Lack of association between a polymorphism of the aldosterone synthase gene and left ventricular structure.

Abstract:

BACKGROUND:Cardiac growth and function may be modulated in part by trophic effects of neurohormones. Specifically, aldosterone has been shown to stimulate the growth of cardiac myocytes and the accumulation of cardiac extracellular matrix proteins. Moreover, a variant of the aldosterone synthase gene (a cytosine/thymidine exchange at position -344 in the transcriptional regulatory region) has been associated with enlargement and disturbed filling of the left ventricle (LV) in a small sample of young white adults. The aim of the present study was to reinvestigate the implications of aldosterone synthase -344C/T allele status for serum aldosterone levels, blood pressure, and LV structure and function in large population-based samples. METHODS AND RESULTS:Individuals who participated in the echocardiographic substudy of the third MONICA (MONitoring trends and determinants in CArdiovascular disease) survey (n=1445) or in the second follow-up of the first MONICA survey (n=562) were studied by standardized anthropometric, echocardiographic, and biochemical measurements as well as genotyping for aldosterone synthase -344C/T allele status. In both surveys, the distribution of sex, age, arterial blood pressure, and body mass index was homogeneous in the aldosterone synthase genotype groups. Echocardiographic LV wall thicknesses, dimensions, and mass indexes were not significantly associated with a specific aldosterone synthase genotype. Likewise, no association was detectable with echocardiographic measures of LV systolic or diastolic function. Data were consistent in both samples and not materially different in subgroups defined by age, sex, or intake of antihypertensive medication. Finally, no significant association was observed for aldosterone synthase allele status and serum aldosterone levels in the group of 562 individuals. CONCLUSIONS:The data are not in favor of a significant contribution of the C/T exchange at position -344 in the aldosterone synthase transcriptional regulatory region to the variability of serum aldosterone levels, blood pressure, or cardiac size or function as found in 2 white population-based samples.

journal_name

Circulation

journal_title

Circulation

authors

Schunkert H,Hengstenberg C,Holmer SR,Broeckel U,Luchner A,Muscholl MW,Kürzinger S,Döring A,Hense HW,Riegger GA

doi

10.1161/01.cir.99.17.2255

subject

Has Abstract

pub_date

1999-05-04 00:00:00

pages

2255-60

issue

17

eissn

0009-7322

issn

1524-4539

journal_volume

99

pub_type

杂志文章
  • Maximizing survival benefit with primary prevention implantable cardioverter-defibrillator therapy in a heart failure population.

    abstract:BACKGROUND:Although implantable cardioverter-defibrillator (ICD) therapy reduces mortality in moderately symptomatic heart failure patients with an ejection fraction

    journal_title:Circulation

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/CIRCULATIONAHA.108.816884

    authors: Levy WC,Lee KL,Hellkamp AS,Poole JE,Mozaffarian D,Linker DT,Maggioni AP,Anand I,Poole-Wilson PA,Fishbein DP,Johnson G,Anderson J,Mark DB,Bardy GH

    更新日期:2009-09-08 00:00:00

  • Sympathetic nervous system-dependent vasoconstriction in humans. Evidence for mechanistic role of endogenous purine compounds.

    abstract::Purine compounds modulate sympathetic neurotransmission; this modulation decreases nervous discharge by stimulating presynaptic inhibitory adenosine receptors, an effect antagonized by theophylline, and causes vasoconstriction through the stimulation of postsynaptic ATP receptors. In humans we evaluated the effect of ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.82.6.2061

    authors: Taddei S,Pedrinelli R,Salvetti A

    更新日期:1990-12-01 00:00:00

  • Statin-sensitive dysregulated AT1 receptor function and density in hypercholesterolemic men.

    abstract:BACKGROUND:Hypercholesterolemia causes an upregulation of vascular angiotensin II type 1 (AT1) receptor expression in cell culture and animal models. The presented studies were undertaken to examine AT1 receptor overexpression in hypercholesterolemic men and therapeutic interventions thereof by HMG CoA reductase inhibi...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.100.21.2131

    authors: Nickenig G,Bäumer AT,Temur Y,Kebben D,Jockenhövel F,Böhm M

    更新日期:1999-11-23 00:00:00

  • Environmental tobacco smoke and coronary heart disease in the American Cancer Society CPS-II cohort.

    abstract:BACKGROUND:Thirteen of 14 epidemiological studies have shown an increased risk of approximately 20% for coronary heart disease (CHD) for never-smokers exposed to environmental tobacco smoke (ETS), but this association remains controversial. If true, ETS might account for an estimated 35,000 to 40,000 heart disease deat...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.94.4.622

    authors: Steenland K,Thun M,Lally C,Heath C Jr

    更新日期:1996-08-15 00:00:00

  • Morphological observations late (greater than 30 days) after clinically successful coronary balloon angioplasty.

    abstract::This report describes clinical, morphological, and histological findings late (1.6-24.1 months [average, 8.2 months]) after clinically successful coronary balloon angioplasty in 20 necropsied patients with coronary angioplasty restenosis. Clinical evidence of restenosis occurred in 14 (70%) of patients, including six ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Waller BF,Pinkerton CA,Orr CM,Slack JD,VanTassel JW,Peters T

    更新日期:1991-02-01 00:00:00

  • Cytomegalovirus infection with interleukin-6 response predicts cardiac mortality in patients with coronary artery disease.

    abstract:BACKGROUND:Prospective data relating previous exposure to cytomegalovirus (CMV) to the risk of cardiac mortality are controversial. We investigated the effect of previous exposure to CMV infection on the risk of future cardiac disease-related death in relation to an underlying inflammatory response. METHODS AND RESULT...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.cir.103.24.2915

    authors: Blankenberg S,Rupprecht HJ,Bickel C,Espinola-Klein C,Rippin G,Hafner G,Ossendorf M,Steinhagen K,Meyer J

    更新日期:2001-06-19 00:00:00

  • Loss of Mdm4 results in p53-dependent dilated cardiomyopathy.

    abstract:BACKGROUND:Although several loci for familial dilated cardiomyopathy (DCM) have been mapped, the origin of a large percentage of DCM remains unclear. Mdm2, a p53-negative regulator, protects cardiomyocytes from ischemic and reperfusion-induced cell death. Mdm4, a homolog of Mdm2, inhibits p53 activity in numerous cell ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.107.689901

    authors: Xiong S,Van Pelt CS,Elizondo-Fraire AC,Fernandez-Garcia B,Lozano G

    更新日期:2007-06-12 00:00:00

  • Regulation of shear stress in the canine coronary microcirculation.

    abstract:BACKGROUND:Physical forces, such as pressure and flow, are well known to affect vascular function in the coronary circulation. Increases in shear stress produce vasodilation in coronary arterioles in vitro, and constant-flow preparations suggest a role for shear stress-induced vasodilation during adjustments to metabol...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.100.14.1555

    authors: Stepp DW,Nishikawa Y,Chilian WM

    更新日期:1999-10-05 00:00:00

  • Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms.

    abstract:BACKGROUND:Proprotein convertase subtilisin kexin type 9 (PCSK9) promotes the degradation of the low-density lipoprotein (LDL) receptor (LDLR), and its deficiency in humans results in low plasma LDL cholesterol and protection against coronary heart disease. Recent evidence indicates that PCSK9 also modulates the metabo...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.113.006720

    authors: Rashid S,Tavori H,Brown PE,Linton MF,He J,Giunzioni I,Fazio S

    更新日期:2014-07-29 00:00:00

  • Effect of latissimus dorsi dynamic cardiomyoplasty on ventricular function.

    abstract::In our approach to dynamic cardiomyoplasty, which consists of wrapping a skeletal muscle around the heart and stimulating the former in synchrony with heart contractions to augment ventricular contractility, we have transferred a latissimus dorsi muscle flap to the heart by way of a partial resection of the second rib...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Chachques JC,Grandjean P,Schwartz K,Mihaileanu S,Fardeau M,Swynghedauw B,Fontaliran F,Romero N,Wisnewsky C,Perier P

    更新日期:1988-11-01 00:00:00

  • Predictive value of noninvasive measures of atherosclerosis for incident myocardial infarction: the Rotterdam Study.

    abstract:BACKGROUND:Several noninvasive methods are available to investigate the severity of extracoronary atherosclerotic disease. No population-based study has yet examined whether differences exist between these measures with regard to their predictive value for myocardial infarction (MI) or whether a given measure of athero...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000120708.59903.1B

    authors: van der Meer IM,Bots ML,Hofman A,del Sol AI,van der Kuip DA,Witteman JC

    更新日期:2004-03-09 00:00:00

  • Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice.

    abstract:BACKGROUND:The lysyl oxidases are extracellular copper enzymes that initiate the crosslinking of collagens and elastin, 5 human isoenzymes having been characterized so far. The crosslinks formed provide the tensile strength and elastic properties for various extracellular matrices, including vascular walls. We studied ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.0000038109.84500.1e

    authors: Mäki JM,Räsänen J,Tikkanen H,Sormunen R,Mäkikallio K,Kivirikko KI,Soininen R

    更新日期:2002-11-05 00:00:00

  • Trans-fatty acids intake and risk of myocardial infarction.

    abstract:BACKGROUND:Concern that trans-fatty acids formed in the partial hydrogenation of vegetable oils may increase the risk of coronary disease has existed for several decades, but direct evidence on this relation in humans is limited. METHODS AND RESULTS:With a case-control design, we studied the association between intake...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.89.1.94

    authors: Ascherio A,Hennekens CH,Buring JE,Master C,Stampfer MJ,Willett WC

    更新日期:1994-01-01 00:00:00

  • Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines.

    abstract:BACKGROUND:Bone marrow implantation (BMI) was shown to enhance angiogenesis in a rat ischemic heart model. This preclinical study using a swine model was designed to test the safety and therapeutic effectiveness of BMI. METHODS AND RESULTS:BM-derived mononuclear cells (BM-MNCs) were injected into a zone made ischemic ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/hc3501.093817

    authors: Kamihata H,Matsubara H,Nishiue T,Fujiyama S,Tsutsumi Y,Ozono R,Masaki H,Mori Y,Iba O,Tateishi E,Kosaki A,Shintani S,Murohara T,Imaizumi T,Iwasaka T

    更新日期:2001-08-28 00:00:00

  • Transluminal stent-graft placements for the treatments of acute onset and chronic aortic dissections.

    abstract:BACKGROUND:Transluminal stent-graft placement (TSGP) for aortic dissection is a relatively new procedure. We performed TSGPs to seal the primary entry site to treat and prevent complications of aortic dissection. The early to mid-term outcomes were analyzed. METHODS AND RESULTS:Thirty-seven patients with a primary int...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:

    authors: Shimono T,Kato N,Yasuda F,Suzuki T,Yuasa U,Onoda K,Hirano T,Takeda K,Yada I

    更新日期:2002-09-24 00:00:00

  • Prioritizing Functional Capacity as a Principal End Point for Therapies Oriented to Older Adults With Cardiovascular Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association.

    abstract::Adults are living longer, and cardiovascular disease is endemic in the growing population of older adults who are surviving into old age. Functional capacity is a key metric in this population, both for the perspective it provides on aggregate health and as a vital goal of care. Whereas cardiorespiratory function has ...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:10.1161/CIR.0000000000000483

    authors: Forman DE,Arena R,Boxer R,Dolansky MA,Eng JJ,Fleg JL,Haykowsky M,Jahangir A,Kaminsky LA,Kitzman DW,Lewis EF,Myers J,Reeves GR,Shen WK,American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and St

    更新日期:2017-04-18 00:00:00

  • Body-surface maps of heart potentials: tentative localization of pre-excited areas in forty-two Wolff-Parkinson-White patients.

    abstract::Heart potentials were recorded from the entire chest surface in 42 patients suffering from Wolff-Parkinson-White syndrome. We were able to identify six types of surface maps, according to the location of the potential maximum and minimum during the delta wave. For each of these types we suggested the most likely locat...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.54.2.251

    authors: De Ambroggi L,Taccardi B,Macchi E

    更新日期:1976-08-01 00:00:00

  • Calcium antagonists and hypothermia: the temperature dependency of the negative inotropic and anti-ischemic properties of verapamil in the isolated rat heart.

    abstract::Using an isolated rat heart preparation under both aerobic and ischemic conditions we have characterized the temperature dependency of the slow calcium channel-blocking drug verapamil. In the first series of studies, isolated working rat hearts were subjected to global ischemia at 37 degrees, 34 degrees, 31 degrees, 2...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Hearse DJ,Yamamoto F,Shattock MJ

    更新日期:1984-09-01 00:00:00

  • Thromboxane A2, prostacyclin and aspirin: effects on vascular tone and platelet aggregation.

    abstract::Novel compounds that induce or inhibit platelet aggregation and constrict or dilate blood vessels were recently discovered. These compounds are all derivatives of arachidonic acid and include prostaglandin endoperoxides, thromboxane A2, prostaglandin E2, prostaglandin D2 and prostacyclin. Thromboxane A2 (TxA2) could b...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:

    authors: Smith JB,Araki H,Lefer AM

    更新日期:1980-12-01 00:00:00

  • The epidemiology of plasma high-density lipoprotein cholesterol levels. The Lipid Research Clinics Program Prevalence Study. Summary.

    abstract::Correlates of high-density lipoprotein (HDL) cholesterol levels were studied in 4756 white males and females ages 20-59 years examined during a population survey conducted by 10 North American Lipid Research Clinics. Multivariable analysis was used to assess the relation of social, demographic, physical and behavioral...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Heiss G,Johnson NJ,Reiland S,Davis CE,Tyroler HA

    更新日期:1980-11-01 00:00:00

  • Continuous recording of direct arterial pressure in unrestricted patients. Its role in the diagnosis and management of high blood pressure.

    abstract::We have compared casual indirect measurements of arterial pressure obtained 1) by the general practitioner (GP) and 2) in the outpatient clinic (OPC) with 24 hour continuous recording of direct arterial pressure in two selected group of unrestricted patients. 1) Eight asymptomatic, untreated patients with suspected hy...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.51.6.1101

    authors: Littler WA,Honour AJ,Pugsley DJ,Sleight P

    更新日期:1975-06-01 00:00:00

  • Metabolic Predictors of Incident Coronary Heart Disease in Women.

    abstract:BACKGROUND:Although metabolomic profiling offers promise for the prediction of coronary heart disease (CHD), and metabolic risk factors are more strongly associated with CHD in women than men, limited data are available for women. METHODS:We applied a liquid chromatography-tandem mass spectrometry metabolomics platfor...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1161/CIRCULATIONAHA.117.029468

    authors: Paynter NP,Balasubramanian R,Giulianini F,Wang DD,Tinker LF,Gopal S,Deik AA,Bullock K,Pierce KA,Scott J,Martínez-González MA,Estruch R,Manson JE,Cook NR,Albert CM,Clish CB,Rexrode KM

    更新日期:2018-02-20 00:00:00

  • Association of fibrinogen with cardiovascular risk factors and cardiovascular disease in the Framingham Offspring Population.

    abstract:BACKGROUND:Fibrinogen has been identified as an independent risk factor for cardiovascular disease and associated with traditional cardiovascular risk factors. Also, the role of elevated fibrinogen in thrombosis suggests that it may be on the causal pathway for certain risk factors to exert their effect. These associat...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.102.14.1634

    authors: Stec JJ,Silbershatz H,Tofler GH,Matheney TH,Sutherland P,Lipinska I,Massaro JM,Wilson PF,Muller JE,D'Agostino RB Sr

    更新日期:2000-10-03 00:00:00

  • Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults.

    abstract:BACKGROUND:Aging results in vascular stiffening and an increase in the velocity of the pressure wave as it travels down the aorta. Increased aortic pulse wave velocity (aPWV) has been associated with mortality in clinical but not general populations. The objective of this investigation was to determine whether aPWV is ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.104.483628

    authors: Sutton-Tyrrell K,Najjar SS,Boudreau RM,Venkitachalam L,Kupelian V,Simonsick EM,Havlik R,Lakatta EG,Spurgeon H,Kritchevsky S,Pahor M,Bauer D,Newman A,Health ABC Study.

    更新日期:2005-06-28 00:00:00

  • Validation of the Bleeding Academic Research Consortium definition of bleeding in patients with coronary artery disease undergoing percutaneous coronary intervention.

    abstract:BACKGROUND:The Bleeding Academic Research Consortium (BARC) has recently proposed a unified definition of bleeding in patients receiving antithrombotic therapy. We investigated the relationship between bleeding events as defined by BARC and 1-year mortality in patients undergoing percutaneous coronary intervention (PCI...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/CIRCULATIONAHA.111.060871

    authors: Ndrepepa G,Schuster T,Hadamitzky M,Byrne RA,Mehilli J,Neumann FJ,Richardt G,Schulz S,Laugwitz KL,Massberg S,Schömig A,Kastrati A

    更新日期:2012-03-20 00:00:00

  • Population characteristics according to recruitment source.

    abstract::Considerable variability was observed among recruitment sources and centers in the proportion of first protocol visits proceeding to entry. Some of the reasons for these differences are explored. Several characteristics of the participants were also analyzed to determine whether significant variability existed among r...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Hunninghake DB,Knoke J,LaDouceur M,Peterson F

    更新日期:1982-12-01 00:00:00

  • Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe-/- Mice.

    abstract:BACKGROUND:Altered composition of the gut microbiota is involved in both the onset and progression of obesity and diabetes mellitus. However, the link between gut microbiota and obesity-related cardiovascular complications has not been explored. The present study was designed to investigate the role of Akkermansia muci...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.115.019645

    authors: Li J,Lin S,Vanhoutte PM,Woo CW,Xu A

    更新日期:2016-06-14 00:00:00

  • Influence of implantable cardioverter-defibrillators on the long-term prognosis of survivors of out-of-hospital cardiac arrest.

    abstract:BACKGROUND:Survivors of out-of-hospital cardiac arrest not associated with acute myocardial infarction are at high risk for recurrent cardiac arrest and sudden cardiac death. The impact of the implantable cardioverter-defibrillator on long-term prognosis in these patients is uncertain. METHODS AND RESULTS:Three hundre...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.88.3.1083

    authors: Powell AC,Fuchs T,Finkelstein DM,Garan H,Cannom DS,McGovern BA,Kelly E,Vlahakes GJ,Torchiana DF,Ruskin JN

    更新日期:1993-09-01 00:00:00

  • Identification of Long Noncoding RNA H19 as a New Biomarker and Therapeutic Target in Right Ventricular Failure in Pulmonary Arterial Hypertension.

    abstract:BACKGROUND:Right ventricular (RV) function is the major determinant for both functional capacity and survival in patients with pulmonary arterial hypertension (PAH). Despite the recognized clinical importance of preserving RV function, the subcellular mechanisms that govern the transition from a compensated to a decomp...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.120.047626

    authors: Omura J,Habbout K,Shimauchi T,Wu WH,Breuils-Bonnet S,Tremblay E,Martineau S,Nadeau V,Gagnon K,Mazoyer F,Perron J,Potus F,Lin JH,Zafar H,Kiely DG,Lawrie A,Archer SL,Paulin R,Provencher S,Boucherat O,Bonnet S

    更新日期:2020-10-13 00:00:00

  • Transmembrane potential properties at the core of functional reentrant wave fronts in isolated canine right atria.

    abstract:BACKGROUND:The characteristics of transmembrane potential (TMP) at the core of functional reentry in the atrium are not well understood. METHODS AND RESULTS:In protocol 1 (11 dogs), isolated perfused canine right atria were mapped from the endocardial surface while simultaneous TMPs were recorded from the epicardial s...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.98.15.1556

    authors: Athill CA,Ikeda T,Kim YH,Wu TJ,Fishbein MC,Karagueuzian HS,Chen PS

    更新日期:1998-10-13 00:00:00