2DM). Electron-beam computed tomography (EBCT) detects coronary artery calcium (CAC), a marker of atherosclerotic plaque. Few studies have described EBCT-defined CHD among ethnic minorities...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000146377.15057.CC
更新日期:2004-11-02 00:00:00
abstract:BACKGROUND:Apolipoprotein E (apoE) has long been known to play an important role in the clearance of plasma lipoproteins. More recently, a direct role for apoE in delaying atherogenesis has been proposed. Macrophage production of apoE in the artery wall has been demonstrated to provide protection against atheroscleroti...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.99.19.2571
更新日期:1999-05-18 00:00:00
abstract:BACKGROUND:Pulmonary hypertension is a fatal disease characterized by vasoconstriction and vascular remodeling. Loss of endothelial nitric oxide bioavailability is implicated in pulmonary hypertension pathogenesis. Recent evidence suggests that the cofactor tetrahydrobiopterin (BH4) is an important regulator of nitric ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000162470.26840.89
更新日期:2005-04-26 00:00:00
abstract:BACKGROUND:The management of asymptomatic severe mitral regurgitation remains controversial. The aim of this study was to evaluate the outcome of a watchful waiting strategy in which patients are referred to surgery when symptoms occur or when asymptomatic patients develop left ventricular (LV) enlargement, LV dysfunct...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.105.599175
更新日期:2006-05-09 00:00:00
abstract:BACKGROUND:A subgroup of patients with hypertrophic obstructive cardiomyopathy remain severely symptomatic despite optimal medical therapy. Septal myectomy reduces or eliminates left ventricular outflow obstruction and produces marked symptomatic improvement. With the recent advent of alternative methods for treatment ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.94.3.467
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:Chimeric molecules comprising the A-chain of tissue-type plasminogen activator (t-PA) and the catalytic domain of urokinase-type plasminogen activator (u-PA) have intact enzymatic characteristics of u-PA, partial fibrin-binding properties of t-PA, and thrombolytic properties in animal models comparable with ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.84.3.1216
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Theoretically, the efficacy of continuous warm blood cardioplegia may be improved when administered retrogradely (RCWBC) rather than antegradely (ACWBC) in the setting of acute regional ischemia because of enhanced oxygen and substrate delivery to myocardial tissue distal to an acute coronary artery occlusio...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:To assess the reliability of pediatric echocardiographic measurements, we compared local measurements with those made at a central facility. METHODS AND RESULTS:The comparison was based on the first echocardiographic recording obtained on 735 children of HIV-infected mothers at 10 clinical sites focusing on...
journal_title:Circulation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/01.cir.104.3.310
更新日期:2001-07-17 00:00:00
abstract:BACKGROUND:Since Mexican Americans have adverse patterns of risk factors for myocardial infarction relative to non-Hispanic whites, the incidence of myocardial infarction should be greater among Mexican Americans than among non-Hispanic whites. This expectation conflicts with reports generated from death certificate re...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.95.6.1433
更新日期:1997-03-18 00:00:00
abstract::The effects of verapamil (0.02-0.2 mg/kg) on contractility in normal and partially ischemic myocardium were compared with the changes following propranolol (0.01-1.0 mg/kg). Regional contractile function was studied in open-chest dogs with ultrasonic crystals and ischemia was controlled by graded occlusion of a caroti...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.54.4.629
更新日期:1976-10-01 00:00:00
abstract::We performed transventricular pulmonary valvotomy as initial surgery in 22 consecutive patients with pulmonary atresia and intact ventricular septum who had a patent infundibulum. Nineteen patients also had placement of a central aortopulmonary shunt. All patients survived surgery, and 16 patients have had preoperativ...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND:Angiotensin (Ang) II type 1 receptor (AT1-R) induces cardiomyocyte hypertrophy and fibroblast proliferation, whereas the physiological role of AT2-R in cardiac remodeling remains poorly defined. METHODS AND RESULTS:Using Bio14.6 cardiomyopathic (CM) hamsters, we found that AT2-R sites were increased by 153%...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.11.3954
更新日期:1997-12-02 00:00:00
abstract::Echocardiography and Doppler ultrasound are useful in evaluating a variety of pathological conditions affecting the pericardium. Cardiac tamponade results in right atrial collapse and right ventricular diastolic collapse detectable by echocardiography. These echocardiographic signs have a high degree of sensitivity an...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1991-09-01 00:00:00
abstract::A clinical study was conducted to evaluate the efficacy and safety of percutaneous coronary excimer laser angioplasty in 60 patients with coronary artery disease. Forty-nine patients had stable exertional angina, and 11 patients had unstable angina despite medical therapy. A novel 1.4-mm diameter catheter with 20 quar...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.81.6.1849
更新日期:1990-06-01 00:00:00
abstract::Arterial oxygen transport (cardiac output x arterial oxygen content) may be decreased in heart failure. We studied the determinants of arterial oxygen transport in 15 patients with chronic, severe myocardial failure at rest and during cycle ergometry. During control therapy at rest, arterial oxygen tension was normal ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.66.1.143
更新日期:1982-07-01 00:00:00
abstract:BACKGROUND:In PTCA patients with multivessel coronary artery disease, incomplete revascularization (IR) is the result of both pre-PTCA strategy and initial lesion outcome. The unique contribution of these components on long-term patient outcome is uncertain. METHODS AND RESULTS:From the Bypass Angioplasty Revasculariz...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.100.9.910
更新日期:1999-08-31 00:00:00
abstract:BACKGROUND:Reperfusion injury is insufficiently addressed in current clinical management of acute limb ischemia. Controlled reperfusion carries an enormous clinical potential and was tested in a new reality-driven rodent model. METHODS AND RESULTS:Acute hind-limb ischemia was induced in Wistar rats and maintained for ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.108.787754
更新日期:2008-11-04 00:00:00
abstract:BACKGROUND:Abnormal vascular reactivity represents a fundamental disturbance in vascular biology with the development of atherosclerosis. Because endothelial vasodilator function plays a pivotal role in controlling vasomotor tone, we hypothesized that atherosclerotic wall thickening might directly interfere with defici...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.89.6.2525
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND:This study was performed to determine whether antibodies against the amino-terminus of the beta-chain of fibrin (anti-beta) could noninvasively distinguish actively enlarging thrombi from thrombi stabilized with anticoagulants. METHODS AND RESULTS:Dogs with unilateral femoral vein thrombi were allocated int...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.9.3173
更新日期:1997-11-04 00:00:00
abstract::We studied 14 patients to determine whether sustained-release diltiazem is a satisfactory long-term substitute for the combination of propranolol plus hydrochlorothiazide (HCTZ), control phase, in the treatment of systemic hypertension with coexisting chronic stable angina pectoris. All patients had either one- or two...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND:We hypothesized that during demand ischemia, abnormal perfusion will precede abnormal function, the spatial extent of perfusion abnormality will be greater than that of functional abnormality, and the spatiotemporal disparity between abnormal perfusion and abnormal function will be more marked in the presenc...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc0802.104326
更新日期:2002-02-26 00:00:00
abstract:BACKGROUND:Elevated pulse pressure is associated strongly with adverse cardiovascular outcome; however, the genetic basis of this condition is unknown. This study examined whether genotypic variation in the extracellular matrix protein fibrillin-1, the Marfan gene, was associated with aortic stiffening and therefore co...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/hc0702.104129
更新日期:2002-02-19 00:00:00
abstract::Forty-four patients with acute transmural myocardial infarction underwent cardiac catheterization 4.7 +/- 1.3 hours (+/- SD) after the onset of persistent chest discomfort. Thirty-nine patients had total occlusion of infarct-related vessels; 27 of these 39 had successful intracoronary thrombolysis. Twenty of these 27 ...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1983-08-01 00:00:00
abstract:BACKGROUND:Cardiac growth and function may be modulated in part by trophic effects of neurohormones. Specifically, aldosterone has been shown to stimulate the growth of cardiac myocytes and the accumulation of cardiac extracellular matrix proteins. Moreover, a variant of the aldosterone synthase gene (a cytosine/thymid...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.99.17.2255
更新日期:1999-05-04 00:00:00
abstract:BACKGROUND:Chronic thromboembolic pulmonary hypertension (CTEPH) is a disorder characterized by pulmonary arterial hypertension as a consequence of organized thrombotic material in the central pulmonary arteries. Incomplete resolution of acute pulmonary emboli is believed to be pathogenically important; however, the me...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.86.4.1241
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:In vivo testing of novel antiplatelet agents requires informative biomarkers. By genetically modifying mouse von Willebrand factor (VWF(R1326H)), we have developed a small animal model that supports human but not mouse platelet-mediated thrombosis. Here, we evaluate the use of this biological platform as a p...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.110.951970
更新日期:2011-01-25 00:00:00
abstract:BACKGROUND:Women have a higher operative mortality (OM) after coronary artery bypass graft (CABG) surgery than men. Suggested contributing factors have included women's increased age, advanced disease, comorbidities, and smaller body surface area (BSA). It is unclear whether women's increased risk factors fully account...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.104.525139
更新日期:2005-08-30 00:00:00
abstract:BACKGROUND:Anisotropy creates nonuniformity in electrical propagation and may contribute to the occurrence of unidirectional conduction block and reentry. We describe the characteristics of reentrant tachycardia in a 2D layer of anisotropic ventricular myocardium. METHODS AND RESULTS:A Langendorff-perfused epicardial ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.21.2650
更新日期:2000-11-21 00:00:00